Sex Hormone Receptor Repertoire in Breast Cancer by Gerald M. Higa, Ryan G. Fell

“…Nonetheless, our understanding of regulatory molecules and resistance mechanisms remains incomplete, further compromising our ability to develop novel therapeutic strategies that could improve disease outcomes. …”
Get full text

The Effects of Affinity Mediated Clonal Expansion of Premigrant Thymocytes on the Periphery T-Cell Repertoire by Guanyu Wang

“…The immune system maintains a highly diverse T-cell repertoire,which is shaped by active interactions between developing thymocytesand endogenous peptide/MHC molecules through the principle ofpositive and negative selections. …”
Get full text

Photodegradation of organic pollutants in aqueous solutions caused by Fe(OH)aq2+ photolysis: Evidence of OH radical formation by I. P. Pozdnyakov, Yu. A. Sosedova, V. F. Plyusnin, E. M. Glebov, V. P. Grivin, D. Yu. Vorobyev, N. M. Bazhin

“…However, realization of an alternative mechanism of photolysis, based on the intermolecular electron transfer from organic molecules located in the second coordination sphere to the light-excited complex could take place. …”
Get full text

Production of Oxidants by Ion Bombardment of Icy Moons in the Outer Solar System by Philippe Boduch, Enio Frota da Silveira, Alicja Domaracka, Oscar Gomis, Xue Yang Lv, Maria Elisabetta Palumbo, Sergio Pilling, Hermann Rothard, Eduardo Seperuelo Duarte, Giovanni Strazzulla

“…Irradiation of carbon dioxide and water frozen mixtures result in the production of molecules among which hydrogen peroxide and ozone. …”
Get full text

Nestin Reporter Transgene Labels Multiple Central Nervous System Precursor Cells by Avery S. Walker, Gwendolyn E. Goings, Yongsoo Kim, Richard J. Miller, Anjen Chenn, Francis G. Szele

“…During embryogenesis, the dorsal telencephalon contained many and the ventral telencephalon few eGFP+ cells. eGFP+ cells were found in postnatal and adult neurogenic regions. eGFP+ cells in the SVZ expressed multiple phenotype markers, glial fibrillary acidic protein, Dlx, and neuroblast-specific molecules suggesting the transgene is expressed through the lineage. eGFP+ cell numbers increased in the SVZ after cortical injury, suggesting this line will be useful in probing postinjury neurogenesis. …”
Get full text

Helminth Parasites and the Modulation of Joint Inflammation by Chelsea E. Matisz, Jason J. McDougall, Keith A. Sharkey, Derek M. McKay

“…Helminth parasites are accomplished masters at modifying their hosts' immune activity, and so attention has focused on rodent-helminth model systems to uncover the workings of the mammalian immune response to metazoan parasites, with the hope of revealing molecules and/or mechanisms that can be translated into better treatments for human autoimmune and idiopathic disorders. …”
Get full text

Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications by Lili Zhang, Jinjin Chu, Wenhao Hao, Jiaojiao Zhang, Haibo Li, Chunjuan Yang, Jinghan Yang, Xiaohua Chen, Honggang Wang

“…Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino acids, and lipopolysaccharide are the main molecules related to T2DM. Many studies have investigated the role of gut microbiota in T2DM, particularly those butyrate-producing bacteria. …”
Get full text

Nature-inspired and medicinally relevant short peptides by Maria G. Ciulla, Monica Civera, Sara Sattin, Kamal Kumar

“…Also presented in this article are important efforts and strategies used to overcome some of the inherent limitations of peptidic molecules and thereby facilitate their progression in the clinical phases towards approved drugs.…”
Get full text

Influence of Physical Activity and Nutrition on Obesity-Related Immune Function by Chun-Jung Huang, Michael C. Zourdos, Edward Jo, Michael J. Ormsbee

“…The deleterious effects of obesity on immunity have been associated with the systemic proinflammatory profile generated by the secretory molecules derived from adipose cells. These include inflammatory peptides, such as TNF-α, CRP, and IL-6. …”
Get full text

Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence by Nicola Alessio, Tiziana Squillaro, Giovanni Di Bernardo, Giovanni Galano, Roberto De Rosa, Mariarosa AB Melone, Gianfranco Peluso, Umberto Galderisi

“…Senescent cells secrete several molecules, collectively named senescence-associated secretory phenotype (SASP). …”
Get full text

Identification of novel 7-hydroxycoumarin derivatives as ELOC binders with potential to modulate CRL2 complex formation by Yonghyeok Kim, Seon Jeong Baek, Eun-Kyung Yoon, Minhee Choi, Jung-Hoon Kim, Kyungtae Kim, Chi Hoon Park, Byung Il Lee

“…Hydroxyproline-based ligands that mimic VHL substrates have been developed as anchor molecules for proteolysis-targeting chimeras (PROTACs) in TPD. …”
Get full text

Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases by Yaw Kuang Chuah, Rusliza Basir, Herni Talib, Tung Hing Tie, Norshariza Nordin

“…RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. …”
Get full text

The Host Genetic Diversity in Malaria Infection by Vitor R. R. de Mendonça, Marilda Souza Goncalves, Manoel Barral-Netto

“…Moreover, polymorphisms in genes related to molecules involved in mechanisms of cytoadherence and their influence on malaria pathology are also discussed. …”
Get full text

Production of antibodies and antibody fragments containing non-natural amino acids in Escherichia coli by Jacquelyn Blake-Hedges, Dan Groff, Wilson Foo, Jeffrey Hanson, Elenor Castillo, Miao Wen, Diana Cheung, Mary Rose Masikat, Jian Lu, Young Park, Nina Abi Carlos, Hans Usman, Kevin Fong, Abigail Yu, Sihong Zhou, Joyce Kwong, Cuong Tran, Xiaofan Li, Dawei Yuan, Trevor Hallam, Gang Yin

“…Using high-density fermentation, it was possible to produce both of these types of molecules with site-specifically incorporated nnAAs at titers > 1 g/L. …”
Get full text

Modeling synergy and individual effects of X-ray induced photodynamic therapy components by Farideh. S. Hossein, Nadia Naghavi, Ameneh Sazgarnia, Atefeh Vejdani Noghreiyan

“…These nanomaterials transform X-ray to visible light that can be absorbed by nearby photosensitizers and in the presence of surrounding oxygen molecules generates reactive oxygen species, which are very toxic to the cells. …”
Get full text

DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences by Gaëlle Lenglet, Marie-Hélène David-Cordonnier

“…Small DNA-interacting molecules share the ability of certain proteins to change the DNA helix's overall organization and geometrical orientation via tilt, roll, twist, slip, and flip effects. …”
Get full text

Quantifying the ability of the CF2H group as a hydrogen bond donor by Matthew E. Paolella, Daniel S. Honeycutt, Bradley M. Lipka, Jacob M. Goldberg, Fang Wang

“…We anticipate that this chemistry will be valuable for designing functional molecules for chemical biology and medicinal chemistry applications.…”
Get full text

In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease by O. H. Nielsen, D. Berild, I. Ahnfelt-Rønne

“…The enhanced oxygen derived free radical production previously reported in active IBD, and especially in CD intestinal lesions, may either be due to an accumulation of productive phagocytes or to a change of the inflammatory profile of these cells when migrating into intestinal lesions, possibly due to interaction with other mediators (e.g. adhesion molecules and interleukins).…”
Get full text

Identification of Bexarotene as a PPARγ Antagonist with HDX by David P. Marciano, Dana S. Kuruvilla, Bruce D. Pascal, Patrick R. Griffin

“…Together these results highlight the complex polypharmacology of lipophilic NR targeted small molecules and the utility of HDX for identifying and characterizing these interactions.…”
Get full text

Heterodyne analysis of high-order partial waves in attosecond photoionization of helium by Wenyu Jiang, Luke Roantree, Lulu Han, Jiabao Ji, Yidan Xu, Zitan Zuo, Hans Jakob Wörner, Kiyoshi Ueda, Andrew C. Brown, Hugo W. van der Hart, Xiaochun Gong, Jian Wu

“…Abstract Partial wave analysis is key to interpretation of the photoionization of atoms and molecules on the attosecond timescale. Here we propose a heterodyne analysis approach, based on the delay-resolved anisotropy parameters to reveal the role played by high-order partial waves during photoionization. …”
Get full text