Glyphosate treatment mediates the accumulation of small discrete 5^′ and 3^′-terminal fragments of 18S rRNA in plant cells by A. V. Zhigailov, A. S. Nizkorodova, K. O. Sharipov, N. S. Polimbetova, B. K. Iskakov

“…We suggest that there is an alternative mechanism for the inhibition of protein synthesis in plant cells and possibly, in other eukaryotes, which is based on the discrete fragmentation of 18S rRNA molecules within small ribosomal subunits. We identified four stressinduced small RNAs, which are 5’and 3’-terminal fragments of 18S rRNA. …”
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Association of Self-DNA Mediated TLR9-Related Gene, DNA Methyltransferase, and Cytokeratin Protein Expression Alterations in HT29-Cells to DNA Fragment Length and Methylation Statu... by István Fűri, Ferenc Sipos, Sándor Spisák, Gergő Kiszner, Barnabás Wichmann, Andrea Schöller, Zsolt Tulassay, Györgyi Műzes, Béla Molnár

“…Type-2 treatment resulted in the overexpression of TLR9-related signaling molecules (MYD88A, TRAF6) and the IL8 gene. In the case of type-3 treatment, significant overexpression of NFkB, IRAK2, and IL8 as well as downregulation of TRAF6 was detected. …”
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Characterization of New Particle Formation in Soft X-ray Radiolysis Reactor: AMCs-to-Secondary Inorganic Aerosols by Jiyoon Shin, Kyungil Cho, Yoonkyeong Ha, Giwon Kang, Jihye Park, Hunkwan Park, Changhyuk Kim

“…The reactor was designed to continuously maintain parabolic laminar flows within the tube reactor and to extend the exposure time of the gas molecules to soft X-rays by increasing the number of reactor modules. …”
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Spray-Induced Gene Silencing (SIGS): Nanocarrier-Mediated dsRNA Delivery Improves RNAi Efficiency in the Management of Lettuce Gray Mold Caused by <i>Botrytis cinerea</i> by Maria Spada, Claudio Pugliesi, Marco Fambrini, Diego Palpacelli, Andrea Caneo, Susanna Pecchia

“…In vitro-synthesized dsRNA molecules (<i>BcBmp1</i>-, <i>BcBmp3</i>-, and <i>BcPls1</i>-dsRNAs) were used naked, or complexed to small layered double hydroxide (sLDH) clay nanosheets. …”
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Toward an Efficient Differentiation of Two <i>Diaporthe</i> Strains Through Mass Spectrometry for Fungal Biotyping by Kathleen Hernández-Torres, Daniel Torres-Mendoza, Gesabel Navarro-Velasco, Luis Cubilla-Rios

“…Studies conducted using this technique allowed us to propose the structure of distinctive molecules that are unique to each strain and share compounds common to this genus (13 compounds in total). …”
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The complete mitochondrial genomes of five critical phytopathogenic Bipolaris species: features, evolution, and phylogeny by Xinzheng Song, Yuehua Geng, Chao Xu, Jiaxin Li, Yashuang Guo, Yan Shi, Qingzhou Ma, Qiang Li, Meng Zhang

“…The five mitogenomes were all circular DNA molecules, with lengths ranging from 106,403 bp to 135,790 bp. …”
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The design of paper-based electroanalytical microfluidic device coupled with post-synthesized molecularly imprinted polymers (rGO/Au@Ag2S/PANI/polyacrylamide) for the detection of... by Mina Adampourezare, Karim Asadpour-Zeynali, Miguel de la Guardia, Jafar Ezzati Nazhad Dolatabadi

“…Ag/GQD/chitosan nano ink was used to construct reference and counter electrodes and Au@Ag2S/GQD/chitosan nano ink was used to construct working electrode. rGO/Au@Ag2S/anline nano-sheets were encapsulated with acrylamide as a functional monomer to create novel nano-sized molecular imprinted polymer (MIP) and was used for the modification of electrode working.Paper substrate was modified for forming a hydrophobic region around the hydrophilic region on the filter paper and were suitable for the evaluation of target molecules in aqueous environment. All steps of making the MIP and non-imprinted polymer (NIP) sensors are illustrated by FE-SEM, Energy-dispersive X-ray spectroscopy (EDS), and FT-IR. …”
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Clinical Outcomes and Patient Experience of Biosimilar to Biosimilar Infliximab Switching in Patients with Inflammatory Bowel Disease: A Prospective, Single-Centre, Phase IV Interv... by Clare Harris, Richard James Harris, David Young, Martin McDonnell, Bridget Clancy, Justin Harvey, Carlos Araujo, Ines Iria, Joao Goncalves, Susan Latter, J. R. Fraser Cummings

“…Regulatory pathways compare biosimilars with originator molecules only and not with other biosimilars. With the development of multiple infliximab biosimilars, patients may be asked to transition between them. …”
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Ethanol extract of Polygonatum cyrtonema Hua mitigates non-alcoholic steatohepatitis in mice by Dongliang Chen, Yue Shen, Yue Shen, Fang Huang, Bo Huang, Shangfu Xu, Shangfu Xu, Lisheng Li, Lisheng Li, Jie Liu, Zheng Li, Xia Li

“…Ingenuity pathway analysis of RNA-seq data revealed key canonical pathways and upstream molecules regulated by PCE.ConclusionOur findings confirm the ability of PCE in alleviating NASH and underscores AMPK/SIRT1 pathway as a potential theraputic target for NASH treatment.…”
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A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis by Nasibeh Khayer, Samira Shabani, Maryam Jalessi, Mohammad Taghi Joghataei, Frouzandeh Mahjoubi

“…Interactions between biological molecules are complex and highly dynamic across various cellular conditions, making traditional co-expression methods inadequate for understanding these intricate relationships. …”
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Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium by Paul Denver, Lucas Tortorelli, Karen Hov, Jens Petter Berg, Lasse M. Giil, Arshed Nazmi, Ana Lopez-Rodriguez, Daire Healy, Carol Murray, Robyn Barry, Leiv Otto Watne, Colm Cunningham

“…It is not known whether these molecules reach higher brain levels when the blood cerebrospinal fluid barrier (BCSFB) is impaired. …”
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Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…The specific design and structural features of ISB 1442 enable: 1) enhanced trans binding to adjacent CD38 molecules to increase Fc density at the cancer cell surface; 2) prevention of avid cis binding to monomeric CD38 to minimize blockade by soluble shed CD38; and 3) greater binding avidity, with a slower off-rate at high CD38 density, for increased specificity. …”
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The Protective Role of HLA-DRB113 in Autoimmune Diseases by Andreia Bettencourt, Cláudia Carvalho, Bárbara Leal, Sandra Brás, Dina Lopes, Ana Martins da Silva, Ernestina Santos, Tiago Torres, Isabel Almeida, Fátima Farinha, Paulo Barbosa, António Marinho, Manuela Selores, João Correia, Carlos Vasconcelos, Paulo P. Costa, Berta Martins da Silva

“…The protective effect of HLA-DRB113 could be explained by a more proficient antigen presentation by these molecules, favouring efficient clonal deletion during thymic selection.…”
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Rutaecarpine alleviates hepatic ischemia‒reperfusion injury in liver transplantation by inhibiting inflammatory response and oxidative stress by Yan Liu, Yan Liu, Feng Qi, Lun-Jian Xiang, Zhu-Jun Yi, Sheng-Wei Li

“…The aim of this study was to investigate whether Rut can alleviate hepatic IRI in liver transplantation (LT) and to explore the underlying mechanisms.MethodsRat DCD LT and oxygen-glucose deprivation/reoxygenation (OGD/R) cell models were established to clarify the effect of Rut on hepatic IRI. The key molecules involved in the hepatoprotective effects of Rut were identified through joint analysis of data from LT patients and drug targets. …”
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A synthetic cyclic peptide for promoting antigen presentation and immune activation by Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

“…Abstract Cyclic peptides are often used as scaffolds for the multivalent presentation of drug molecules due to their structural stability and constrained conformation. …”
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Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing by Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel

“…These findings strengthen the hypothesis for the MR-mediated mAb interaction and contribute to a deeper understanding of the MR-mAb interaction, which could affect the criticality of high-mannose containing mAbs development strategies of IgG-based molecules and improve their PK profiles.…”
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Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis by Erika Kapp, Jacques Joubert, Samantha L. Sampson, Digby F. Warner, Ronnett Seldon, Audrey Jordaan, Margaretha de Vos, Rajan Sharma, Sarel F. Malan

“…Results point to the possibility of combining an azapentacycloundecane carrier with a side chain that promotes antimycobacterial activity to develop dual acting molecules for the treatment of Mycobacterium tuberculosis.…”
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Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C by Masanori Sato, Koji Miyanishi, Shingo Tanaka, Akira Sakurada, Hiroki Sakamoto, Yutaka Kawano, Kohichi Takada, Masayoshi Kobune, Junji Kato

“…We measured the expression of a panel of molecules associated with duodenal iron absorption and serum hepcidin levels to determine the mechanism of iron accumulation in the CHC liver. …”
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A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases by Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Karthik Krishna, Tianhao Wang, Kang Bei, Chithra Changalath, Shiny Matilda, Alex J. Rai, Renata Welc-Falęciak, Agnieszka Pawełczyk, Lucas S. Blanton, Aleš Chrdle, Andrea Fořtová, Daniel Růžek, Gheyath K. Nasrallah, Laith J. Abu-Raddadi, Duaa W. Al-Sadeq, Marah Abed Alhakim Abdallah, Daniele Lilleri, Chiara Fornara, Piera D’Angelo, Milena Furione, Maria Söderlund-Venermo, Klaus Hedman, Dimosthenis Chochlakis, Eirini Makridaki, Artemis Ntoula, Anna Psaroulaki, Angélica Escárcega-Ávila, John J. Rajasekaran

“…Our microarray in its present form can accommodate 400 antigens (molecules that can bind to specific antibodies) and can multiplex across antigen types, whole cell lysates, recombinant proteins, and peptides. …”
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Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against Paracoccidioides brasiliensis by Juliana Carvalho de Quaglia e Silva, Amanda Manoel Della Coletta, Taiane Priscila Gardizani, Graziela Gorete Romagnoli, Ramon Kaneno, Luciane Alarcão Dias-Melicio

“…The interaction between surface molecules of pathogens and homologous receptors, present on the surface membrane of phagocytes, modulates the innate immune cell activation. …”
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