Enantiospecific mirror-imaged growth in overlayers of enantiopure thiadiazole-[9]helicene on Au(111) without commensurability by Fumi Nishino, Keisuke Fukutani, Jonas Brandhoff, Marco Gruenewald, Elise Fuerch, Maximilian Schaal, Felix Otto, Daniel Stelter, Roman Forker, Zheng Zhang, Takashi Hirose, Torsten Fritz, Satoshi Kera

Subjects: Get full text

Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis by Da-Long Dong, Guang-Zhen Jin

Subjects: Get full text

Stretching and immobilizing a single DNA molecule on a glass surface using pressure flow in a microchannel for super-resolution imaging by Naoki Azuma, Ryotaro Suzuki, Kenji Fukuzawa, Shintaro Itoh, Hedong Zhang

“…Single-DNA analysis combines fluorescence microscopy with a method of stretching a single DNA molecule from its random coil shape to a linear shape. …”
Get full text

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

Get full text

Theoretical Calculations and Molecular Docking Analysis of 4-(2-(4-Bromophenyl)Hydrazineylidene)-3,5-Diphenyl-4H-Pyrazole Molecule by Ümit Yıldıko, Veysel Tahiroğlu, Mehmet Bağlan, Kenan Gören

“…The molecular structure of 4-(2-(4-bromophenyl)hydrazineylidene)-3,5-diphenyl-4h-pyrazole (BHDH) molecule, which is a pyrazole derivative, was investigated theoretically using the Gaussian 09 program according to the Moller-Plesset (MP2) method. …”
Get full text

SERS Detection of Hydrophobic Molecules: Thio-β-Cyclodextrin-Driven Rapid Self-Assembly of Uniform Silver Nanoparticle Monolayers and Analyte Trapping by Qi Yuan, Yunqing Wang

“…High-sensitivity and repeatable detection of hydrophobic molecules through the surface-enhanced Raman scattering (SERS) technique is a tough challenge because of their weak adsorption and non-uniform distribution on SERS substrates. …”
Get full text

Gene Expression of Adhesion Molecules in Endothelial Cells from Patients with Peripheral Arterial Disease Is Reduced after Surgical Revascularization and Pharmacological Treatment by Franca Marino, Luigina Guasti, Matteo Tozzi, Laura Schembri, Luana Castiglioni, Elisabetta Molteni, Gabriele Piffaretti, Patrizio Castelli, Marco Cosentino

“…We investigated gene expression of the adhesion molecules (AMs) ICAM-1, VCAM-1, and β1-integrin in endothelial cells (ECs) isolated from venous blood (circulating EC, cEC) and purified from femoral plaques (pEC) obtained from 9 patients with peripheral artery disease (PAD) submitted to femoral artery thrombendarterectomy (FEA). …”
Get full text

Characterization and Evaluation of Zeolite A/Fe3O4 Nanocomposite as a Potential Adsorbent for Removal of Organic Molecules from Wastewater by Emmanuel Nyankson, Jonas Adjasoo, Johnson Kwame Efavi, Reuben Amedalor, Abu Yaya, Gloria Pokuaa Manu, Kingsford Asare, Nii Amarkai Amartey

“…The potential of Z-Fe3O4 NC as an adsorbent for removing methylene blue molecules (MB) from solution was examined using UV-Vis and kinetic and equilibrium isotherm models. …”
Get full text

Study of adsorption behavior of HCN and H2S molecules over undoped and Al-doped zinc oxide monolayer: A DFT approach by Dipak Oli, Om Shree Rijal, Ravi Kiran Neupane, Pitamber Shrestha, Shriram Sharma, Leela Pradhan Joshi, Rajendra Parajuli

Get full text

A comprehensive analysis of the effect of quorum-sensing molecule 3-oxo-C12-homoserine lactone on Candida auris and Candida albicans by Fruzsina Kovács, Ágnes Jakab, Noémi Balla, Zoltán Tóth, Dávid Balázsi, Lajos Forgács, Andrea Harmath, Aliz Bozó, Ágota Ragyák, László Majoros, Renátó Kovács

“…To gain deeper insights into this relationship, phenotypic and transcriptomic analyses were conducted in the presence of the primary P. aeruginosa quorum-sensing molecule, N-(3-oxododecanoyl)-l-homoserine lactone (HSL), against C. auris, with the results compared to those of C. albicans. …”
Get full text

MDFGNN-SMMA: prediction of potential small molecule-miRNA associations based on multi-source data fusion and graph neural networks by Jianwei Li, Xukun Zhang, Bing Li, Ziyu Li, Zhenzhen Chen

Subjects: “…Small molecule-miRNA association…”
Get full text

Changes of Cell Adhesion Molecules and T Cell Subset Populations in Acute Myeloid Leukemia Patients Undergoing Intravenous Administration of Cytarabine Supplemented with Idarubicin by Jinhua Piao, Didi Wang, Siying Pei, Tangdong Ge, Jing Li, Pengxia Zhang

“…Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), IL-10, and IL-35 were measured by ELISA methods. …”
Get full text

The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients by Mohamed Adel Abd Elaziz, Asmaa Mustafa Gouda Elewa, Dina Zaki Mohamed Zaki Abdel Hamid, Nohier Essam Soliman Ahmed Hassan, Éva Csongrádi, Emad Hamdy Hamouda Mohammed, Mohammed Abdel Gawad

Subjects: “…urinary kidney injury molecule-1…”
Get full text

PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors by Lan Zou, Rujing Wang, Mengnan Zhao, Yuke Li, Chen Sun, Jinjin Xie, Yan Chen, Qian Jing, Dandan Mi, Sanjun Shi

Subjects: “…Nonfluorescent invisible molecules…”
Get full text

Label-free (fluorescence-free) sensing of a single DNA molecule on DNA origami using a plasmon-enhanced WGM sensor by Ghamari Shahin, Chiarelli Germán, Kołątaj Karol, Subramanian Sivaraman, Acuna Guillermo P., Vollmer Frank

Subjects: “…single-molecule techniques…”
Get full text

Bioactive Molecules from the Invasive Blue Crab <i>Callinectes sapidus</i> Exoskeleton: Evaluation of Reducing, Radical Scavenging, and Antitumor Activities by Francesco Longo, Alessandro Attanzio, Laura Marretta, Claudio Luparello, Serena Indelicato, David Bongiorno, Giampaolo Barone, Luisa Tesoriere, Ilenia Concetta Giardina, Giulia Abruscato, Manuela Perlotti, Lucie Branwen Hornsby, Vincenzo Arizza, Mirella Vazzana, Aiti Vizzini, Chiara Martino, Angelica Listro, Vinicius Queiroz, Antonio Fabbrizio, Paolo Salvatore Francesco Ciaccio, Stella Maria Cascioferro, Francesca Di Gaudio, Manuela Mauro

Get full text

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage by Ji Eon Kim, Hyun Su Kim, Wonsik Kim, Eun Hae Lee, Soyeon Kim, Taewoo Kim, Eun-Ae Shin, Kyung-hee Pyo, Haesong Lee, Seo Hee Jin, Jae-Ho Lee, Soo-Min Byeon, Dong Joo Kim, Jinwook Jeong, Jeongwon Lee, Minjae Ohn, Hyojung Lee, Su Jong Yu, Dongyun Shin, Semi Kim, Jun Yeob Yoo, Seung-Chul Lee, Young-Ger Suh, Jung Weon Lee

“…We used comprehensive structure activity relationship analysis to identify TM4SF5-specific isoxazole (TSI)-based small molecules that inhibit TM4SF5-mediated effects. TM4SF5 expressed by hepatocytes reduced NK cell cytotoxicity by downregulating stimulatory ligands/receptors, including signaling lymphocytic activation molecule family member 7 (SLAMF7). …”
Get full text

Effect of HLA-G5 Immune Checkpoint Molecule on the Expression of ILT-2, CD27, and CD38 in Splenic B cells by Hana Rohn, Cordula Lang, Sabine Schramm, Falko M. Heinemann, Mirko Trilling, Anja Gäckler, Oliver Witzke, Peter A. Horn, Vera Rebmann

“…The human leukocyte antigen G (HLA-G) is an immune checkpoint molecule with a complex network of interactions with several inhibitory receptors. …”
Get full text

Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal Plants by Franklyn Nonso Iheagwam, Solomon Oladapo Rotimi

“…The findings suggest these molecules may play a role as therapeutic leads in tackling this pandemic due to their multitarget activity.…”
Get full text

Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2 and Other Selected Circulating Signaling Molecules in Patients with Diabetic Foot Ulcer by Jerzy Hohendorff, Anna Drozdz, Sebastian Borys, Agnieszka H. Ludwig-Slomczynska, Beata Kiec-Wilk, Ewa L. Stepien, Maciej T. Malecki

“…The mechanism of NPWT’s action may be associated with its influence on circulating molecules. We assessed NPWT’s effect on the plasma levels of angiopoietin-2 (Ang2), a key regulator of angiogenesis, and its microvesicular receptors (Tie2) as well as the microvesicles (MVs) themselves in DFU patients. …”
Get full text