Genetics of Cerebral Vasospasm by Travis R. Ladner, Scott L. Zuckerman, J Mocco

“…In our review, we summarize the most recent research involving key areas within the genetics and vasospasm discussion: (1) Prognostic role of genetics—risk stratification based on gene sequencing, biomarkers, and polymorphisms; (2) Signaling pathways—pinpointing key inflammatory molecules responsible for downstream cellular signaling and altering these mediators to provide therapeutic benefit; and (3) Gene therapy and gene delivery—using viral vectors or novel protein delivery methods to overexpress protective genes in the vasospasm cascade.…”
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Transcription factor specificity protein (SP) family in renal physiology and diseases by Wei Zhou, Jiaxi Fang, Qingqing Jia, Hanyan Meng, Fei Liu, Jianhua Mao

“…A detailed analysis of their expression and cellular localization in the healthy human kidney is presented, highlighting their involvement in fatty acid metabolism, electrolyte regulation, and the synthesis of important molecules. The review also delves into the diverse roles of SPs in various renal diseases, including renal ischemia/reperfusion injury, diabetic nephropathy, renal interstitial fibrosis, and lupus nephritis, elucidating their molecular mechanisms and potential as therapeutic targets. …”
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Reductive sulfinylation by nucleophilic chain isomerization of sulfonylpyridinium by Yifan Li, Weigang Zhang, Jeonguk Kweon, Yi Pan, Qing Wang, Sukbok Chang, Yi Wang

“…The late-stage modification of complex molecules and the ability to rapidly synthesize numerous sulfinyl bioisosteres of various drugs highlights the utility of this protocol.…”
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Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications by Sorina Dinescu, Simona Rebeca Ignat, Andreea Daniela Lazar, Ștefania Marin, Elena Danilă, Maria M. Marin, Denisa Ioana Udeanu, Mihaela Violeta Ghica, Mădălina G. Albu-Kaya, Marieta Costache

“…Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and regeneration by triggering molecules. To reduce the inflammation associated with skin burns, the addition of an anti-inflammatory factor in these scaffolds would greatly increase the quality of the therapy. …”
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Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications by Claudio Campa, Ciro Costagliola, Carlo Incorvaia, Carl Sheridan, Francesco Semeraro, Katia De Nadai, Adolfo Sebastiani, Francesco Parmeggiani

“…However, many other molecules, distinctive of the inflammatory response, act as neovascular activators in CNV. …”
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Synthesis of Cr(III)-Morin Complex: Characterization and Antioxidant Study by Qadeer K. Panhwar, Shahabuddin Memon

“…In addition, TG-DTA denotes the presence of coordinated and crystalline water molecules. The melting point of the complex was found to be 389°C by DSC. …”
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Fabrication of Si3N4 Nanocrystals and Nanowires Using PECVD by Jingwei Song, Xiying Ma, Wang Zui, Chen Wei, Zhongpin Chen

“…With Fe catalyst, Si3N4 nanowires were developed, indicating that Fe catalyst played a role for Si3N4 molecules directionally depositing into strings. The density of the nanowires is closely related to the density of Fe catalyst. …”
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Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases by Wenyan Zhou, Yan Yi, Wenyu Cao, Xiaolin Zhong, Ling Chen

“…N7-methylguanosine (m7G) modification is one of the most prevalent forms of chemical modification in RNA molecules, which plays an important role in biological processes such as RNA stability, translation regulation and ribosome recognition. …”
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Structure‐based computational design of antibody mimetics: challenges and perspectives by Elton J. F. Chaves, Danilo F. Coêlho, Carlos H. B. Cruz, Emerson G. Moreira, Júlio C. M. Simões, Manassés J. Nascimento‐Filho, Roberto D. Lins

“…Structure‐based computational approaches have emerged as indispensable tools in the rational design of those molecules, enabling the precise manipulation of their structural and functional properties. …”
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Unveiling the therapeutic potential of insect-derived natural products for drug discovery by Jasha Momo H. Anal, Lobeno Mozhui, Samuel Lalthazuala Rokhum

“…Medicinal insects are reservoirs for exploring bioactive molecules, which have various benefits. Their use in traditional medicinal practices explains why uncovering new chemical substances is worthwhile. …”
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Synthesis and crystal structure of 2,2,2-trichloroethyl N-{4-[6-(1-hydroxyethyl)-1,2,4,5-tetrazin-3-yl]benzyl}carbamate by J. Voss, H.G. Stammler, N. Sewald

“…The carbamate moieties form intermolecular hydrogen bonds, stacking the tetrazine molecules above each other, while lateral hydrogen bonds are formed between a tetrazine N atom and a hydroxyl group, the latter interaction being a scarcely explored structural feature of 1,2,4,5-tetrazines.…”
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Cutting Edge: Biomarkers for Chronic Spontaneous Urticaria by Marco Folci, Enrico Heffler, Giorgio W. Canonica, Raffaello Furlan, Enrico Brunetta

“…Some groups are trying to detect molecules which would be able to help clinicians in reaching a proper diagnosis; additionally, the opportunity to describe disease severity which leads to cluster patients in different groups could fill the gap in the numerous unmet clinical needs. …”
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Traditional uses, botanical description, phytochemistry, and pharmacological activities of Phytolacca acinosa: a review by Tooba Khalid, Chieh-Wei Chang, Samir Anis Ross, Faiza Naseer, Abdul Qadeer, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Hafiz Abdul Rafey

“…The traditional use, phytochemistry, and pharmacological properties of Phytolacca acinosa are outlined in this article.Main textTo date, few bioactive molecules have been identified and isolated from the plant, such as phytolacacinoside A, esculentoside H, jaligonic acid and esculentoside B, phytolaccanol and epiacetyl aleuritolic acid, esculentoside A, esculentoside C, esculentoside D, esculentoside T, esculentoside S, sitosterol. …”
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Changes in the Surface Chemistry and Adsorptive Properties of Active Carbon Previously Oxidised and Heat-Treated at Various Temperatures. II. Electrochemical Investigations of Surf... by M. Pakuła, S. Biniak, A. Świątkowski

“…The electrochemical behaviour of powdered carbon suggested electro-oxidation of the surface of the electrode material with participation of adsorbed hydroxy ions and water molecules. The possible electrochemical reactions and mechanisms of the surface processes were discussed in order to explain the observed phenomena.…”
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Reductive Thermal ALD of Pd and Pd2Ge From a Novel Recyclable Palladium Chloride Adduct by Anton Vihervaara, Timo Hatanpää, Mikko‐Ilmari Selänne, Kenichiro Mizohata, Mikko Ritala

“…Finally, full recyclability of the PdCl2(PEt3)2 is observed: unused molecules condensed in the exhaust tube can be collected by dissolving them into acetone, purified by recrystallization, and reused.…”
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e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease by Samuela Cataldi, Michela Codini, Stéphane Hunot, François-Pierre Légeron, Ivana Ferri, Paola Siccu, Angelo Sidoni, Francesco Saverio Ambesi-Impiombato, Tommaso Beccari, Francesco Curcio, Elisabetta Albi

“…The possibility that the overexpression of the e-cadherin might be implicated in the anti-inflammatory reaction to MPTP treatment by influencing the behavior of the other analyzed molecules is discussed.…”
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Identification of microbial exopolymer producers in sandy and muddy intertidal sediments by compound-specific isotope analysis by Hubas, Cédric, Gaubert-Boussarie, Julie, D’Hondt, An-Sofie, Jesus, Bruno, Lamy, Dominique, Meleder, Vona, Prins, Antoine, Rosa, Philippe, Stock, Willem, Sabbe, Koen

“…Extracellular polymeric substances (EPS) refer to a wide variety of high molecular weight molecules secreted outside the cell membrane by biofilm microorganisms. …”
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Synthesis and crystal structure of [Sr(urea)(NO3)2]n by Aysanem Bektursinova, Zulfiya Djumanazarova, Zamira Uzakbergenova, Jamshid Ashurov, Akram A Khan, Shakhnoza Kadirova, Batirbay Torambetov

“…Crystallizing in the orthorhombic space group Aba2, the asymmetric unit consists of an SrII cation, two nitrate anions, and two half urea molecules. The SrII cation adopts a distorted decahedral geometry coordinated by ten oxygen atoms, with Sr—O bond lengths ranging from 2.573 (3) to 2.847 (5) Å. …”
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The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation by Monica Molteni, Sabrina Gemma, Carlo Rossetti

“…In addition, it also binds endogenous molecules produced as a result of tissue injury. Hence, TLR4 represents a key receptor on which both infectious and noninfectious stimuli converge to induce a proinflammatory response. …”
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Phototreatment of Water by Organic Photosensitizers and Comparison with Inorganic Semiconductors by Merlyn Thandu, Clara Comuzzi, Daniele Goi

“…These photosensitizers cause cell death by generating reactive oxygen species (ROS) especially singlet oxygen in the presence of light. Such molecules are also being explored for photodynamically treating microbial infections, killing of unwanted pathogens in the environment, and oxidation of chemical pollutants. …”
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