Lyophilized and Oven-Dried <i>Manilkara zapota</i> Extracts: Characterization and <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Analyses by María Fernanda Rivas-Gastélum, Patricia Ariadna Galindo-Castillo, Juan Esparza-Sánchez, Miriam Irene Jiménez-Pérez, Yocanxóchitl Perfecto-Avalos, Luis Eduardo Garcia-Amezquita, Diego E. Navarro-López, Edgar R. López-Mena, Eugenio Sánchez-Arreola, Juan Pablo Tamayo-Martínez, Humberto L. Mendoza-Figueroa, María Magdalena Crosby-Galván, Elsa Margarita Crosby-Galván, Jorge L. Mejía-Méndez, Angélica Lizeth Sánchez-López

“…The phytochemical content of fruits was assessed by gas chromatography flame ionization detector (GC-FID), and their biological performance was studied using <i>in vitro</i> antibacterial and antioxidant assays (DPPH and ABTS) and <i>in vivo</i> toxicity models. Molecular docking was implemented to evaluate the interaction between polar compounds from chicozapote fruits with receptors involved in the pathogenesis of bacterial strains. …”
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The DnaJ-Hsp70-Hsp90 co-chaperon networks in scallops under toxic Alexandrium dinoflagellates exposure by Moli Li, Jie Cheng, Huizhen Wang, Jiaoxia Shi, Xiaogang Xun, Wei Lu, Xubo Wang, Jingjie Hu, Zhenmin Bao, Xiaoli Hu

“…Heat shock proteins (Hsps) are highly conserved molecular chaperones with essential roles against biotic and abiotic stressors. …”
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Global research trends in Chinese medicine for the treatment of non-alcoholic fatty liver disease (NAFLD): A bibliometric study by Kangjie li, Jie Wang, Ming Dang, Runxin Ren, Maomao Fu, Jing Wang, Qiao Zhang, Chongbo Zhao

“…Keyword analysis reveals that high-frequency terms such as steatohepatitis are prevalent, addressing topics like pathogenesis, indirect therapeutic effects, and molecular biological mechanisms. Recent outbreak word analysis highlights 'cell' and 'steatohepatitis' as current hotspots, with 'NASH' anticipated to be a focal point in 2024. …”
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The transcriptional regulator Lrp activates the expression of genes involved in the biosynthesis of tilimycin and tilivalline enterotoxins in Klebsiella oxytoca by Miguel A. De la Cruz, Hilda A. Valdez-Salazar, Diana Rodríguez-Valverde, Santa Mejia-Ventura, Nayely Robles-Leyva, Tania Siqueiros-Cendón, Quintín Rascón-Cruz, Nancy León-Montes, Jorge Soria-Bustos, Fernando Chimal-Cázares, Roberto Rosales-Reyes, María L. Cedillo, Jorge A. Yañez-Santos, J. Antonio Ibarra, Javier Torres, Jorge A. Girón, James G. Fox, Miguel A. Ares

“…Our results underscore a molecular mechanism by which TM and TV production by toxigenic K. oxytoca strains is regulated and shed further light on developing strategies to prevent the intestinal illness caused by this enteric pathogen.…”
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immun... by Qian Yang, Ruijing Zhang, Peng Tang, Yu Sun, Candice Johnson, Jason Saredy, Susu Wu, Jiwei Wang, Yifan Lu, Fatma Saaoud, Ying Shao, Charles Drummer, Keman Xu, Daohai Yu, Rongshan Li, Shuping Ge, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…Our analysis suggests novel molecular mechanisms that are utilized by LIUS to induce tumor suppression and inflammation inhibition. …”
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Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐cat... by Shaojun Chu, Lingling Jia, Yulong Li, Jiachao Xiong, Yulin Sun, Qin Zhou, Dexiang Du, Zihan Li, Xin Huang, Hua Jiang, Baojin Wu, Yufei Li

“…The hair follicle stem cells (HFSCs) have displayed clinical improvements on AGA. However, the molecular mechanism of HFSCs against AGA remains elusive. …”
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Clinical Significance of Perioperative Minimal Residual Disease Detected by Circulating Tumor DNA in Patients With Lung Cancer With a Long Follow-up Data: An Exploratory Study by Shuta Ohara, MD, PhD, Kenichi Suda, MD, PhD, Sumedha Sudhaman, PhD, Akira Hamada, MD, PhD, Masato Chiba, MD, PhD, Masaki Shimoji, MD, PhD, Toshiki Takemoto, MD, PhD, Ekaterina Kalashnikova, PhD, Samantha K. Cheung, PhD, Michael Krainock, MD, PhD, Jordan Feeney, BS, Himanshu Sethi, MPH, Minetta C. Liu, MD, Junichi Soh, MD, PhD, Yasuhiro Tsutani, MD, PhD, Tetsuya Mitsudomi, MD, PhD

“…Introduction: Molecular residual disease detected by circulating tumor DNA (ctDNA) has been reported to be predictive of patients’ outcomes in various types of cancers after curative intent treatment. …”
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Abnormal preoperative haematological parameters in Endometrial cancer; reflecting tumour aggressiveness or reduced response to radiotherapy? by Stephanie W. Vrede, Hannah Donkers, Casper Reijnen, Anke Smits, Nicole C.M. Visser, Peggy M. Geomini, Huy Ngo, Dennis van Hamont, Brenda M. Pijlman, Maria Caroline Vos, Marc P.L.M. Snijders, Roy Kruitwagen, Ruud L.M. Bekkers, Khadra Galaal, Johanna M.A. Pijnenborg

“…Prospective validation in a larger study cohort is required to verify anaemia as predictive biomarker for radiotherapy and to further evaluate the prognostic/predictive impact of anaemia in addition to the molecular subgroups.…”
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The fibronectin-targeting PEG-FUD imaging probe shows enhanced uptake during fibrogenesis in experimental lung fibrosis by Thomas J. Harr, Nikesh Gupta, Babita Rahar, Kristen Stott, Yadira Medina-Guevara, Metti K. Gari, Angie T. Oler, Ivy Sohee McDermott, Hye Jin Lee, Morteza Rasoulianboroujeni, Ashley M. Weichmann, Amir Forati, Kelsey Holbert, Trevor S. Langel, Kade W. Coulter, Brian M. Burkel, Bianca R. Tomasini-Johansson, Suzanne M. Ponik, Jonathan W. Engle, Reinier Hernandez, Glen S. Kwon, Nathan Sandbo, Ksenija Bernau

“…These data suggest that PEG-FUD targets fibronectin associated with active fibrogenesis in this model, making it a promising candidate for a clinically translatable molecular imaging probe to non-invasively determine pulmonary fibrosis disease activity, enabling accelerated therapeutic decision-making.…”
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Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic by Volker Arndt, Daniela Doege, Stefan Fröhling, Peter Albers, Hana Algül, Ralf Bargou, Carsten Bokemeyer, Martin Bornhäuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Brümmendorf, Hartmut Döhner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann

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Recent Progress in Polyolefin Plastic: Polyethylene and Polypropylene Transformation and Depolymerization Techniques by Acácio Silva de Souza, Patricia Garcia Ferreira, Iva Souza de Jesus, Rafael Portugal Rizzo Franco de Oliveira, Alcione Silva de Carvalho, Debora Omena Futuro, Vitor Francisco Ferreira

“…Recent advances in the pyrolysis and hydrogenolysis of polyolefins focus on their potential for advanced recycling, breaking down plastics at a molecular level to create feedstocks for new products or fuels. …”
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Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…In vitro, mouse brain microvascular endothelial cell line (b.End3) were exposed to CD40L for 24 h at 5.5 mM or 30 mM glucose media after silencing CD40 and HIF1α or not to investigate the effects of CD40 on BBB disruption and the underlying molecular pathways. Inhibition of platelet activation improved cognitive behaviors in diabetic mice, accompanied with reduced BBB permeability, increased tight junction proteins, balanced Aβ transporters, as well as attenuated Aβ deposition and hippocampal neurons damage. …”
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Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism by Hong Gong, Yao Lu, Shi-Long Deng, Ke-Yi Lv, Jing Luo, Yi Luo, Zhu-Lin Du, Ling-Feng Wu, Tian-Yao Liu, Xia-Qing Wang, Jing-Hui Zhao, Lian Wang, Mei-Ling Xia, Dong-Mei Zhu, Li-Wei Wang, Xiao-Tang Fan

“…A combination of behavioral, pharmacological, immunological, genetic, molecular, and transcriptomics approaches were used to uncover the potential role of S100A9 in autism. …”
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Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy by Diana Peixoto, João M. Ravasco, Barbara Blanco-Fernandez, Francisco Veiga, Angel Concheiro, João Conde, Ana Cláudia Paiva-Santos, Carmen Alvarez-Lorenzo

“…Accordingly, two enzyme-responsive structural units composed of Vitamin D3 (VD3) conjugated with polyethylene glycol of different molecular weights (600 Da and 2000 Da) were synthesized and characterized using different analytical methods. …”
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Diverse fox circovirus (Circovirus canine) variants circulate at high prevalence in grey wolves (Canis lupus) from the Northwest Territories, Canada by Canuti, Marta, King, Abigail V.L., Franzo, Giovanni, Cluff, H. Dean, Larsen, Lars E., Fenton, Heather, Dufour, Suzanne C., Lang, Andrew S.

“…We analyzed spleen samples from 159 grey wolves from the Northwest Territories, Canada, to investigate the molecular epidemiology of CanineCV and formulate hypotheses about virus ecology and evolution. …”
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Donor-derived cell-free DNA for detection of acute rejection in lung transplant recipients by Gökce Yavuz, Julia Walter, Julia Walter, Kaimo Hirv, Oliver Wachter, Andrea Dick, Julia Kovacs, Julia Zimmermann, Olaf M. Glueck, Maximilian Vorstandlechner, Nicole Samm, Jan M. Fertmann, Wulf Sienel, Sebastian Michel, Sebastian Michel, Michael Irlbeck, Nikolaus Kneidinger, Nikolaus Kneidinger, Nikolaus Kneidinger, Rudolf Hatz, Rudolf Hatz, Jürgen Behr, Jürgen Behr, Christian Schneider, Christian Schneider, Teresa Kauke, Teresa Kauke

“…This study aims to explore the potential utility of donor-derived cell-free DNA (ddcfDNA) as a non-invasive biomarker for detecting acute rejection in lung transplant recipients (LTR).MethodsWe developed a molecular method based on digital droplet PCR to determine the total amount and the proportion of ddcfDNA. …”
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Contusión medular en ratas tratadas con hipotermia sistémica. Expresión de proteínas inducibles por frío experimental by Aníbal José Sarotto, María Agustina Toscanini, Daniela Contartese, Verónica B. Dorfman, Ronan Nakamura, Micaela Besse, Ignacio M. Larráyoz, Alfredo Martínez, Elena De Matteo, Manuel Rey-Funes, César Fabián Loidl

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Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice by Jin Qiu, Yuhan Guo, Xiaozhen Guo, Ziqi Liu, Zixuan Li, Jun Zhang, Yutang Cao, Jiaqi Li, Shuwu Yu, Sainan Xu, Juntong Chen, Dongmei Wang, Jian Yu, Mingwei Guo, Wenhao Zhou, Sainan Wang, Yiwen Wang, Xinran Ma, Cen Xie, Lingyan Xu

“…To understand the potential crosstalk, RNA‐seq and metabolomic analysis were performed on adipose tissue and muscle in aging mice and revealed that creatine levels are increased both in iWAT and muscle of UCP1 KO mice. Interestingly, molecular analysis and metabolite tracing revealed that creatine biosynthesis is increased in iWAT while creatine uptake is increased in muscle in UCP1 KO mice, suggesting creatine transportation from iWAT to muscle. …”
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Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts by Feng Ding, Wanfei Liu, Chi Wu, Chi Wu, Wensi Zhang, Shuyan Chen, Shuyan Chen, Wenjie Lai, Wenjie Lai, Jiayao Qu, Jiayao Qu, Qiang Lin, Shuihua Lu, Jiuxin Qu, Jiuxin Qu

“…Drug susceptibility testing (DST) was performed using both phenotypic DST (pDST) and molecular DST (mDST). Sample diversity was evaluated by SNPs and transmission clusters were identified based on SNP differences of 12 or fewer in genetic clusters.ResultsExcept four samples identified as non-tuberculous mycobacteria, 282 MTB samples (181 patients) underwent mDST, with 244 samples (162 patients) undergoing pDST. …”
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Clinical and genetic characteristics of a total or partial congenital aniridia by N.V. Sukhanova, V.V. Kadyshev, T.A. Vasilieva, A.V. Marakhonov, L.A. Katargina, S.I. Kutsev, R.A. Zinchenko

“…All patients underwent a comprehensive eye exam, molecular and genetic testing, as well as specialist consultation. …”
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