High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression by Zhengyi Wu, Chao Li, Shouhua Zhang, Liang Sun, Junwen Hu, Bingbing Qiu, Shuiqiu Liu, Yiran Hong, Tianxiang Chen, Kai Wang, Xiangbao Yin, Jinlong Yan

“…Omics analysis and subsequent molecular validation revealed that KIF11 protein levels were markedly upregulated under HIFP, despite no significant change in mRNA levels. …”
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Pushing the Atacama Large Millimeter/submillimeter Array to the Limit: 140 pc Resolution Observations of a z = 6.6 Quasar–Galaxy Merger Resolve Strikingly Different Morphologies of... by Romain A. Meyer, Bram Venemans, Marcel Neeleman, Roberto Decarli, Fabian Walter

“…The absence of significant [C ii ] emission by structures with physical scale ≲ 1 kpc implies that [C ii ] emission is not produced in dense PDRs located at the boundary of giant molecular clouds. We argue instead that [C ii ] is produced in low-density PDRs in the interstellar medium and diffuse H i gas tidally stripped during the ongoing merger.…”
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Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease by Yuyan Li, Yueming Luo, Yilan Hu, Siting Li, Guandong Li, Wanyangchuan Zhang, Xiufen Gu, Jianting Wang, Shunmin Li, Hong Cheng

“…In clinical practice, the Chinese patent herbal medicine Jianpi-Yishen (JPYS) formula is commonly used to treat CKD. However, the molecular mechanisms by which JPYS targets and modulates the host immune response remain unclear.MethodsThis study utilized network pharmacology, RNA sequencing (RNA-seq), and metabolic analyses using in vivo and in vitro models to investigate the impact of the JPYS formula on inflammation and the immune system. …”
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Melatonin induces drought stress tolerance by regulating the physiological mechanisms, antioxidant enzymes, and leaf structural modifications in Rosa centifolia L by Muhammad Ahsan, Adnan Younis, Aftab Jamal, Mohammed O. Alshaharni, Uthman Balgith Algopishi, Abeer Al-Andal, Mateen Sajid, Muhammad Naeem, Jawad Ahmad Khan, Emanuele Radicetti, Mohammad Valipour, Gulzar Akhtar

“…Future studies should focus on molecular responses of R. centifolia to drought stress to further develop stress alleviation strategies in floricultural crops.…”
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$$\hbox {H}_2$$ -roaming dynamics in the formation of $$\hbox {H}_{3}^{+}$$ following two-photon double ionization of ethanol and aminoethanol by Aaron Ngai, Sebastian Hartweg, Jakob D. Asmussen, Björn Bastian, Matteo Bonanomi, Carlo Callegari, Miltcho Danailov, Michele di Fraia, Raimund Feifel, Sarang Dev Ganeshamandiram, Sivarama Krishnan, Aaron LaForge, Friedemann Landmesser, Ltaief Ben Ltaief, Moritz Michelbach, Nitish Pal, Oksana Plekan, Nicolas Rendler, Lorenzo Raimondi, Fabian Richter, Audrey Scognamiglio, Tobias Sixt, Richard J. Squibb, Katrin Dulitz, Frank Stienkemeier, Marcel Mudrich

“…Abstract Roaming reactions involving a neutral fragment of a molecule that transiently wanders around another fragment before forming a new bond are intriguing and peculiar pathways for molecular rearrangement. Such reactions can occur for example upon double ionization of small organic molecules, and have recently sparked much scientific interest. …”
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Effect Of Magnesium Perchlorate Content on the Mechanical, Thermal Stability, and Dielectric Properties of Plasticized PMMA/PVC-g-PMMA Electrolytes by Nguyen Thi Kim Dung, Nguyen Thi Dieu Linh, Do Quang Tham, Nguyen Thuy Chinh, Man Minh Tan, Tran Thi Mai, Nguyen Thi Thu Trang, Do Minh Thanh, Nguyen Quang Tung, Thai Hoang

“…Fourier transform infrared (FTIR) spectra of the electrolytes showed mutual molecular interactions between Mg(ClO4)2 and organic moieties. …”
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Anticoagulant management of cancer-associated thrombosis and thrombocytopenia: a retrospective chart review by Umaima Abbas, Robin MacKenzie, Ushra Khan, Rija Fatima, Tzu-Fei Wang, Rong Luo, Caroline Hamm, Andrea Cervi

“…While direct oral anticoagulants (DOACs) are used in the management of CAT, low molecular weight heparin (LMWH) continues to be recommended for CAT with thrombocytopenia. …”
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Inhibition of anti-tumour reactivity of immune cells in the salivary gland cancer: A proteomic approach by Rajdeep Chakraborty, Charbel Darido, Aidan Tay, Thiri Zaw, Shoba Ranganathan, Fei Liu, Giuseppe Palmisano

“…While MEC has shown some response to pembrolizumab; however, ACC is the least responsive. At the molecular level, head and neck cancers produce immunosuppressive molecules, resulting in immune evasion. …”
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Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment by Christian Klein, Maria Amann, Jacob Gadwa, Laurel B Darragh, Miles Piper, Diemmy Nguyen, Sana D Karam, Michael W Knitz, Justin Yu, Nicholas Olimpo, Sophia Corbo, Jessica I Beynor, Brooke Neupert, Alexander T Nguyen, Chloe Hodgson, Khalid NM Abdelazeem, Anthony Saviola, Laurene Pousse, Ali Bransi, Mudita Pincha

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Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions by Aviva Levina, Debbie C. Crans, Peter A. Lay

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Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P. aeruginosa Clinical Strains by Daria Bortolotti, Claudio Trapella, Alessandra Bragonzi, Paolo Marchetti, Vinicio Zanirato, Andrea Alogna, Valentina Gentili, Carlo Cervellati, Giuseppe Valacchi, Mariangela Sicolo, Giulia Turrin, Anna Fantinati, Dario Di Luca, Roberta Rizzo

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Effect of triple-frequency sono-germination and soaking treatments on techno-functional characteristics of barley by Tabussam Tufail, Huma Bader Ul Ain, Jawad Ashraf, Muhammad Safiullah Virk, Zahoor Ahmed, Mokhtar Dabbour, Tawfiq Alsulami, Suleiman Althawab, Bin Xu

“…Strong intermolecular interactions were observed in both ZQ2000 and XMLY22 samples subjected to TFUT, GE, TFUT + GE, and TS, as validated by FTIR and molecular docking analyses. The structural configuration of two barley types, ZQ2000 and XMLY22, was determined using Fourier transform infrared (FTIR) spectroscopy, which indicated an increase in α-helix and β-sheet conformation and a decrease in random coil conformation in samples treated with TFUT + GE. …”
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Intratumoral and peritumoral radiomics using multi-phase contrast-enhanced CT for diagnosis of renal oncocytoma and chromophobe renal cell carcinoma: a multicenter retrospective st... by Yongsong Ye, Bei Weng, Yan Guo, Lesheng Huang, Shanghuang Xie, Guimian Zhong, Wenhui Feng, Wenxiang Lin, Zhixuan Song, Huanjun Wang, Tianzhu Liu

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Dichlormid protect wheat from fomesafen residual injury by increasing PPO expression and the photosynthesis characterize by Dongzhi Li, Yilin Liu, Li Xu, Hao Yu, Yunchao Kan, Runqiang Liu, Guangling Li

“…We found that dichlormid treatment could restore the growth of wheat seedlings exposed to fomesafen stress. To explore its molecular mechanism, RNA-Seq was conducted to analysis transcript profiles between fomesafen and fomesafen+dichlormid treated wheat seedlings. …”
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Structural characterization and anti-inflammatory activities of novel polysaccharides obtained from Pleurotus eryngii by Han Wang, Sai Ma, Alfred Mugambi Mariga, Qiuhui Hu, Qian Xu, Anxiang Su, Ning Ma, Gaoxing Ma

“…Results showed that molecular weights of these polysaccharides were 3235, 2041 and 23933 Da, respectively. …”
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Polydatin enhances oxaliplatin-induced cell death by activating NOX5-ROS-mediated DNA damage and ER stress in colon cancer cells by Qi Zhao, Qi Zhao, Qi Zhao, Yan Zhang, Yan Zhang, Jieyu Liu, Peipei Chen, Annabeth Onga, Namki Cho, Ri Cui, Chenguo Zheng

“…The relative gene and protein expressions were analyzed by quantitative real time-PCR (qRT-PCR) and Western blot assays. Molecular docking analysis predicted the interaction between PD and potential targets.ResultsWe found that PD exerted anti-CRC activity by promoting Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase 5 (NOX5)-mediated ROS production, activating the endoplasmic reticulum (ER) stress, and inducing DNA damage. …”
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Transarterial Chemoembolization Plus Radiofrequency Ablation and Iodine-125 Seed Implantation for Hepatocellular Carcinoma in High-Risk Locations: A Propensity Score-Matched Analys... by Zhang G, Ren Y, Liu J, Cao Y, Xiong F, Liang B, Zheng C, Kan X

“…Guilin Zhang,1– 3,* Yanqiao Ren,1– 3,* Jiayun Liu,1– 3 Yanyan Cao,1– 3 Fu Xiong,1– 3 Bin Liang,1– 3 Chuansheng Zheng,1– 3 Xuefeng Kan1– 3 1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan, 430022, People’s Republic of China; 3Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuefeng Kan; Chuansheng Zheng, Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, Hubei province, 430022, People’s Republic of China, Email xkliulang1314@163.com; hqzcsxh@sina.comBackground & Aims: The effect of transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) (TACE-RFA) for hepatocellular carcinoma (HCC) in high-risk locations is not satisfactory. …”
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Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping by Hannah L. Cornman, Martin P. Alphonse, Arbor Dykema, Alexander L. Kollhoff, Kevin K. Lee, Jaya Manjunath, Emily Z Ma, Varsha Parthasarathy, Junwen Deng, Thomas Pritchard, Anusha Kambala, Melika Marani, Kayla A. Parr, Javid P. Mohammed, Madan M. Kwatra, Jay H. Bream, Won Jin Ho, Shawn G. Kwatra

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PER3 suppresses tumor metastasis of oral squamous cell carcinoma by promoting HIF-1α degradation by Yaoxu Li, Bing Li, Kai Yang, Lihua Zhu, Hong Tang, Yinpei Huang, Jinhai Deng, Jun Duan

“…Here, we investigated the role and molecular mechanism of PER3 in regulating HIF-1α and metastasis in oral squamous cell carcinoma (OSCC) by using bioinformatics analyses and in vitro and in vivo experiments. …”
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Prevalence of intestinal parasites and Helicobacter pylori co-infection in people with gastrointestinal symptoms in Africa: a systematic review and meta-analysis by Yenesew Mihret Wondmagegn, Getu Girmay, Gashaw Azanaw Amare, Muluneh Assefa, Mebratu Tamir, Zufan Yiheyis Abriham, Abebaw Setegn

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