AI-driven prediction of drug activity against Toxoplasma gondii: Data augmentation and deep neural networks for limited datasets by Natalia V. Karimova, Ravithree D. Senanayake

“…Finally, the model was applied to screen FDA-approved drugs after filtering out molecules that did not align with the characteristics of the training dataset. …”
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Extend Plastron Longevity on Superhydrophobic Surface Using Gas Soluble and Gas Permeable Polydimethylsiloxane (PDMS) by Ankit Gupta, Hangjian Ling

“…However, the longevity of the plastron is significantly affected by gas diffusion, a process where gas molecules slowly diffuse into the ambient liquid. In this work, we demonstrated that plastron longevity could be extended using a gas-soluble and gas-permeable polydimethylsiloxane (PDMS) surface. …”
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The Role of TLR4 on B Cell Activation and Anti-β2GPI Antibody Production in the Antiphospholipid Syndrome by Si Cheng, Haibo Wang, Hong Zhou

“…However, TLR4 provides a third signal for B cell activation and then promotes B cells better receiving signals from both B cell antigen receptor (BCR) and CD40, thus promoting B cell activation, surface molecules expression, anti-β2GPI Ab production, and cytokines secretion and making B cell functioning like an antigen presenting cell (APC). …”
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Do cytokines play a role in the transition from acute to chronic musculoskeletal pain? by Andrea Ebersberger, Hans-Georg Schaible

“…Possible mechanisms for the development of such pain states are often reflected in inflammatory or neuropathic processes involving, among others, cytokines and other molecules. Since biologics such as blockers of TNF or IL-6 can attenuate inflammation and pain in a subset of patients with rheumatoid arthritis, the question arises to what extent cytokines are involved in the generation of pain in human musculoskeletal diseases. …”
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Effects of α-ZrP on Crystallinity and Flame-Retardant Behaviors of PA6/MCA Composites by Yuanfang Xiao, Jiayou Xu, Siwen Huang, Haiming Deng

“…MCA-α-ZrP were synthesized through the self-assembly of α-ZrP, Melamine (ME), and cyanuric acid (CA) molecules. The results of differential scanning calorimetry (DSC) and X-ray diffraction (XRD) showed that the incorporation of enough α-ZrP (30 wt% MCA) caused the increased crystallinity of PA6 and tended to form γ phase. …”
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In silico identification of switching nodes in metabolic networks by Mairet, Francis

“…A major challenge to better understand metabolic regulation is to identify, from the hundreds or thousands of molecules, the key metabolites where the re-orientation of fluxes occurs. …”
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Knowledge on the Use of Biosimilars in Hematological Malignancies Amongst Health Care Workers at a Tertiary Hospital in Northeast Nigeria by Rufai A. Dachi, Mustapha S. Umar, Maryam Mahdi, Nura H. Alkali, Falmata G. Mustapha, Fatima M. Muhammad, Alhaji Abdu

“…Their treatments have been revolutionized using biological molecules (biologics and biosimilars). These novel agents are used in the care of cancer patients and have significantly improved survival. …”
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Green Biosynthesis of Silver Nanoparticles from Moringa oleifera Leaves and Its Antimicrobial and Cytotoxicity Activities by Gufran Mahmood Mohammed, Sumaiya Naeema Hawar

“…Fourier transform infrared analysis shows the possible interactions between silver and bioactive molecules in Moringa oleifera leaves extracts, which may be responsible for the synthesis and stabilization of silver nanoparticles. …”
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Production of HMF-derivatives from wine residues using Saccharomyces cerevisiae as whole-cell biocatalyst by Joana T. Cunha, Aloia Romaní, Lucília Domingues

“…Transitioning to a bio-based economy requires prioritizing chemical production processes that utilize renewable resources, ensuring sustainability and environmental responsibility. 5-Hydroxymethylfurfural (HMF) and its derivatives are promising building blocks, ranked among the top 12 bio-based molecules derived from biomass. This study investigates the potential of wine residues as substrates for HMF production and explores the yeast Saccharomyces cerevisiae, a robust industrial microbial cell factory, as a whole-cell biocatalyst for converting HMF into high-value compounds, offering an alternative to chemical synthesis. …”
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Protonation and Solvation Thermodynamics of Some Naphthol Derivatives in KCl Aqueous Solution of Different Ionic Strengths by Farid I. El-Dossoki

“…The results reveal that naphthalen-1-ol and naphthalene-1,5-diol molecules have two ionisable protons (of the hydroxyl groups) while 4-amino-3-hydroxynaphthalene-1-sulphonic acid has three ionisable protons (hydrogen ion of the hydroxyl group, SO3H, and NH3+). …”
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COVID‐19 in early 2023: Structure, replication mechanism, variants of SARS‐CoV‐2, diagnostic tests, and vaccine & drug development studies by Ilker Polatoğlu, Tulay Oncu‐Oner, Irem Dalman, Senanur Ozdogan

“…Drug studies, therapeutic targets, various immunomodulators, and antiviral molecules applied to patients with COVID‐19 have been reviewed.…”
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Structural evolution characteristics of sulfur in coal during gold-tube thermal simulation by Liping Xue, Yuegang Tang, Shuo Gao

“…At Easy%Ro = 1.75, small molecules of free organic sulfur are most abundant in coal. …”
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Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants by Firza Rajasa Gunawan, Siti Mariyah Ulfa, Anna Safitri

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Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs by Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren

“…<b>Methods</b>: Model development was performed using published studies in mice leveraging the PK-Sim^® standard implementation for large molecules with added implementations of ASGPR-mediated liver disposition and downstream target effects. …”
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A Smart Chatbot for Interactive Management in Beta Thalassemia Patients by Alma Mohammed Alturaiki, Haneen Reda Banjar, Ahmed Salleh Barefah, Salwa Abdulrahman Alnajjar, Salwa Hindawi

“…Background. β-thalassemia is an inherited blood disorder that affects the production of hemoglobin molecules owing to the reduction or absence of beta chains. …”
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Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis by Jiasheng Xu, Kaili Liao, Weimin Zhou

“…Exosomes, as extracellular vesicles, participate in physiological and pathological processes by transmitting signaling molecules such as proteins, nucleic acids, and lipids. …”
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Mesenchymal Stem Cell–Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease by Carl Randall Harrell, Valentin Djonov, Ana Volarevic, Aleksandar Arsenijevic, Vladislav Volarevic

“…MSC-Exos contain a variety of bioactive proteins (growth factors, immunoregulatory molecules, cytokines, and chemokines) lipids, and microRNAs (miRNAs) which affect viability, proliferation, phenotype, and function of eye-infiltrated immune cells. …”
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The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells by Chenyi Ling, Marc D. Cook, Heather Grimm, Maitha Aldokhayyil, Dulce Gomez, Michael Brown

“…More than just a pure bystander, CRP directly interacts with endothelial cells to decrease endothelial nitric oxide synthase (eNOS) expression and bioactivity, decrease nitric oxide (NO) production, and increase the release of vasoconstrictors and adhesion molecules. Race is significantly associated with CRP levels and CVD risks. …”
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Screening of multi deep learning-based de novo molecular generation models and their application for specific target molecular generation by Yishu Wang, Mengyao Guo, Xiaomin Chen, Dongmei Ai

“…With the development of deep learning techniques for the de novo generation of molecules, also known as inverse molecular design, the increasingly widespread application of various types of deep learning algorithms has led to revolutionary changes in de novo molecular generation research. …”
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Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study by Ezhil Arasan Ramanan, Sailatha Ravi, K. R. Radha Anbu, Margaret Michael

“…Inositol and associated molecules display inhibitory properties against 5-α reductase, COX-2, and lipase enzymes in addition to their antimicrobial and anti-inflammatory properties. …”
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