Pien Tze Huang Attenuates Neuro-inflammatory Injury in BV2 Microglial Cells Induced by Lipopolysaccharide via Inhibition of TLR4/MAPK Signaling Pathway by Zhenwei HUANG, Qing ZHANG, Lili HUANG, Xiaoqin ZHANG, Mingqing HUANG

“…Objective:To investigate the protective effect and the molecular mechanism of Pien Tze Huang (PZH) on Lipopolysaccharide (LPS) -induced neuro-inflammatory injury in BV2 microglial cells.Methods:BV2 microglial cells were cultured with RPMI-1640 medium supplemented with 10%fetal bovine serum and 1%penicillin/streptomycin at 5%CO₂and 37℃in a humidified incubator. …”
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Comparison of immune responses to SARS-CoV-2 spike following Omicron infection or Omicron BA.4/5 vaccination in kidney transplant recipients by Inga Tometten, Tobias Brandt, Maike Schlotz, Ricarda Stumpf, Sinje Landmann, Marta Kantauskaite, Joshua Lamberti, Jonas Hillebrandt, Lisa Müller, Margarethe Kittel, Katrin Ivens, Katrin Ivens, Henning Gruell, Anja Voges, Heiner Schaal, Nadine Lübke, Eva Königshausen, Eva Königshausen, Lars Christian Rump, Lars Christian Rump, Florian Klein, Florian Klein, Florian Klein, Johannes Stegbauer, Johannes Stegbauer, Jörg Timm

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N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis by Haisheng Zhang, Cheng Yi, Jianing Li, Yunqing Lu, Haoran Wang, Lijun Tao, Jiawang Zhou, Yonghuang Tan, Jiexin Li, Zhuojia Chen, Gholamreza Asadikaram, Jie Cao, Jianxin Peng, Wanglin Li, Junming He, Hongsheng Wang

“…Abstract Background Recent studies indicate that N6-methyladenosine (m6A) RNA modification may regulate ferroptosis in cancer cells, while its molecular mechanisms require further investigation. …”
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Effects of Mussel Peptides on Growth and Development and Microbial Community Structure of the Thick-Shelled Mussel Mytilus coruscus Plantigrades by Qian LIN, Zheng LI, Jinlong YANG, Fan MA, Xiao LIANG

“…As a protein hydrolysate, mussel peptide is also a probiotic element with high nutritional value and multiple functions such as antimicrobial, antioxidant, and immune enhancement. In particular, low molecular weight mussel peptide has the function of anti-lipid peroxidation protective activity and scavenging of excess free radicals, which can be used as a natural antimicrobial food additive. …”
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Clinical expression of facioscapulohumeral muscular dystrophy in carriers of 1–3 D4Z4 reduced alleles: experience of the FSHD Italian National Registry by Antonio Di Muzio, Corrado Angelini, Tiziana Mongini, Liliana Vercelli, Lucia Morandi, Giovanni Antonini, Gabriele Siciliano, Lucio Santoro, Maurizio Moggio, Giacomo Brisca, Luisa Villa, Giuliano Tomelleri, Francesco Sera, Carmelo Rodolico, Lorenzo Maggi, Giulia Ricci, Angela Berardinelli, Elena Pegoraro, Sabrina Ravaglia, Chiara Fiorillo, Michelangelo Cao, Rossella Tupler, Ana Nikolic, Elisabetta Bucci, Monica Govi, Fabiano Mele, Marta Rossi, Lucia Ruggiero, Maria Chiara D'Amico, Maria Grazia D'Angelo, Claudio Bruno

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Chronic Airflow Limitation, Lower Respiratory Symptoms, COPD and Chronic Rhinosinusitis in a Middle-Aged Population: The Swedish CArdioPulmonary bioImage Study (SCAPIS). A Link Bet... by Andersson A, Bergqvist J, Schiöler L, Bossios A, Farnebo L, Holmlund T, Janson C, Keceli S, Ljunggren M, Malinovschi A, Memarian E, Nihlén U, Nilsson PM, Pesonen I, Sjöström M, Stenfors N, Sundbom F, Werner M, Torén K, Sköld M, Hellgren J

“…Anders Andersson,1,2,* Joel Bergqvist,3,4,* Linus Schiöler,5 Apostolos Bossios,6,7 Lovisa Farnebo,8,9 Thorbjörn Holmlund,10 Christer Janson,11 Sumru Keceli,12 Mirjam Ljunggren,11 Andrei Malinovschi,13 Ensieh Memarian,14 Ulf Nihlén,15 Peter M Nilsson,16,17 Ida Pesonen,18,19 Marcus Sjöström,10 Nikolai Stenfors,20 Fredrik Sundbom,11 Mimmi Werner,10 Kjell Torén,5,21 Magnus Sköld,22,23 Johan Hellgren24,25 1COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden; 2COPD Center, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 3Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden; 4Centre for Sleep and Wake Disorders, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 5Occupational and Environmental Medicine, School of Public Health and Community Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 6Karolinska Severe Asthma Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden; 7Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 8Linköping University Faculty of Medicine and Health Sciences, Department of Biomedical and Clinical Sciences, Division of Sensory Organs and Communication, Linköping, Sweden; 9Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Otorhinolaryngology, Linköping, Sweden; 10Department of Clinical Sciences, Otorhinolaryngology, Umeå University, Umeå, Sweden; 11Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; 12Department of Otorhinolaryngology in Linköping, Region Östergötland, Linköping, Sweden; 13Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden; 14Department of Clinical Sciences, IKVM, Internal Medicine, Lund University, Malmö, Sweden; 15Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund University, Lund, Sweden; 16Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; 17Clinical Research Unit, Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden; 18Respiratory Medicine Unit, Department of Medicine, Karolinska Institutet, Solna, Stockholm, Sweden; 19Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden; 20Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; 21Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; 22Department of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden; 23Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; 24Department of Otorhinolaryngology, Head & Neck Surgery, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden; 25Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden*These authors contributed equally to this workCorrespondence: Anders Andersson, COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Bruna Stråket 11B, Göteborg, 413 46, Sweden, Email Anders.Andersson@lungall.gu.sePurpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). …”
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Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights by Juan Li, Xuan Wang, Li Zhou, Jun Guo, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xiangyong Gu, Binlei Liu, Hui Tian, Han Hu

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Evaluation of S100A8/A9 and neutrophils as prognostic markers in metastatic melanoma patients under immune-checkpoint inhibition by Yasmin F Melzer, Nadine L Fergen, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Ysabel A Schwietzer, Julian Kött, Klaus Pantel, Stefan W Schneider, Jochen Utikal, Ewa Wladykowski, Sabine Vidal-y-Sy, Alexander T Bauer, Christoffer Gebhardt

“…Our retrospective study assessed liquid biopsies and tumor tissue analyses for two potential biomarkers: danger-associated molecular pattern (DAMP) S100A8/A9 and its source, neutrophils. …”
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Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression by Jian Pang, Xiaoyan Huang, Ya Gao, Xinyu Guan, Lejia Xiong, Lun Li, Nana Yin, Mei Dai, Tong Han, Wenjun Yi

“…A deeper understanding of the role of NET1 may provide new insights into the molecular mechanisms of cancer progression and metastasis. …”
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2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment by Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang

“…A combination of behavioral, proteomic, and molecular biology approaches was used to explore specific regulatory mechanisms and identify potential pharmacological targets. …”
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Correlations between primary tumour location, biomarkers of inflammation and lung injury, and postoperative pulmonary complications in patients underwent laparoscopic colorectomy:... by Hui-xian Li, Li Che, Yuan Li, Tai-hang Wang, Fang-di Min, Lei Xu, Meng Wang, Zhao-xu Zheng, Shi-ning Qu, Fei Wang, Wei Tang, Shi-jing Wei, Yu-lin Sun, Hui Zheng, Tao Yan

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The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled tria... by Zehua Zhang, Shiyun Tang, Shiyu Liu, Yulin Leng, Xiaoxu Fu, Hongyan Xie, Hong Gao, Hong Gao, Chunguang Xie, Chunguang Xie

“…More long-term high-quality clinical studies and in-depth molecular research are still necessary to provide stronger evidence regarding the benefits and safety of GBE in DKD.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
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Reduced p63 expression is linked to unfavourable prognosis in muscle‐invasive urothelial carcinoma of the bladder by Kira Furlano, Henning Plage, Sebastian Hofbauer, Sarah Weinberger, Bernhard Ralla, Annika Fendler, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Martina Kluth, Maximilian Lennartz, Niclas C. Blessin, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Tobias Klatte, Thorsten Schlomm, David Horst, Henrik Zecha

“…Recently proposed RNA expression‐based molecular classifiers of bladder cancer identified high p63 expression as a component of a basal/squamous subtype linked to poor patient prognosis. …”
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Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway by Yan Li, Hong Wang, Xiaoyang Li, Yuan He, Huiquan Liu, Dong Han, Ting Mei, Yixuan Li, Zilong Xu, Xiaoying Wei, Jianguo Wang, Peijie Zhou, Yuwen Wang, Ziye Li, Junhao Ning, Anlin Wang, Jingjing Cheng, Dong Qian

“…Immunofluorescence, chromatin-immunoprecipitation, ELISA, mass spectrometry were conducted to explore the molecular pathway. Macrophages were depleted to investigate whether the effects of tumor-intrinsic PGAM5 on TAMs could affect immunotherapy efficacy in HCC orthotopic and subcutaneous mouse models.Results PGAM5 expression in tumor was positively correlated with M2-phenotype TAM infiltration in patients with both HCC and mouse HCC tumor models. …”
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Dipropyl phthalate induces craniofacial chondrogenic defects in zebrafish embryos by Qinyuan Shen, Weitao Hu, Fasheng Liu, Si Dong, Xinya Peng, Yihang Zhong, Chao Chen, Yuhua Zuo, Chenkai Ge, Weirong Li, Wenwen Zha, Zhijun Ye, Zigang Cao, Lan Liao

“…Transcriptome sequencing and molecular docking analyses revealed that DPRP down-regulated chondrocyte-related genes and induced activation of the FoxO signaling pathway, which in turn interfered with cell proliferation and apoptosis. …”
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miR-317 regulates the proliferation and apoptosis of duck follicle granulosa cells by targeting VIPR1 by Li Li, Qingwu Xin, Linli Zhang, Zhongwei Miao, Zhiming Zhu, Xiaopan Liu, Qiannan Cai, Wenli Shi, Bangzhe Zhao, Changtao Liu, Zhengkui Zhou, Azheng Liang, Qinlou Huang, Nenzhu Zheng

“…This study further reveals the molecular mechanism underlying follicular atresia and serves as a reference for reducing the broodiness of Muscovy ducks.…”
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Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective coho... by Stefanie Aeschbacher, David Conen, Diederick E Grobbee, Raphael Twerenbold, Thomas Lung, Theo Rispens, Jakob Kjellberg, Lorenz Risch, Martin Risch, Marianna Mitratza, Harald Renz, Spiros Denaxas, Billy Franks, Diederick Grobbee, Martina Rothenbühler, Janneke Wijgert, Santiago Montes, Richard Dobson, Hans Reitsma, Christian Simon, Titia Leurink, Charisma Hehakaya, Patricia Bruijning, Kirsten Grossmann, Ornella C Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Daniel Leibovitz, Vladimir Kovacevic, Andjela Markovic, Paul Klaver, Timo B Brakenhoff, George S Downward, Ariel Dowling, Maureen Cronin, Brianna M Goodale, Brianna Goodale, Ornella Weideli, Regien Stokman, Hans Van Dijk, Eric Houtman, Jon Bouwman, Kay Hage, Lotte Smets, Marcel van Willigen, Maui Chodura, Niki de Vink, Tessa Heikamp, Timo Brakenhoff, Wendy van Scherpenzeel, Wout Aarts, Alison Kuchta, Antonella Chiucchiuini, Steve Emby, Annemarijn Douwes, George Downward, Nathalie Vigot, Pieter Stolk, Duco Veen, Daniel Oberski, Amos Folarin, Pablo Fernandez Medina, Eskild Fredslund

“…SARS-CoV-2 infection was diagnosed by molecular and/or serological assays.Results A total of 1.5 million hours of physiological data were recorded from 1163 participants (mean age 44±5.5 years). …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

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Tobacco control environment: cross-sectional survey of policy implementation, social unacceptability, knowledge of tobacco health harms and relationship to quit ratio in 17 low-inc... by Annika Rosengren, Li Wei, Khalid Yusoff, Martin McKee, Clara K Chow, Rajeev Gupta, Koon Teo, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Rafael Diaz, Alvaro Avezum, Fernando Lanas, Noorhassim Ismail, Romaina Iqbal, Jephat Chifamba, Gilles Dagenais, Salim Yusuf, Anna B Gilmore, Scott Lear, Wang Yang, Omar Rahman, Katarzyna Zatonska, Prem Mony, Rajesh Kumar, Afzalhussein Yusufali, Daniel J Corsi, Ehimario Igumbor, V Mohan, Annamarie Kruger, Krishnapillai Vijayakumar, Yuksel Altuntas, Ahmad Bahonar

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Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

“…These compounds have been characterized by elemental analyses and molecular weight determinations. The probable structures of the ligand as well as antimony complex have been tentatively proposed on the basis of IR and NMR (<mml:math> <mml:mmultiscripts> <mml:mtext>H</mml:mtext> <mml:mprescripts/> <mml:none/> <mml:mtext>1</mml:mtext> </mml:mmultiscripts> </mml:math> and <mml:math> <mml:mmultiscripts> <mml:mtext>C</mml:mtext> <mml:mprescripts/> <mml:none/> <mml:mrow> <mml:mtext>13</mml:mtext> </mml:mrow> </mml:mmultiscripts> </mml:math>) spectral evidences. …”
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