Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…Although considerable progress in understanding the molecular pathways involved in ulcerative colitis has led to improved treatment options, there is currently no definitive cure for ulcerative colitis, there remain considerable unmet needs in terms of long-term efficacy and safety, and there are many patients who continue to be burdened by physical and psychological symptoms. …”
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SARS-CoV-2 SPIKE Antibody Levels can Indicate Immuno-Resilience to Re-infection: a Real-World Study by Yue Jin, Fei Yang, Christopher M. Rank, Stanley Letovsky, Peter Ramge, Simon Jochum

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Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study by Behnam Ermian, Noosha Samieefar, Aida Vahidi, Daryoush Fahimi, Niloufar Peirovi, Mohamed Husein Aldokhi, Behnaz Bazargani, Arash Abbasi, Fahimeh Askarian, Mastaneh Moghtaderi

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Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study by Matthew A. Lee, Kate L. Burley, Emma L. Hazelwood, Sally Moore, Sarah J. Lewis, Lucy J. Goudswaard

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Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure? by Anna C. Roberts, Jai Gohil, Laura Hudson, Kyle Connolly, Philip Warburton, Rakesh Suman, Peter O’Toole, David J. O’Regan, Neil A. Turner, Kirsten Riches, Karen E. Porter

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Identification and validation of diagnostic genes IFI44 and IRF9 in insomnia-associated autoimmune uveitis by Chao Wu, Hui Feng, Meng Tian, Baorui Chu, Xianyang Liu, Shuhao Zeng, Yakun Wang, Hong Wang, Shengping Hou, Qingfeng Liang

“…Least absolute shrinkage and selection operator regression was employed to screen for candidate biomarkers, and their diagnostic performance was evaluated using receiver operating characteristic (ROC) curves and quantitative polymerase chain reaction (qPCR). Finally, molecular docking was applied to verify binding activities.ResultsWe identified 138 up-regulated and 85 down-regulated DEGs that were common to insomnia and AU. …”
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GWAS identifies a polyembryony locus in mango: development of KASP and PACE markers for marker-assisted breeding by Gul Shad Ali, Shamseldeen Eltaher, Shamseldeen Eltaher, Jin Li, Barbie Freeman, Sukhwinder Singh

“…In Mangifera indica L. commercially important rootstocks are raised from apomictic seeds, which are then grafted with desired cultivars. Identifying molecular markers for polyembryony and understanding its genetics would facilitate introducing this trait in commercially important cultivars. …”
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Integrated analysis of cell cycle and p53 signaling pathways related genes in breast, colorectal, lung, and pancreatic cancers: implications for prognosis and drug sensitivity for... by Jiyauddin Khan, Priyanjana Ghosh, Urmi Bajpai, Kountay Dwivedi, Daman Saluja

“…In this study, we analyzed gene expression datasets to identify common molecular signatures across breast, colorectal, lung and pancreatic cancers. …”
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Salivary metabolomics in oral cancer: A systematic review by Rita Antonelli, Giacomo Setti, Nathaniel S. Treister, Thelma A. Pertinhez, Elena Ferrari, Mariana Gallo, Ronell Bologna-Molina, Paolo Vescovi, Marco Meleti

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Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway by Guixing Jiang, Bicheng Wu, Kaikai Wang, Xiaofan Pu, Senhao Zhou, Xin Zhong, Xiaolong Liu, Suihan Wang, Tianyu Lin

“…Abstract Objectives SOX10 is crucially implicated in various cancer, yet the regulatory role in pancreatic cancer (PC) remains enigmatic. Underlying molecular mechanisms of SOX10 in PC were explored in our study. …”
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Biological insights into alleviating heavy metal toxicity through the simultaneous supply of biochar biofilters derived from the Mikania micrantha and molybdenum nanoparticles by Muhammad Shoaib Rana, Hongyu Chen, Shiwen Deng, Muhammad Imran, Yousif Abdelrahman Yousif Abdellah, Wanting Li, Jiayu Lin, Jiaxi Li, Ruilong Wang

“…This study introduces an innovative approach combining molybdenum nanoparticles (Mo NPs, 1 µM) and biochar biofilters derived from the invasive plant Mikania micrantha (IPMM), targeting the biochemical and molecular responses of wheat under Cd stress (100 µM). …”
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POVEIKIS IR ATSAKAS BIOLOGINIUOSE VYKSMUOSE by Jonas Rubikas

“…In biological processes the affect-response dependence can be regarded as taking place at two levels: the first is that of molecular interaction, atomic and linkage exchange, the second is that of cell and individual and organism. …”
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Prevalence of Hyper virulence and Multidrug resistance Klebsiella pneumoniae isolates from UTI patients by Manar Abdul karim, Zainab Mohammed Alzubaidy, Khazal Dabua Wadi

“…Out of the total isolates of K. pneumoniae, 18 (60%) were identified as ESBL producers, while the remaining 12 (40%) were found to be non-producers.  Molecular detection was carried out to detect some virulence genes in K. pneumoniae. …”
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Exploration of metastasis-related signatures in osteosarcoma based on tumor microenvironment by integrated bioinformatic analysis by Shiyao Liao, Xing Gao, Kai Zhou, Yao Kang, Lichen Ji, Xugang Zhong, Jun Lv

“…Background: The present study aims to explore the metastasis-related signatures in connection with tumor microenvironment (TME), revealing new molecular targets promising in improving osteosarcoma (OS) patients’ outcomes. …”
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Underlying Mechanisms of Chromatographic H/D, H/F, <i>cis/trans</i> and Isomerism Effects in GC-MS by Dimitrios Tsikas

“…The examination suggests that the H/D-isotope effects and the <i>cis/trans</i>-effects observed in GC-MS are based on differences in the inter-molecular interaction strengths of the analyte derivatives with the stationary phase of GC columns. …”
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Facile Synthesis of Novel Conducting Copolymers Based on N-Furfuryl Pyrrole and 3,4-Ethylenedioxythiophene with Enhanced Optoelectrochemical Performances Towards Electrochromic App... by Huixian Li, Xiaomeng Sun, Datai Liu, Xinchang Liu, Xianchao Du, Shuai Li, Xiaojing Xing, Xinfeng Cheng, Dongqin Bi, Dongfang Qiu

“…In this article, a series of novel conducting copolymers P(FuPy-<i>co</i>-EDOT) are prepared via cyclic voltammetry electropolymerization method by using N-furfuryl pyrrole (FuPy) and 3,4-ethylenedioxythiophene (EDOT) as comonomers. The molecular structure, surface morphology, electrochemical, and optical properties of the resulting copolymers are characterized in detail upon varying the feed ratios of FuPy/EDOT in the range of 1/1 to 1/9. …”
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Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease by Ana R. Pérez, Ana R. Pérez, Oscar A. Bottasso, Oscar A. Bottasso, Oscar A. Bottasso, Natalia E. Santucci, Natalia E. Santucci

“…These diseases remain significant global health concerns, particularly in developing countries, highlighting the importance of understanding the molecular mechanisms underlying host-pathogen interactions mediated by NRs.…”
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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Understanding the mechanisms of tumorigenesis and the underlying molecular pathways in TNBC could aid in identifying new therapeutic targets. …”
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Perspectives of proteomic analysis in ophthalmology by A.A. Krylova, A.V. Zakharchuk, O.I. Krivosheina, S.I. Pekov, I.A. Popov

“…., oxidative stress with autophagy (and, as a result, tissue dystrophy), initiation of inflammation, and impairment of metabolic processes at the molecular level with activation of pathological proteolysis (that ultimately lead to cellular and tissue changes with the development of the above-mentioned diseases) are of particular importance. …”
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Comprehensive profiling of gut bacterial communities in hybrid red tilapia with and without streptococcosis by Pathamawan Amthungphong, Natthaphong Sombuttra, Triwit Rattanarojpong, Kanthida Kusonmano, Saengchan Senapin, Satid Chatchaiphan, Watanalai Panbangred, Jirayut Euanorasetr

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