The Molecular Effects of SGLT2i Empagliflozin on the Autophagy Pathway in Diabetes Mellitus Type 2 and Its Complications by Ranin Saad, Hagar Tadmor, Offir Ertracht, Nakhoul Nakhoul, Farid Nakhoul, Farber Evgeny, Shaul Atar

“…We aim to investigate the molecular effect of sodium-glucose transporter 2 inhibitor (SGLT2i) on the expression of ATG5 and its downstream collaborator LC3-II in diabetic nice model. …”
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Molecularly redefining small bowel adenocarcinoma to accelerate precision patient care – protocol of a multicenter observational cohort biomarker study by Rasmus Haunstrup Døssing, Julia Johanna Almer Broman, Colm J. O’Rourke, Elizaveta Mitkina Tabaksblat, Jesper Bøje Andersen, Carsten Palnæs Hansen, Tim Svenstrup Poulsen, Estrid V. S. Høgdall, Jakob Hagen Vasehus Schou, Dan Høgdall

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Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization by Xiaoxuan Zhang, Meile Zhang, Yihao Li, Ping Deng

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Leveraging computational approaches in identifying novel HER-2 + breast cancer potential therapeutics: integrating virtual screening and molecular dynamics simulation by Olawale Quadri Bolaji, Temitope Isaac Adelusi, Taiwo Ooreoluwa Ojo, Ibrahim Damilare Boyenle, Abdul-Quddus Kehinde Oyedele, Taiwo Temitope Ogunjobi, Adegboye Oyewole Oyaronbi, Sukurat Oluwatoyin Ayoola, Abdeen Tunde Ogunlana

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Cutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies by Jay Gabriel B. Larga, Wrynan T. Munabirul, Abu Tayab Moin, Md Maisum Sarwar Jyoti, Mst Sanjida Nasrin, Minhaz Abdullah Al Mueid, Abdul Ahad, Anwar Parvez, Mst Sabrina Yeasmin, Rupali M. Barhate, Rajesh B. Patil, Margel C. Bonifacio

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Red Stellar Populations and Dust Extinction toward W3 by J. L. Campbell, P. G. Martin, S. Song, M. Rahman, L. Einstein

Subjects: “…Giant molecular clouds…”
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DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

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Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis by Ganesh Sharma, Neeraj Kumar, Chandra Shekhar Sharma, Taha Alqahtani, Yewulsew Kebede Tiruneh, Sharifa Sultana, Gabriel Vinícius Rolim Silva, Gabriela de Lima Menezes, Magdi E. A. Zaki, Jonas Ivan Nobre Oliveira

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Molecular phylogeny and morphology reveal four new wood-inhabiting fungi of Asterostroma and Radulomyces (Basidiomycota) from Southwestern China by Junhong Dong, Qiaohua Deng, Minglan Chen, Daxiang Chen, Chunqin Zhou, Changlin Zhao

“…In this study, four new wood-inhabiting fungal species, Asterostroma paramuscicola, Radulomyces bambusinus, R. fissuratus, and R. sinensis, were collected from southwestern China and were proposed based on the morphological and molecular evidence. Asterostroma paramuscicola is characterised by the felted-membranous to pellicular basidiomata with pinkish to slightly salmon-buff, a smooth hymenial surface, a monomitic hyphal system, and generative hyphae bearing simple-septate and subglobose, thin-walled, echinulate basidiospores measuring as 8–8.8 × 7–8 µm. …”
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Crystal and Molecular Structure of Bis(2,2-diphenyl-N-(di-n-propylcarbamothioyl) acetamido)copper(II) Complex by Hakan Arslan, Ulrich Flörke, Demet Sezgin Mansuroglu

“…Bis(2,2-diphenyl-N-(di-n-propylcarbamothioyl) acetamido)copper(II) complex has been synthesized and characterized by elemental analysis and FT-IR spectroscopy. The crystal and molecular structure of the title compound has been determined from single crystal X-ray diffraction data. …”
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Effects of Machining Parameters on Abrasive Flow Machining of Single Crystal γ-TiAl Alloy Based on Molecular Dynamics by Junye Li, Chao Song, Xin Du, Hongcai Xie, Jinghe Zhao, Ying Chen

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First report of Haemaphysalis bispinosa, molecular-geographic relationships of Ixodes granulatus and a new Dermacentor species from Vietnam by Sándor Hornok, Jenő Kontschán, Gergő Keve, Nóra Takács, Dat Van Nguyen, Khanh Ngoc Phuong Ho, Tamás Görföl, Yuanzhi Wang, Róbert Farkas, Thanh Thi Ha Dao

“…After DNA extraction, these were molecularly or phylogenetically analyzed based on the cytochrome c oxidase subunit I (cox1) and 16S rRNA genes. …”
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Elucidating the Molecular Mechanisms and Comprehensive Effects of Sludge‐Derived Plant Biostimulants on Crop Growth: Insights from Metabolomic Analysis by Yu Hua, Shuxian Chen, Tong Tong, Xiaoou Li, Rongting Ji, Qiujin Xu, Yue Zhang, Xiaohu Dai

“…However, there remains a gap in understanding SPB's molecular‐level effects and its comprehensive impact on crops throughout their growth cycle. …”
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Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review by Taiga Nishihori, Kenneth Shain

“…Our review focuses on current evidence and understanding of myeloma biology with characterization in the context of genomic and molecular alterations. We also discuss future clinical application of the genomic and molecular knowledge, and more translational research is needed to benefit our myeloma patients.…”
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A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action by Shira Cohen, Faina Barer, Sara Bar-Yehuda, Adriaan P. IJzerman, Kenneth A. Jacobson, Pnina Fishman

“…LUF6000 administration induced anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice. The molecular mechanism of action points to deregulation of signaling proteins including PI3K, IKK, IκB, Jak-2, and STAT-1, resulting in decreased levels of NF-κB, known to mediate inflammatory effects. …”
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Isolation and Molecular Identification of Pathogenic Fungi from Cockroaches Caught from Babol Teaching Hospitals during 2021-2022 by Hanie Pooshideh, Jalal Jafarzade, Ali Heidarpour, Mojtaba Taghizade Armaki, saeid Mahdavi Omran, Firoozeh Kermani, Mohsen Karami

“…Considering the importance of these insects in the transmission of pathogenic fungi and their impact on the health of hospitalized people, the aim of this study was isolation and molecular identification of pathogenic fungi from the external and internal surfaces of cockroaches collected from three educational hospitals of Babol city, Mazandaran Province, Iran. …”
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Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer by Vito D’Alessandro, Lucia Anna Muscarella, Massimiliano Copetti, Leopoldo Zelante, Massimo Carella, Gianluigi Vendemiale

“…The aim of this study is to develop a sensitive and quantitative molecular real-time PCR assay to detect SCLC cells in peripheral blood (PB) through nELAV-like transcripts quantification.…”
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Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction by Sarah K. Macklin, Katelyn A. Bruno, Charitha Vadlamudi, Haytham Helmi, Ayesha Samreen, Ahmed N. Mohammad, Stephanie Hines, Paldeep S. Atwal, Thomas R. Caulfield

“…We describe this finding following detection in a proband with an extensive history of aortic, carotid, and abdominal dissections. Neoteric molecular modeling techniques to help determine the impact of this deletion on protein function indicated loss of function due to lack of any kinase domain. …”
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