Network Medicine‐Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD‐L1 Expression via Targeting SPOP in Cancer by Saisai Tian, Mengting Xu, Xiangxin Geng, Jiansong Fang, Hanchen Xu, Xinying Xue, Hongmei Hu, Qing Zhang, Dianping Yu, Mengmeng Guo, Hongwei Zhang, Jinyuan Lu, Chengyang Guo, Qun Wang, Sanhong Liu, Weidong Zhang

“…Abstract Immune checkpoint inhibitors (ICIs) are drugs that inhibit immune checkpoint (ICP) molecules to restore the antitumor activity of immune cells and eliminate tumor cells. …”
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Inertial Memory Effects in Molecular Transport Across Nanoporous Membranes by Slobodanka Galovic, Milena Čukić, Dalibor Chevizovich

“…It has been demonstrated that both causal models, one with exponentially fading inertial memory and the other with power-law fading memory, predict that the concentration perturbation propagates as a damped wave, leading to an increased time required for the cumulative amount of molecules passing through the membrane to reach a steady state compared to the classical model. …”
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Investigation of the Influence of Atmospheric Scattering on Photolysis Rates Using the Cloud-J Module by Anastasia Imanova, Eugene Rozanov, Sergei Smyshlyaev, Vladimir Zubov, Tatiana Egorova

“…This study analyses the wide-band algorithm, Cloud-J v.8.0, from the point of view of the validity of the choice of wide spectral intervals to accelerate the calculations of photolysis rates in the lower and middle atmosphere, considering the features of solar radiation propagation, and to assess the influence of the processes of reflection and scattering on molecules, aerosols, and clouds. The results show that the calculations performed using Cloud-J v.8.0 are in agreement with the data obtained using the high-resolution LibRadtran model. …”
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Tissue‐resident memory T cells in diseases and therapeutic strategies by Daoyuan Xie, Guanting Lu, Gang Mai, Qiuyan Guo, Guofeng Xu

“…Their unique retention and activation mechanisms, including interactions with local epithelial cells and the expression of adhesion molecules, enable their persistence and immediate functionality in diverse tissues. …”
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Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives by Amit Pithadia, Jeffrey R. Brender, Carol A. Fierke, Ayyalusamy Ramamoorthy

“…Furthermore, we have outlined possible mechanistic discoveries of the interaction of these small molecules with the peptide and how they may mitigate toxicity associated with peptide aggregation. …”
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Entire Irregularity Indices: A Comparative Analysis and Applications by Anwar Saleh, Samirah Alsulami, Maryam Alsulami

“…Specific expressions for these indices are derived for various molecular structures, such as bridge molecules, polyomino chains of n-cycles, triangular benzenoid graphs, graphene, and dendrimer stars <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>D</mi><mn>3</mn></msub><mrow><mo>[</mo><mi>n</mi><mo>]</mo></mrow></mrow></semantics></math></inline-formula>. …”
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Killer-Cell Inhibitory Receptors, CD158a/b, are Upregulated by Interleukin-2, but not Interferon-γ or Interleukin-4 by Toshiaki Kogure, Hiroshi Fujinaga, Atsushi Niizawa, Le Xuan Hai, Yutaka Shimada, Hiroshi Ochiai, Katsutoshi Terasawa

“…These findings suggest that IL-2 plays an important role in the regulation of CD158a/b expression, and might be involved in controlling NK activity via regulating expression of these molecules.…”
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Molecular Imaging of IGF-1R in Cancer by Yingying Sun PhD, Xilin Sun PhD, Baozhong Shen MD, PhD

“…In this review, we will summarize the current status of IGF-1R molecular imaging in cancer, in which 5 major classes of ligands that have been developed for noninvasive IGF-1R molecular imaging will be discussed: natural ligands, monoclonal antibodies, antibody fragments, affibodies, and small molecules. For decades, IGF-1R molecular imaging is studied in full swing and more effort is needed in the future.…”
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Emerging Pollutants in Moroccan Wastewater: Occurrence, Impact, and Removal Technologies by Yassine Jari, Nicolas Roche, Mohamed Chaker Necibi, Souad El Hajjaji, Driss Dhiba, Abdelghani Chehbouni

“…In order to improve the understanding of emerging pollutants, this review discusses the source, occurrence, and impacts of bisphenol A, atrazine, amoxicillin, and paracetamol as model molecules of emerging environmental pollutants, an issue that remains underrepresented in Morocco. …”
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An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity by Chun-Bing Chen, Riichiro Abe, Ren-You Pan, Chuang-Wei Wang, Shuen-Iu Hung, Yi-Giien Tsai, Wen-Hung Chung

“…The drug presentation models that explain how small drug antigens might interact with HLA and T cell receptor (TCR) molecules in drug hypersensitivity include the hapten theory, the p-i concept, the altered peptide repertoire model, and the altered TCR repertoire model. …”
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Unveiling the role of lncRNA ERDR1 in immune cell regulation by Aihua Shu, Xu Tian, Jie Yue, Yuxia Jiang, Yifei Liu

“…Long non-coding RNAs (lncRNAs) are a class of RNA molecules that exceed 200 nucleotides in length and lack the capacity to encode proteins. …”
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Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia by Yasunori Sato, Kenichi Harada, Motoko Sasaki, Yasuni Nakanuma

“…For mucin staining, Alcian blue pH 2.5 was used. Most of the molecules examined here showed similar expression patterns in BilIN and PanIN, in which their expression tended to increase along with the increase in atypia of the epithelial lesions. …”
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Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention by Xuan Lu, Ying Chen, Yue Shi, Yi Shi, Xianbin Su, Peijie Chen, Die Wu, Hui Shi

“…Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. These bioactive molecules, which include hepatokines, myokines, adipokines, osteokines, and neurokines, act both locally and systemically to exert protective effects against the detrimental aspects of aging. …”
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Cytokine Levels in the Serum of Healthy Subjects by Giulio Kleiner, Annalisa Marcuzzi, Valentina Zanin, Lorenzo Monasta, Giorgio Zauli

“…Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response. Indeed, when the cytokine production is deregulated, diseases often occur. …”
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Synthesis, Crystal Structure, and Theoretical Studies of N-(4-((4-chlorobenzyl)oxy)phenyl)-4- (trifluoromethyl)pyrimidin-2-amine by Jian-Chang Jin, Zhao-Hui Sun, Ming-Yan Yang, Jing Wu, Xing-Hai Liu

“…X-ray analysis reveals that intermolecular N–H⋯N interactions exist in the adjacent molecules. Theoretical calculation of the title compound was carried out with HF/6-31G (d,p), B3LYP/6-31G (d,p). …”
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The Expanding Role for Retinoid Signaling in Heart Development by Loretta L. Hoover, Elizabeth G. Burton, Bonnie A. Brooks, Steven W. Kubalak

“…Germline and conditional knockout mice have revealed which molecular players in the vitamin A signaling cascade are potentially responsible for regulating specific developmental events, and many of these molecules have been temporally and spatially characterized. …”
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Nuclear Alarmin Cytokines in Inflammation by Lili Jiang, Yijia Shao, Yao Tian, Changsheng Ouyang, Xiaohua Wang

“…In this article, we review the involvement of nuclear alarmins such as HMGB1, IL-33, and IL-1α under physiological state or stress state and suggest a novel activity of these molecules as central initiators in the development of sterile inflammation.…”
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Fast and sensitive measurements of sub-3&thinsp;nm particles using Condensation Particle Counters For Atmospheric Rapid Measurements (CPC FARM) by D. Cheng, D. Cheng, S. Amanatidis, G. S. Lewis, C. N. Jen, C. N. Jen

“…<p>New particle formation (NPF) is the atmospheric process whereby gas molecules react and nucleate to form detectable particles. …”
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A Simulation Study on the Swelling and Shrinking Behaviors of Nanosized Montmorillonite Based on Monte Carlo and Molecular Dynamics by Kaiwen Tong, Jianhua Guo, Shanxiong Chen, Fei Yu, Shichang Li, Zhangjun Dai

“…The relative concentration of water molecules conveyed information such as the thickness and position of the hydration film and explained the difference in swelling and shrinking caused by the above variables. …”
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Understanding pectin cross-linking in plant cell walls by Irabonosi Obomighie, Iain J. Prentice, Peter Lewin-Jones, Fabienne Bachtiger, Nathan Ramsay, Chieko Kishi-Itakura, Martin W. Goldberg, Tim J. Hawkins, James E. Sprittles, Heather Knight, Gabriele C. Sosso

“…The extent to which pectin chains crosslink with one another determines crucial properties including cell wall strength, porosity, and the ability of small, biologically significant molecules to access the cell. Despite its importance, significant gaps remain in our comprehension, at the molecular level, of how pectin cross-links influence the mechanical and physical properties of cell walls. …”
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