Ferroptosis-related genes participate in the microglia-induced neuroinflammation of spinal cord injury via NF-κB signaling: evidence from integrated single-cell and spatial transcr... by Siqiao Wang, Li Yang, Zhourui Wu, Chen Li, Shaoke Wang, Zhihui Xiao, Bei Ma, Rongrong Zhu, Liming Cheng

“…Abstract Background Ferroptosis and immune responses are critical pathological events in spinal cord injury (SCI), whereas relative molecular and cellular mechanisms remain unclear. Methods Micro-array datasets (GSE45006, GSE69334), RNA sequencing (RNA-seq) dataset (GSE151371), spatial transcriptome datasets (GSE214349, GSE184369), and single cell RNA sequencing (scRNA-seq) datasets (GSE162610, GSE226286) were available from the Gene Expression Omnibus (GEO) database. …”
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset... by Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer, Li Li, Sheng Wu, Satya P. Kunapuli, Gerard J. Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…Our findings shed new light on the functions of upregulated m6A-RMRs in 41 diseases and cancers, nine cellular and molecular mechanisms, novel therapeutic targets for inflammatory disorders, metabolic cardiovascular diseases, autoimmune diseases, organ failures, and cancers.…”
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Genotyping-by-sequencing derived SNP markers reveal genetic diversity and population structure of Dactylis glomerata germplasm by Muhammad Tanveer Altaf, Pablo Federico Cavagnaro, Kağan Kökten, Amjad Ali, Andres Morales, Andres Morales, Muhammed Tatar, Mehmet Bedir, Muhammad Azhar Nadeem, Muhammad Aasim, Nafiz Çeliktaş, Sheikh Mansoor, Faheem Shehzad Baloch, Faheem Shehzad Baloch

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Identification of microbial exopolymer producers in sandy and muddy intertidal sediments by compound-specific isotope analysis by Hubas, Cédric, Gaubert-Boussarie, Julie, D’Hondt, An-Sofie, Jesus, Bruno, Lamy, Dominique, Meleder, Vona, Prins, Antoine, Rosa, Philippe, Stock, Willem, Sabbe, Koen

“…Extracellular polymeric substances (EPS) refer to a wide variety of high molecular weight molecules secreted outside the cell membrane by biofilm microorganisms. …”
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Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma by Chun-Nan Yeh, Yu-Chan Chang, Yi-Chen Yeh, Yu-Chao Wang, Dennis Shin-Shian Hsu, Meng-Lun Lu, Michael Hsiao, Ming-Huang Chen, Nai-Jung Chiang, Shin-Yi Chung, Chien-Jung Huang, Ming-Hsien Chan, Tzu-Sheng Hsu, Yi-Ping Hung

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A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome by Sujie Xiong, Guangyao Hu, Yao Zhou, Fei Sun, Yanlin Ma

“…Methods Cytogenetic and molecular genetic analyses of amniotic fluid via whole-genome sequencing (WGS), routine G-banded karyotype analysis, fluorescent quantitative polymerase chain reaction, and whole-exome sequencing (WES) were performed at 19 weeks. …”
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Distinct Neutralising and Complement-Fixing Antibody Responses Can Be Induced to the Same Antigen in Haemodialysis Patients After Immunisation with Different Vaccine Platforms by Nadezhda Wall, Rachel Lamerton, Fiona Ashford, Marisol Perez-Toledo, Aleksandra Jasiulewicz, Gemma D. Banham, Maddy L. Newby, Sian E. Faustini, Alex G. Richter, Haresh Selvaskandan, Roseanne E. Billany, Sherna F. Adenwalla, Ian R. Henderson, Max Crispin, Matthew Graham-Brown, Lorraine Harper, Adam F. Cunningham

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HDAC10 and its implications in Sézary syndrome pathogenesis by Monika Pieniawska, Karolina Rassek, Bogumiła Skwara, Magdalena Żurawek, Iwona Ziółkowska-Suchanek, Lydia Visser, Monique Lodewijk, Małgorzata Sokołowska-Wojdyło, Małgorzata Sokołowska-Wojdyło, Berenika Olszewska, Roman J. Nowicki, Roman J. Nowicki, Tomasz Stein, Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Marta Szymoniak-Lipska, Natalia Rozwadowska, Katarzyna Iżykowska

“…Our findings demonstrate that HDAC10 plays a key role in the molecular background of Sézary syndrome, highlighting its importance in the cellular mechanisms of the disease.…”
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Reinforcing cancer immunotherapy with engineered porous hollow mycobacterium tuberculosis loaded with tumor neoantigens by Jie Jiang, Feng-Ying Huang, Shu-Zhen Dai, Guang-Hong Tan, Ming-Hui Chen, Hengyu Chen, Wu-Ping Zheng, Ri-Hong Wu, Weijing Xie

“…Mycobacterium tuberculosis (MTb) contains pathogen-associated molecular patterns (PAMPs) recognized by APCs and adhesion molecules that facilitate MTb invasion of APCs. …”
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3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis by Sayan Deb Dutta, Jeong Man An, Jin Hexiu, Aayushi Randhawa, Keya Ganguly, Tejal V. Patil, Thavasyappan Thambi, Jangho Kim, Yong-kyu Lee, Ki-Taek Lim

“…Biomaterial composition and surface charge play a critical role in macrophage polarization, providing a molecular cue for immunomodulation and tissue regeneration. …”
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Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models by Linglin Tian, Huiyang Gao, Tian Yao, Tian Yao, Yuhao Chen, Linna Gao, Jingxiang Han, Lanqi Zhu, He Huang, He Huang, He Huang

“…Growing evidence highlights the pivotal role of nicotinamide adenine dinucleotide (NAD+) metabolism in UC pathogenesis, prompting our investigation into the subtype-specific molecular underpinnings and diagnostic potential of NAD+ metabolism-related genes (NMRGs).MethodsTranscriptome data from UC patients and healthy controls were downloaded from the GEO database, specifically GSE75214 and GSE87466. …”
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Regulation of Shade Avoidance Under Low‐Blue‐Light by MTA in Soybean by Liya Zhang, Jun Liu, Jiaqi Chen, Yanyan Zhang, Chao Qin, Xiangguang Lyu, Zhuang Li, Ronghuan Ji, Bin Liu, Hongyu Li, Tao Zhao

“…The findings reveal a novel molecular mechanism regulating shade resistance in soybean, providing insights into the epigenetic mechanisms of plant adaptation to changing light environments and paving the way for the development of shade‐tolerant soybean varieties.…”
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miR-9-5p/HMMR regulates the tumorigenesis and progression of clear cell renal cell carcinoma through EMT and JAK1/STAT1 signaling pathway by Xinyang Niu, Dingheng Lu, Weitao Zhan, Jiazhu Sun, Yuxiao Li, Yuchen Shi, Kai Yu, Suyuelin Huang, Xueyou Ma, Xiaoyan Liu, Ben Liu

“…HMMR is closely associated with tumor-related progression, treatment resistance, and poor prognosis, and has yet to be fully investigated in terms of its expression patterns and molecular mechanisms of action in ccRCC. Further research is imperative to elucidate these aspects. …”
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Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of Escherichia coli and Klebsiella pneumoniae in Two Kenyan Facilities: A... by Sylvia M. Maveke, Gabriel O. Aboge, Laetitia W. Kanja, Alfred O. Mainga, Naftaly Gachau, Beatrice W. Muchira, Gervason A. Moriasi

“…The isolates’ ESBL production and antibiotic susceptibility were phenotypically confirmed using a standard procedure. Molecular analysis was done through conventional polymerase chain reaction (PCR) with appropriate primers for gadA, rpoB, blaTEM, blaSHV, blaOXA, blaCTX-M-group-1, blaCTX-M-group-2, blaCTX-M-group-9, and blaCTX-M-group-8/25 genes, sequencing and BLASTn analysis. …”
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Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection by Wei Zhang, Chao Wu, Hanchen Huang, Paulina Bleu, Wini Zambare, Janet Alvarez, Lily Wang, Philip B. Paty, Paul B. Romesser, J. Joshua Smith, X. Steven Chen

“…Background: Colorectal cancer (CRC) presents significant challenges in chemotherapy response prediction due to its molecular heterogeneity. Current methods often fail to account for the complexity and variability inherent in individual tumors. …”
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Effects of oil pollution on the growth and rhizosphere microbial community of Calamagrostis epigejos by Ying Wei, Yukun Zhu, Liqun Yang, Chen Chen, Ming Yue, Zhuxin Mao, Yuchao Wang, Qian Li, Yang Li, Jinlin Lv, Wenyan Xue

“…Metagenomic sequencing technology was employed to analyze the community structure and diversity of soil bacteria, fungi, archaea, and viruses. Additionally, molecular ecological network analysis was integrated to explore species interactions and ecosystem stability within these microbial communities. …”
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Evolution of phase composition and luminescent characteristics of the La1-x-ySmxCayVO4-δ nanocrystalline phosphor by S.G. Nedilko, O. Chukova, A. Dorofieieva, S.A. Nedilko, V. Shcherbatskyi, T. Voitenko, M. Etter, H.S. Rahimi Mosafer, W. Paszkowicz, Y. Zhydachevskyy, A. Suchocki

“…The PL excitation spectra of the La1-x-ySmxCayVO4-δ nanoparticles consist of both the wide UV wavelength band (260–360 nm) caused by transition in the VO43− molecular groups and in a set of narrow lines caused by inner f-f transitions in the Sm3+ ions (spectral range 350–520 nm). …”
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Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer by Luca Mastracci, Patrizio Castagnola, Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

“…Cancer dimensions/survival time were monitored, while, at the molecular level, system biology approaches based on graph theory and experimental proteomic data were performed.Results SFNs were efficiently in vitro uptaken by cancer and dendritic cells. …”
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Circulation of <i>Mycobacterium tuberculosis</i> strains of the Beijing Central Asian Outbreak genotype in the Kemerovo region — Kuzbass in 2018–2022 by Svetlana N. Zhdanova, Anna A. Vyazovaya, Irina B. Lebedeva, Vyacheslav V. Sinkov, Ilya G. Kondratov, Yakov Sh. Schwartz, Lyubov V. Rychkova, Elena B. Brusina, Igor V. Mokrousov, Oleg B. Ogarkov

“…Objective: to study the molecular genetic structure of the M. tuberculosis population, to assess the prevalence and possible routes of emergence of Beijing CAO strains in the Kemerovo region — Kuzbass. …”
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A New MEN2 Syndrome with Clinical Features of Both MEN2A and MEN2B Associated with a New RET Germline Deletion by Carlotta Giani, Teresa Ramone, Cristina Romei, Raffaele Ciampi, Alessia Tacito, Laura Valerio, Laura Agate, Clara Ugolini, Michele Marinò, Fulvio Basolo, Alessandro Franchi, Simona Borsari, Angela Michelucci, Cesare Selli, Gabriele Materazzi, Filomena Cetani, Rossella Elisei

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