β-Hydroxybutyrate Protects Against Cisplatin-Induced Renal Damage via Regulating Ferroptosis by Ruixue Tian, Shuqin Tang, Jingyu Zhao, Yajie Hao, Limei Zhao, Xiutao Han, Xingru Wang, Lijun Zhang, Rongshan Li, Xiaoshuang Zhou

“…This study provided evidence of the protective effects of β-HB against cisplatin-induced nephrotoxicity and identified inhibited ferroptosis and Camkk2 as potential molecular mechanisms.…”
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LncRNA TUG1 mitigates chronic kidney disease through miR-542-3p/HIF-1α/VEGF axis by Luoxiang Qian, Wanru Hu, Yanping Wang, Yousuf Abdulkarim Waheed, Shuqun Hu, Dong Sun, Shulin Li

“…CKD has been discovered to be closely associated with both long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), while the precise molecular processes behind this relationship are still unclear. …”
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Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis... by P. S. Demenkov, E. A. Antropova, A. V. Adamovskaya, E. I. Mishchenko, T. M. Khlebodarova, T. V. Ivanisenko, N. V. Ivanisenko, A. S. Venzel, I. N. Lavrik, V. A. Ivanisenko

“…The reconstruction of gene networks describing the molecular mechanisms of interaction of aberrantly methylated genes with key participants of the extrinsic apoptosis pathway and their regulation by HCV proteins can provide important information when searching for pharmacological targets. …”
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Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples by M. F. Kearney, K. Lee, R. K. Bagni, A. Wiegand, J. Spindler, F. Maldarelli, P. A. Pinto, W. M. Linehan, C. D. Vocke, K. A. Delviks-Frankenberry, R. W. deVere White, G. Q. Del Prete, J. W. Mellors, J. D. Lifson, V. N. KewalRamani, V. K. Pathak, J. M. Coffin, S. F. J. Le Grice

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The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Additionally, network pharmacology and molecular docking results show that the main active components of XFC, namely, calycosin-7-O-beta-D-glucoside, calycosin, and formononetin, exhibit excellent docking with the core targets HIF1A, PTGS2, and MMP9. …”
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Nanoscale polarization transient gratings by Laura Foglia, Björn Wehinger, Giovanni Perosa, Riccardo Mincigrucci, Enrico Allaria, Francesco Armillotta, Alexander Brynes, Matthew Copus, Riccardo Cucini, Dario De Angelis, Giovanni De Ninno, W. Dieter Engel, Danny Fainozzi, Luca Giannessi, Ezio Iacocca, Nupur N. Khatu, Simone Laterza, Ettore Paltanin, Jacopo Stefano Pelli-Cresi, Giuseppe Penco, Denny Puntel, Primož Rebernik Ribič, Filippo Sottocorona, Mauro Trovò, Clemens von Korff Schmising, Kelvin Yao, Claudio Masciovecchio, Stefano Bonetti, Filippo Bencivenga

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Structural characterization of oligosaccharide from Spirulina platensis and its effect on the faecal microbiota in vitro by Bingna Cai, Xiangxi Yi, Qian Han, Jianyu Pan, Hua Chen, Huili Sun, Peng Wan

“…The prebiotic activity of SPO-1 on the growth of Lactobacillus paracasei and Bifidobacterium animalis, and its effect on human gut microbiota were examined in vitro. The molecular weight of the tetrasaccharide SPO-1 was 650.2 Da, and it was mainly composed of glucose with α-type glycosidic linkages. …”
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Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat by Duo Su, Tingting Jiang, Yulong Song, Die Li, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Li Li, Hongping Zhang, Linjie Wang

“…Abstract Uncoupling protein 1 (UCP1) is a crucial protein located in the mitochondrial inner membrane that mediates nonshivering thermogenesis. However, the molecular mechanisms by which enhancer–promoter chromatin interactions control Ucp1 transcriptional regulation in brown adipose tissue (BAT) are unclear. …”
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Variation in a single allele drives divergent yield responses to elevated CO2 between rice subspecies by Yunlong Liu, Siyu Zhang, Haoyu Qian, Chengbo Shen, Shuijin Hu, Weijian Zhang, Yong Wang, Shan Huang, Songhan Wang, Zhenghui Liu, Ganghua Li, Xiangdong Fu, Yanfeng Ding, Shan Li, Kees Jan van Groenigen, Yu Jiang

“…Abstract Rising atmospheric CO2 generally increases yield of indica rice, one of the two main Asian cultivated rice subspecies, more strongly than japonica rice, the other main subspecies. The molecular mechanisms driving this difference remain unclear, limiting the potential of future rice yield increases through breeding efforts. …”
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Validation of Immersion Precooling and Drip Sanitation Standard Operating Procedures on Weight, Temperature, Microbiological Quality, and Safety of Chicken Carcasses by Angela B.P.S. Fernandes, Clair F.S. Pereira, Hiago M. Pereira, Marco A.C. Batista, Luiz F.S. Dionisio, Amauri A. Alfieri, Bruna Alexandrino, José C. Ribeiro-Júnior

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Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy by Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi

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A density functional theory investigation of the substituent effect on acyclovir and guanine derivatives for applications on energetic materials by Luciana Amorim da Silva, Gabriel Monteiro-de-Castro, Erick Braga Ferrão Galante, Itamar Borges Jr, Aline Cardoso Anastácio

“…In this work, to evaluate the potential of acyclovir and guanine derivatives as energetic materials, density functional theory (DFT) calculations were carried out to investigate the influence of the type and position of the explosophore substituent groups –NO2, –NHNO2, –N3, –ONO2, –CN, −N=N−, and −N=N(O)− on the energetic properties and chemical reactivity of 91 acyclovir- and guanine-based molecules, including thirty one nitramines, three nitroheterocycles, seventeen azides, seventeen nitrate esters, seventeen nitriles, three azo and three azoxy compounds. Several molecular properties were computed, including the chemical reactivity, the heat of formation and the detonation velocities and pressures using semiempirical equations. …”
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Nationwide observational study of incidence, management and outcome of spontaneous coronary artery dissection: a report from the Swedish Coronary Angiography and Angioplasty regist... by Per Tornvall, Eva Swahn, Dimitrios Venetsanos, Troels Yndigegn, Sofia Sederholm Lawesson, Lena Jonasson, Nina Johnston, Henrik Wilander, Christos Pagonis, Christian Dworeck, Thomas Kellerth

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Identification of microorganisms at different times in a bioleaching process for the recovery of gold and silver from minerals in oxide form by Cuauhtémoc Contreras Mora, Juan Antonio Rojas Contreras, Mayra Cristina Rosales Villarreal, José Luis Urban Martínez, Efren Delgado, Hiram Medrano Roldan, Felipe Samuel Hernández Rodarte, Damián Reyes Jáquez

“…Four native microorganisms were identified using molecular biology techniques and a 16S rRNA gene fragment: Acidovorax citrulli, Brevundimonas albigilva, Sphingomonas korenensis, and Methylobacterium organophilum. …”
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Parámetros de laboratorio clínico en pacientes con la COVID-19 by Naivy Sánchez Vera, Danay Saavedra Hernández, Carlos Jorge Hidalgo Mesa, Maykel Aguila López, Gladys Abreu Gutiérrez, Vivian Herrera González, Iliana Teresa Rodríguez García

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AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation by Serena Sagliocchi, Elisabetta Schiano, Lucia Acampora, Fortuna Iannuzzo, Annunziata Gaetana Cicatiello, Caterina Miro, Annarita Nappi, Federica Restolfer, Mariano Stornaiuolo, Stefano Zarrilli, Fabrizia Guerra, Gian Carlo Tenore, Monica Dentice, Ettore Novellino

“…Over 30 days, C57BL/6 mice were treated with the ABA-rich infusion, and various metabolic and molecular parameters were assessed. The results showed that the AbaComplex significantly increased the expression of browning markers, such as UCP1 and PGC1-α, in both visceral and subcutaneous WAT. …”
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Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain by Binglin Chen, Jiabao Guo, Chan Gong, Chenchen Zhu, Yang Wu, Shengbo Wang, Yili Zheng, Haixia Lu

“…Therefore, the purpose of this study is to investigate how prior exercise affects protein expression in NP model rats and thus gain comprehensive insights into the molecular mechanisms involved. To achieve this objective, 6-week-old male Sprague–Dawley rats were randomly assigned into three groups, named as chronic constriction injury (CCI) of the sciatic nerve, CCI with prior 6-week swimming training (CCI_Ex), and sham operated (Sham). …”
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Statistical optimization of pectinases from thermophilic Aspergillus fumigatus BT-4 employing response surface methodology through submerged fermentation using agricultural wastes by Imran Ali, Roheena Abdullah, Sana Saqib, Kinza Nisar, Afshan Kaleem, Mehwish Iqtedar, Irfana Iqbal, Xiaoming Chen

“…The pectinase enzyme was purified through ammonium sulfate precipitation, gel filtration, and ion-exchange chromatography, resulting in a 2.3-fold purification. The molecular weight of the purified enzyme was determined to be 48 kDa. …”
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Developmental Proteomics Reveals the Dynamic Expression Profile of Global Proteins of <i>Haemaphysalis longicornis</i> (Parthenogenesis) by Min-Xuan Liu, Xiao-Pei Xu, Fan-Ming Meng, Bing Zhang, Wei-Gang Li, Yuan-Yuan Zhang, Qiao-Ying Zen, Wen-Ge Liu

“…Here, we used the isobaric tags for a relative and absolute quantification (iTRAQ) technique to systematically describe and analyze the dynamic expression of the protein and the molecular basis of the proteome of <i>H. longicornis</i> in seven differential developmental stages (eggs, unfed larvae, engorged larvae, unfed nymphs, engorged nymphs unfed adults, and engorged adults). …”
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Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States by Pablo D. Jimenez Castro, Jennifer L. Willcox, Haresh Rochani, Holly L. Richmond, Heather E. Martinez, Cecilia E. Lozoya, Christian Savard, Christian M. Leutenegger

“…This study highlights the value of an accessible diagnostic qPCR test with fast turnaround in unraveling the molecular epidemiology of hookworms and benzimidazole resistance, as well as explore potentially important risk factorsin dogs with routine veterinary care.…”
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