A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications by Rousseau, Coralie, Demoulinger, Gautier, Rousvoal, Sylvie, Champeval, Delphine, Dolly, Maurane, Michel, Gurvan, Thomas, François, Markov, Gabriel V., Potin, Philippe, Dittami, Simon M., Prado, Soizic, Leblanc, Catherine, Le Guillard, Cécile

“…For some compounds, an alternative to wild harvesting could be the production of molecules of interest by organic synthesis or by biotechnological production, e.g., in microbial cell factories incorporating selected members of the algal microbiota. …”
Get full text

Broad Spectrum Anti-Quorum Sensing Activity of Tannin-Rich Crude Extracts of Indian Medicinal Plants by Varsha Shukla, Zarine Bhathena

“…In Gram negative bacteria the autoinducer molecules that mediate QS are acyl homoserine lactones (AHL) and in Gram positive bacteria they are peptides called autoinducing peptides (AIP). …”
Get full text

Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma by V. H. J. van der Velden

“…Glucocorticoids inhibit many inflammation-associated molecules such as cytokines, chemokines, arachidonic acid metabolites, and adhesion molecules. …”
Get full text

Synthesis and photodegradation studies of analogues of muscle relaxant 1,4-dihydropyridine compounds by Gündüz Miyase Gözde, Ragno Gaetano, Şimşek Rahime, De Luca Michele, Şafak Cihat, Grande Fedora, El-Khouly Ahmed, İşli Fatma, Yildirim Şeniz, Öztürk Fincan Gökçe Sevim, Ioele Giuseppina

“…Pharmacological tests on the molecules showed a good muscle relaxing effect, with a mechanism similar to that of nifedipine, however, proving to be more stable to light.…”
Get full text

Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases by Ballazhi Lulzime, Popovski Emil, Jashari Ahmed, Imeri Faik, Ibrahimi Ibrahim, Mikhova Bozhana, Mladenovska Kristina

“…These molecules possessed significantly higher potency against both test cell lines compared to 4-hydroxycoumarin…”
Get full text

CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity by Catia S. Pereira, M. Fatima Macedo

“…Lipid-specific T cells comprise a group of T cells that recognize lipids bound to the MHC class I-like CD1 molecules. There are four isoforms of CD1 that are expressed at the surface of antigen presenting cells and therefore capable of presenting lipid antigens: CD1a, CD1b, CD1c, and CD1d. …”
Get full text

Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes: Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia by Irene Mavroudi, Helen A. Papadaki

“…Various alleles and haplotypes of human leucocyte antigen (HLA) molecules have been implicated in the predisposition of developing the above diseases, as well as polymorphisms of inhibitory cytokines such as interferon-γ, tumor necrosis factor-α, and transforming growth factor-β1 along with polymorphisms on molecules of the immune system including the T-bet transcription factor and signal transducers and activators of transcription. …”
Get full text

The Laws of Natural Deduction in Inference by DNA Computer by Łukasz Rogowski, Petr Sosík

“…We present a DNA-based implementation of reaction system with molecules encoding elements of the propositional logic, that is, propositions and formulas. …”
Get full text

Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection by Yasushi Shintani, Yasuko Terao, Hiroyuki Ohta

“…To predict precise target molecules, we took advantage of the therapeutic time window and duration of hypothermia necessary to exert neuroprotective effects. …”
Get full text

Study of the Accessibility of Zeolite Crystals in Polyimide Matrices. A Route to Coatings Exhibiting Selective Permeation by Marie Šnáblová Fryčová, Milan Kočiřík, Arlette Zikánová, Petr Sysel, Bohumil Bernauer, Vladislav Krystl, Ivan Hüttel, Jiri Hradil, Mladen Eić

“…IIT was used to estimate the adhesion between the PI matrix and the zeolitic phase, the accessibility of the zeolite void space for gas molecules as well as for characterizing the spatial distribution of embedded crystals in the composite. …”
Get full text

Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming by Androniki Kretsovali, Christiana Hadjimichael, Nikolaos Charmpilas

“…Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. …”
Get full text

Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives by Pravin O. Patil, Sanjay B. Bari

“…In an attempt to identify potential lead antidepressant agents, a number of indole molecules, incorporating isoxazoline, were synthesized by microwave-assisted synthesis. …”
Get full text

The Drug Excipient Cyclodextrin Interacts With -Luciferin and Interferes With Bioluminescence Imaging by Jeyan S. Kumar MSc, Lisa M. Miller Jenkins PhD, Michael M. Gottesman MD, Matthew D. Hall PhD

“…Cyclodextrins are well-characterized, barrel-shaped molecules that can solubilize organic small molecules in aqueous solution via host–guest interactions. …”
Get full text

Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy by Yu-Zhe Chen, Xing-Lei Yao, Yasuhiko Tabata, Shinsaku Nakagawa, Jian-Qing Gao

“…In several studies, DCs were genetically engineered by tumor-associated antigens or by immune molecules such as costimulatory molecules, cytokines, and chemokines. …”
Get full text

Boosting disassembly of π–π stacked supramolecular nanodrugs under tumor microenvironment by introducing stimuli‐responsive drug‐mates by Wenzhe Xu, Ruixu Yang, Yingke Xue, Yang Chen, Shuwei Liu, Songling Zhang, Yonggang Wang, Yi Liu, Hao Zhang

“…Abstract Numerous reports have demonstrated the construction of supramolecular nanodrugs (SNDs) via the π–π stacking of drug molecules for antitumor applications because most drugs possess aromatic rings or other planar conjugate units. …”
Get full text

Recent Developments in the Physical Adsorption of Toxic Organic Vapours by Activated Carbons by Robert H. Bradley

“…The size of vapour molecules relative to the (slit) width of pores is also discussed, as is the effect of the presence of wider (> 2 nm) pores. …”
Get full text

Expression Profile of Tyrosine Phosphatases in HER2 Breast Cancer Cells and Tumors by Maria Antonietta Lucci, Rosaria Orlandi, Tiziana Triulzi, Elda Tagliabue, Andrea Balsari, Emma Villa-Moruzzi

“…Background: HER2-overexpression promotes malignancy by modulating signalling molecules, which include PTPs/DSPs (protein tyrosine and dual-specificity phosphatases). …”
Get full text

APBIO: bioactive profiling of air pollutants through inferred bioactivity signatures and prediction of novel target interactions by Eva Viesi, Ugo Perricone, Patrick Aloy, Rosalba Giugno

“…Abstract More sophisticated representations of compounds attempt to incorporate not only information on the structure and physicochemical properties of molecules, but also knowledge about their biological traits, leading to the so-called bioactivity profile. …”
Get full text

MicroRNA-155 Participates in the Expression of LSD1 and Proinflammatory Cytokines in Rheumatoid Synovial Cells by Ziliang Yu, Hao Liu, Jianbo Fan, Feihu Chen, Wei Liu

“…Subsequently, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was applied to probe into the level of miRNA-155 in FLS when stimulated by miRNA-155 molecules. Moreover, RT-qPCR was used to explore the relative LSD1 miRNA expression in FLS when stimulated by miRNA-155 molecules, and Western blot and immunofluorescence assay were applied to probe into the expression level of LSD1. …”
Get full text

Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite by Yanjing Gao, Jielin Chen, Jiangbo Liu, Mingqiang Li, Yichun Wang

Get full text