Retracted: Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β-Cell Mass in Middle-Aged Obese Diabetic Mice by Journal of Diabetes Research

Get full text

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i> by Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan

“…Two identified allosteric inactive state pockets appear to be feasible alternatives to a larger closed pocket near the active site, and they can be targeted with specific drug-like small-molecule inhibitors. Virus-specific sequence and structure implications and the feasibility of multi-viral inhibitors are discussed.…”
Get full text

A new perspective on apoptosis: Its impact on meat and organoleptic quality in different animals by Boin Lee, Young Min Choi

Subjects: Get full text

Serum levels of neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and cystatin-C in renal artery stenosis: A pilot study by Raghunandan Prasad, Reeta Choudhary, Anuradha Singh, Surabhi Agarwal, P Kaushik, Kritika Singh, Rajanikant R Yadav, Amar Singh Yadav, Dharmendra Singh Bhadauria, Hira Lal

Subjects: Get full text

Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GCâMS and molecular docking by Deepu Mathew, Lidiya John P., Manila T.M., Divyasree P., Sandhya Rajan V.T.K.

“…This paper presents a precise account of the chemoprofile of pigeon pea leaves, stems and seeds, interaction of these molecules with target proteins and suggests 26 highly potential molecules which are drug candidates for multiple human diseases. …”
Get full text

EOLA1 Inhibits Lipopolysaccharide-Induced Vascular Cell Adhesion Molecule-1 Expression by Association with MT2A in ECV304 Cells by Weiling Leng, Xiaotian Lei, Hao Meng, Xinshou Ouyang, Ziwen Liang

“…In this report, we determined the subcellular localization of EOLA1 and the regulatory capacity of EOLA1 on vascular cell adhesion molecule-1 (VCAM-1) in response to LPS in ECV304 cells. …”
Get full text

Computational Studies on the Molecule 1-(2-Hydroxyethyl)-5-Fluorouracil in Gas Phase and Aqueous Solution and Prediction of Its Confinement inside Capped Nanotubes by Y. Tadjouteu Assatse, G. W. Ejuh, F. Tchoffo, J. M. B. Ndjaka

“…The calculated ∆Gsol values suggest that the studied molecule is more soluble than the 5-FU molecule. The results of quantum molecular descriptors show that the studied molecule is hard electrophile and strongly reactive.…”
Get full text

Solar energy driven photocatalytic membrane modules for water reuse in agricultural and food industries. Pre-industrial experience using s-triazines as model molecules by Ignazio Renato Bellobono, Franca Morazzoni, Riccardo Bianchi, Emilia Simona Mangone, Rodica Stanescu, Cristina Costache, Paola Maria Tozzi

“…A membrane module, utilizing photocatalytic membranes, has been employed in a pilot plant, in conditions of solar irradiation, to investigate photomineralisation of atrazine, propazine, terbutylazine, symazine, prometryn, and ametryn, as model molecules of s-triazine herbicides, at a standard concentration (1.0 ppm) simulating those of contaminated aquifers, by using ozone as oxygen supplier. …”
Get full text

Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury by Ren Zhou, Jibao Chen, Yunhan Tang, Chuijin Wei, Ping Yu, Xinmei Ding, Li’ao Zhu, Jiajia Yao, Zengqiang Ouyang, Jing Qiao, Shumin Xiong, Liaoliao Dong, Tong Yin, Haiqing Li, Ye Feng, Lin Cheng

Get full text

Soliton Molecules and Some Novel Types of Hybrid Solutions to (2 + 1)-Dimensional Variable-Coefficient Caudrey-Dodd-Gibbon-Kotera-Sawada Equation by Shuxin Yang, Zhao Zhang, Biao Li

“…Moreover, soliton molecules can become asymmetric solitons when the distance between two solitons of the molecule is small enough. …”
Get full text

The Increased Expression of HLA-DR and ICAM-1 Molecules by Human Bronchial Epithelial Cells, Induced by Activated Mononuclear Cells, is Downregulated by Nedocromil Sodium by O. Sacco, S. Lantero, L. Scarso, V. Frangova, V. Ottolini, G. A. Rossi

“…The presence of HLA-DR and ICAM-1 molecules on BECs was then evaluated by specific antibody staining and flow-cytometry analysis. …”
Get full text

Autoriser pour interdire. La fabrique des savoirs sur les molécules et leurs risques dans le règlement européen REACH by Henri Boullier

Get full text

Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules by Lisa M. James, Apostolos P. Georgopoulos

“…Since the binding of a peptide to an HLA-II molecule is the first and necessary step in initiating the production of antibodies, the findings above support our hypothesis that the severity of GWI symptomatology is partly due to a lack of HLA-II protection. …”
Get full text

Identifying the determining factors of detonation properties for linear nitroaliphatics with high-throughput computation and machine learning by Wen Qian, Jing Huang, Shi-tai Guo, Bo-wen Duan, Wei-yu Xie, Jian Liu, Chao-yang Zhang

Subjects: “…Energetic molecule…”
Get full text

NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD by Jinlong Zhang, Quan Jing, Longlong Yuan, Xianhui Zhou, Duolong Di, Jinyao Li, Dong Pei, Zhongxiong Fan, Jun Hai

Subjects: “…Gas signal molecule…”
Get full text

Evaluation of serum leptin and adiponectin and their associations with obesity-related renal injury among Egyptian adolescents by Azza A El-Shaheed, Reham F. Fahmy, Nermine N. Mahfouz, Salwa R El-Zayat, Hiba Sibaii, Rehab S.I. Moustafa

Subjects: Get full text

Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway by Ji-Ji Dao, Ji-Ji Dao, Wei Zhang, Wei Zhang, Chong Liu, Chong Liu, Qian Li, Qian Li, Chen-Meng Qiao, Chen-Meng Qiao, Chun Cui, Chun Cui, Yan-Qin Shen, Yan-Qin Shen, Shuang-Xi Chen, Shuang-Xi Chen, Wei-Jiang Zhao, Wei-Jiang Zhao

Subjects: Get full text

Clinical Significance of Negative Costimulatory Molecule PD-1/PD-L1 on Peripheral Blood Regulatory T Cell Levels among Patients with Pulmonary Tuberculosis by Chenchen Yang, Fanchao Dai, Rexiti Pulati, Yan Jiao, Qian Xu

“…This study aimed to investigate the expression and clinical significance of negative costimulatory molecules programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) on CD4+CD25+CD127low regulatory T cells (Tregs) in peripheral blood of patients with active pulmonary tuberculosis (TB). …”
Get full text

The PI3K/Akt Signaling Pathway Mediates the High Glucose-Induced Expression of Extracellular Matrix Molecules in Human Retinal Pigment Epithelial Cells by Dong Qin, Guo-ming Zhang, Xun Xu, Li-ya Wang

“…Extracellular matrix molecules, such as fibronectin, collagen IV, and laminin, are associated with fibrotic membranes. …”
Get full text

Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid by Kirstine Mejlstrup Hymøller, Kirstine Mejlstrup Hymøller, Stig Hill Christiansen, Stig Hill Christiansen, Anders Grønnegaard Schlosser, Uffe B. Skov Sørensen, Jean C. Lee, Steffen Thiel, Steffen Thiel

Get full text