Occurrence of Surface Active Agents in the Environment by Ewa Olkowska, Marek Ruman, Żaneta Polkowska

“…Due to the specific structure of surfactants molecules they are applied in different areas of human activity (industry, household). …”
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Pancreatic lipase inhibitory activity of selected pharmaceutical agents by Hamdan Imad I., Kasabri Violet N., Al-Hiari Yusuf M., El-Sabawi Dina, Zalloum Hiba

“…Docking studies for the most active molecules were performed and molecular interaction forces with the PL active site were identified. …”
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Synthesis of silver leaves and their potential application for analysis and degradation of phenolic pollutants by Jianan Sun, Xianhui Gao, Wei Wei

“…In addition, silver leaves exhibit excellent Raman enhancement effect (SERS) and chemical catalytic activities for phenolic molecules. Interestingly, the SERS and catalytic activities increase as the size of the silver leaves decrease within a certain range, but when the size is too small, both of these performances weaken. …”
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Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application by Ziyuan Liang, Lixian Deng, Xiaoying Zhou, Zhe Zhang, Weilin Zhao

“…Ketone bodies (KBs), which are generated during lipid metabolism, are fundamental bioactive molecules that can be modulated to satisfy the escalating metabolic needs of cancer cells. …”
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Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling by Jayalakshmi Krishnan, Sangdun Choi

“…Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-protein coupled receptors (GPCRs), whose interaction with their cognate ligands activates heterotrimeric G proteins and regulates specific downstream effectors, including immuno-stimulating molecules. Once TLRs are activated, they lead to the expression of hundreds of genes together and bridge the arm of innate and adaptive immune responses. …”
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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…Clinical data are currently available for sodium channel isoform-specific antagonists, anti-nerve growth factor molecules, and fatty acid amide hydrolase inhibitors.…”
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Topological analysis and predictive modeling of amino acid structures with implications for bioinformatics and structural biology by Huili Li, Anisa Naeem, Shamaila Yousaf, Adnan Aslam, Fairouz Tchier, Keneni Abera Tola

“…We have developed linear, quadratic, and logarithmic regression models to estimate the five physical/chemical properties of twenty-two amino acids molecules. The findings reveal novel insights into the structural determinants of amino acid properties and present efficient predictive models for various attributes. …”
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Rational engineering of minimally immunogenic nucleases for gene therapy by Rumya Raghavan, Mirco J. Friedrich, Indigo King, Samuel Chau-Duy-Tam Vo, Daniel Strebinger, Blake Lash, Michael Kilian, Michael Platten, Rhiannon K. Macrae, Yifan Song, Lucas Nivon, Feng Zhang

“…SaCas9 and AsCas12a Redi variants are substantially less recognized by adaptive immune components, including reduced binding affinity to MHC molecules and attenuated generation of cytotoxic T cell responses, yet maintain wild-type levels of activity and specificity. …”
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The Role of Oxidative Stress in the Aging Process by Barbara F. Oliveira, José Augusto Nogueira-Machado, Míriam M. Chaves

“…ROS include a number of chemically reactive molecules derived from oxygen. Not only oxygen, but also nitrogen can be deleterious species. …”
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Identification of musk compounds as inhibitors of the main SARS-CoV-2 protease by molecular docking and molecular dynamics studies by Belhassan Assia, Salgado Guillermo, Mendoza-Huizar Luis Humberto, Zaki Hanane, Chtita Samir, Lakhlifi Tahar, Bouachrine Mohammed, Gerli Candia Lorena, Cardona Wilson

“…With this in mind, we have systematically screened potential odorant molecules in the treatment of this infection based on the affinity of the selected odorant compounds on the studied enzyme and the sequence identity of their target proteins (olfactory receptors) to the same enzyme (the main protease of SARS-CoV-2). …”
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CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation by Jingjing Yang, Jingjing Yang, Qiqi Fan, Yiyun Wang, Yuanyue Liu, Xiaoning Xu, Yeqi Liang, Jiakang Xie, Jiajie Li, Fengting Ai, Yong Cao, Shangzhen Yu, Jinman Liu

“…In recent years, circular RNAs (circRNAs), a novel class of non-coding RNA molecules, have emerged as a research focus due to their unique stability and functional roles. …”
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Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens by Chloé O. Sebilleau, Steven J. Sucheck

“…In the case of vaccines, they allow for modulation and increase of the immune response. Lipopeptides are molecules of choice because of their ability to activate specific cell surface receptors, penetrate the outer membrane of GNB, safety and ease of synthesis. …”
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Aptamers: A Feasible Technology in Cancer Immunotherapy by M. M. Soldevilla, H. Villanueva, F. Pastor

“…Some of them have been conjugated to other molecules to target the immune system and reduce off-target side effects. …”
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Purification and Characterization of a Novel Intracellular Sucrase Enzyme of Leishmania donovani Promastigotes by Arpita Singh, Debjani Mandal

“…The promastigote stage of Leishmania resides in the sand fly gut, enriched with sugar molecules. Recently we reported that Leishmania donovani possesses a sucrose uptake system and a stable pool of intracellular sucrose metabolizing enzyme. …”
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Triple jump for the optimal management of psoriatic arthritis: diet, sleep and exercise – a review by Ennio Lubrano, Kurt de Vlam, Rik Lories, Silvia Scriffignano, Fabio Massimo Perrotta, Mario Ronga

“…Treatment of PsA has rapidly evolved by the introduction of new biological drugs and small molecules which allow to achieve disease remission or low disease activity in most of the patients. …”
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Effect of Adsorption Characteristics of Rhodamine 6G Dye Solution in Fe3O4 Magnetic Nanoparticles on Fluorescence Quantum Yield by Suwaphit Phoemphoonthanyakit, Panpailin Seeharaj, Pattareeya Damrongsak, Kitsakorn Locharoenrat

“…We believe that our study makes a significant contribution to the literature because Fe3O4 magnetic nanoparticles were found to be able to quench rhodamine 6G dye molecules, which will aid in eliminating toxic and hazardous pollutants from dye wastewater, which are otherwise detrimental to the environment and human health.…”
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Current Overview of Allergens of Plant Pathogenesis Related Protein Families by Mau Sinha, Rashmi Prabha Singh, Gajraj Singh Kushwaha, Naseer Iqbal, Avinash Singh, Sanket Kaushik, Punit Kaur, Sujata Sharma, Tej P. Singh

“…The three-dimensional structures of some of these allergens have also been evaluated to elucidate the antigenic determinants of these molecules and to explain the cross-reactivity among the various allergens.…”
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Managing negative linear compressibility and thermal expansion through steric hindrance: a case study of 1,2-bis(4′-pyridyl)ethane cocrystals by Ewa Patyk-Kaźmierczak, Kornelia Szymańska, Michał Kaźmierczak

“…It was revealed that the minor structural difference between the acid molecules does not significantly affect the packing under ambient conditions, but has far-reaching consequences when it comes to the deformation of the structure when exposed to external stimuli.…”
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Characteristics and Origin of Methane Adsorption Capacity of Marine, Transitional, and Lacustrine Shales in Sichuan Basin, China by Xianglu Tang, Wei Wu, Guanghai Zhong, Zhenxue Jiang, Shijie He, Xiaoxue Liu, Deyu Zhu, Zixin Xue, Yuru Zhou, Jiajing Yang

“…The water content has a significant effect on methane adsorption largely because water molecules occupy the adsorption site. Additionally, the temperature and pressure in a specific range significantly affect methane adsorption capacity.…”
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High throughput method for simultaneous screening of membrane permeability and toxicity for discovery of new cryoprotective agents by Nima Ahmadkhani, James D. Benson, Ali Eroglu, Adam Z. Higgins

“…This limitation is in part due to the challenge of rapidly screening compounds to identify candidate molecules that are highly membrane permeable and non-toxic at high concentrations. …”
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