Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone by Jianping Jiang, Astrid V. Cienfuegos-Galletd, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen

“…Methods One hundred and one CG147 strains were sequenced and additional 911 publicly available CG147 genome sequences were included for analysis. The molecular epidemiology, population structure, and time phylogeny were investigated. …”
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Different cortex activation between young and middle-aged people during different type problem-solving: An EEG&fNIRS study by Mevhibe Saricaoglu, Meryem Ayşe Yücel, Miray Budak, Ahmet Omurtag, Lutfu Hanoglu

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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…We previously identified cetylpyridinium chloride and dinotefuran as a potential binary biocidal combination associated with pulmonary fibrosis, based on two intersecting adverse outcome pathways (AOPs) using the molecular initiating events (MIE) modeling method and in vitro testing. …”
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Research on the Anxiety and Depression of Patients with Mechanical Ocular Injuries: A Cross-Sectional Study by Li M, Wang Y, Chen H, Zheng F, Su Z, Li J, Yan H

“…Mengxuan Li,1– 3 Yuhao Wang,4 Hanhui Chen,4 Fang Zheng,5 Zhitao Su,5 Jie Li,4 Hua Yan1– 3 1Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China; 2Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin, 300070, People’s Republic of China; 3Key Laboratory of Ocular Trauma, Tianjin, 300070, People’s Republic of China; 4Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, People’s Republic of China; 5Eye Center, The Second Affiliated Hospital Zhejiang University School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Hua Yan, Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China, Fax +86-22-27813550, Email zyyyanhua@tmu.edu.cnPurpose: The present study aimed to investigate the prevalence of anxiety and depression in patients with mechanical ocular injuries, and the effects of worry and resilience on anxiety and depression.Patients and Methods: Patients with one eye of mechanical ocular injuries and healthy residents were recruited from June 8, 2022, to March 1, 2023. …”
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Effect of hard segment content on the phase separation and properties of hydroxyl-terminated polybutadiene thermoplastic polyurethane by Boxin Liu, Zhihao Niu, Zhanglei Wang, Yimin Wang, Hua Zou, Xiuying Zhao, Shikai Hu

“…Additionally, all-atom molecular dynamics simulations were conducted to determine the number of hydrogen bonds. …”
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Genome-wide association study analysis of single nucleotide variants in L. infantum associated with IL-6 inflammatory response in visceral leishmaniasis by Amanda Miranda da Silva, Kátia Silene Sousa Carvalho, Caio Andrey Bezerra Januário, Raquel Gomes de Sena Carneiro Caldas, Bianka Lopes da Silva Paulino, Débora Cavalcante Braz, Dorcas Lamounier Costa, Gabriel da Luz Wallau, Wilson Jose da Silva Junior, Carlos Henrique Nery Costa

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Petrophysical Characterization and Gas Accumulation of Wufeng-Longmaxi Shale Reservoir in Eastern Margin of Sichuan Basin, SW China by Wei Wang, Dahua Li, Lijun Cheng, Ye Zhang, Jinxi Wang, Zhiping Zhang, Hualian Zhang, Dongxin Guo, Yuelei Zhang, Qing Hua, Jun Liu

“…Besides, the drying coefficient indicates the dry gas is the dominate molecular composition in the gas content of WL shale. …”
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Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies by Marcus Bruno Soares Forte, Élen Cristina Luna Elias, Heloise O. Pastore, Francisco Maugeri Filho, Maria Isabel Rodrigues

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Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis by Jose Rafael Villafan-Bernal, Mariana Acevedo-Alba, Rodrigo Reyes-Pavon, Guillermo Andres Diaz-Parra, Diana Lucia Lip-Sosa, Hilda Imelda Vazquez-Delfin, Martha Hernandez-Muñoz, Daniel Ely Bravo-Aguirre, Francesc Figueras, Raigam Jafet Martinez-Portilla

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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice by Bing Li, Yu Cheng, Songyan Yu, Li Zang, Yaqi Yin, Jiejie Liu, Lin Zhang, Yiming Mu

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Salivary proteomics profiling reveals potential biomarkers for chronic kidney disease: a pilot study by Bianca Uliana Picolo, Nathália Rabello Silva, Mário Machado Martins, Hebréia Oliveira Almeida-Souza, Letícia Cristina Machado de Sousa, Richard Costa Polveiro, Luiz Ricardo Goulart Filho, Robinson Sabino-Silva, Vivian Alonso-Goulart, Luciana Saraiva da Silva

“…Gene ontology (GO) analysis revealed data on molecular functions, biological processes, cellular components, and protein classes.ConclusionWe can conclude that the salivary API5, PI-PLC, and Sgsm2 can be potential biomarker candidates for CKD detection. …”
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Effects of Source on the Nitrogen Uptake, Allocation Patterns, and Performance of Strawberry (<i>Fragaria × ananassa</i> Duch.): A ¹⁵N-Tracer Study by Sirajo Salisu Jibia, Kanokwan Panjama, Chaiartid Inkham, Takashi Sato, Norikuni Ohtake, Soraya Ruamrungsri

“…Future research should focus on refining mixed N application ratios and timings, exploring molecular mechanisms of N metabolism, and evaluating long-term impacts on strawberry production sustainability.…”
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Selectively expressed RNA molecules as a versatile tool for functionalized cell targeting by Frederik Rastfeld, Marco Hoffmann, Sylvie Krüger, Patrick Bohn, Anne-Sophie Gribling-Burrer, Laura Wagner, Nils Hersch, Carina Stegmayr, Lukas Lövenich, Sven Gerlach, Daniel Köninger, Christina Hoffmann, Helene L. Walter, Dirk Wiedermann, Hajaani Manoharan, Gereon R. Fink, Rudolf Merkel, Heribert Bohlen, Redmond P. Smyth, Maria A. Rueger, Bernd Hoffmann

“…The specific combination of the molecular properties of antisense technology and mRNA therapy with functional RNA secondary structures allowed us to develop selectively expressed RNA molecules for medical applications. …”
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Enzymatic Activity and Horizontal Gene Transfer of Heavy Metals and Antibiotic Resistant Proteus vulgaris from Hospital Wastewater: An Insight by Manzar Alam, Nilofer Bano, Tarun Kumar Upadhyay, Reem Binsuwaidan, Nawaf Alshammari, Amit Baran Sharangi, Radhey Shyam Kaushal, Mohd Saeed

“…Plasmids were present in all the selected resistant isolates and varied in size from 42.5 to 57.0 kb and molecular weight from 27.2 to 37.0 MD. The transmission of the antibiotic/metal resistance genes was evaluated between a total of 7 pairs of isolates. …”
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Clinical validation and optimization of machine learning models for early prediction of sepsis by Xi Liu, Meiyi Li, Xu Liu, Yuting Luo, Dong Yang, Hui Ouyang, Jiaoling He, Jinyu Xia, Fei Xiao, Fei Xiao, Fei Xiao

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Systematic Review and Network Meta-Analysis on Treating Hormone Receptor-Positive Metastatic Breast Cancer After CDK4/6 Inhibitors by Neha Pathak, Abhenil Mittal, Sudhir Kumar, Chitrakshi Nagpal, Eitan Amir, Partha Haldar, Bharath B. Gangadharaiah, Akash Kumar, Ashutosh Mishra, Atul Batra

“…NMA was executed using WINBUGS (Microsoft Excel). Three molecular subgroups were analyzed: HER2-low, PI3K/AKT/mTOR, and the ESR1 mutation subgroup for selective estrogen receptor degrader (SERD). …”
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A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research by Sun Young Lee, Mikael Klingeborn, Jeff W. M. Bulte, Daniel T. Chiu, Michael Chopp, Christopher W. Cutler, Saumya Das, Charles E. Egwuagu, Christie D. Fowler, Sarah F. Hamm‐Alvarez, Hakho Lee, Yutao Liu, Ben Mead, Tara L. Moore, Sriram Ravindran, Ashok K. Shetty, Johan Skog, Kenneth W. Witwer, Ali R. Djalilian, Alissa M. Weaver

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Heat Tolerance Differences Between Hu Sheep and Hu Crossbred Sheep in Microbial Community Structure and Metabolism by Jing-Da Yuan, Li-Wei Wang, Shao-Yin Fu, Ri-Ge-Li-Tu E, Xiao-Qi Ren, Hua Sun, Fang Liu, Biao Wang, Jiang-Hong An, Meng-Ran Zhao, Jiang-Feng He, Xiao-Long He

“…Therefore, delving into the differences in the physiological and molecular mechanisms of heat stress across different sheep breeds is crucial for developing effective management and breeding strategies. …”
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Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes by Fresia Pareja, Rohit Bhargava, Virginia F. Borges, Edi Brogi, Rita Canas Marques, Fatima Cardoso, Christine Desmedt, Malini Harigopal, Sunil R. Lakhani, Adrian Lee, Jose Pablo Leone, Hannah Linden, Christopher J. Lord, Caterina Marchio, Sofia D. Merajver, Emad Rakha, Jorge S. Reis-Filho, Andrea Richardson, Elinor Sawyer, Pepper Schedin, Christopher J. Schwartz, Andrew Tutt, Naoto T. Ueno, Anne Vincent-Salomon, Britta Weigelt, Y. Hannah Wen, Stuart J. Schnitt, Steffi Oesterreich

“…Abstract Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. …”
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Parishin B blocking TRIB3-AKT1 interaction inhibits breast cancer lung metastasis by Xiongtao Cheng, Xiongtao Cheng, Jianguo Sun, Shouhong Chen, Nan Wang, Weijing Tang, Zijian Xia, Yuhong Shu, Shouhong Gao, Zhipeng Wang, Xinxia Wang, Rongzi Shao, Jianxiong Cao, Jianxiong Cao

“…Thus, this study aim to find drugs that can bind to TRIB3 to inhibit BC progression, and further elucidate its mechanism.MethodsThe possible inhibitors of TRIB3 were screened by high-throughput molecular docking, CETSA, and CO-IP assay. Then, the effect of TRIB3 inhibitor anti BC was assessed by CCK-8 assay, flow cytometry, plate colony formation assay, and transwell assay; and the RNA-seq was empolyed to study the potential mechanism of Parishin B (PB) anti-BC. …”
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