Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil by Mohamed Bouhrim, Nour Elhouda Daoudi, Hayat Ouassou, Amina Benoutman, El Hassania Loukili, Abderrahim Ziyyat, Hassane Mekhfi, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham

“…Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of O. dillenii seeds oil (ODSO), in vivo. …”
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4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies by Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed Maulana Abdul Rasheed, Md. Ataur Rahman, Saleha Anwar, Shahzaib Ahamad, Dinesh Gupta

“…The drug-likeness feature and toxicity of the molecules were evaluated using QikProp and other tools.ResultsCompounds were synthesized following a multi-step approach and characterized using multi-nuclear magnetic resonance (1H/13C-NMR) and mass spectrometry. …”
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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…Besides highlighting new potential drug targets, PAL can provide valuable information on efficacy and liabilities of small molecules at the molecular level, which could be exploited to greatly facilitate the rational optimization of compounds in terms of potency and safety. …”
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Liquid Chromatography-Mass Spectrometry-Based Metabolomic Analysis of Metabolites and Metabolic Pathways of Selenium-Enriched Auricularia auricula by YUE Shibo, CUI Hang, SHEN Qin, CAO Dongmei

“…It was found that selenization had a great effect on the contents of organic acids and their derivatives, lipids and lipid-like molecules in A. auricula, and the effect of organic selenization was more pronounced. …”
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On‐chip label‐free impedance‐based detection of antibiotic permeation by Jaspreet Kaur, Hamed Ghorbanpoor, Yasin Öztürk, Özge Kaygusuz, Hüseyin Avcı, Cihan Darcan, Levent Trabzon, Fatma D. Güzel

“…We have found that permeation of antibiotic molecules can be easily monitored over time using the proposed integrated device. …”
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Increase in methemoglobin fraction due to the use of glyceryl trinitrate patches in preterm infants: a case report and literature review by Andrea Calandrino, Andrea Calandrino, Francesco Vinci, Francesco Vinci, Marcella Battaglini, Marcella Battaglini, Samuele Caruggi, Samuele Caruggi, Chiara Andreato, Chiara Andreato, Carolina Montobbio, Marianna Vannati, Diego Minghetti, Giorgia Brigati, Luca Antonio Ramenghi, Luca Antonio Ramenghi

“…BackgroundOxidized heme iron forms methemoglobin (MeHb), impairing the oxygen-binding capability of hemoglobin molecules. Nitric oxide (NO) obtained from glyceryl trinitrate (GTN) patches can cause MeHb formation during limb ischemia topical treatment. …”
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Effect of opercular deformity on morphological and transcriptomic profiling of gills in golden pompano (Trachinotus ovatus) by Yuwei Wu, Qian Ma, Dihao Huang, Liuyong Wang, Qiling Zhou, Chunli Ran, Gang Chen

“…KEGG pathway enrichment analysis of the DEGs indicated notable enrichment in pathways related to immune response and inflammation, including Staphylococcus aureus infection, leukocyte transendothelial migration, tight junction, and cell adhesion molecules pathways. These enrichment analysis results suggest that functions associated with immunity and disease, ion homeostasis, energy metabolism, and apoptosis may be influenced by the opercular deformity.…”
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ISCOM-type matrix from beta-escin and glycyrrhizin saponins by V. Petkov, S. Tsibranska, I. Manoylov, L. Kechidzhieva, K. Ilieva, S. Bradyanova, N. Ralchev, N. Mihaylova, N. Denkov, A. Tchorbanov, S. Tcholakova

“…The versatility of these nanoparticles allows for the encapsulation of various molecules, either within the vesicle interior for water-soluble components or within the vesicle walls for hydrophobic components. …”
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Potential Involvement of IL-17F in Asthma by Kyoko Ota, Mio Kawaguchi, Satoshi Matsukura, Masatsugu Kurokawa, Fumio Kokubu, Junichi Fujita, Yuko Morishima, Shau-Ku Huang, Yukio Ishii, Hiroaki Satoh, Nobuyuki Hizawa

“…Several studies have demonstrated that IL-17F plays a pivotal role in allergic airway inflammation and induces several asthma-related molecules such as CCL20. IL-17F-induced CCL20 may attract Th17 cells into the airway resulting in the recruitment of additional Th17 cells to enhance allergic airway inflammation. …”
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Influence of the Clinical Status on Stress Reticulocytes, CD 36 and CD 49d of SSFA2 Homozygous Sickle Cell Patients Followed in Abidjan by Duni Sawadogo, Aïssata Tolo-Dilkébié, Mahawa Sangaré, Nelly Aguéhoundé, Hermance Kassi, Toussaint Latte

“…The expression of adhesion molecules is only one of the parameters involved in sickle cell disease crisis.…”
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Isolation of Actinobacteria from Date Palm Rhizosphere with Enzymatic, Antimicrobial, Antioxidant, and Protein Denaturation Inhibitory Activities by Maria Smati, Amina Bramki, Fatima Zohra Makhlouf, Rihab Djebaili, Beatrice Farda, Fatima Zohra Abdelhadi, Nahla Abdelli, Mahmoud Kitouni, Marika Pellegrini

“…Arid ecosystems constitute a promising source of actinobacteria producing new bioactive molecules. This study aimed to explore different biological activities of actinomycetes isolated from the rhizosphere of <i>Phoenix dactylifera</i> L. in the Ghardaia region, Algeria. …”
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Lysosphingolipids in ceramide-deficient skin lipid models by Georgios Paraskevopoulos, Lukáš Opálka, Andrej Kováčik, Anna Paraskevopoulou, Eleni Panoutsopoulou, Irene Sagrafena, Petra Pullmannová, Robert Čáp, Kateřina Vávrová

“…However, when the missing ceramides were replaced by lysosphingolipids and FFAs, no further increase in permeability was observed. Conversely, these molecules partially mitigated the negative effects of ceramide deficiency, particularly with 5%–10% SPC, which reduced permeability even compared to control with “healthy” lipid composition. …”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…The PGEVs were isolated by ultracentrifugation and sucrose gradient centrifugation method and contained adequate functional components such as proteins, lipids, RNAs and active molecules. PGEVs exhibited remarkable stability, tolerating acidic digestion and undergoing minimal changes in simulated gastrointestinal fluid. …”
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Novel Insights into Surface Energies and Enhanced Gas-Sensing Capabilities of ZnGa₂O₄(111) via Ab Initio Studies by Cheng-Lung Yu, Yan-Cheng Lin, Sheng-Yuan Jhang, Jine-Du Fu, Yi-Chen Chen, Po-Liang Liu

“…It explores the interactions of gas molecules such as NO, NO₂, and CH₃COCH₃ with Ga-terminated, O-terminated, and Ga-Zn-O-terminated surfaces. …”
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The role of the interleukin family in liver fibrosis by Zixin Zhang, Zixin Zhang, Jiahui Wang, Hui Li, Qun Niu, Qun Niu, Yujing Tao, Yujing Tao, Xin Zhao, Xin Zhao, Zijian Zeng, Zijian Zeng, Haijian Dong, Haijian Dong

“…Among these, the interleukin family activates a complex cascade of responses, including cytokines, chemokines, adhesion molecules, and lipid mediators, playing a key role in the initiation and regulation of inflammation, as well as innate and adaptive immunity. …”
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Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy by Run‐Wei Song, Tian‐Ci Jiang, Xue‐Yang Zhang, Cheng‐Long Shen, Qing Lou, Chong‐Xin Shan

“…As a proof‐of‐concept, the photosensitizers of carbon nanodots (CDs)‐loaded chlorin e6 (CDs‐Ce6) are designed and integrated with the peroxalate molecules, and the as‐prepare polymer carbon nanodots (p‐CDs) exhibit novel tumor microenvironment (TME)‐responsive long‐persistent near‐infrared CL and photochemical reactions, evoking the in vivo imaging and synergistic dynamic therapy in tumor tissue. …”
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Disk in the Circumstellar Envelope of Carbon Mira V Cygni by Boris S. Safonov, Sergey G. Zheltoukhov, Andrey M. Tatarnikov, Ivan A. Strakhov, Victor I. Shenavrin

“…Asymptotic giant branch (AGB) stars are the primary source of dust and complex molecules in the interstellar medium. The determination of outflow parameters is often hindered by the unknown geometry of the circumstellar environment, creating a demand for high-angular resolution observations. …”
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Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection by Michal Holub, David A. Lawrence, Nancy Andersen, Alžběta Davidová, Ondřej Beran, Vilma Marešová, Pavel Chalupa

“…The laboratory analyses were performed using Luminex technology, and the following molecules were examined: IL-1Ra, IL-2, IL-4, IL-6, IL-8, TNF-α, INF-γ, MIP-1β, and MCP-1. …”
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Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses by Hongyu Yu, Shaoyuan Cui, Yan Mei, Qinggang Li, Lingling Wu, Shuwei Duan, Guangyan Cai, Hanyu Zhu, Bo Fu, Li Zhang, Zhe Feng, Xiangmei Chen

“…Flow cytometry analysis was used to study the expression of antigen-presenting cell surface markers and costimulatory molecules in mesangial cells. CD4+ T cell activation induced by mesangial cells was detected in terms of T cell proliferation and cytokine production. …”
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Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

“…Signal transducer and activator of transcription (STAT)1, STAT3, and STAT5A phosphorylation was significantly increased in the back skin and eyelids of vehicle-treated GVHD mice; topical delgocitinib administration significantly reduced the expression of these phosphorylated STAT molecules. Delgocitinib eye drops significantly attenuated corneal epithelial damage, MG acinar depletion, and inflammatory cells infiltration in GVHD mouse corneas. …”
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