A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment by Yuanhui Wang, Jie Gao, Ziyi Ren, Ziyi Shen, Wei Gu, Qinyi Miao, Xiaomeng Hu, Xiaomeng Hu, Yan Wu, Yan Wu, Wei Liu, Jia Jia, Jia Jia, Yi Cai, Chunpeng (Craig) Wan, Lei Sun, Tingdong Yan, Tingdong Yan

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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells by Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J. Clark, Simon J. Clark, Simon J. Clark, Marius Ueffing

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Protein kinase inhibitors as targeted therapy for glioblastoma: a meta-analysis of randomized controlled clinical trials by José Pinto-Fraga, Celia García-Chico, Simone Lista, Pedro Miguel Lacal, Giuseppe Carpenzano, Maurizio Salvati, Alejandro Santos-Lozano, Grazia Graziani, Claudia Ceci

“…Upon disease progression, the anti-vascular endothelial growth factor-A (VEGF-A) monoclonal antibody bevacizumab, can be considered.Given the limited efficacy of pharmacological treatments, particularly for the recurrent disease, several molecularly targeted interventions have been explored, such as small-molecule protein kinase inhibitors (PKIs), inhibiting tyrosine kinase growth factor receptors and downstream signaling pathways involved in GBM angiogenesis and infiltrative behavior.This meta-analysis, based on searches in PubMed and Web Of Science, evaluated 12 randomized controlled trials (RCTs) examining PKIs in patients with newly diagnosed or recurrent GBM. …”
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The transcriptional analysis of pepper shed light on a proviral role of light-harvesting chlorophyll a/b binding protein 13 during infection of pepper mild mottle virus by Weihong Lin, Shugen Zhang, Hao Zhang, Xiaomei Deng, Tong Jiang, Xifeng Chen, Laihua Dong, Qin Yan, Lianyi Zang, Yongping Xing, Zhenquan Wang, Qin Zhang, Kaitong Du, Huolin Shen, Junmin Zhang, Tao Zhou

“…This study provides valuable insights into the molecular mechanisms underlying resistance and susceptibility in pepper plants and may inform future strategies for disease management.…”
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Associations Between Complement C4, Habitual Constipation, and Sleep Disturbance in Oldest-Old and Centenarian Chinese Adults by Sun Z, Nie Y, Pei J, Gao M, Luan Z, Zhao Y, Li Z, Fu S

“…Zhigao Sun,1,* Yan Nie,2,* Jianqiu Pei,3,* Ming Gao,4,* Zhe Luan,5,* Yali Zhao,6 Zhaoxing Li,7 Shihui Fu8,9 1Traditional Chinese Medicine Department, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People’s Republic of China; 2Department of Gastroenterology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People’s Republic of China; 3Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of China; 4School of Engineering Medicine, Beihang University, Beijing, People’s Republic of China; 5Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 6Central Laboratory, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People’s Republic of China; 7Department of General Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 8Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People’s Republic of China; 9Department of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaoxing Li, Department of General Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China, Email lizhaoxing1984@hebmu.edu.cn Shihui Fu, Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People’s Republic of China, Email xiaoxiao0915@126.comBackground: Sleep disturbance is an immune-related disease, and the gut–brain axis is an important regulatory pathway. …”
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Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator by Peng Ma, Jie Xiao, Biyu Hou, Ping He, Xinyu Yang, Yisa Wang, Zijing Wang, Tianshu Xu, Xiuying Yang, Xuan Zhu, Shasha Xiang, Song Li, Guanhua Du, Jian Ying, Guifen Qiang

“…Specifically, utilizing in silico approach of network pharmacology and molecular docking, we identified carbonic anhydrase 2 (CA2) in nitrogen metabolism as anti-obesity target of BTE and further elucidated that protein kinase B (AKT) signaling pathway linked CA2 and UCP1. …”
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Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4 by Shaoliang Zhu, Gang Wang, Yuxuan Zhang, Mengjie Zou, Zhi Li, Shenhong Qu, Xiaosu Zou, Wenqian Nong, Weiwei Miao, Qicong Chen, Juanmei Mo, Huibing Chen, Lequn Li, Xiaofeng Dong, Honglin Luo

“…Background: Hepatocellular carcinoma (HCC) represents a major malignancy globally, characterized by high malignancy and intricate molecular mechanisms. This study aims to explore the role of the long non-coding RNA (lncRNA) lnc-EST885 in HCC development. …”
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Transcriptome analysis reveals hypoxic response key genes and modules as well as adaptive mechanism of crucian carp (Carassius auratus) gill under hypoxic stress by Mengchao Xing, Mengchao Xing, Zhen Rong, Zhen Rong, Xin Zhao, Xin Zhao, Xiaowei Gao, Xiaowei Gao, Zhiguang Hou, Lihan Zhang, Lihan Zhang, Waiho Khor, Yihuan Xu, Yihuan Xu, Li Chen, Li Chen, Chengbin Wu, Chengbin Wu

“…In summary, this study reveals the molecular mechanism by which crucian carp adapt to hypoxic stress. …”
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Longitudinal serological and virological survey of hepatitis E virus in wild boar (Sus scrofa majori, Maremman wild boar) and fallow deer (Dama dama) populations in a protected are... by Luca De Sabato, Mariagiovanna Domanico, Paola De Santis, Daniele Cecca, Giulia Bonella, Giovanni Mastrandrea, Roberta Onorati, Luigi Sorbara, Bianca Maria Varcasia, Barbara Franzetti, Andrea Caprioli, Antonio Battisti, Fabio Ostanello, Ilaria Di Bartolo

“…From 2016 to 2024, during several hunting seasons, we conducted a molecular and serological longitudinal survey on the circulation of HEV in Maremman wild boar (Italian subspecies/ecotype, Sus scrofa majori) and fallow deer (Dama dama) populations in a protected area in Central Italy. …”
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The Influences of Rootstock on the Performance of Pinot Noir (Vitis vinifera L.): Berry and Wine Composition by Yipeng Chen, Zijian Liang, Mark Krstic, Peter Clingeleffer, Kate Howell, Deli Chen, Pangzhen Zhang

“…Furthermore, the results could guide future studies in understanding the roles of rootstocks in regulating the metabolic pathways of phenolic and volatile production in the berries of grafted Pinot noir at the molecular level.…”
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Production of ACE inhibitory peptides via ultrasonic-assisted enzymatic hydrolysis of microalgal Chlorella protein: Process improvement, fractionation, identification, and in silic... by Jeeraporn Pekkoh, Apiwit Kamngoen, Antira Wichaphian, May Thu Zin, Supakit Chaipoot, Kamon Yakul, Wasu Pathom-aree, Wageeporn Maneechote, Benjamas Cheirsilp, Kuan Shiong Khoo, Sirasit Srinuanpan

“…Interestingly, the fractionated low molecular weight (LMW) peptides (<3 kDa) demonstrated notable levels of both ABTS radical scavenging (IC50 at 3.34 µg/mL) and ACE inhibition activities (IC50 at 2.95 µg/mL), alongside a significant abundance of essential amino acids, reaching up to 34.98 %. …”
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Prevalence of common diarrheagenic enterobacteriaceae in Iran (2000–2023): a systematic review and meta-analysis by Mozhgan Derakhshan-Sefidi, Fereshteh Eidy, Somayyeh Nadi-Ravandi, Sareh Bagheri-Josheghani, Maryam Mirfakhraei

“…Further research should investigate the factors contributing to the prevalence of diarrheagenic Enterobacteriaceae, including genetic diversity of diarrheagenic Enterobacteriaceae isolates, molecular mechanisms underlying the virulence of these pathogens, or antibiotic resistance patterns.…”
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Multidrug-resistant ESBL E. coli in urban surface waters and public health implications: A Case Study from Goranchatbari, Dhaka by Md. Sakib Hossain, Ahmed Ishtiaque Amin Chowdhury, Mohammad Rafiqul Islam, Ripan Kirtunia, Md. Foysal Abedin, Mohammad Atique Ul Alam, Shampa, Sonia Binte Murshed, Md Shadman Sakib, Siam Alam, M. Shahjahan Mondal, Zahid Hayat Mahmud

“…This study addresses the severity of surface water pollution in urban Bangladesh, focusing on the molecular characterization of ESBL E. coli in surface waters from the Goranchatbari sub-catchment of Dhaka. …”
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Epidemiology of hereditary eye disease in the populations of Russian Federation by V.V. Kadyshev, E.K. Ginter, S.I. Kutsev, Zh.G. Oganezova, R.A. Zinchenko

“…The rate of segregation was evaluated using the Weinberg proband method. Molecular genetic tests (Sanger sequencing, MLPA, AFLP, RFLP, whole exome sequencing) were applied. …”
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Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo by Xiangwei Liu, Naiwen Tan, Yuchao Zhou, Xueying Zhou, Hui Chen, Hongbo Wei, Ji Chen, Xiaoru Xu, Sijia Zhang, Guodong Yang, Yingliang Song

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smu_1558c-mediated regulation of growth and biofilm formation in Streptococcus mutans by Jing Zhou, Jing Zhou, Qizhao Ma, Qizhao Ma, Jingou Liang, Jingou Liang, Yangyang Pan, Yangyang Pan, Yang Chen, Yang Chen, Shuxing Yu, Shuxing Yu, Yaqi Liu, Yaqi Liu, Qiong Zhang, Qiong Zhang, Yuqing Li, Jing Zou, Jing Zou

“…This study provides novel insights into the molecular mechanisms governing S. mutans pathogenicity and suggests potential therapeutic targets for caries prevention.…”
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AAV2 serotype demonstrates the highest transduction efficiency in porcine lung-derived cells by Won Seok Ju, Seokho Kim, Areum Choi, Jae-Yeong Lee, Haesun Lee, Jingu No, Seunghoon Lee, Keonbong Oh, Jae Gyu Yoo

“…Background: The ability of adeno-associated viruses (AAVs) to transduce various cell types with minimal immune responses renders them prominent vectors for gene editing (GE), with different AAV serotypes exhibiting distinct transduction efficiencies due to their specific cellular tropism. However, detailed molecular processes of AAV infection and penetration, as well as the optimal serotype for specific purposes, remain poorly understood. …”
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Nitrate–Nitrite–Nitric Oxide Pathway, Oxidative Stress, and Fertility Outcomes in Morbidly Obese Women Following Bariatric Surgery: A Systematic Review by Charalampos Voros, Despoina Mavrogianni, Aspasia Minaoglou, Alexios Karakasis, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Raphail Mantzioros, Panagiota Kondili, Menelaos Darlas, Regina Sotiropoulou, Diamantis Athanasiou, Dimitrios Loutradis, Georgios Daskalakis

“…This review investigates the molecular mechanisms by which bariatric surgery affects eNOS activity, the NO₃-NO₂-NO pathway, and oxidative stress reduction, with an emphasis on intracellular activities including mitochondrial biogenesis and NO production. …”
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CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…The limited therapeutic options available emphasize the need for a better understanding of the molecular pathways involved in its pathogenesis. While much of the previous research has focused on transcriptional changes, this study examines translational alterations, specifically the role of cytoplasmic polyadenylation element binding protein 4 (CPEB4), a key regulator of translation. …”
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New multilocus sequence typing scheme for Enterococcus faecium reveals sequential outbreaks of vancomycin-resistant E. faecium ST1162 and ST610 in a Japanese tertiary medical cente... by Masaki Karino, Masashi Yanagihara, Tetsuya Harada, Megumi Sugo, Mizuki Karino, Hirofumi Ohtaki, Hiroyuki Hanada, Toru Takano, Masaya Yamato, Shigefumi Okamoto

“…ABSTRACT Vancomycin-resistant Enterococcus faecium (VREfm) is a major nosocomial pathogen, and molecular epidemiological tools are crucial for controlling its spread. …”
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