Mental health phenotypes of well-controlled HIV in Uganda by Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Kyu Cho, Jacob Bolzenius, Julie Mannarino, Rebecca E. Easter, Raha M. Dastgheyb, Aggrey Anok, Stephen Tomusange, Deanna Saylor, Maria J. Wawer, Noeline Nakasujja, Gertrude Nakigozi, Robert Paul

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Extraction of American ginseng polysaccharide by ultrasound-assisted deep eutectic solvents-based three-phase partitioning: Process optimization, structural characterization, and a... by Zhongnan Wu, Chong Li, Junhao Li, Tanggan Wang, Meifeng Li, Leyi Zhao, Huimei Ye, Jiaheng Chen, Jiajia Zan, Lijun Song, Qian Zhang, Shaojie Zhang

“…AGP-DES-4 has a broad molecular weight distribution (2.48–174.64 kDa) and mainly consists of mannose, glucose, galactose, and arabinose. …”
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Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

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Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats by Manman Li, Nange Ma, Shujie Luo, Yuyi Lu, Xixi Yan, Yang Li, Xinmei Li, Zhuohui Li, Zhipei Wu, Zhenyu Wei, Wei Wang, Huimei Fan, Yu Jiang, Yan Xiong, Yu Wang

“…Altogether, our results make a significant contribution to the molecular and cellular mechanisms behind the whitening of thermogenic adipocytes, and providing new insights into obesity prevention in humans and cold adaptation in animals.…”
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The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study by S. A. Zavaleta-Muñiz, B. T. Martín-Márquez, L. Gonzalez-Lopez, N. G. Gonzalez-Montoya, M. L. Díaz-Toscano, J. M. Ponce-Guarneros, A. J. Ruiz-Padilla, M. Vázquez-Del Mercado, M. Maldonado-González, M. Fafutis-Morris, S. E. Flores-Martínez, E. A. Martínez-García, J. I. Gamez-Nava

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Comparison of human-induced pluripotent stem cell-derived macrophages with peripheral blood-derived macrophages using single-cell genomics by ZHANG Yutong, HOU Guojun, SHEN Nan

“…GO analysis of DEGs showed enrichment in the molecular functions such as ubiquitin-like protein ligase binding, cellular components such as the nuclear speck and nuclear envelope, and biological processes such as the regulation of translation. …”
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Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient by Stéfanie Parisien-La Salle, Florence Perreault, Gilles Corbeil, Julie Morisset, Charles Poirier, Catherine Beauregard, Agnès Räkel, Marjorie Labrecque, Martine Tétreault, Martine Tétreault, Christian Cohade, Pasquale Ferraro, Isabelle Bourdeau

“…Further research is necessary to elucidate the genetic and molecular mechanisms underlying PCCs in this specific case and determine its link with hypoxemia in the context of pulmonary disease.…”
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Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy by Wen-Ying Yu, Wen-Ying Yu, Jing Liu, Jing Liu, Ze-Hao Lin, Ze-Hao Lin, Hong Liu, Hong Liu, Liang-Zhi Zhang, Liang-Zhi Zhang, Xiang-Long Feng, Xiang-Long Feng, Zhong-Biao Xiu, Zhong-Biao Xiu, Zhong-Biao Xiu

“…Additionally, ultrasound-guided acupotomy operations were performed on the rabbit model of late-stage KOA, and alterations in the key molecular markers of rectus femoris fibrosis were determined using Western Blot and qPCR methods.ResultsAs the disease progressed, the elastic modulus of the rectus femoris muscle in KOA rabbits gradually increased, the cross-sectional area gradually decreased, and the degree of fibrosis increased. …”
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AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma by Lu Li, Qing Xu, Xiuzhen Zhang, Yuan Jiang, La Zhang, Jiao Guo, Haichuan Liu, Bin Jiang, Shenglong Li, Qiling Peng, Ning Jiang, Jianwei Wang

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Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Biomarker analyses of serial blood and tumor samples are planned to clarify predictive markers and molecular mechanisms underlying treatment resistance by multifaceted analytical methods (e.g., flow cytometry, DNA sequencing [DNAseq]/RNA sequencing [RNAseq]). …”
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Deciphering the Differences Between Epstein–Barr Virus‐Associated and Negative Gastric Cancer in the Prospect of CDKN2A Genomic Alterations and Lymphoid Infiltration by Fuda Xie, Bonan Chen, Yang Lyu, Peiyao Yu, Canbin Fang, Kam Tong Leung, Shouyu Wang, Dazhi Xu, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang

“…One important contributing factor is the presence of the Epstein‐Barr virus (EBV). However, the molecular pattern of how EBV participates in the malignant transition process remains unclear. …”
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Hsp70/Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model by Guoxia Zhu, Yongxiang Wu, Yang Qiu, Keyong Tian, Wenjuan Mi, Xinqin Liu, Yuanyuan Chen, Jinwen Jia, Jiasheng Luo, Lianjun Lu, Jianhua Qiu

“…Finally, we sought to identify the possible molecular mechanisms associated with the beneficial effects of SC against noise-induced trauma. …”
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Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children by Diego O. Miranda, Deise A. O. Silva, Jorge F. C. Fernandes, Meimei G. J. Queirós, Hamilton F. Chiba, Leandro H. Ynoue, Rafael O. Resende, Janethe D. O. Pena, Sun-Sang J. Sung, Gesmar R. S. Segundo, Ernesto A. Taketomi

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In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

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Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction by Jing J. Zhang, Rodrigue Rizk, Xiaoping Li, Brandon G. Lee, Mason L. Matthies, Kennedy A. Bietz, Kang Kim, Kang Kim, Kang Kim, Johnny Huard, Yadong Wang, William C. W. Chen

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GmERF57 negatively regulates root development and phosphate absorption in soybean by Hongqing Zhu, Dandan Hu, Yifei Yang, Xuhao Zhai, Shanshan Zhang, Mengshi He, Huifang Zuo, Lina Zhang, Mengjun Xu, Shanshan Chu, Haiyan Lü, Hengyou Zhang, Yu Zhang, Dan Zhang

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Aqueous extracts of Moringa oleifera and Cinnamomum cassia as promising sources of antibiofilm compounds against mucoid and small colony variants of Pseudomonas aeruginosa and Stap... by Eduarda Silva, Pedro Ferreira-Santos, José A. Teixeira, Maria Olivia Pereira, Cristina M.R. Rocha, Ana Margarida Sousa

“…Recognizing that the antibiofilm properties of moringin, a common compound in both moringa seed and cinnamon bark extracts, remain underexplored, we conducted potential target identification via PharmMapper and molecular docking analyses to provide a foundation for future research. …”
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De Novo Mutation of m.3243A>G together with m.16093T>C Associated with Atypical Clinical Features in a Pedigree with MIDD Syndrome by Zhixin Jiang, Yinan Zhang, Jingbin Yan, Fengwen Li, Xinqian Geng, Huijuan Lu, Xiaoer Wei, Yanmei Feng, Congrong Wang, Weiping Jia

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Toxicological Characterization of Six Plants of the Beninese Pharmacopoeia Used in the Treatment of Salmonellosis by Boris Legba, Victorien Dougnon, Esther Deguenon, Jerrold Agbankpe, Maximin Senou, Alidah Aniambossou, Carène Gbaguidi, Kevin Sintondji, Lamine Baba-Moussa, Jacques Dougnon

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ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3 by Shiyang Wang, Xi Wu, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du, Mingxin Zhang, Di Liu, Shuiling Jin, Xiaojing Shi, Yuhua Tian, Jianwei Shuai, Maksim V. Plikus, Moshi Song, Zhaocai Zhou, Lu Yu, Cong Lv, Zhengquan Yu

“…Abstract Aberrant release of mitochondrial reactive oxygen species (mtROS) in response to cellular stress is well known for promoting cancer progression. However, precise molecular mechanism by which mtROS contribute to epithelial cancer progression remains only partially understood. …”
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