Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum by Tabish Qidwai, Farrukh Jamal, Mohd Y. Khan, Bechan Sharma

“…Emergence of rapid drug resistance to existing antimalarial drugs in Plasmodium falciparum has created the need for prediction of novel targets as well as leads derived from original molecules with improved activity against a validated drug target. …”
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A mutation in porcine pre-miR-15b alters the biogenesis of MiR-15b\16-1 cluster and strand selection of MiR-15b. by Wenyang Sun, Jing Lan, Lei Chen, Jinjie Qiu, Zonggang Luo, Mingzhou Li, Jinyong Wang, Jiugang Zhao, Tinghuan Zhang, Xi Long, Jie Chai, Zunqiang Yan, Zongyi Guo, Shuangbao Gun

“…MicroRNAs (miRNAs) are small non-coding RNAs that are involved in translational regulation of the messenger RNA molecules. Sequence variations in the genes encoding miRNAs could influence their biogenesis and function. …”
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Molecular Simulation of Hydrogen Storage in Ion-Exchanged X Zeolites by Xiaoming Du

“…Adsorption temperature has an important effect on the distribution of hydrogen molecules in zeolite pores.…”
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The Role of Exosomes in Cancer Progression and Therapy by Shynggys Sergazy, Roza Seydahmetova, Alexandr Gulyayev, Zarina Shulgau, Mohamad Aljofan

“…Interestingly, tumor-derived exosomes carry oncogenic molecules, such as proteins and microRNAs, which can reprogram recipient cells, promote angiogenesis, and stimulate cancer pre-metastatic niche, supporting cancer growth and metastasis. …”
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Metabolomic profiles as a new understanding of disease processes by O. Yu. Zolnikova, M. S. Reshetova, M. N. Ivanova, V. T. Ivashkin

“…A new diagnostic direction is associated with high-sensitive spectral analysis of biomarker molecules. This review will discuss some of the latest advances with an emphasis on the use of metabolomics to identify major metabolic changes in various diseases. …”
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Fecal lipid markers in tandem with ancient sedimentary DNA as a tool for tracing past livestock farming from soils and sediments by Sabine Fiedler, Sascha Scherer, Ben Krause-Kyora

“…The study of organic molecules, which remain as traces in the environment over millennia, represents one way to overcome this drawback. …”
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Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1) by Dao Viet Hung, Tran Khac Vu

“…This phytoxin was found to inhibit selectively CaPkc1 and constitutes an interesting model for the design of novel antifungal molecules. In this research, 4,7,9-trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide (13) derived from (–)-cercosporamide was synthesized via a seven-step procedure by well-known reactions and evaluation of cytotoxicity and inhibition of CaPkc1. …”
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Leguminous Lectins as Tools for Studying the Role of Sugar Residues in Leukocyte Recruitment by N. M. N. Alencar, E. H. Teixeira, A. M. S. Assreuy, B. S. Cavada, C. A. Flores, R. A. Ribeiro

“…The natural physiological ligands for selectins are oligosaccharides found in glycoprotein or glycolipid molecules in cell membranes. In order to study the role of sugar residues in the in vivo lectin anti-inflammatory effect, we tested three leguminous lectins with different carbohydrate binding affinities in the peritonitis and paw oedema models induced by carrageenin in rats. …”
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Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides by Ji Eun Lee

“…Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms. …”
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Nonlinear Dynamics in a Chemical Reaction under an Amplitude-Modulated Excitation: Hysteresis, Vibrational Resonance, Multistability, and Chaos by A. V. Monwanou, A. A. Koukpémèdji, C. Ainamon, P. R. Nwagoum Tuwa, C. H. Miwadinou, J. B. Chabi Orou

“…This paper deals with the effects of an amplitude-modulated (AM) excitation on the nonlinear dynamics of reactions between four molecules. The computation of the fixed points of the autonomous nonlinear chemical system has been made in detail using the Cardan’s method. …”
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Complex formation between 3;3´-diethylthiacarbocyanine iodide and DNA and its investigation in aqueous solution by M. Y. Anikovsky, A. S. Tatikolov, V. A. Kuzmin

“…The binding of 3;3′-diethylthiacarbocyanine iodide (DTCC) with molecules of DNA was investigated by different photochemical methods. …”
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The Biological and Metabolic Fates of Endogenous DNA Damage Products by Simon Wan Chan, Peter C. Dedon

“…In DNA, this damage affects both the nucleobases and 2-deoxyribose, with a host of damage products that reflect the local chemical pathology such as oxidative stress and inflammation. These damaged molecules represent a potential source of biomarkers for defining mechanisms of pathology, quantifying the risk of human disease and studying interindividual variations in cellular repair pathways. …”
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Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers by Warut Tulalamba, Tavan Janvilisri

“…Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. …”
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Effects of Immersion Time and 5-Phenyl-1H-tetrazole on the Corrosion and Corrosion Mitigation of Cobalt Free Maraging Steel in 0.5 M Sulfuric Acid Pickling Solutions by El-Sayed M. Sherif, Asiful H. Seikh

“…Scanning electron spectroscopy and energy dispersive X-ray investigations confirmed that the inhibition of the steel corrosion is achieved via the adsorption of the PHTA molecules onto the steel precluding its surface from being dissolved.…”
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Sustainable Battery Biomaterials by Frank N. Crespilho, Carlos M. Costa, Senentxu Lanceros‐Méndez

“…This Perspective explores the transformative potential of biomaterials – specifically biopolymers, bioinspired redox molecules, and bio‐derived gels – in contributing to sustainable energy storage. …”
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Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, 1H NMR and 13C NMR spectroscopies by Refat Moamen S., Saad Hosam A., Adam Abdel Majid A., Al-Omar Mohamed A., Naglah Ahmed M.

“…This study suggests that the complexation of Allop with either the DDQ or CHL acceptor leads to a direct p®p* transition, whereas the molecules of Allop and PA are linked by intermolecular hydrogen- bonding interactions.…”
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Gelatin Used as a Transductor in an Optical Hygrometer Based on a Fabry-Perot Interferometer by Sergio Calixto

“…The transductors that have been probed are gelatin-thin films that are inserted between the mirrors of the FP. When water molecules are absorbed (desorbed) by the gelatin film, its refractive index and thickness change giving a movement of the rings in the interference pattern. …”
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Bile acids and incretins as modulators of obesity-associated atherosclerosis by Andrijana Kirsch, Juergen Gindlhuber, Diana Zabini, Elena Osto, Elena Osto

“…In recent years BAs and incretins are increasingly recognized as key signaling molecules, which target multiple tissues and organs, beyond the gastro-intestinal system. …”
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Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines by Antonio Pulcinella, Stefano Bonciolini, Robin Stuhr, Damiano Diprima, Minh Thao Tran, Magnus Johansson, Axel Jacobi von Wangelin, Timothy Noël

“…This approach broadens the synthetic utility of amides, facilitating late-stage modifications of drug-like molecules and the synthesis of saturated N-substituted heterocycles. …”
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Pre-T cell receptor-α immunodeficiency detected exclusively using whole genome sequencing by Daniele Merico, Nigel Sharfe, Harjit Dadi, Bhooma Thiruvahindrapuram, Jill de Rijke, Zakia Dahi, Mehdi Zarrei, Abdulrahman Al Ghamdi, Azhar Al Shaqaq, Linda Vong, Stephen W. Scherer, Chaim M. Roifman

“…Genetic aberrations in key molecules involved in T cell development lead to profound T cell immunodeficiency. …”
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