Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from No... by Xinlong Zhou, Kailash Wagh, Guizhen Lv, Devender Sharma, Wei Lei

Get full text

Te fauna of mosquitoes (Diptera: Culicidae) of Armenia by V.A. Burlak, Yu.V. Andreeva, O.V. Shcherbakov, V.S. Fedorova, E.S. Soboleva, M.K. Haidara, S.S. Alekseeva, R.V. Slobodyanik, H.S. Gevorgyan, S.A. Aghayan, G.N. Artemov

“…In addition to using cytogenetic and molecular diagnostic methods, the larvae and adults morphological characteristics or egg chorion pattern were used to identify 1607 adults and 392 larvae. …”
Get full text

Prenatal diagnosis of chromothripsis causing complex chromosomal rearrangement involving chromosomes 5, 7 and 11 leading to TWIST1 deletion and Saethre-Chotzen syndrome by Ivana Joksic, Mina Toljic, Nela Maksimovic, Dijana Perovic, Tatjana Damnjanovic, Aleksandar Jurisic

“…Conclusion: Use of advanced molecular diagnostic techniques in combination with cytogenetic methods allows for precise characterization of CCRs and detection of molecular mechanisms of their origin. …”
Get full text

γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies by Eric X. Wei, Vasiliki Leventaki, John K. Choi, Susana C. Raimondi, Elizabeth M. Azzato, Sheila A. Shurtleff, Menchu G. Ong, Diana M. Veillon, James D. Cotelingam, Rodney E. Shackelford

“…Here we report two pediatric T-ALL cases and present their clinical features, histology, immunophenotypes, cytogenetics, and molecular diagnostic findings. The first patient is a two-year-old girl with leukocytosis, circulating lymphoblasts, and a cryptic insertion of a short-arm segment at 10p12 into the long-arm segment of 11q23 resulting in an MLL and AF10 fusion transcript, which may be the first reported in γδ T-ALL. …”
Get full text

Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma by Abdulrazzaq Neamah Zghair, Sumayah Faruq Kasim, Nazar Sh. Mohammed, Anil K. Sharma

“…Further, this could lead to the development of a novel molecular diagnostic tool. …”
Get full text

Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor by Ryan S. Chiang, Ashton A. Connor, Brant A. Inman, Wen-Chi Foo, David N. Howell, John F. Madden, Matthew J. Ellis, Aparna S. Rege, Michael R. Harrison

“…Herein, we describe a 60-year-old woman with metastatic donor-derived upper tract urothelial carcinoma (UTUC) discovered nine years postrenal transplant. Molecular diagnostic studies using polymerase chain reaction amplification of short tandem repeat alleles and HLA tissue typing proved that the urothelial carcinoma originated from donor tissue. …”
Get full text

Optimal Molecular Methods in Detecting p190BCR-ABL Fusion Variants in Hematologic Malignancies: A Case Report and Review of the Literature by Rebecca J. Sonu, Brian A. Jonas, Denis M. Dwyre, Jeffrey P. Gregg, Hooman H. Rashidi

“…In the era of molecular diagnostic medicine and targeted therapy, it is essential to have an understanding of the limitations of molecular assays and to follow a comprehensive diagnostic approach in order to detect common abnormalities and rare variants. …”
Get full text

Pituitary adenoma: important genetic factors and clinical diagnostic issues by G. Juknytė, E. Karinauskė, R. Liutkevičienė

“…Attempts are also being made to find new molecular diagnostic and prognostic targets that would contribute to more effective treatment of pituitary adenomas. …”
Get full text

Comparative analysis of selected methods of carbapenemase determination among clinical Klebsiella pneumoniae. by Agata Pruss, Alicja Skierska, Paweł Kwiatkowski, Helena Masiuk, Joanna Jursa-Kulesza, Stefania Giedrys-Kalemba, Iwona Bilska, Monika Sienkiewicz, Maria V Melnyk, Barbara Dołęgowska

“…Two types of tests play an important role here: phenotypicand molecular diagnostic methods. The latter complement phenotypic tests and a mandatory procedure to confirm the detection of carbapenemases. …”
Get full text

Evaluation of the performance of diagnostic methods of canine parvovirus-2 and canine enteric coronavirus infections under different storage conditions and determination of molecul... by Irmak Dik, H. Pelin Aslim, Oya Bulut

“…<p> <b>Conclusion:</b> The importance of choosing molecular diagnostic methods and using fresh samples for accurate diagnosis of virological infections can be emphasized.…”
Get full text

Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep by Fulya Altınok Yipel, Hüseyin Güngör

“…<p> <b>Conclusion:</b> In conclusion, it is thought that further studies techniques such as molecular diagnostic methods are needed in terms of hemostatic, hematological and biochemical effects of increasing single doses of meloxicam in sheep.…”
Get full text

Proceedings of clinical trials on bile tract cancer by XIONG Yichen, YANG Ziyi, SANG Yuer, GONG Wei

“…Along with the advances of tumor molecular diagnostic technology and the in-depth mining of gene expression information of BTC, BTC precision medical research has entered a new era. …”
Get full text

Tuberculosis of the thyroid gland: A rare case report by Manisha Kamlesh Galani, Kamlesh Jamnadas Galani, Swati Nileshkumar Lakhani

“…Confirmation typically involves detecting acid-fast bacilli through staining techniques like Ziehl Neelsen (ZN), molecular diagnostic methods such as TB Gene Expert or polymerase chain reaction for Mycobacterium tuberculosis (TB PCR), and histopathological examination of excised specimens. …”
Get full text

Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis by Jifeng Tang, Jinfang Xia, Huiming Sheng, Jinpiao Lin

“…We described the B-cell-related molecular landscape of RA synovium and constructed a molecular diagnostic model in RA. The three genes FAS, GPR183, and TFRC may be potential targets for clinical diagnosis and immunoregulatory therapy of RA.…”
Get full text

PYROSEQUENCING: ITS POTENTIAL AND LIMITATIONS IN DIAGNOSIS OF INHERITED DISEASES IN CATTLE by Н. A. Kirsanova, A. V. Sukhoedova, M. A. Pleskacheva, I. V. Soltynskaya, I. A. Timofeeva, О. V. Prasolova, E. V. Krylova

“…The abundance of lethal mutations in the populations requires a broader application of molecular diagnostic methods for detection of monogenic hereditary diseases. …”
Get full text

Development and Validation of LAMP Assays for Distinguishing MPXV Clades with Fluorescent and Colorimetric Readouts by Nazente Atceken, Sara Asghari Dilmani, Ahmed Choukri Abdullah, Mutlu Sarıkaya, Defne Yigci, Gozde Korkmaz, Savas Tasoglu

“…As a result, we successfully developed three highly specific molecular diagnostic tests that distinctly differentiate between MPXV clades, delivering essential tools for the precise diagnosis and effective control of Mpox.…”
Get full text

A cross-sectional pilot study to estimate the frequency of minor blood group alleles and phenotypes in RhD-negative North Indian blood donors by DNA microarray analysis by Gita Negi, Sheetal Malhotra, Bela Goyal, Praveen Kumar Singh, Anissa Atif Mirza

“…INTRODUCTION: There are scarce data on Indian blood donors with respect to blood group phenotypes using molecular diagnostic modalities. Hence, we planned to estimate frequencies of blood group alleles/phenotypes using DNA microarray analysis in the north Indian RhD-negative blood donor population. …”
Get full text

PWS/AS MS-MLPA Confirms Maternal Origin of 15q11.2 Microduplication by Angelika J. Dawson, Janice Cox, Karine Hovanes, Elizabeth Spriggs

Get full text

Identification of Nontuberculous Mycobacterium and Mycobacterium tuberculosis Complex in Sputum Patients with Suspected Tuberculosis by Fanny Indriyani Biyang, Muhammad Nasrum Massi, Lisa Tenriesa Muslich, Andi Rofian Sultan, Mochammad Hatta, Ahmad Rahmat Ramadhan, Baedah Madjid

“…Conclusions: The study underscores the challenges in differentiating between MTBC and NTM, highlighting the necessity for molecular diagnostic approaches. Notably, we found NTM in sputum samples from patients previously treated for TB. …”
Get full text

Identifying RBBP7 as a Promising Diagnostic Biomarker for BK Virus-Associated Nephropathy by Yicun Wang, Yuxuan Wang, Di Zhang, Hao Zhang, Wei Wang, Xiaopeng Hu

“…BK virus-associated nephropathy (BKVN) remains a major infectious complication due to powerful immunosuppression in kidney transplant recipients, and its histologic appearance can mimic rejection, leading to diagnostic and treatment dilemmas thus molecular diagnostic methods would be beneficial. We collected gene expression profiles of 169 kidney biopsies taken from BKVN, rejection, and stable functioning allografts, based on single sample gene set enrichment analysis and random forest algorithm, and three hallmark activities associated with DNA damage and proliferation were found to be relatively specific in BKVN. …”
Get full text