Synergistic effects of Vachellia nilotica-derived zinc oxide nanoparticles and melatonin on drought tolerance in Fragaria × ananassa by Tauseef Anwar, Alia Safdar, Huma Qureshi, Ejaz Hussain Siddiqi, Naimat Ullah, Muhammad Tahir Naseem, Walid Soufan

“…These findings highlight the combined application of ZnO NPs and MT as a promising strategy to enhance growth and stress tolerance in strawberry plants, warranting further research on optimized concentrations, delivery methods, and molecular mechanisms.…”
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Visfatin Induces Inflammation and Insulin Resistance via the NF-κB and STAT3 Signaling Pathways in Hepatocytes by Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim

“…Here, we evaluated the effects of visfatin on hepatic inflammation and insulin resistance in HepG2 cells and examined the molecular mechanisms involved. Methods. After treatment with visfatin, the inflammatory cytokines IL-6, TNF-α, and IL-1β were assessed by real-time polymerase chain reaction (RT-PCR) and immunocytochemical staining in HepG2 cells. …”
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Preparation of pH-Responsive Tanshinone IIA-Loaded Calcium Alginate Nanoparticles and Their Anticancer Mechanisms by Tianying Ren, Jing Wang, Yingxin Ma, Yichen Huang, Somy Yoon, Lijun Mu, Ru Li, Xuekun Wang, Lina Zhang, Pan Li, Lusha Ji

“…Further investigation into the molecular mechanisms revealed that the anticancer effects of Tan IIA/CA were mediated through apoptosis, ferroptosis, and autophagy pathways. …”
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Prevalence of Hepatitis C Virus Infection in a Surgical Population of Southeast China: A Large-Scale Multicenter Study by Ping Chen, Yang Zheng, Yubo Cai, Pengfei Zou, Nan Li, Conggao Peng, Hainv Gao, Jimin Liu, Yongping Chen, Zhaowei Tong, Lanjuan Li

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Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review by Amy Sturt, Tanvier Omar, Isaiah Hansingo, Paul Kamfwa, Amaya Bustinduy, Helen Kelly

“…Of 4 studies evaluating the association of FGS and cervical pre-cancer, one reported an increased risk of VIA abnormalities in women with molecular-FGS compared to those without (aOR 6.08, 95% CI 1.58 – 23.37). …”
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Transcriptional profiles analysis of effects of Toxoplasma gondii rhoptry protein 16 on THP-1 macrophages by Ningai Yang, Ningai Yang, Ningai Yang, Mingyang Li, Hong Yang, Jiaming Li, Tiantian Dang, Guangqi Li, Zhijun Zhao, Zhijun Zhao, Zhijun Zhao

“…Immuno-featured differential analysis showed that type 17 T helper cells were more strongly correlated with GPR158 and STRA13, while CD8 T-cell was most strongly correlated with STOML1.DiscussionTherefore, we conclude that the ROP16 protein plays a pivotal role in THP-1 macrophage infection and these five differentially expressed genes may serve as promising molecular targets for the prevention or control of toxoplasmosis. …”
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MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma by Camille Niveau, Mélanie Cettour-Cave, Stéphane Mouret, Eleonora Sosa Cuevas, Mylene Pezet, Benoît Roubinet, Hugo Gil, Florence De Fraipont, Ludovic Landemarre, Julie Charles, Philippe Saas, Caroline Aspord

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Disease resistance traits of IPB-D2 chickens: Characterization of IgY concentrations, Newcastle disease antibody titers, and leukocyte profiles by Dwi Lestari, Sri Murtini, Niken Ulupi, Asep Gunawan, Isyana Khaerunnisa, Anneke Anggraeni, Cece Sumantri

“…Future research should focus on molecular selection through transcriptomic analysis to identify candidate genes associated with disease resistance traits, enabling further genetic improvements.…”
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In vitro and in vivo studies on bioactive hydroxyapatite-coated magnesium for glaucoma drainage implant by Huanhuan Gao, Yi Chen, Xia Chen, Liandi Huang, Hao Yao, Xiaomin Zhu, Min Tang, Yong Wang, Xiangji Li, Lin Xie

“…In this study, we further demonstrated the anti-fibrosis effect of Mg@HA from the molecular signal level and the efficacy of implantation in the rabbit filtration surgery model. …”
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Stem Cell Therapy for Diseases of Livestock Animals: An In-Depth Review by Raghavendra B. Narasimha, Singireddy Shreya, Vijay Anand Jayabal, Vikas Yadav, Prasana Kumar Rath, Bidyut Prava Mishra, Sudhakar Kancharla, Prachetha Kolli, Gowtham Mandadapu, Sudarshan Kumar, Ashok Kumar Mohanty, Manoj Kumar Jena

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Exploring the Potential of Selenium-Containing Amine (Se-AMA) to Enhance Photosynthesis and Leaf Water Content: New Avenues for Carbonic Anhydrase Modulation in <i>Arabidopsis thal... by Sara Beltrami, Francesca Alderotti, Antonella Capperucci, Damiano Tanini, Cecilia Brunetti, Francesco Ferrini, Ermes Lo Piccolo, Antonella Gori

“…Global changes and growing demands have led to the development of new molecular approaches to improve crop physiological performances. …”
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Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Naso... by K. H. Chan, K. K. W. To, P. T. W. Li, T. L. Wong, R. Zhang, K. K. H. Chik, G. Chan, C. C. Y. Yip, H. L. Chen, I. F. N. Hung, J. F. W. Chan, K. Y. Yuen

“…The results of this study should help clinical laboratory professionals to be aware of the different performances of commercially available molecular multiplex RT-PCR assays that are commonly adopted in many clinical diagnostic laboratories.…”
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An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice by Qing Yin Zheng, Lihong Kui, Fuyi Xu, Tihua Zheng, Bo Li, Melinda McCarty, Zehua Sun, Aizheng Zhang, Luying Liu, Athena Starlard-Davenport, Ruben Stepanyan, Bo Hua Hu, Lu Lu

“…Further studies to define candidate genes in the ahp locus and related molecular mechanisms involved in age-related resilience or resistance to AHL are warranted.…”
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The Clinicopathological Features and Prognostic Significance of HER2-Low in Early Breast Tumors Patients Prognostic Comparison of HER-Low and HER2-Negative Breast Cancer Stratified... by Sanaa Gamrani, Laila Akhouayri, Sara Boukansa, Mehdi Karkouri, Hinde El Fatemi

“…There has been increased interest in HER2-low breast tumors recently, as these tumors may have distinct clinical and molecular characteristics compared to HER2-negative and HER2-positive tumors. …”
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Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression by Acharya Balkrishna, Ritu Paliwal, Surjeet Singh, Rani Singh, Vivek Gohel, Rishabh Dev, Kunal Bhattacharya, Sandeep Sinha, Anurag Varshney

“…Livogrit treatment protect the rats against ANIT-induced increase in blood serum markers (total bile acids, ALT, AST, GGT, ALP, total cholesterol, and total bilirubin) and reduced manifestation of liver necrosis, inflammation, and periportal fibrosis. At molecular level, Livogrit inhibited up-regulation of BAX, TGF-β, α-SMA, and MMP-9 mRNA expressions, associated with the liver damages. …”
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A Novel Sesterterpenoid, Petrosaspongin and γ-Lactone Sesterterpenoids with Leishmanicidal Activity from Okinawan Marine Invertebrates by Takahiro Jomori, Nanami Higa, Shogo Hokama, Trianda Ayuning Tyas, Natsuki Matsuura, Yudai Ueda, Ryo Kimura, Sei Arizono, Nicole Joy de Voogd, Yasuhiro Hayashi, Mina Yasumoto-Hirose, Junichi Tanaka, Kanami Mori-Yasumoto

“…The structure–activity relationship and molecular docking simulation suggest that γ-lactone is a key functional group for leishmanicidal activity. …”
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Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways by Jing Huang, Lei Li, Liyan Xu, Lixin Feng, Yuxin Wang, Attila Gabor SIK, Meng Jin, Rongchun Wang, Kechun Liu, Xiaobin Li

“…Network pharmacology analysis, molecular docking, transcriptomics sequencing and RT-PCR were conducted to investigate the potential mechanism. …”
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Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors by Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer

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Highly Stable Antitumor Silver-Lipid Nanoparticles Optimized for Targeted Therapy by Darwish A, Sándor N, Szenti I, Marosvölgyi T, Juhász K, Rónavári A, Kachal E, Kutus B, Kónya Z, Balogi Z

“…Ammar Darwish,1 Nikolett Sándor,1 Imre Szenti,2 Tamás Marosvölgyi,3 Kata Juhász,1 Andrea Rónavári,2 Edi Kachal,2 Bence Kutus,4 Zoltán Kónya,2 Zsolt Balogi1 1Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, H-7624, Hungary; 2Department of Applied and Environmental Chemistry, University of Szeged, Szeged, H-6720, Hungary; 3Institute of Bioanalysis, Medical School, University of Pécs, Pécs, H-7624, Hungary; 4Department of Molecular and Analytical Chemistry, University of Szeged, Szeged, H-6720, HungaryCorrespondence: Zsolt Balogi, Email zsolt.balogi@aok.pte.huBackground: Silver nanoparticles (AgNPs) have a broad spectrum of biocidal effects, allowing also their antitumor application. …”
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Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

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