The continually evolving landscape of novel therapies in oncogene-driven advanced non-small-cell lung cancer by Barbara Melosky, Rosalyn A. Juergens, Shantanu Banerji, Adrian Sacher, Paul Wheatley-Price, Stephanie Snow, Ming-Sound Tsao, Natasha B. Leighl, Ilidio Martins, Parneet Cheema, Geoffrey Liu, Quincy S. C. Chu

“…Non-small-cell lung cancer (NSCLC) is a highly heterogeneous disease that is frequently associated with a host of known oncogenic alterations. Advances in molecular diagnostics and drug development have facilitated the targeting of novel alterations such that the majority of NSCLC patients have driver mutations that are now clinically actionable. …”
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Sero-molecular prevalence of toxoplasmosis in hemodialysis and peritoneal dialysis patients in Markazi Province, Iran by Hossein Sarmadian, Mana Shojapour, Fereshteh chegeni, Mohammad Amin Tabatabaiefar, Farshid Haghverdi, Roham Sarmadian, Reza Ghasemikhah

“…Given the limitations of serological tests, molecular diagnostics like PCR should be considered for better detection in immunocompromised patients.…”
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Impact of pollution on microbiological dynamics in the pistil stigmas of Orobanche lutea flowers (Orobanchaceae) by Karolina Wiśniewska, Sebastian Wojciech Przemieniecki, Krzysztof Krawczyk, Anna Hoffmann, Renata Piwowarczyk

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Synthesis of Specifically Modified Oligonucleotides for Application in Structural and Functional Analysis of RNA by Nico Rublack, Hien Nguyen, Bettina Appel, Danilo Springstubbe, Denise Strohbach, Sabine Müller

“…Nowadays, RNA synthesis has become an essential tool not only in the field of molecular biology and medicine, but also in areas like molecular diagnostics and material sciences. Beyond synthetic RNAs for antisense, aptamer, ribozyme, and siRNA technologies, oligoribonucleotides carrying site-specific modifications for structure and function studies are needed. …”
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Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies by Tara Chand, Ashwini Kumar Dubey, Gauri Misra

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Isolation of Intestinal Parasites of Public Health Importance from Cockroaches (Blattella germanica) in Jimma Town, Southwestern Ethiopia by Haji Hamu, Serkadis Debalke, Endalew Zemene, Belay Birlie, Zeleke Mekonnen, Delenasaw Yewhalaw

“…Moreover, further identification of the Strongyloides-like worm is required using molecular diagnostics.…”
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A Multiplex High-Resolution Melting (HRM) assay to differentiate Fusarium graminearum chemotypes by Lovepreet Singh, Milton T. Drott, Hye-Seon Kim, Robert H. Proctor, Susan P. McCormick, J. Mitch Elmore

“…Together, our results demonstrate that this simple, rapid, and accurate assay can be applied to F. graminearum molecular diagnostics and population surveillance programs.…”
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Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations by Maria Del Valle Estopinal, Lavinia P. Middleton, Bita Esmaeli, Keyur P. Patel, Sara Nowroozizadeh, Michelle D. Williams

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Addressing the emerging threat of Oropouche virus: implications and public health responses for healthcare systems by Olalekan John Okesanya, Blessing Olawumi Amisu, Olaniyi Abideen Adigun, Mohamed Mustaf Ahmed, Abdulmajeed Opeyemi Agboola, Tolga Kab, Gilbert Eshun, Bonaventure Michael Ukoaka, Tolutope Adebimpe Oso, Jerico Bautista Ogaya, Don Eliseo Lucero-Prisno

“…Advancements in molecular diagnostics and vector control strategies can mitigate Oropouche fever’s impact. …”
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Isolation and Molecular Identification of Lactic Acid Bacteria Using 16s rRNA Genes from Fermented Teff (Eragrostis tef (Zucc.)) Dough by Belay Tilahun, Anteneh Tesfaye, Diriba Muleta, Andualem Bahiru, Zewdu Terefework, Gary Wessel

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Heterogeneous adverse childhood experiences and cognitive function in an elderly Chinese population: a cohort study by Ya Fang, Manqiong Yuan, Fengzhi Qin, Chuanhai Xu

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Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach by Navid Kashani, Amir Sabbaghian, Fatemeh EmamiPari, Mohammad Khalili Gorjimahalleh, Mahdi Aalikhani

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Advancements in the integration of isothermal nucleic acid amplification methods for point-of-care testing in resource-limited settings by Noemi Bellassai, Roberta D'Agata, Giuseppe Spoto

“…This review focuses on the applications of molecular diagnostics for POC devices in low-resource settings, with a particular emphasis on isothermal nucleic acid amplification assays integrated into microfluidic platforms. …”
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Cost-effectiveness of diagnostic tools and strategies for the screening and diagnosis of tuberculosis disease and infection: a scoping review by Colin A Russell, Morten Ruhwald, Brooke E Nichols, Shaukat Khan, Tom Ockhuisen, Alexandra de Nooy, Helen E Jenkins, Alvin Han, Sarah Girdwood, Mikashmi Kohli

“…Further scale-up with molecular diagnostics, such as GeneXpert and Truenat, was shown to be broadly cost-effective, with a multitest approach likely to be cost-effective for both screening and diagnosis. …”
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RETRACTED ARTICLE: Establishment of an Acanthamoeba keratitis mouse model confirmed by amoebic DNA amplification by Heekyoung Kang, Hae-Jin Sohn, A-Young Park, A-Jeong Ham, Jeong-Heon Lee, Young-Hwan Oh, Yong-Joon Chwae, Kyongmin Kim, Sun Park, Hongseok Yang, Suk-Yul Jung, Jong-Hyun Kim, Ho-Joon Shin

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Kidney REPLACEment therapies in patients with acute kidney injury and RHABDOmyolysis (ReplaceRhabdo): a pilot trial by Lorenz Weidhase, Antonia Borrmann, Anja Willenberg, Meinhard Mende, Christina Scharf-Janßen, Sirak Petros, Jonathan de Fallois

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Epidemiology and Mechanism of Drug Resistance of Multidrug-Resistant Klebsiella Pneumoniae Isolated from Patients with Urinary Tract Infection in Beijing Teaching Hospital, China by Xie Z, Jian J, Chen L

“…Zeqiang Xie,1– 3 Jiyong Jian,1– 3 Liang Chen1– 3 1Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Peking University Ninth School of Clinical Medicine, Beijing, People’s Republic of China; 3Beijing Key Laboratory of Urinary Cellular Molecular Diagnostics, Beijing, People’s Republic of ChinaCorrespondence: Liang Chen, Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University, NO. 10, Tie Yi Road, Yang Fang Dian, Beijing, Haidian District, 100038, People’s Republic of China, Tel +86 18911726950, Email chenliang2254@bjsjth.cnPurpose: Klebsiella pneumoniae is an important pathogenic bacterium in causing urinary tract infection. …”
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<i>Solanum nigrum</i> L. is a potato spindle tuber viroid reservoir by N. V. Mironenko, A. V. Khiutti, E. I. Kyrova, N. M. Lashina, O. S. Afanasenko

“….), is ubiquitous in Russia.Materials and methods. Molecular diagnostics of the viroid was performed using RT-PCR with the P3/P4 primers specific for PSTVd and 6Pospi F/R specific for the Pospiviroidae family of viroids. …”
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Case study of a neuroendocrine tumor of uncertain origin: single-cell transcriptomics unravels potential primary location by Frolova Tatyana, Ekaterina Avsievich, Diana Salimgereeva, Zoia Antysheva, Alesia Maluchenko, Denis Maksimov, Ilia Feidorov, Mark Voloshin, Olga Glazova, Natalia Bodunova, Nikolay Karnaukhov, Pavel Volchkov, Julia Krupinova

“…This study explores the histogenesis of a retroperitoneal, non-functional NET localized between the duodenum and pancreatic head, utilizing advanced molecular diagnostics to elucidate its probable primary source. …”
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Insights into the Correlation between Toll-Like Receptor 2 Polymorphism and HBV-Related Disease Progression and Occurrence of Hepatocellular Carcinoma: A Case-Control Study in Egyp... by Naglaa S. Elabd, Marwa L. Helal, Mohsen Elkhayat, Heba Kamal Abd-ElKhalek, Doaa M. Ahmed, Asmaa M. El-Shemy, Yara S. Elsaadawy, Rasha A. Abdelmoneum, Hind S. AboShabaan, Randa M. Seddik

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