Suggested Topics within your search.
Suggested Topics within your search.
- Physics 1
-
2581
The Role of Inflammation in the Pathogenesis of Macular Edema Secondary to Retinal Vascular Diseases
Published 2014-01-01“…We focus on the inflammatory mediators implicated, the effect of the different intravitreal therapies, the recruitment of leukocytes mediated by adhesion molecules, and the role of retinal Müller glial (RMG) cells.…”
Get full text
Article -
2582
-
2583
Development of RNA interference-based therapy for rare genetic diseases
Published 2024-08-01“…RNAi employs small RNA molecules, such as small interfering RNA (siRNA) and microRNA (miRNA), to bind specific mRNA molecules and prevent their translation into proteins. …”
Get full text
Article -
2584
Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications
Published 2020-01-01“…Reviewing available articles, we have concluded that various concentrations of these molecules at different stages of retinopathy may exert different effects. …”
Get full text
Article -
2585
Spatio-temporal models of synthetic genetic oscillators
Published 2017-01-01“…Recent computational modelling has demonstrated that spatial movement of the molecules is a vital component of GRNs and may cause the oscillations. …”
Get full text
Article -
2586
PharmRL: pharmacophore elucidation with deep geometric reinforcement learning
Published 2024-12-01“…We also conduct experiments on the LIT-PCBA dataset and show that it provides efficient solutions for identifying active molecules. Finally, we test our method by screening the COVID moonshot dataset and show that it would be effective in identifying prospective lead molecules even in the absence of fragment screening experiments. …”
Get full text
Article -
2587
Role of topological indices in predictive modeling and ranking of drugs treating eye disorders
Published 2025-01-01“…By combining modeling and decision-makings approaches, this study presents a cost-effective way to comprehend the behavior of molecules. First, the topological indices of chemical graphs of molecules are determined, which provides valuable insights into their behavior. …”
Get full text
Article -
2588
Established and emerging prebiotics for gut microbiota
Published 2024-10-01“…The concept of prebiotics was introduced more than two decades ago, but these bioactive molecules still represent an attractive area of research. …”
Get full text
Article -
2589
Recent advances in electrochemical copper catalysis for modern organic synthesis
Published 2025-01-01“…Combining electrochemistry with transition-metal catalysis is a promising and rapidly growing methodology for effectively forming challenging C–C and C–heteroatom bonds in complex molecules in a sustainable manner. In this review, we summarize the recent advances in the combination of electrochemistry and copper catalysis for various organic transformations.…”
Get full text
Article -
2590
Surface Properties of Synthetic Calcium Hydroxyapatite
Published 2005-09-01“…It was concluded that the adsorbability of organic compounds depends on the relationship between the greatest effective charges on their atoms and the atoms of water molecules.…”
Get full text
Article -
2591
Optical Emission of the Nuclear-Induced Plasmas of Gas Mixtures
Published 2014-01-01“…The excitation kinetics of the first negative system of CO, heteronuclear ionic molecules of inert gases, and halogenides of inert gases under ionizing radiation are considered.…”
Get full text
Article -
2592
HLA Class II Defects in Burkitt Lymphoma: Bryostatin-1-Induced 17 kDa Protein Restores CD4+ T-Cell Recognition
Published 2011-01-01“…The observed defect was not associated with low levels of BL-expressed costimulatory molecules, as addition of external co-stimulation failed to result in BL-mediated CD4+ T-cell activation. …”
Get full text
Article -
2593
Specific Antibody Production by Blood B Cells is Retained in Late Stage Drug-naïve HIV-infected Africans
Published 2004-01-01“…The in vitro antibody production by drug-naïve individuals' PBMCs depended on exogenous cytokines (IL-2 and IL-10) but neither on the re-stimulation of reactive cells in cultures by purified HIV-1-gp 160 antigen nor on the re-engagement of CD40 surface molecules. Further, it was not abrogated by the addition of various monoclonal Abs (mAbs) to co-stimulatory molecules. …”
Get full text
Article -
2594
An Aminated Bacterial Biosorbent Capable of Effectively Binding Negatively Charged Pollutants in Aqueous Solution
Published 2008-10-01“…Amine groups were found to be responsible for accommodating negatively charged Reactive Red 4 (RR4) molecules via electrostatic interaction. Thus, increasing the number of amine groups on C. glutamicum , via amination, resulted in an enhanced RR4 biosorption capacity. …”
Get full text
Article -
2595
Crystal structure of poly[μ3-acetato-diaqua-μ3-sulfato-cerium(III)]: serendipitous synthesis of a layered coordination polymer exhibiting interlayer O—H...O hydrogen bonding
Published 2025-02-01“…Its asymmetric unit consists of one CeIII cation, one sulfate dianion, one acetate anion and two crystallographically independent water molecules, all of them located in general positions. …”
Get full text
Article -
2596
Effect of Functional Groups in Coal on the Depth of Adsorption Potential Well
Published 2021-01-01“…The different types and quantities of functional groups on the surface of coal samples lead to different forces between coal molecules and methane gas molecules, thus affecting the distribution of different depths of adsorption potential wells in coal samples.…”
Get full text
Article -
2597
N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential
Published 2025-01-01“…On the other hand, the aberrant expression of m7G modification-associated molecules is linked to clinicopathological characteristics, including tumour staging, lymph node metastasis, and unfavourable prognoses in patients with cancer, indicating their potential as tumour biomarkers. …”
Get full text
Article -
2598
Perspectives and Limitations of Mesenchymal Stem Cell–Based Therapy for Corneal Injuries and Retinal Diseases
Published 2025-01-01“…This protection is ensured by the production of a variety of immunosuppressive molecules, which create the immune privilege of the eye. …”
Get full text
Article -
2599
Oleogels for development of health-promoting food products
Published 2020-03-01“…This review explored the strategies in place to develop and produce oleogels, foreseeing their introduction in foods and how they might represent an important source of functionality through the use of healthy molecules. It also explored how oleogels can act on the human overall metabolic health if they are used in human diet. …”
Get full text
Article -
2600
Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia
Published 2011-01-01“…In later phases, the placenta promotes villous angiogenesis and vascular maturation that are finely controlled by angiogenic and antiangiogenic molecules. Among various molecules involved in placental neovascularization, vascular endothelial growth factor receptors (VEGFRs) and angiotensin II receptor type 1 (AT1) mediate important signaling pathways for maternal circulatory system and fetal growth. …”
Get full text
Article