Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways by W. Nie, A. M. Deters

“…TSw and TSc predominantly enhanced the phosphorylation of molecules that referred to Erk signaling in NHEK. In NHDF parts of the integrin signaling and SAPK/JNK pathway were affected. …”
Get full text

Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease by Jason P. Weick

“…These features critically depend on the coordinated expression and localization of hundreds of ion channels and receptors, as well as scaffolding and signaling molecules. In this review I will highlight the current state of knowledge regarding functional properties of human stem cell-derived neurons, with a primary focus on pluripotent stem cells. …”
Get full text

The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants by Dala N. Daraghmeh, Rafik Karaman

“…These systems are generally referred to as oxidant scavengers or antioxidants, and they work to neutralize these harmful molecules (i.e., oxidants). While their antioxidative capabilities are essential to their physiological functions and delivering oxygen to tissues, their pro-oxidant behavior plays a part in several human pathologies. …”
Get full text

Caffeine-Induced Suppression of GABAergic Inhibition and Calcium-Independent Metaplasticity by Masako Isokawa

“…Recent evidence suggests the elevation of intracellular calcium ([Ca2+]i) and calcium-dependent signaling molecules underlie the modulations. Caffeine induces a release of calcium from intracellular stores. …”
Get full text

Early Growth Response Genes Signaling Supports Strong Paracrine Capability of Mesenchymal Stem Cells by Kenichi Tamama, Dominique J. Barbeau

“…EGR2 appears to regulate the expression of immunomodulatory molecules. Chronic nonhealing wounds are ischemic, inflammatory, and often fibrotic, and the hypoxic micro-environment of these wounds may compromise MSCs' wound healing properties in vivo by upregulating the EGR1's fibrogenic effects and downregulating the EGR2's immuno-modulatory effects. …”
Get full text

The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis by Mohsin H. K. Roshan, Amos Tambo, Nikolai P. Pace

“…TLRs recruit adaptor molecules, including myeloid differentiation primary response protein (MYD88) and TIRF-related adaptor protein (TRAM), to mediate activation of MAPKs and NF-kappa B pathways. …”
Get full text

Screening of a Novel Peptide Targeting the Proteoglycan-Like Region of Human Carbonic Anhydrase IX by Shoaib Rana, Felix Nissen, Thomas Lindner, Annette Altmann, Walter Mier, Juergen Debus, Uwe Haberkorn, Vasileios Askoxylakis

“…The aim of the present study was the development of novel molecules with specificity for PGLR, which may be used for tumor targeting and imaging. …”
Get full text

Age-related features of the pattern of oral fluid patients with non-alcoholic fatty liver disease by Nataliya Emelyanova, Dmitry Emelyanov

“…The metabolic dysfunction negatively affect the organization of protein molecules and the formation of marginal zone in which pathology markers are spread – fissures, wrinkles, pigment inclusions. …”
Get full text

FTIR Analysis of Pesticide Active Ingredients into Seasonal Vegetables: Ensuring Food Safety and Raising Awareness by Md. Mejbah Uddin Mithu, Sadia Akter Shormela

“…It is crucial to limit and avoid misuse and overdose of pesticides in vegetables to prevent the distribution of pesticide molecules and prevent acute and chronic health complications.…”
Get full text

Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis by Qinghua Fang, Jiaxin Ou, Kutty Selva Nandakumar

“…Interplay between several molecules (cytokines, chemokines, proteases, and inflammatory mediators) culminates in causing damage to the articular cartilage and bones. …”
Get full text

Targeting glycolysis: exploring a new frontier in glioblastoma therapy by Lu Yang, Sijia Li, Lei Yu, Jiao Leng, Na Li

“…Additionally, this review systematically analyzes potential therapeutic strategies targeting key molecules within the glycolytic pathway, such as Glucose Transporters (GLUTs), Monocarboxylate Transporters(MCTs), Hexokinase 2 (HK2), 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3), Pyruvate Kinase Isozyme Type M2 (PKM2), and the Lactate Dehydrogenase A (LDHA). …”
Get full text

Molecular–Genetic Imaging: A Nuclear Medicine–Based Perspective by Ronald G. Blasberg, Juri Gelovani Tjuvajev

“…Nuclear-based molecular imaging can be viewed in terms of three different imaging strategies: (1) “indirect” reporter gene imaging; (2) “direct” imaging of endogenous molecules; or (3) “surrogate” or “bio-marker” imaging. …”
Get full text

Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment by Wu S, Hu Y, Sui B

“…The tumor microenvironment (TME), composed of tumor cells, stromal cells, extracellular matrix, surrounding blood vessels, and other signaling molecules, plays a pivotal role in the development of lung cancer. …”
Get full text

Graph Energy Variants and Topological Indices in Platinum Anticancer Drug Design: Mathematical Insights and Computational Analysis with DFT and QTAIM by Suha Wazzan, Nurten Urlu Ozalan

“…Quantum theory of atoms in molecules QTAIM was carried out at the bond critical point BCP, to reveal the nature of the intermolecular interactions in the investigated ten Pt anticancer drugs, especially, the nature of bonds between Pt atoms and their bond atoms. …”
Get full text

Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs by Kiana Sojoudi, Maryam Solaimani, Hossein Azizi

“…Exosomes, which carry a variety of molecules such as proteins, lipids, DNA, and non-coding RNAs, have recently emerged as promising tools for early cancer detection. …”
Get full text

Antibodies Recognizing Yersinia enterocolitica Lipopolysaccharides of Various Chemotypes in Synovial Fluids From Patients With Juvenile Idiopathic Arthritis by Katarzyna Kasperkiewicz, Anna S. Świerzko, Mateusz Michalski, Łukasz Eppa, Mikael Skurnik, Zbigniew Żuber, Maciej Cedzyński

“…Interestingly, YeO3 wild-type LPS was processed by host cells, resulting in truncated LPS molecules presenting the core region. Previously, we reported the immunogenicity but not adjuvanticity of YeO3 LPSs of wild (S) type, Ra, Rd, or Re chemotypes in mice. …”
Get full text

The effect of surface texturing in the sliding surface on tribological characteristics of alloy steel under wet condition by H. S. Patil, D. C. Patel

“…Surface texturing may act as wear debris trapper, lubricant reservoirs, hydrodynamic lift, and retarding the lubricant molecules flow in a particular path where potential exists. …”
Get full text

FTIR and Raman Spectroscopy Study of Soot Deposits Produced in the Infrared Multiphoton Dissociation of Vinyl Bromide by B. Samoudi, O. Bendaou, I. Hanafi, A. Asselman, K. Haboubi

“…Using a CO2 photolysis laser, the samples were obtained via infrared multiphoton dissociation (IRMPD) of vinyl bromide (VBr, C2H3Br) molecules. The solid deposit formed in the IRMPD of VBr when a relatively high fluence of the order of 204 J.cm−2 was analyzed by FTIR, and it was discovered that the majority of its composition is aromatic and aliphatic hydrocarbons. …”
Get full text

Red-Shifted Aequorin-Based Bioluminescent Reporters for in Vivo Imaging of Ca Signaling by Thomas Curie, Kelly L. Rogers, Cesare Colasante, Philippe BrûClet

“…VA and RA will therefore improve optical access to Ca 2+ signaling events in deeper tissues, such as the heart and brain, and offer insight for engineering new hybrid molecules.…”
Get full text

Induction of systemic resistance through calcium signaling in Arabidopsis exposed to air plasma-generated dinitrogen pentoxide. by Shota Sasaki, Hiroto Iwamoto, Keisuke Takashima, Masatsugu Toyota, Atsushi Higashitani, Toshiro Kaneko

“…Plasma technology, which can instantaneously transform air molecules into reactive species stimulating plants, potentially contributes to developing a sustainable agricultural system with high productivity and low environmental impact. …”
Get full text