CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis by Chu Hao, Yunju Pu, Jiunian Li, Zhi Zhong, Zhaohui Huang, Xue Wang

“…These noncoding RNA molecules, characterized by their unique closed loop structure, displayed close associations with the progression of tumors. …”
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The Function of Two <i>Brassica napus</i> β-Ketoacyl-CoA Synthases on the Fatty Acid Composition by Dongfang Zhao, Bingqian Zhou, Bo Hong, Jiajun Mao, Hu Chen, Junjie Wu, Li Liao, Chunyun Guan, Mei Guan

“…Various types of fatty acid products are used to build lipid molecules, such as oils, suberin, wax, and membrane lipids. …”
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Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…Some species of marine snails have been demonstrated to be potential sources of novel anticancer molecules. This study analyzed the anticancer effects in vitro and in vivo of two peptides found in <i>C. californicus</i>. …”
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Towards New Scaffolds for Antimicrobial Activity—In Silico/In Vitro Workflow Introducing New Lead Compounds by Maria Mangana, George Lambrinidis, Ioannis K. Kostakis, Ioanna Kalpaktsi, Marina Sagnou, Chrysoula Nicolaou, Emmanuel Mikros, Stylianos Chatzipanagiotou, Anastasios Ioannidis

“…<b>Results</b>: In silico screening identified twenty promising molecules from the NCI and seven from the Pharmalab databases. …”
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Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache by Gurueswar Nagarajan, Yumin Zhang

“…Subsequently, quantitative PCR, in situ hybridization and immunohistochemistry were used to examine mRNA and protein expression of glia specific markers and pain associated molecules. Results The repetitive impacts at the bregma, but not pre-bregma site led to periorbital hypersensitivity, which was correlated with enhanced inflammatory gene expression in multiple brain regions. …”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…Western blot and qRT-PCR were used to measure changes in pyrimidine metabolism-related markers and active molecules involved in the AMPK/mTOR signaling pathway. …”
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Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab by Ziping Li, Fujing Zhang, Xianghong Jin, Junling Zhuang

“…Methods Human protein microarrays were used to examine the expression of 440 protein molecules in MM patients treated with bispecific T-cell engagers (BiTe) (n = 9), anti-CD38 monoclonal antibodies (mAbs) (n = 10), and proteasome inhibitor (PI)-based regimens (n = 10). …”
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Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma. by Anton W Roodnat, Chelsey Doyle, Breedge Callaghan, Karen Lester, Megan Henry, Carl Sheridan, Declan J McKenna, Colin E Willoughby, Sarah D Atkinson

“…The sub-interactomes of genes involved in specific pseudoexfoliation glaucoma related enrichment terms such as oxidative stress, unfolded protein response, signal molecules and ECM remodelling were determined. This is the first study to present a genome-wide microRNA-mRNA regulatory network for human trabecular meshwork cells treated with TGF-β1 and may serve to generate unbiased hypotheses about regulatory functions and mRNA targets of miRNAs in pseudoexfoliation glaucoma and may help to develop miRNA-based therapeutics.…”
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Increased Fas and Bcl-2 Expression on Peripheral Blood T and B Lymphocytes from Juvenile-Onset Systemic Lupus Erythematosus, but not from Juvenile Rheumatoid Arthritis and Juvenile... by Bernadete L. Liphaus, Maria H. B. Kiss, Solange Carrasco, Claudia Goldenstein-Schainberg

“…Freshly isolated peripheral blood mononuclear cells (PBMC) were stained for lymphocyte markers CD3, CD4, CD8, CD19 and for Fas and Bcl-2 molecules. Expressions were measured by three-color flow cytometry. …”
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Effects of polyamines and indole on the expression of ribosome hibernation factors in <i>Escherichia coli</i> at the translational level by E. A. Khaova, A. G. Tkachenko

“…Polyamines and indole are small regulatory molecules that are involved in the adaptation to stress in bacteria, including the regulation of gene expression. …”
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Extracellular Vesicles in Periodontitis: Pathogenic Mechanisms and Therapeutic Potential by Zhang L, Li X, Zhang B, Li R

“…They play a key role in intercellular communication by transporting multiple signaling molecules. Recent research has indicated that EVs derived from periodontal pathogens can trigger periodontitis, exacerbate the periodontal damage, and potentially disseminate to other parts of the body, leading to systemic conditions. …”
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Effectiveness of Contrast Agents and Molecular Indicators in Alzheimer's Diagnosis Through PET and SPECT Imaging on Animal Models by Yasaman Abaszadeh, Ramin Ardalani, Athena Dehghan Najm Abadi

“…Early detection and diagnosis of AD are crucial, but current research on the effectiveness of contrast agents and molecules is limited. To address this gap, we conducted a comprehensive study on PET and SPECT imaging to evaluate the role of these agents and indicators in diagnosing the disorder. …”
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A graph neural network approach for hierarchical mapping of breast cancer protein communities by Xiao Zhang, Qian Liu

“…Then, a group-lasso algorithm was applied to identify protein communities that are under both mutation burden and survival burden, undergo significant alterations when targeted by specific drug molecules, and show cancer-dependent perturbations. …”
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Zinc oxide seed priming enhances drought tolerance in wheat seedlings by improving antioxidant activity and osmoprotection by Rasha M. El-Shazoly, A. A. Othman, Muhammad Saqlain Zaheer, Ahmed F. Al-Hossainy, Dalia A. Abdel-Wahab

“…Experimental and computational methods (time-dependent density functional theory (TD-DFT)) were employed to perform IR and XRD analyses of the isolated molecules of the ZnO NPs/Iso. In conclusion, the application of ZnO NPs or bulk ZnO was found to create effective mechanical and physiological barriers, as confirmed by the analysis of antioxidant enzyme activities, nonenzymatic components, free radical scavenging, and osmoprotectant constituents.…”
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Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire by Michael Kaiser, Jim Kaufman, Susan J. Lamont

“…In our study, erythrocytes from 6 diverse and highly inbred lines of chickens, a closed broiler line, and a highly advanced intercross line were evaluated for MHC class I antigen expression level by flow cytometry using monoclonal antibodies to chicken MHC class I molecules. In chickens, the B blood group antigens include the MHC class I antigen expressed from the MHC. …”
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Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon by Kagoué Simeni Luc-Aimé, Yindom Louis-Marie, Loni Ekali Gabriel, Clauvis Kunkeng Yengo, F. Esemu Livo, Nguedia Jules Clement Assob

“…This may be partly due to differences in host immunogenetic factors in highly polymorphic regions of the human genome such as those encoding the killer-cell immunoglobulin-like receptor (KIR) molecules which modulate the activities of natural killer cells. …”
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Relationship between the Molecular Coil Dimension and the Energy Storage Modulus of Polymer Solution Configured with Oilfield-Produced Sewage by Peng Wang, Wenguo Ma, Yunbao Zhang, Qiuyan Yan

“…The elasticity characteristics of the polymer solution are sensitive to the molecular coil dimension. As Dh of polymer molecules becomes larger, the contribution of the elastic portion to the viscosity of the polymer solution increases. …”
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In silico analysis of SNPs and miRNAs of KCTD13, CSDE1, SLC6A1 genes associated with autism spectrum disorder by Kübra Çoruh Kınalı, Ebru Özkan Oktay, Mesut Karahan

“…Micro-RNAs (miRNAs) are short, non-coding RNA molecules that control gene expression after transcription. …”
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Timosin alpha-1 immunomodulating properties by M. V. Mayevskaya

“…Direct antiviral mechanism of Timosin alpha-1 consists in increase of expression of major histocompatibility complex molecules of the 1st class on infected cells and direct suppression of virus replication, and also in elevation of endocellular level of glutathione. …”
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Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells by Laura Hyväri, Sari Vanhatupa, Heidi T. Halonen, Minna Kääriäinen, Susanna Miettinen

“…To study the role of MRTF-A activity in the differentiation process, hASCs were cultured in adipogenic and osteogenic media supplemented with inhibitor molecules CCG-1423 or CCG-100602 that have been shown to block the expression of MRTF-A/SRF-activated genes. …”
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