Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…Through the integration of in vitro cultured BV-2 microglia with primary microglia datasets, we identify critical molecular determinants of microglial cellular aging confirmed in human-aged brain tissue. …”
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Melting curve analyses in the quantitative real-time polymerase chain reaction of methylated/non-methylated DNA toward the detection of oral cancer using gargle fluid by Yusaku Noma, Hayate Sawayama, Kouta Yamashiro, Keitaro Nishi, Haruka Yoshinaga, Ryota Takaoka, Tsuyoshi Sugiura, Tomonori Sasahira, Tomofumi Hamada, Yasuo Suda, Tatsuo Okui

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Oligogenic effect is associated with the clinical heterogeneity of autosomal dominant deafness-15 by Jianyan Pan, Hua Teng, Fang Liu, Siyi Chen, Yaning Liu, Yanling Teng, Desheng Liang, Zhuo Li, Lingqian Wu

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Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota by Polina V. Popova, Artem O. Isakov, Anastasiia N. Rusanova, Stanislav I. Sitkin, Anna D. Anopova, Elena A. Vasukova, Alexandra S. Tkachuk, Irina S. Nemikina, Elizaveta A. Stepanova, Angelina I. Eriskovskaya, Ekaterina A. Stepanova, Evgenii A. Pustozerov, Maria A. Kokina, Elena Y. Vasilieva, Lyudmila B. Vasilyeva, Soha Zgairy, Elad Rubin, Carmel Even, Sondra Turjeman, Tatiana M. Pervunina, Elena N. Grineva, Omry Koren, Evgeny V. Shlyakhto

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Effect of Estradiol-17β Injection on Gonad Development of White Shrimp (Litopenaeus vannamei) by . Tarsim, M. Zairin Junior, E. Riani

“…The polypeptide sub unit was observed in vitellin of ovari by SDS-PAGE. The molecular weights of approximately 95, 98, 109 and two units higher than 118 kDa of protein marker. …”
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Electroacupuncture alleviates damage to myopic RGCs probably through lncRNA-XR_002789763.1-mediated mitophagy by Xuejun Wang, Qinghong Lin, Li Tian, Xiaoying Li, Teruko Fukuyama, Weijung Ten, Xiehe Kong, Yanting Yang, Xiaopeng Ma, Xingtao Zhou

“…A core ceRNA network was constructed by incorporating PINK1 and verified by related molecular experiments, and we found that EA treatment may induce mitophagy and attenuated RGC injury in guinea pigs with FDM by sponging miR-342-5p through lncRNA-XR_002789763.1 to activate the PINK1/Parkin signaling pathway and promote Mfn2 ubiquitination. …”
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The anti-cancerous mechanism of licochalcone A on human hepatoma cell HepG2 based on the miRNA omics by Jun Wang, Xiuxiu Zhang, Zhijing Ni, Elnur Elam, Kiran Thakur, Kexin Li, Chuyan Wang, Jianguo Zhang, Zhaojun Wei

“…These identified miRNAs, transcription factors, targets, and regulatory networks may offer hints to understand the molecular mechanism of licochalcone A as a natural anticarcinogen.…”
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Small extracellular vesicles derived from sequential stimulation of canine adipose-derived mesenchymal stem cells enhance anti-inflammatory activity by Saranyou Oontawee, Parkpoom Siriarchavatana, Watchareewan Rodprasert, Irma Padeta, Yudith Violetta Pamulang, Poorichaya Somparn, Trairak Pisitkun, Boondarika Nambooppha, Nattawooti Sthitmatee, Daneeya Na Nan, Thanaphum Osathanon, Hiroshi Egusa, Chenphop Sawangmake

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Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…To gain insight into the molecular signaling mechanisms, we determined the effect of iguratimod on the activation of mitogen-activated protein kinases (MAPK) signaling pathways by the cellular thermal shift assay (CETSA) and western blot. …”
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The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies by Katongo Hope Mutengo, Katongo Hope Mutengo, Bruno Bezerra Lima, Wilbroad Mutale, Aggrey Mweemba, Lorrita Kabwe, Clive Banda, Callistus Kaayunga, Mutale Mulenga, Douglas Heimburger, Sepiso K. Masenga, John Jeffrey Carr, Annet Kirabo

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METTL16 is Required for Meiotic Sex Chromosome Inactivation and DSB Formation and Recombination during Male Meiosis by Lisha Yin, Nan Jiang, Wenjing Xiong, Shiyu Yang, Jin Zhang, Mengneng Xiong, Kuan Liu, Yuting Zhang, Xinxin Xiong, Yiqian Gui, Huihui Gao, Tao Li, Yi Li, Xiaoli Wang, Youzhi Zhang, Fengli Wang, Shuiqiao Yuan

“…However, the key regulators involved in this process and the underlying molecular mechanisms remain unclear. Here, we report an essential role of the m6A methyltransferase METTL16 in meiotic sex chromosome inactivation (MSCI), double‐strand break (DSB) formation, homologous recombination and SYCP1 deposition during male meiosis. …”
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The epididymal microenvironment in Akodon cursor (Muridae, Sigmodontinae, Akodontini): The lifetime of spermatozoa from production to maturation by Tatiana Prata Menezes, Fernanda Carolina Ribeiro Dias, Nara Clara Lazaroni e Merchid, Camila Folly Batista, Camilo Jose Ramirez-Lopez, Arabela Guedes de Azevedo Viana, Renner Philipe Rodrigues Carvalho, Adrielli Ribeiro Araújo, José Lino-Neto, Gisele Lessa, Arlindo A. Moura, Mariana Machado-Neves

“…These findings provide valuable insights into the molecular mechanisms underlying sperm maturation in this species. …”
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Genomic Characterization of Carbapenemase-Producing Enterobacteriaceae from Clinical and Epidemiological Human Samples by Alexander Tristancho-Baró, Laura Eva Franco-Fobe, Monica Pilar Ariza, Ana Milagro, Ana Isabel López-Calleja, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, Rosa Martínez, Carmen Torres, Antonio Rezusta

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Metal-free production of natural blue colorants through anthocyanin–protein interactions by Wenxin Wang, Peiqing Yang, Fuqing Gao, Yongtao Wang, Zhenzhen Xu, Xiaojun Liao

“…Methods: Using human serum albumin (HSA) as a model protein, we investigated the structural influences of ACNs on their blue color generation using visible absorption spectroscopy, fluorescence quenching, and molecular simulations. Additionally, we examined the bluing effects of six proteins derived from milk and egg and identified the remarkable roles of bovine serum albumin (BSA) and lysozyme (LYS). …”
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Correction: Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic by Volker Arndt, Daniela Doege, Stefan Fröhling, Peter Albers, Hana Algül, Ralf Bargou, Carsten Bokemeyer, Martin Bornhäuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Brümmendorf, Hartmut Döhner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann

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A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin by Bowei Wang, Dingkun Qiu, Yihui Gu, Zhu Shan, Ruonan Shi, Jing Luo, Shuang Qi, Yilin Wang, Bo Jiang, Yongcan Jin

“…Such lignin-based controlled/sustained release hydrogel that integrates the molecular structure and biological difunctional features of lignin gives new insight into cost-effective, easy-to-operate manufacturing of load-bearing and bioactive materials.…”
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Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats by Faisal A. Alzahrani, Mohammed A. El-Magd, Ahmed Abdelfattah-Hassan, Ayman A. Saleh, Islam M. Saadeldin, Eman S. El-Shetry, Abdelnaser A. Badawy, Saleh Alkarim

“…All these cellular, functional, and molecular changes were reversed following injection of BM-MSCs-exosomes. …”
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Insights from the single-cell level: lineage trajectory and somatic-germline interactions during spermatogenesis in dwarf surfclam Mulinia lateralis by Yajuan Li, Huilan Wei, Xiaoting Dai, Lijing Zhang, Liangjie Liu, Xiaomei Chen, Tian Liu, Ya Shu, Yaxin Yang, Shi Wang, Zhenmin Bao, Lingling Zhang

“…However, a substantial gap remains in our understanding of the molecular mechanisms and key driver genes that underpin this process, particularly in invertebrates. …”
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Downregulation of hnRNPA1 inhibits hepatocellular carcinoma cell progression by modulating alternative splicing of ZNF207 exon 9 by Qi Ouyang, Qi Ouyang, Wenhui He, Yiping Guo, Lin Li, Ying Mao, Xiang Li, Shuanglin Xiang, Xiang Hu, Jun He

“…We identified that hnRNPA1 bound to ZNF207 and regulated its exon 9 skipping, influencing ZNF207 splicing and the PI3K/Akt/mTOR pathway, key regulators of cell growth and survival.ConclusionOur findings demonstrate that hnRNPA1 promotes HCC progression by regulating ZNF207 splicing and the PI3K/Akt/mTOR pathway. hnRNPA1-ZNF207 interaction represents a potential therapeutic target for HCC, providing insights into the molecular mechanisms underlying HCC progression.…”
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Dust Scattering Albedo at Millimeter Wavelengths in the TW Hya Disk by Tomohiro C. Yoshida, Hideko Nomura, Takashi Tsukagoshi, Kiyoaki Doi, Kenji Furuya, Akimasa Kataoka

“…We propose to break this degeneracy by using multiple optically thin molecular lines as a dust–albedo-independent thermometer. …”
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