Prevention and treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage by Kyle McGrath, Grace Hey, Ghaidaa Ebrahim, Noah Gilberstadt, David Mahan, Brandon Lucke-Wold

“…Further exploration of the neuroinflammatory reaction following aSAH will continue to identify targetable molecules involved in PHCV pathogenesis.…”
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TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation by Agnieszka Loboda, Mateusz Sobczak, Alicja Jozkowicz, Jozef Dulak

“…Recent findings indicate the prominent role of microRNAs, small noncoding RNA molecules that inhibit gene expression through the posttranscriptional repression of their target mRNAs, in different pathologic conditions, including renal pathophysiology. miR-21 was also shown to play a dynamic role in inflammatory responses and in accelerating injury responses to promote organ failure and fibrosis. …”
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Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway by Tae-Young Gil, Yun-Mi Kang, Ye-Jin Eom, Chul-Hee Hong, Hyo-Jin An

“…In addition, SF reduced the phosphorylation of signal transducer and activator of transcription 1, which is one of the major signaling molecules involved in cellular inflammation. These results suggested that SF could be a potential therapeutic alternative for the treatment of AD.…”
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Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma by Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda

“…While previous strategies have focused on small molecules that modulate blood-brain barrier permeability or penetrate the barrier, there is an increased focus on biomedical devices—external or implanted—for improving drug delivery. …”
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Spatial integration of multi-omics single-cell data with SIMO by Penghui Yang, Kaiyu Jin, Yue Yao, Lijun Jin, Xin Shao, Chengyu Li, Xiaoyan Lu, Xiaohui Fan

“…Through comprehensive analysis of real-world data, SIMO uncovers multimodal spatial heterogeneity, offering deeper insights into the spatial organization and regulation of biological molecules. These findings position SIMO as a powerful tool for advancing spatial biology by revealing previously inaccessible multimodal insights.…”
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Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? by Matthieu Sawaf, Hélène Dumortier, Fanny Monneaux

“…Interestingly, some of these TFH-related molecules have been described to be dysregulated in lupus patients. …”
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Inflammatory pathways and anti‐inflammatory therapies in sickle cell disease by Karina Tozatto‐Maio, Felipe A. Rós, Ricardo Weinlich, Vanderson Rocha

“…Over the past few decades, the role of different cells and molecules in the regulation of the inflammatory process has been elucidated. …”
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Solar-driven production of renewable chemicals via biomass hydrogenation with green methanol by Guangyu Chen, Cenfeng Fu, Wenhua Zhang, Wanbing Gong, Jun Ma, Xiaomin Ji, Lisheng Qian, Xuefei Feng, Chuansheng Hu, Ran Long, Yujie Xiong

“…Here, we report a TiO2 supported Cu single-atom catalyst with a four-coordinated Cu1−O4 structure, which can be universally applied for solar-driven production of various renewable chemicals from lignocellulosic biomass-derived platform molecules with good yields using green methanol as a hydrogen donor, to address this challenge. …”
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MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation by Thomas J. Kean, Paul Lin, Arnold I. Caplan, James E. Dennis

“…These cell targeting methodologies focus on the modification of cell surface molecules through chemical, genetic, and coating techniques to promote selective adherence to particular organs or tissues. …”
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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

“…It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. …”
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In Vitro Systems for the Study of Hepatitis C Virus Infection by Garrick K. Wilson, Zania Stamataki

“…Consequently, host cell receptor molecules that potentiate HCV infection were identified over a decade after the virus was discovered. …”
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Evaluating the risk of data loss due to particle radiation damage in a DNA data storage system by Christopher N. Takahashi, David P. Ward, Carlo Cazzaniga, Christopher Frost, Paolo Rech, Kumkum Ganguly, Sean Blanchard, Steve Wender, Bichlien H. Nguyen, Jake A. Smith

“…We develop a mass action kinetics model to estimate the rate of damage accumulation in DNA strands due to neutron interactions with both nucleotides and residual water molecules, then utilize the model to evaluate the effect several design parameters of a typical DNA data storage scheme have on expected data longevity. …”
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Analytical Methods Used for the Detection and Quantification of Benzodiazepines by Zidane Qriouet, Zineb Qmichou, Nadia Bouchoutrouch, Hassan Mahi, Yahia Cherrah, Hassan Sefrioui

“…The present review provides a summary of sample preparation techniques (solid-phase extraction and Liquid-liquid phase extraction) and the methods for the detection and quantification of BZDs molecules in the commonly used biological specimens over the ten last years which may potentially lead to better and accurate evaluation of the physiological state of a given person. …”
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A deep learning-based integrated analytical system for tumor exosome on-chip isolation and automated image identification by Yunxing Lu, Haihui Wang, Zhou Zeng, Jianan Hui, Jiangyu Ji, Hongju Mao, Qiang Shi, Xiaoyue Yang

“…They carry a wide range of bioactive molecules and serve as a crucial role in intercellular communication and tumor progression. …”
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Understanding water reaction pathways to control the hydrolytic reactivity of a Zn metal-organic framework by Shoushun Chen, Zelin Zhang, Wei Chen, Bryan E. G. Lucier, Mansheng Chen, Wanli Zhang, Haihong Zhu, Ivan Hung, Anmin Zheng, Zhehong Gan, Dongsheng Lei, Yining Huang

“…The two distinct ZnMOF-1 water reaction pathways are linked to the diffusion rate of incorporated guest dimethylformamide (DMF) molecules: slow diffusion of DMF triggers evolution of the initial MOF into a water-stable MOF product exhibiting enhanced water adsorption, while fast exchange of DMF with water leads to decomposition. …”
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A Study of Clinical Profile of Patients Presenting with Topical Corticosteroid Induced Facial Dermatoses by Abhineetha Hosthota, BC Chandan, Bhargavi Chitturi, Afreena Nilofer, Ankitha Ramesh, Abhishek Bharti

“…Indian market is flooded with more than 18 different steroid molecules. Methodology: A hospital-based cross-sectional study was conducted on 170 patients at a tertiary care centre. …”
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A novel label-free method to determine equilibrium dissociation constants of antibodies binding to cell surface proteins by Eilyn R. Lacy, Rupesh Nanjunda, Scott L. Klakamp, Deborah Kwok, Jennifer F. Nemeth, Gordon D. Powers, H. Hugo Caicedo, Steven A. Jacobs

“…Abstract Solution-based affinity assays are used for the selection and characterization of proteins that could be developed into therapeutic molecules. However, these assays have limitations for cell-surface proteins as in most cases their purification requires detergent solubilization and are unlikely to assume conformations in solution that resemble their native states in cell membranes. …”
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Bioengineering in Solid-State Fermentation for next sustainable food bioprocessing by Muyideen Olaitan Bamidele, Micheal Bola Bamikale, Eliseo Cárdenas-Hernández, Motolani Adepeju Bamidele, Guillermo Castillo-Olvera, José Sandoval-Cortes, Cristóbal Noe Aguilar

“…The present document also describes some of the important developments in the extraction and purification of bioactive molecules from SSF processes, with special emphasis on their potential for using waste from the food industry to reduce the environmental burden. …”
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Mitochondria as a Therapeutic Target: Focusing on Traumatic Brain Injury by Randhall Bruce Carteri

“…Furthermore, mitochondrial metabolism produces signaling molecules such as reactive oxygen species (ROS), regulating calcium levels and controlling the expression profile of intrinsic pro-apoptotic effectors influenced by TBI. …”
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Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis by Stylianos Kontos, Georgia Sotiropoulou-Bonikou, Athina Kominea, Maria Melachrinou, Eleni Balampani, Dionysis Bonikos

“…The possible coordinated upregulation of NF𝜅B and COX-2, during bladder carcinogenesis, indicates that agents inhibitors of these two molecules may represent a possible new treatment strategy, by virtue of their role in bladder carcinogenesis.…”
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