New Discoveries in Enantiomeric Separation of Racemic Tofisopam by Miklós Hunor Bosits, Emese Pálovics, János Madarász, Elemér Fogassy

“…Opposed to previous assumptions, we have actually found that a different solvate composition, (R)-TOF‐(R,R)-DBTA-CHCl3, forms with chloroform, in which molecules of CHCl3 are captured and held with different strengths. …”
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Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue by Josep Mercader, Zsuzsa Iffiú-Soltész, Sandy Bour, Christian Carpéné

“…Although SSAO physiological functions remain unclear, several molecules inhibiting its activity have been described to limit fat accumulation in preadipocyte cultures or to reduce body weight gain in obese rodents. …”
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The Role of NK Cells in Pig-to-Human Xenotransplantation by Gisella Puga Yung, Mårten K. J. Schneider, Jörg D. Seebach

“…Specific molecular strategies to overcome human anti-pig NK cell responses include (1) blocking of the molecular events leading to recruitment (chemotaxis, adhesion, and transmigration), (2) expression of human MHC class I molecules on pECs that inhibit NK cells, and (3) elimination or blocking of pig ligands for activating human NK receptors. …”
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Organic Photovoltaic Cells Based on PbPc Nanocolumns Prepared by Glancing Angle Deposition by Yang Liu, Fujun Zhang, Jian Wang

“…It is worthwhile to mention that C60 molecules firstly fill the voids between PbPc nanocolumns and then form impact C60 layer. …”
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Opportunities for gas-phase science at short-wavelength free-electron lasers with undulator-based polarization control by Markus Ilchen, Enrico Allaria, Primož Rebernik Ribič, Heinz-Dieter Nuhn, Alberto Lutman, Evgeny Schneidmiller, Markus Tischer, Mikail Yurkov, Marco Calvi, Eduard Prat, Sven Reiche, Thomas Schmidt, Gianluca Aldo Geloni, Suren Karabekyan, Jiawei Yan, Svitozar Serkez, Zhangfeng Gao, Bangjie Deng, Chao Feng, Haixiao Deng, Wolfram Helml, Lars Funke, Mats Larsson, Vitali Zhaunerchyk, Michael Meyer, Tommaso Mazza, Till Jahnke, Reinhard Dörner, Francesca Calegari, Olga Smirnova, Caterina Vozzi, Giovanni De Ninno, Jonas Wätzel, Jamal Berakdar, Sadia Bari, Lucas Schwob, Jérémy R. Rouxel, Shaul Mukamel, Klaus Bartschat, Kathryn Hamilton, Luca Argenti, Nicolas Douguet, Nikolay M. Novikovskiy, Philipp V. Demekhin, Peter Walter

“…A core aspect of FEL science is the study of isolated and prototypical systems in the gas phase with the possibility of addressing well-defined electronic transitions or particular atomic sites in molecules. Notably for polarization-controlled short-wavelength FELs, the gas phase offers new avenues for investigations of nonlinear and ultrafast phenomena in spin-orientated systems, for decoding the function of the chiral building blocks of life as well as steering reactions and particle emission dynamics in otherwise inaccessible ways. …”
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Effects of Hydrophobic Nanospaces on Structures of Lysozyme by Koki Takenaka, Tomonori Ohaba, Kazuo Takei, Kuniko Akama, Joaquin Silvestre-Albero, Hirofumi Kanoh

“…However, because the size of lysozyme is less than 5 nm in length, this adsorption behaviour suggests that lysozyme molecules may associate with one another to form clusters on mesopores of CAs. …”
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Muscle Satellite Cells: Exploring the Basic Biology to Rule Them by Camila F. Almeida, Stephanie A. Fernandes, Antonio F. Ribeiro Junior, Oswaldo Keith Okamoto, Mariz Vainzof

“…Every phase of satellite cell activity is highly regulated and orchestrated by many molecules and signaling pathways; the elucidation of players and mechanisms involved in satellite cell biology is of extreme importance, being the first step to expose the crucial points that could be modulated to extract the optimal response from these cells in therapeutic strategies. …”
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Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults by Wellington F. Rodrigues, Camila B. Miguel, Ferdinando Agostinho, Gabriela V. da Silva, Javier E. Lazo-Chica, Sandra M. Naressi Scapin, Marcelo H. Napimoga, Carlos A. Trindade-da-Silva, José E. Krieger, Alexandre da Costa Pereira, Carlo J. Freire Oliveira, Siomar de Castro Soares, Carlos Ueira-Vieira

“…Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. …”
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Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis by Maria Eduarda Souza Guerra, Giulia Destro, Brenda Vieira, Alice S. Lima, Lucio Fabio Caldas Ferraz, Anders P. Hakansson, Michelle Darrieux, Thiago Rojas Converso

“…A great number of factors contribute to biofilm establishment and maintenance in K. pneumoniae, which highlights the importance of this mechanism for the bacterial fitness. Some of these molecules could be used in future vaccines against this bacterium. …”
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Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy by Ting Gong, Boon Chin Heng, Edward Chin Man Lo, Chengfei Zhang

“…This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. …”
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Classification of Coffee Beans by GC-C-IRMS, GC-MS, and 1H-NMR by Victoria Andrea Arana, Jessica Medina, Pierre Esseiva, Diego Pazos, Julien Wist

“…Although statistically significant information could be obtained by all three methods, the results show that the quality of the classifiers depends mainly on the number of variables included in the analysis; hence NMR provides an advantage since more molecules are detected to obtain a model with better predictions.…”
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A Novel ZnO-Methylene Blue Nanocomposite Matrix for Biosensing Application by Shibu Saha, S. K. Arya, S. P. Singh, Vinay Gupta

“…The low oxidation potential (−0.23 V) of the hybrid bioelectrode, in a mediatorless electrolyte, makes it resistant against interference from other bio-molecules. The low value of Michaelis-Menten constant (2.65 mM) indicates that immobilized GOx retains its enzymatic activity significantly on the surface of nanocomposite hybrid matrix that results in an enhanced affinity towards its substrate (glucose). …”
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Synthesis, Anti-Inflammatory Activity, and Docking Simulation of a Novel Styryl Quinolinium Derivative by Mina Todorova, Rumyana Bakalska, Mehran Feizi-Dehnayebi, Ghodsi Mohammadi Ziarani, Mina Pencheva, Kirila Stojnova, Miglena Milusheva, Paraskev Nedialkov, Emiliya Cherneva, Tsonko Kolev, Stoyanka Nikolova

“…Stilbenes, like resveratrol, are natural small molecules with several applications in the treatment of chronic illnesses, diabetes, and neurological and cardiovascular conditions. …”
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Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis by Raghu Adya, Bee K. Tan, Harpal S. Randeva

“…Adiponectin, circulating at a much higher concentration, exists in different molecular weight forms, essentially made up of the collagenous fraction and a globular domain, the latter being investigated minimally for its involvement in proinflammatory processes including activation of NF-κβ and endothelial adhesion molecules. The opposing actions of the two forms of adiponectin in endothelial cells have been recently demonstrated. …”
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How mechanochemistry affects the composition and properties of disordered fluorite BaSnF4? by Mercadier, Briséïs, Legein, Christophe, Duttine, Mathieu, Body, Monique, Gutierrez, Ana Gabriela Porras, Leclerc, Sandrine, Lebedev, Oleg,  Masquelier, Christian, Dambournet, Damien

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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…Specifically, compared to the lipopolysaccharide stimulation group, 4-OI reduced the levels of positive regulatory factors of Th17 cell differentiation (IL-1: p < 0.001, IL-6: p < 0.001), key effector molecules (IL-17A: p < 0.001, IL-17F: p = 0.004), and downstream effector molecules in the IL-17 signaling pathway (CCL2: p < 0.001, MMP13: p < 0.001). …”
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Mechanism of Delaying Cartilage Degeneration in Knee Osteoarthritis with Rongjin Niantong Recipe Based on lncRNA NEAT1 and Nrf2/ARE Pathway by FU Changlong, XIE Xinyu, QIU Zhiwei, HUANG Yanfeng, JIN Linglu, LI Xihai

“…The mechanism may be related to the down-regulation of lncRNA NEAT1 level, up-regulation of Nrf2 signal and antioxidant signal molecules expressions, and down-regulation of pro-oxidation signal molecules and inhibition of oxidative stress level.…”
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Use of Autoantibodies to Detect the Onset of Breast Cancer by Jérôme Lacombe, Alain Mangé, Jérôme Solassol

“…We will focus on these molecules highlighted in the past two years and discuss the potential future use of autoantibodies as biomarkers of early-stage breast cancer.…”
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One-Pot Synthesis, X-Ray Diffraction and MAS NMR Spectroscopic Study of Gallosilicate Nitrate Cancrinite Na8[GaSiO4]6(NO3)4(H2O)6 by Ashok V. Borhade, Sanjay G. Wakchaure

“…A distribution of the quadrupolar interaction of the sodium cations caused by the enclatherated water molecules and motional effects can be suggested from the 23Na MAS NMR. …”
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Computational Modeling and Theoretical Calculations on the Interactions between Spermidine and Functional Monomer (Methacrylic Acid) in a Molecularly Imprinted Polymer by Yujie Huang, Qiujin Zhu

“…At 1 : 5 SPD to MAA ratio, the binding energy is minimum, while the amount of transferred charge between the molecules is maximum; SPD and MAA form a stable complex at 1 : 5 molar ratio through six hydrogen bonds. …”
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