Virtual Screening as a Technique for PPAR Modulator Discovery by Stephanie N. Lewis, Josep Bassaganya-Riera, David R. Bevan

“…VS is a cost- and time-effective means for identifying small molecules that have therapeutic potential. Our long-term goal is to devise computational approaches for testing the PPARγ-binding activity of extensive naturally occurring compound libraries prior to testing agonist activity using ligand-binding and reporter assays. …”
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Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release by Jinjing Xing, Yeqiang Cai, Yikun Wang, Haifu Zheng, Yujia Liu

“…In this paper, we use mesoporous CaCO3 nanoparticles as intelligent carrier, sodium alginate, and chitosan as alternating assembly materials, folic acid as target molecules, and exploit layer-by-layer assembly technology to achieve sensitive molecular targeting and pH response drug release. …”
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Advancements in synthesis of Molecularly Imprinted Polymer (MIPs) for highly selective alcohol sensors by Wulan Khaerani, Abdullahi Umar Ibrahim, Uji Pratomo, Souvia Rahimah, Irkham, Yeni Wahyuni Hartati

“…Molecularly Imprinted Polymer (MIPs) is a highly selective polymer with active recognition sites in the form of cavities that can specifically bind to target molecules, including alcohol compounds. The use of MIPs in combination with alcohol targets is advantageous due to their reusability and high selectivity. …”
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Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches by Marta Barba, Claudia Cicione, Camilla Bernardini, Vincenzo Campana, Ernesto Pagano, Fabrizio Michetti, Giandomenico Logroscino, Wanda Lattanzi

“…The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications. …”
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Lipid-Induced Mechanisms of Metabolic Syndrome by Yulia K. Denisenko, Oxana Yu Kytikova, Tatyana P. Novgorodtseva, Marina V. Antonyuk, Tatyana A. Gvozdenko, Tatyana A. Kantur

“…In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. …”
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Phenotypic alterations in articulating joint cells: Role of mechanically loaded MSC secretome by Yann D. Ladner, Ursula Menzel, Keith Thompson, Angela R. Armiento, Martin J. Stoddart

“…Apart from their differentiation potential, MSCs secrete a multitude of molecules with therapeutic properties that benefit chondrogenesis and immunomodulation. …”
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Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials by Juthatip Manissorn, Jaturong Promsuk, Kittikhun Wangkanont, Peerapat Thongnuek

“…This review focuses on the design and integration of biomimetic peptides into these biopolymer platforms to control the release of bioactive molecules, thereby enhancing their functionality for drug delivery, tissue engineering, and regenerative medicine. …”
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The Immune Response to Tumors as a Tool toward Immunotherapy by F. Pandolfi, R. Cianci, D. Pagliari, F. Casciano, C. Bagalà, A. Astone, R. Landolfi, C. Barone

“…Immunotherapy of tumors has developed several techniques: immune cell transfer, vaccines, immunobiological molecules such as monoclonal antibodies that improve the immune responses to tumors. …”
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IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells by Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge

“…IL-23, in particular, affects key molecules and pathways related to autoimmunity and cytotoxic functions. …”
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Divergent alkynylative difunctionalization of amide bonds through C–O deoxygenation versus C–N deamination by Feng Liu, Xueyuan Yan, Fangfang Cai, Wenjuan Hou, Jianyu Dong, Shuang-Feng Yin, Genping Huang, Tieqiao Chen, Michal Szostak, Yongbo Zhou

“…The particularly wide substrate scope, including late-stage modification of bioactive molecules, demonstrates its potential broad applications in organic synthesis.…”
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Modeling and simulation of carbon-nanocomposite-based gas sensors by Roopa Hegde, Punya Prabha V, Shipra Upadhyay, Krishna S B

“…The surface coverage over the range of 14% to 32.94% for the given range of concentrations is achieved giving the information of the amount of gas molecules adsorbed onto the surface of the sensing material at a given time. …”
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Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery by Wei Wang, Kepan Chen, Ting Jiang, Yiyang Wu, Zheng Wu, Hang Ying, Hang Yu, Jing Lu, Jinzhong Lin, Defang Ouyang

“…Nearly 20 million ionizable lipids were evaluated through two iterations of AI-driven generation and screening, yielding three and six new molecules, respectively. In mouse test validation, one lipid from the initial iteration, featuring a benzene ring, demonstrated performance comparable to the control DLin-MC3-DMA (MC3). …”
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TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells by Yijia Zhou, Yuandong Liao, Chunyu Zhang, Junxiu Liu, Wei Wang, Jiaming Huang, Qiqiao Du, Tianyu Liu, Qiaojian Zou, Hua Huang, Pan Liu, Shiyin Ooi, Run Chen, Meng Xia, Hongye Jiang, Manman Xu, Yuwen Pan, Shuzhong Yao

“…Here, we analyzed published data from public databases and our global transcriptome data, thus identifying cancer-related signaling pathways and molecules. According to our findings, upregulated TAB2 was correlated to stem cell-like properties of cervical cancer. …”
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Optical control of sphingolipid biosynthesis using photoswitchable sphingosines by Matthijs Kol, Alexander J.E. Novak, Johannes Morstein, Christian Schröer, Tolulope Sokoya, Svenja Mensing, Sergei M. Korneev, Dirk Trauner, Joost C.M. Holthuis

“…Deciphering the biological relevance of this network is challenging as numerous intermediates of sphingolipid metabolism are short-lived molecules with often opposing biological activities. …”
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An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice by Xiaojuan Wang, Guohui Zhang, Zhiwei Bian, Vimanda Chow, Marina Grimaldi, Coralie Carivenc, Savannah Sirounian, Hao Li, Lucia Sladekova, Stefano Mott, Yulia Luperi, Yufeng Gong, Cait Costello, Linhao Li, Matthew Jachimowicz, Miao Guo, Shian Hu, Derek Wilson, Patrick Balaguer, William Bourguet, Sridhar Mani, Laura Bonati, Hui Peng, John March, Hongbing Wang, Shengpeng Wang, Henry M. Krause, Jiabao Liu

“…Abstract The literature documenting the value of drug-like molecules found in natural products is vast. Although many dietary and herbal remedies have been found to be effective for treating intestinal inflammation, the identification of their active components has lagged behind. …”
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Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized Crosslinkers by Bin Liu, Zhaoyan Hou, Yi Bao, Lei Hua, Xiao Wang, Yuanyuan Li, Lanying Zhou, Zhuo Lv

“…Furthermore, the orthogonality of the crosslinkers allowed molecular functionalization of a wide range of molecules of interest to the hydrogels by thiol-ene Michael addition (nucleophilic addition of sulfhydryl and carbon-carbon double bonds) in a friendly manner as demonstrated in our work.…”
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Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes by Arpeeta Sharma, Pascal N. Bernatchez, Judy B. de Haan

“…In particular, endogenous signaling molecules that positively modulate EDNO synthesis and mimetics of endogenous antioxidant enzymes will be highlighted. …”
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Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture by Alexander Fisher, Wichat Srikusalanukul, Michael Davis, Paul Smith

“…The relationships between these molecules in human osteoporosis are still unclear. …”
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Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies by Ren Mingliang, Zhang Bo, Wang Zhengguo

“…The possible causes for the limited effects of stem cell in curing heart failure are the stem cells which have been transplanted into the ischemic heart muscle may suffer low survival rate, affected by inflammatory molecules, proapoptotic factor, and lack of nutrients and oxygen, and then the stem cells which home and have been completely transplanted to the site of myocardial infarction become very small. …”
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AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer by Guansong Zheng, Zhaojie Yan, Junrong Zou, Junrong Zou, Junrong Zou, Xiaofeng Zou, Keqiang Chai, Guoxi Zhang

“…In this review, we examine the interactions and underlying mechanisms between AR and YAP, the key molecules in these two signaling pathways. AR regulates the stability and function of YAP by modulating its transcription, translation, and phosphorylation status, while YAP exerts both promotional and inhibitory regulatory effects on AR. …”
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