Genome editing in cultured fishes by Eric Hallerman

“…As reviewed here, advances in knowledge of key molecular pathways and, in some cases, favorable alterations of phenotype have been achieved. …”
Get full text

Non-coding RNAs and exosomal ncRNAs in colorectal cancer by Yalda Zhoulideh

“…In this review, we discuss the molecular pathways involved in CRC and the emerging roles of ncRNAs and exogenous ncRNAs in the regulation of these pathways. …”
Get full text

Busting the Breast Cancer with AstraZeneca’s Gefitinib by S. Chemmalar, A. R. Intan Shameha, Che Azurahanim Che Abdullah, Nor Asma Ab Razak, Loqman Mohamad Yusof, Mokrish Ajat, Kim Wei Chan, Md Zuki Abu Bakar Zakaria

“…Hence, additional in-depth experiments are needed regarding various molecular pathways and crosstalk pathways to comprehend GEF’s action mechanism thoroughly in breast cancer patients. …”
Get full text

Therapeutic Applicability of Anti-Inflammatory and Proresolving Polyunsaturated Fatty Acid-Derived Lipid Mediators by Gerard L. Bannenberg

“…It is held that counter-regulatory lipid mediators and the specific molecular pathways activated by such endogenous agonists may be suitable for pharmacological use in the treatment of inflammatory disease. …”
Get full text

The forgotten link: how the oral microbiome shapes childhood growth and development by Raymond Rubianto Tjandrawinata, Nurlinah Amalia, Nurlinah Amalia, Nurlinah Amalia, Yosi Yohanes Putra Tandi, Ariq Fadhil Athallah, Caesaroy Afif Wibowo, Muhammad Reva Aditya, Muhammad Reva Aditya, Athaya Rahmanardi Muhammad, Athaya Rahmanardi Muhammad, Maghfira Rahma Azizah, Maghfira Rahma Azizah, Farizky Martriano Humardani, Ammar Nojaid, Jeremy Alvaro Christabel, Alfi Agnuristyaningrum, Fahrul Nurkolis, Fahrul Nurkolis

“…Future research should focus on elucidating the molecular pathways linking the oral microbiome to stunting and developing personalized interventions that optimize microbiome health in early life.…”
Get full text

Synaptic plasticity in fronto-insular circuits underlying stress susceptibility and resilience by Devin Rocks, Conor Liston

“…We discuss the roles of various synaptic and molecular pathways in these processes, their interaction with circadian rhythms, and their contributions to the regulation of mood, with a particular focus on anhedonia. …”
Get full text

Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis by Xiangyang Xia, Quanwei Tao, Qunchao Ma, Huiqiang Chen, Jian’an Wang, Hong Yu

“…The analyses provide new insights into molecular pathways of MSCs-based therapies and their augmentation by GHRH analogues.…”
Get full text

Comprehensive Analysis of Transcriptome Sequencing Data in the Lung Tissues of COPD Subjects by Woo Jin Kim, Jae Hyun Lim, Jae Seung Lee, Sang-Do Lee, Ju Han Kim, Yeon-Mok Oh

“…Gene expression profiling of lung tissue was performed to define the molecular pathways that are dysregulated in COPD. Methods. …”
Get full text

A Microfluidic-Based Cell-Stretching Culture Device That Allows for Easy Preparation of Slides for Observation with High-Magnification Objective Lenses by Momoko Kato, Kae Sato

“…Microfluidic-based cell-stretching devices are vital for studying the molecular pathways involved in cellular responses to mechanobiological processes. …”
Get full text

miRNAs and Melanoma: How Are They Connected? by Adriana Taveira da Cruz, Miriam Galvonas Jasiulionis

“…Despite being rare, its metastatic form is usually incurable, which makes melanoma the major death cause of all skin cancers. Some molecular pathways are frequently disrupted in melanoma, and miRNAs probably have a decisive role on these alterations. …”
Get full text

Transcriptomic signatures of subcutaneous adipose tissue in patients with diabetes and coronary artery disease: a pilot study by Ilias P. Doulamis, Bernard Pan, Aspasia Tzani, Jorge Plutzky, G. William Wong, Ahmet Kilic, Risa M. Wolf

“…Our results demonstrated that pathways related to apoptosis and immune response were significantly dysregulated in the adipose tissue of T2D subjects. The main molecular pathways involved were CXCR, NOTCH, STAT, NFKB1 and FGFR pathways, which have a well-documented role in diabetes and CAD. …”
Get full text

Phytonanoparticles as novel drug carriers for enhanced osteogenesis and osseointegration by Nandita Suresh, Nebu George Thomas, Matti Mauramo, Tuomas Waltimo, Timo Sorsa, Sukumaran Anil

“…We examine the mechanisms by which phytonanoparticles, particularly those derived from gold, silver, and zinc oxide, influence key molecular pathways in osteogenesis, including RUNX2 and Osterix signaling. …”
Get full text

Epithelial mesenchymal transition and cancer stem cell markers in oral epithelial dysplasia and oral squamous cell carcinoma by Burcu Tokozlu, Özlem Özer Yücel, Sibel E. Gültekin, Leyla Arslan Bozdağ

“…Yet, the existence of CSC in dysplastic tissue and the molecular pathways of progression from dysplasia to malignancy remain to be explored. …”
Get full text

Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells by Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone

“…However, although to a lesser extent, curcumin also impaired cell survival in HCT 116 p53 null cells, suggesting that other molecular pathways or factors, beyond p53, may be involved in curcumin-induced cytotoxicity.…”
Get full text

Development of animal models to study aggressive thyroid cancers by Shovan Dutta, Jeffrey A Knauf

“…The development of mouse models for thyroid cancer has significantly advanced over the years, enhancing our understanding of thyroid tumorigenesis, molecular pathways and treatment responses. The earliest mouse models of thyroid cancer relied on hormone, radiation or chemical carcinogenesis to induce tumors. …”
Get full text

Organoid development and applications in gynecological cancers: the new stage of tumor treatment by Yang Li, Meiying Qin, Ning Liu, Chunmei Zhang

“…Tumor-derived organoids preserve the histological and molecular characteristics of the original tumors, making them invaluable for studying tumor biology, molecular pathways, and the tumor immune microenvironment. …”
Get full text

Jingui Shenqi Wan alleviates bone loss induced by primary osteoporosis by inhibiting osteoblast pyroptosis by Yuwangxuan Qian, Yihe Yu, Fan Yang, Qixing Liang, Dan Xu, Jiaxiang Chen, Xueqin Hu

“…Through a systematic investigation, we sought to identify the specific molecular pathways through which JGSQW modulates the progression of PMOP, thereby providing a scientific basis for its clinical application. …”
Get full text

Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal by Seyed Mohammad Doodmani, Payman Rahimzadeh, Najma Farahani, Seyedalireza Mirilavasani, Mina Alimohammadi, Noushin Nabavi, Elmira Alaei, Afshin Taheriazam, Maryam Abedi, Nadia Shafiee, Salman Daneshi, Mehrdad Hashemi

“…In conclusion, SFN shows significant promise in cancer therapy by targeting multiple molecular pathways, improving the efficacy of chemotherapy, and overcoming drug resistance, particularly when incorporated into advanced nanoparticle delivery systems.…”
Get full text

Current Treatment Regimens and Promising Molecular Therapies for Chronic Hepatobiliary Diseases by Marilena Durazzo, Arianna Ferro, Victor Manuel Navarro-Tableros, Andrea Gaido, Paolo Fornengo, Fiorella Altruda, Renato Romagnoli, Søren K. Moestrup, Pier Luigi Calvo, Sharmila Fagoonee

“…Drugs targeting molecular pathways involved in chronic hepatobiliary diseases, such as inflammation, hepatic stellate cell activation and proliferation, and extracellular matrix production, are being developed. …”
Get full text

Host RNA-Binding Proteins as Regulators of HIV-1 Replication by Sebastian Giraldo-Ocampo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo

“…During HIV-1 infection, these proteins are key players in the fine-tuning of viral and host cellular and molecular pathways, including (but not limited to) viral entry, transcription, splicing, RNA modification, translation, decay, assembly, and packaging, as well as the modulation of the antiviral response. …”
Get full text