Novel N-quaternary coumarin-3-yl-imidazo[1,2-a]pyridines as fluorescent hybrids: Their synthesis and biological evaluation in cancer cells by Karla Armendariz-Barrientos, Luis A. Pérez, Selene Lagunas-Rivera, Yolanda Alcaraz-Contreras, Marco A. García-Revilla, Heriberto Prado-Garcia, Rocío García-Becerra, Miguel A. Vazquez

“…Conversely, molecules lacking substituents are the least polar. …”
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Dexmedetomidine Attenuates Monocyte-Endothelial Adherence via Inhibiting Connexin43 on Vascular Endothelial Cells by Yunfei Chai, Runying Yu, Yong Liu, Sheng Wang, Dongdong Yuan, Jimei Chen

“…U937-HUVEC adhesion, adhesion-related molecules, and the activation of the MAPK (p-ERK1/2, p-p38, and p-JNK1/2) signaling pathway were detected. …”
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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

“…The creation of large omics datasets for F. buski by our group has accelerated the discovery of key molecules involved in intestinal fluke biology, toxicity, and virulence that can be targeted for vaccine development. …”
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Molecular mechanisms induced by phase modifiers used in hydrometallurgy: consequences on transfer efficiency and process safety by El Maangar, Asmae, Prévost, Sylvain, Dourdain, Sandrine, Zemb, Thomas

“…In this paper, we study a new class of molecules opening new possibilities beyond the commonly used phase modifiers (i.e., n-octanol). …”
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Multi-Omics Insights into Rumen Microbiota and Metabolite Interactions Regulating Milk Fat Synthesis in Buffaloes by Ye Yu, Runqi Fu, Chunjia Jin, Lin Han, Huan Gao, Binlong Fu, Min Qi, Qian Li, Jing Leng

“…By clustering these differential metabolites, most of those clustered in the HF group were lipid and lipid-like molecules such as secoeremopetasitolide B, lucidenic acid J LysoPE (0:0/18:2 (9Z, 12Z)), and 5-tetradecenoic acid. …”
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Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy by Eleni Paizanis, Michel Hamon, Laurence Lanfumey

“…Neurogenesis concerns mainly two areas in the brain: the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone, where it is controlled by several trophic factors and neuroactive molecules. Neurogenesis is involved in processes such as learning and memory and accumulating evidence implicates hippocampal neurogenesis in the physiopathology of depression. …”
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Characterizations of Physico-chemical properties for non-kekulean benzenoid hydrocarbon using m-polynomial by Muhammad Kamran, Aamir Khan, Zeeshan Anwar, Aiman Ishtiaq, Anns Uzair, Shanzay Khan, Sawaira Saeed, Sajid Ali, Saara Fatima, Ajwa Faisal, Baqir Hussain, Misbah Rasheed, Saba Mehmood

“…This work involves the computation of several degree-based topological indices that are helpful in figuring out how reactive the associated molecules are. In particular, we found these calculations to be helpful in examining the thermodynamic parameter entropy, which could be important for successfully reworking the structure of non-kekulean benzoid hydrocarbons.…”
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Antimony Resistance in Leishmania, Focusing on Experimental Research by Fakhri Jeddi, Renaud Piarroux, Charles Mary

“…However, resistance toward these compounds has recently emerged in areas where the replacement of these drugs is mainly limited by the cost of alternative molecules. In this paper, we reviewed the studies carried out on antimonial resistance in Leishmania. …”
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Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro by Pavić Kristina, Rajić Zrinka, Mlinarić Zvonimir, Uzelac Lidija, Kralj Marijeta, Zorc Branka

“…Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide an insight into the design of new anticancer agents.…”
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Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents by Ammad Ahmad Farooqi, Iqra Mobeen, Rukset Attar, Khalida I. Noel, Baojun Xu, William C. Cho

“…High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and resolution. …”
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A Promising Material by Using Residue Waste from Bisphenol A Manufacturing to Prepare Fluid-Loss-Control Additive in Oil Well Drilling Fluid by Zhi-Lei Zhang, Feng-Shan Zhou, Yi-He Zhang, Hong-Wei Huang, Ji-Wu Shang, Li Yu, Hong-Zhen Wang, Wang-Shu Tong

“…The results indicated that the residues were complex mixture of several molecules. 3-(2-Hydroxyphenyl)-1,1,3-trimethyl-2,3-dihydro-1H-inden-5-ol and phenol were the main components of the residues. …”
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Changes in Blood Profile from Steady State in Patients with Sickle Cell Anemia Admitted for Vaso-occlusive Crisis and Acute Chest Syndrome by Timothy Klouda, Deepti Raybagkar, Bruce Bernstein, Nataly Apollonsky

“…Close to half of all patients with sickle cell disease (SCD) will have at least one episode of acute chest syndrome (ACS) during their lifetime. Multiple cells and molecules involved with the inflammatory cascade play a role in the development of ACS. …”
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Studies of Electrolytic Conductivity of Some Polyelectrolyte Solutions: Importance of the Dielectric Friction Effect at High Dilution by Anis Ghazouani, Sondes Boughammoura, Jalel M'Halla

“…We present a general description of conductivity behavior of highly charged strong polyelectrolytes in dilute aqueous solutions taking into account the translational dielectric friction on the moving polyions modeled as chains of charged spheres successively bounded and surrounded by solvent molecules. A general formal limiting expression of the equivalent conductivity of these polyelectrolytes is presented in order to distinguish between two concentration regimes and to evaluate the relative interdependence between the ionic condensation effect and the dielectric friction effect, in the range of very dilute solutions for which the stretched conformation is favored. …”
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Cell-Specific Aptamers as Emerging Therapeutics by Cindy Meyer, Ulrich Hahn, Andrea Rentmeister

“…Since then, numerous aptamers with specificities for a variety of targets from small molecules to proteins or even whole cells have been selected. …”
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Photobiomodulation Process by Yang-Yi Xu, Timon Cheng-Yi Liu, Lei Cheng

“…It was found that the primary process of cellular PBM might be the key process of cellular PBM so that the transition rate of cellular molecules can be extended to discuss the dose relationship of PBM. …”
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On a mathematical model of bone marrow metastatic niche by Ana Isabel Muñoz, J. Ignacio Tello

“…The model considers the evolution of the signaling molecules CXCL-12 secreted by osteoblasts (bone cells responsible of the mineralization of the bone) and PTHrP (secreted by tumor cells) which activates osteoblast growth. …”
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Calculated characterisation of a sensitive gas sensor based on PEDOT:PSS by Mokhtar Aarabi, Alireza Salehi, Alireza Kashaninia

“…Abstract The interactions between poly (3,4‐ethylene dioxythiophene) poly (styrenesulfonate) (PEDOT:PSS) and small gas molecules are studied using non‐equilibrium Green's function formalism based on the density functional theory. …”
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Synthesis, Adsorption, and Recognition Properties of a Solid Symmetric Tetramethylcucurbit[6]uril-Based Porous Supramolecular Framework by Fei-Yang Tian, Rui-Xue Cheng, Yun-Qian Zhang, Zhu Tao, Qian-Jiang Zhu

“…In this work, we reported a porous supramolecular framework (A) constructed of a symmetric tetramethylcucurbit[6]uril (TMeQ[6]) in aqueous HCl solutions; the driving force was the outer surface interaction of cucurbit[n]urils, as well as hydrogen bonding between latticed water molecules and portal carbonyl oxygens of TMeQ[6]. Adsorption experimental results revealed that the porous supramolecular framework can absorb certain fluorophore guests (FGs) to form luminescent assemblies (FG@As) by fluorescence enhancement or colour change, and some of them can respond to certain volatile organic compounds. …”
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The big chill: Growth of in situ structural biology with cryo-electron tomography by Mikhail Kudryashev

“…In situ structural biology with cryo-electron tomography (cryo-ET) and subtomogram averaging (StA) is evolving as a major method to understand the structure, function, and interactions of biological molecules in cells in a single experiment. Since its inception, the method has matured with some stellar highlights and with further opportunities to broaden its applications. …”
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Development of Integrated Actinide Chemistry Application, AACE, for Acceleration of Actinide Chemistry Experiments by Nakase Masahiko, Nishihara Takahiro, Ikhwan Fauzia Hanum, Okamura Tomohiro, Matsui Kota

“…To efficiently find the candidate molecules we developed Acceleration of Actinide Chemistry Experiment (AACE), which can deploy transfer learning (TL) and human-in-the-loop machine learning (HITL-ML). …”
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