Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ by Yong-Jik Lee, Hyun Soo Kim, Hong Seog Seo, Jin Oh Na, You-Na Jang, Yoon-Mi Han, Hyun-Min Kim

“…It also activated those energetic molecules and mitochondrial oxidative phosphorylation with cardiomyocytes, endothelial cells, adipocytes, macrophages, and hepatic cells and affected their relevant cell-specific biological functions. …”
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Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis by Jéssica Adriana de Jesus, Márcia Dalastra Laurenti, Leila Antonangelo, Caroline Silvério Faria, João Henrique Ghilardi Lago, Luiz Felipe Domingues Passero

“…Natural products are an interesting alternative to treat leishmaniasis, because some purified molecules are selective toward parasites and not to the host cells. …”
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New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells by Zélia Silva, João Amorim Rabaça, Vanessa Luz, Rita Adubeiro Lourenço, Mariolina Salio, Alexandra Couto Oliveira, Pedro Bule, Sebastian Springer, Paula Alexandra Videira

“…Particularly, at the molecular level, the increased stability of surface MHC-I molecules in monocyte-derived DCs (MoDCs) underpins an improved DC: T cell interaction. …”
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Antistaphylococcal Triazole-Based Molecular Hybrids: Design, Synthesis and Activity by Kostiantyn Shabelnyk, Alina Fominichenko, Oleksii Antypenko, Olexandr Gaponov, Svitlana Koptieva, Svitlana Shyshkina, Oleksii Voskoboinik, Sergiy Okovytyy, Serhii Kovalenko, Valentyn Oksenych, Oleksandr Kamyshnyi

“…In this regard, we developed and successfully implemented a strategy for the search for new hybrid molecules, namely, the not broadly known [2-(3-R-1<i>H</i>-[1,2,4]-triazol-5-yl)phenyl]amines. …”
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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

“…Bulk RNA-Seq of isolated LSECs from CDAA-fed and control mice was performed. Levels of adhesion molecules (VCAM1, ICAM1, E-selectin) were monitored, and ICAM1 and VCAM1 antibody therapy was employed. …”
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Crystal structures of zinc(II) coordination complexes with isoquinoline N-oxide by Erin N. Groneck, Nathan Peek, Will E. Lynch, Clifford W. Padgett

“…The nitrate ions and non-coordinated iQNO molecules engage in π-stacking and hydrogen-bonding interactions with the coordinated water molecules. …”
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Fluorescence, Decay Time, and Structural Change of Laser Dye Cresyl Violet in Solution due to Microwave Irradiation at GSM 900/1800 Mobile Phone Frequencies by Fuat Bayrakceken, Korkut Yegin

“…For most laser dyes, this is not a trivial task because laser dye molecules possess a relatively complex structure. They usually consist of an extended system of conjugated double or aromatic π-bonds with attached auxochromic (electron donating) groups shifting the absorption band further towards longer wavelength. …”
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Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy by Benjamin L. Franc, Stefanie J. Mandl, Zurab Siprashvili, Paul Wender, Christopher H. Contag

“…PTD imaging conjugates have included small molecules, peptides, proteins, DNA, metal chelates, and magnetic nanoparticles. …”
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Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins by Gerd Bendas, Lubor Borsig

“…Cell adhesion molecules play a significant role in cancer progression and metastasis. …”
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Protective Actions of PPAR-γ Activation in Renal Endothelium by Peter E. Westerweel, Marianne C. Verhaar

“…The presentation of adhesion molecules and release of cytokines recruiting inflammatory cells are inhibited by PPAR-γ-agonism. …”
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Evidence-based management of dermatophytosis in India today by Aparajita Ghosh, Saumya Panda

“…This review aims to take a look at the current status of evidence regarding the effectiveness of major antifungal molecules, with particular reference to the current epidemic-like scenario of resistant dermatophytosis in India. …”
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Posttranslational Modifications and the Immunogenicity of Biotherapeutics by Roy Jefferis

“…The individual is naturally tolerant to molecular forms of self-molecules but nonself variants can provoke an immune response with the generation of anti-drug antibodies (ADA); aggregated forms can exhibit enhanced immunogenicity and QC procedures are developed to avoid or remove them. …”
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The secreted host-cell protein clusterin interacts with PmpD and promotes Chlamydia trachomatis infection by Fabienne Kocher, Johannes H. Hegemann

“…However, the host-cell molecules involved have so far remained unknown. Here, we show that a fragment of Ctr PmpD, which forms high-molecular-weight oligomers in solution and adheres to epithelial cells, also binds to secreted clusterin (sCLU), a chaperone-like protein that is secreted into the extracellular space by the host cell, and forms part of the chaperone- and receptor-mediated extracellular protein degradation (CRED) pathway. …”
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Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation by Junquan Weng, Haidong Fan, Huijuan Liu, Su Tang, Yuyan Zheng

“…However, the mechanisms underlying the persistence of diabetic peri-implantitis, as well as the essential connections and key molecules that regulate its start and progression, remain unknown. …”
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Environnement politique et réglementaire des pharmacultures au Canada : la contamination pharmaceutique à l’horizon ? by Marie-Hélène Bacon

“…Within these multiple fields of GM crops grows, since 1994, transgenic plants which could eventually produce pharmaceutical molecules.  Called pharma-crops, these new genetically modified organisms (GMO) could, among many other things, contaminate the food system and the environment. …”
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Liposomal Antioxidants for Protection against Oxidant-Induced Damage by Zacharias E. Suntres

“…Liposomes are biocompatible, biodegradable, and nontoxic artificial phospholipid vesicles that offer the possibility of carrying hydrophilic, hydrophobic, and amphiphilic molecules. This paper focus on the use of liposomes for the delivery of antioxidants in the prevention or treatment of pathological conditions related to oxidative stress.…”
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Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond by Geehoon Chung, Sang Jeong Kim

“…In turn, these effector molecules bind to or phosphorylate the mGlu C-terminal binding domains and consequently regulate the activation state of the mGlu.…”
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Increase of the Photocatalytic Activity of TiO𝟐 by Carbon and Iron Modifications by Beata Tryba

“…The presence of carbon can increase the concentration of organic pollutants on the surface of TiO2 facilitating the contact of the reactive species with the organic molecules. Carbon-doped TiO2 can extend the absorption of the light to the visible region and makes the photocatalysts active under visible-light irradiation. …”
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Comparative Analysis of Nanoparticle-Antibody Conjugations: Carbodiimide Versus Click Chemistry by Daniel L.J. Thorek, ew R. Elias, Andrew Tsourkas

“…Although click chemistries have been used to functionalize nanoparticles with small molecules, they have not previously been used to functionalize nanoparticles with antibodies. …”
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Effect of His-Tag on Expression, Purification, and Structure of Zinc Finger Protein, ZNF191(243-368) by Dongxin Zhao, Zhongxian Huang

“…Furthermore, the hydrolase activity of ZNF191(243-368)-His8 has provided new insights into the design of biological functional molecules.…”
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