Bioinformatic identification of important roles of COL1A1 and TNFRSF12A in cartilage injury and osteoporosis by Muzi Liu, Shiguo Gong, Xin Sheng, Zihong Zhang, Xichun Wang

“…Immune infiltration analysis further revealed the possible key role of COL1A1 and TNFRSF12A in regulating immune cell infiltration in osteoporosis and cartilage injury.Conclusion COL1A1 and TNFRSF12A as key regulatory molecules in osteoporosis and cartilage injury.…”
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Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan

“…Tumor cells in MIBC displayed enhanced glycolytic activity and downregulation of chemokines and MHC-II molecules, reducing immune cell recruitment and facilitating immune evasion. …”
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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson’s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

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Enhancement of Cytomegalovirus-Specific Cytokine Production after Modulation of the Costimulation in Kidney Transplant Patients by Theresa Dornieden, Benjamin Wilde, Johannes Korth, Kai Werner, Peter A. Horn, Oliver Witzke, Monika Lindemann

“…Hence, the aim of this study was to investigate if the function of CMV-specific cells of kidney transplant recipients could be restored by a modulation of costimulatory molecules. To address this question, lymphocytes of kidney transplant patients were stimulated with CMV-specific antigens and incubated with programmed death-ligand 1 (PD-L1), programmed cell death protein 1 (PD-1), or B- and T-lymphocyte attenuator (BTLA) antibodies. …”
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Project ChemicalBlooms: Collaborating with citizen scientists to survey the chemical diversity and phylogenetic distribution of plant epicuticular wax blooms by Le Thanh Dien Nguyen, Nicole Groth, Kylie Mondloch, Edgar B. Cahoon, Keith Jones, Lucas Busta

“…The ability to synthesize basic wax molecules appears to be shared among virtually all land plants, and our knowledge of ubiquitous wax compound synthesis is reasonably advanced. …”
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In silico comparative genomic analysis unravels a new candidate protein arsenal specifically associated with Fusarium oxysporum f. sp. albedinis pathogenesis by Hafida Ayada, Boutayna Dhioui, Hamid Mazouz, Abdelhay El harrak, Fatima Jaiti, Bouchra Ouhmidou, Mohammed Diouri, Mohieddine Moumni

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Biotemplated Synthesis of Titanium Oxide Nanoparticles in the Presence of Root Extract of Kniphofia schemperi and Its Application for Dye Sensitized Solar Cells by Eneyew Tilahun Bekele, Enyew Amare Zereffa, Noto Susanto Gultom, Dong-Hau Kuo, Bedasa Abdisa Gonfa, Fedlu Kedir Sabir

“…Among the biosynthesized TiO2 different volume ratios, TiO2 (3 : 2) NPs showed relatively maximum solar cell efficiency and IPCE value due to its uniform spherical shape that enables to absorb large dye molecules on its surface, and this intern improves device efficiency.…”
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Characterization of a chitinase from Trichinella spiralis and its immunomodulatory effects on allergic airway inflammation in mice by Jia Xu, Ye Yao, Qisheng Zhuang, Zixuan Li, Min Zhang, Shouan Wang, Hongxin Hu, Jianbin Ye

“…Research has been done to clarify the processes by which helminth-derived molecules can inhibit immunological disorders. This study aimed to evaluate the ability of Trichinella spiralis chitinase (Ts-chit) to ameliorate the symptoms of allergic airway inflammation. …”
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Impact of MMP2 rs243865 and MMP3 rs3025058 Polymorphisms on Clinical Findings in Alzheimer’s Disease Patients by Vladimira Durmanova, Juraj Javor, Zuzana Parnicka, Gabriel Minarik, Agata Ocenasova, Barbora Vaseckova, Veronika Reznakova, Maria Kralova, Tomas Hromadka, Ivana Shawkatova

“…Among various MMPs, MMP-2 and MMP-3 belong to candidate molecules related to AD pathology. In our study, we aimed to evaluate the association of MMP2 rs243865 and MMP3 rs3025058 polymorphisms with AD susceptibility and their influence on age at onset and MoCA score in patients from Slovakia. …”
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Impact of HIF-1α, LOX and ITGA5 Synergistic Interaction in the Tumor Microenvironment on Colorectal Cancer Prognosis by Hayriye Tatlı Doğan, Mehmet Doğan, Seda Kahraman, Doğukan Çanakçı, Mehmet Ali Nahit Şendur, Mustafa Tahtacı, Fazlı Erdoğan

“…<b>Conclusions</b>: These markers may be useful in predicting treatment responses and may also guide the development of alternative or combined treatments that specifically target molecules such as HIF and LOX. Our study should be supported by more comprehensive studies addressing the tumor stroma and its prognostic importance.…”
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Effect of Massage on the TLR4 Signalling Pathway in Rats with Neuropathic Pain by Qian Wang, Jing Lin, Peng Yang, Yingye Liang, Dongming Lu, Kailong Wang, Wei Gan, Jianping Fu, Zhenbao Gan, Mingchen Ma, Pingting Wu, Fengshi He, Jun Pang, Hongliang Tang

“…SNL rats showed higher levels of TLR4, IRAK1, TRAF6, IL-6, and TNF-α, and massage effectively lowered the expression levels of these molecules. Inhibiting activation of the TLR4 signalling pathway, which can reduce the release of inflammatory factors, may be one mechanism by which massage treats neuropathic pain.…”
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Synthesis and Characterization of Modified Kaolin-Bentonite Composites for Enhanced Fluoride Removal from Drinking Water by Ebenezer Annan, Emmanuel Nyankson, Benjamin Agyei-Tuffour, Stephen Kofi Armah, George Nkrumah-Buandoh, Joanna Aba Modupeh Hodasi, Michael Oteng-Peprah

“…The FTIR analyses of bentonite (3550 cm−1–4000 cm−1) and kaolin (400–1200 cm−1) correspond to the structural hydroxyl groups and water molecules in the interlayer space of bentonites and the vibrational modes of SiO4 tetrahedron of kaolin, respectively. …”
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Enhancing CO₂ selectivity in MOFs through a dual-ligand strategy: Experimental and theoretical insights by Amir Kazemi, Akram Karbalaee Hosseini, Mahyar Ashourzadeh Pordsari, Mohsen Tamtaji, Saber Keshavarz, Faranak Manteghi, Azadeh Tadjarodi, Ahad Ghaemi, Sohrab Rohani, William A. Goddard

“…This superior performance is attributed to the synergistic interaction of Cd and Zn, which strengthens the coordination between CO₂ molecules and open metal sites. In addition, to validate the data and improve the analysis, theoretical studies indicated moderate interactions between CO₂ and the metal centers. …”
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Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris by Pavel Borsky, Zdenek Fiala, Ctirad Andrys, Martin Beranek, Kvetoslava Hamakova, Andrea Malkova, Tereza Svadlakova, Jan Krejsek, Vladimir Palicka, Lenka Borska, Vit Rehacek

“…Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. …”
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Ethnobotany, floristic and phytochemical studies of medicinal plants used to treat uterine fibroids in Mbarara City, Uganda by Calton Nantinda, Esther Lynnet Kisakye, David Musana, Isaac Ssessanga, Ukashar Ssenabulya, Timothy Omara, Ivan Kahwa, Florence Nalimu

“…With initial evidence of the bioactive secondary metabolites, this study underscores the need for further bioassay-guided studies to isolate and characterize bioactive molecules associated with the anti-fibroid efficacy of the species.…”
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Designing a broad-spectrum multi-epitope subunit vaccine against leptospirosis using immunoinformatics and structural approaches by Guneswar Sethi, Guneswar Sethi, Young Kyu Kim, Su-Cheol Han, Jeong Ho Hwang, Jeong Ho Hwang

“…Population coverage analysis revealed that T-cell epitopes significantly interacted with HLA molecules, covering 95.7% of the global population. …”
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Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders by Maojun Cheng, Maojun Cheng, Fang Ding, Fang Ding, Liyang Li, Liyang Li, Changmao Dai, Changmao Dai, Xiaolan Sun, Xiaolan Sun, Jia Xu, Jia Xu, Feier Chen, Feier Chen, Mingxiu Li, Xueping Li

“…Lipid metabolism plays a crucial role in maintaining homeostasis and overall health, as lipids are essential molecules involved in bioenergetic processes. An increasing body of research indicates that disorders of lipid metabolism can contribute to the development and progression of various diseases, including hyperlipidemia, obesity, non-alcoholic fatty liver disease (NAFLD), diabetes mellitus, atherosclerosis, and cancer, potentially leading to poor prognoses. …”
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Modelling of a new form of nitrogen doped activated carbon for adsorption of various dyes and hexavalent chromium ions by Mohamed A. El-Nemr, Uyiosa Osagie Aigbe, Kingsley Eghonghon Ukhurebor, Kingsley Obodo, Adetunji Ajibola Awe, Mohamed A. Hassaan, Safaa Ragab, Ahmed El Nemr

“…The adsorbent was also explored in the treatment of acid brown 14 (AB14) and acid orange 7 (AO7) dye molecules and hexavalent chromium (Cr6+) ions. The pH controls the sorption of individual contaminants, with an observed superlative % of individual contaminants removed at pH 1.5. …”
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Development of a stable eukaryotic strain producing fully human monoclonal antibody on the basis of the human antibody against ectromelia virus by A. L. Matveev, Ya. A. Khlusevich, I. K. Baykov, I. V.  Babkin, E. P. Goncharova, V. V. Morozova, N. V. Tikunova

“…Fully­human antibodies have a great therapeutic importance; however, the development of stable strains providing a high level of production of full­size antibodies is a challenging task, as antibody molecules contain two types of polypeptide chains. …”
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Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2 by C.F. Pulliam, M.A. Fath, S. Sho, S.T. Johnson, B.A. Wagner, M. Singhania, A.L. Kalen, K. Bayanbold, S.R. Solst, B.G. Allen, B.N. George, J.M. Caster, G.R. Buettner, D.P. Riley, J.L. Keene, R.A. Beardsley, D.R. Spitz

“…Differences in cancer and normal cell oxidative metabolism provide a unique therapeutic opportunity for developing combined modality approaches with redox-active small molecules as radio-chemosensitizers that are well-tolerated by normal tissues. …”
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