Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…Neuritin, significantly expressed in injured brain tissues, is implicated in the molecular mechanisms underlying acute brain injury. …”
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Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

“…Eight healthy controls and 20 individuals with VUS were screened. Results All molecular compounds and positive controls showed significant changes on their cognate assays, confirming assay sensitivity. …”
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SUMO-Specific Peptidase 5 Promotes Oesophageal Squamous Cell Carcinoma Growth through the NF-κB-SLC1A3 Axis by Chaoxiang Du, Yunfan Hu, Xinyu Yang, Zhe Zhang, Jianmin Gu, Tao Zhang, Renfeng Wang, Shaoyuan Zhang, Lijie Tan, Guiping Yu

“…Background: This study investigates the role of small ubiquitin-like modifier (SUMO)-specific peptidase 5 (SENP5), a key regulator of SUMOylation, in esophageal squamous cell carcinoma (ESCC), a lethal disease, and its underlying molecular mechanisms. …”
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High clinical utility of long-read sequencing for precise diagnosis of congenital adrenal hyperplasia in 322 probands by Yunpeng Wang, Gaohui Zhu, Danhua Li, Yu Pan, Rong Li, Ting Zhou, Aiping Mao, Libao Chen, Jing Zhu, Min Zhu

“…Abstract Background The molecular genetic diagnosis of congenital adrenal hyperplasia (CAH) is very challenging due to the high homology between the CYP21A2 gene and its pseudogene CYP21A1P. …”
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DNA barcoding reveals an unexpected distribution of two Megaleporinus species in the La Plata Basin system by Florencia Paola Coronel, Gisela Loretán, Gisela Loretán, Gisela Loretán, Sebastián Sanchez, Sebastián Sanchez, Natalia Silva, Natalia Silva, Gualberto Pacheco-Sierra, Florencia Brancolini, Florencia Brancolini, Danilo Aichino, Facundo Vargas, Pablo Scarabotti, Pablo Scarabotti, Luis Espínola, Luis Espínola, Carla Simone Pavanelli, Eva Carolina Rueda, Eva Carolina Rueda

“…Despite various approaches, including cytogenetics, molecular data, and morphological analysis, the taxonomic classification of the boga fish remains debated among researchers, resulting in discrepancies in the literature.MethodsThis study aimed to assess the diversity of specimens captured in the La Plata River Basin, initially classified as Megaleporinus obtusidens by fishers, using DNA barcoding. …”
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Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids by Xiao Han, Yuanlin He, Yuanhao Wang, Wenzhu Hu, Chu Chu, Lei Huang, Yuan Hong, Lu Han, Xu Zhang, Yao Gao, Yuan Lin, Hongxia Ma, Hongbing Shen, Xiaoyan Ke, Yan Liu, Zhibin Hu

“…ASD individuals with a shared clinical phenotype might contribute to revealing the molecular mechanism underlying ASD progression. Here, it is generated induced pluripotent stem cell (iPSC)‐derived cerebral organoids from normocephalic individuals with ASD in a prospective birth cohort with a shared clinical diagnosis. …”
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Characteristic of the active substance of the Saccharomyces cerevisiae preparation having radioprotective properties by G. S. Ritter, V. P. Nikolin, N. A. Popova, A. S. Proskurina, P. E. Kisaretova, O. S. Taranov, T. D. Dubatolova, E. V. Dolgova, E. A. Potter, S. S. Kirikovich, Y. R. Efremov, S. I. Bayborodin, M. V. Romanenko, M. I. Meschaninova, A. G. Venyaminova, N. A. Kolchanov, S. S. Bogachev

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Trends and advances in Leptospira, a bibliometric analysis by Wei Wang, Wei Wang, Wei Wang, Yamin Gao, Yamin Gao, Yamin Gao, Jianyu Ji, Jianyu Ji, Jianyu Ji, Zhai Huang, Zhai Huang, Bin Xiong, Bin Xiong, Shulin Xiang, Shulin Xiang

“…Research focus has shifted from early genomic and antigenic studies to investigations into outer membrane protein functions and environmental persistence, culminating in recent advances in molecular mechanisms and diagnostic technology development.ConclusionThis bibliometric analysis provides a comprehensive snapshot of leptospirosis research, emphasizing collaborations and impact among authors, countries, institutions, and journals. …”
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A scATAC-seq atlas of stasis zone in rat skin burn injury wound process by Ruikang Li, Jiashan Li, Shuai Liu, Xinya Guo, Jianyu Lu, Tao Wang, Tao Wang, Junjie Chen, Yue Zheng, Yue Yuan, Jiaxin Du, Jiaxin Du, Bolin Zhu, Bolin Zhu, Xiaoyu Wei, Pengcheng Guo, Longqi Liu, Longqi Liu, Xun Xu, Xi Dai, Runzhi Huang, Xin Liu, Xin Liu, Xiaoyan Hu, Shiwei Wang, Shizhao Ji

“…This comprehensive cellular and molecular atlas of the stasis zone provides a powerful resource for developing targeted therapies aimed at improving burn injury recovery and minimizing long-term consequences.…”
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Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model by Risheng Hao, Haobo Li, Xincheng Li, Jixiang Liu, Xiaofan Ji, Hong Zhang, Zhu Zhang, Peiran Yang, Zhenguo Zhai

“…These results provide insights into the molecular mechanisms of VTE and suggest potential biomarkers and therapeutic targets for thrombosis.…”
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Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections by Yuehan Ni, Jiamiao Wu, Fengqi Liu, Yating Yi, Xiangjiao Meng, Xiang Gao, Luyi Xiao, Weiwei Zhou, Zexi Chen, Peng Chu, Dan Xing, Ye Yuan, Donghui Ding, Ge Shen, Min Yang, Ronjie Wu, Ling Wang, Luiza Martins Nascentes Melo, Sien Lin, Xiaoguang Cheng, Gang Li, Alpaslan Tasdogan, Jessalyn M. Ubellacker, Hu Zhao, Shentong Fang, Bo Shen

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Response of alcohol fermentation strains, mixed fermentation and extremozymes interactions on wine flavor by Ling-Zhi Zhao, Ling-Zhi Zhao, Jing Chen, Jing Chen, Jing Chen, Xiang-Ying Wei, Xiang-Ying Wei, Xiang-Ying Wei, Bo Lin, Feng-Jin Zheng, Krishan K. Verma, Gan-Lin Chen, Gan-Lin Chen, Gan-Lin Chen

“…Extremophilic microorganisms have established different molecular strategies to survive amidst the adverse conditions. …”
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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein by Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

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Single-cell RNA sequencing of the spleen reveals differences in Salmonella typhimurium infection mechanisms between different chicken breeds by Qi Zhang, Qiao Wang, Jumei Zheng, Jin Zhang, Gaomeng Zhang, Fan Ying, Dawei Liu, Jie Wen, Qinghe Li, Guiping Zhao

“…Bacterial infections remain an important cause of morbidity in poultry production. The molecular characteristics and dynamic changes in immune cell populations after bacterial infection have yet to be fully understood. …”
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Early changes of peripheral circulating immune subsets induced by PD-1 inhibitors in patients with advanced malignant melanoma and non-small cell lung cancer by Simona Borilova, Peter Grell, Iveta Selingerova, Lenka Gescheidtova, Marie Mlnarikova, Ondrej Bilek, Radek Lakomy, Alexandr Poprach, Jan Podhorec, Igor Kiss, Rostislav Vyzula, Barbora Vavrusakova, Jiri Nevrlka, Lenka Zdrazilova-Dubska

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Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort st... by Charles Agyemang, Ellis Owusu-Dabo, Erik Beune, Karlijn Meeks, Bert-Jan H van den Born, Liffert Vogt, Felix P Chilunga, Charles F Hayfron-Benjamin, Sampson Twumasi-Ankrah, Muhulo Muhau Mungamba, Eva L van der Linden, Engwa A Godwill, Samuel N Darko, Benedicta N Chungag

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Production and bioactivity test of recombinant protein common carp growth hormone by Deny Sapto Chondro Utomo, . Alimuddin, Agus Oman Sudrajat, Irvan Faizal

“…The result showed that rGH with molecular weight of about 25 kDa was obtained. Common carp juveniles with average body weight of 5.2±0.4 g were intramuscularly injected once a week for 4 weeks with rGH protein solution from 1 μg bacterial cells per gram fish body weight. …”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

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Medullary thyroid cancer in MEN2 pediatric/adolescent carriers of RET mutation: genotype/phenotype correlation and outcome in a retrospective series of 23 patients by Guenda Di Benedetto, Ignazio Barca, Laura De Gregorio, Claudia Scollo, Fiorenza Gianì, Federica Martorana, Marco Russo, Francesco Frasca, Gabriella Pellegriti, Gabriella Pellegriti, Giulia Sapuppo

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Prevalence of Myocardial Infarction With Obstructive and Non-Obstructive Coronary Arteries in a Middle-Aged Population With Chronic Airflow Limitation: A Cross-Sectional Study by Sundh J, Ekström M, Blomberg A, Lindberg E, Malinovschi A, Olin AC, Sköld CM, Torén K, Wollmer P, Östgren CJ, Jernberg T

“…Josefin Sundh,1 Magnus Ekström,2 Anders Blomberg,3 Eva Lindberg,4 Andrei Malinovschi,5 Anna-Carin Olin,6 C Magnus Sköld,7,8 Kjell Torén,6 Per Wollmer,6 Carl Johan Östgren,9,10 Tomas Jernberg11,12 1Department of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 2Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine, Allergology and Palliative Medicine, Lund, Sweden; 3Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; 4Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; 5Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden; 6Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 7Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; 8Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden; 9Department of Translational Medicine, Lund University, Malmö, Sweden; 10Centre of Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; 11Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; 12Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, SwedenCorrespondence: Josefin Sundh, Department of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, 701 82, Sweden, Tel +46702349517, Email josefin.sundh@regionorebrolan.se; josefin.sundh@oru.sePurpose: Myocardial infarctions (MIs) can occur in underlying obstructive coronary artery disease (MI-CAD) or in non-obstructive coronary arteries (MINOCA). …”
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