Blobby is a synaptic active zone assembly protein required for memory in Drosophila by J. Lützkendorf, T. Matkovic-Rachid, S. Liu, T. Götz, L. Gao, O. Turrel, M. Maglione, M. Grieger, S. Putignano, N. Ramesh, T. Ghelani, A. Neumann, N. Gimber, J. Schmoranzer, A. Stawrakakis, B. Brence, D. Baum, Kai Ludwig, M. Heine, T. Mielke, F. Liu, A. M. Walter, M. C. Wahl, S. J. Sigrist

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Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1 by Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran

“…Domperidone was identified by pharmacophore-based virtual screening as a small molecule that can bind to both the viral envelope (E) and the nonstructural protein 1 (NS1) of DENV. Molecular dynamics (MD) simulations and surface plasmon resonance (SPR) analysis were subsequently performed to determine specific interactions of domperidone with the DENV E and NS1 proteins and their binding affinity. …”
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A variant in GRN of Spanish origin presenting with heterogeneous phenotypes by M. Menéndez-González, A. García-Martínez, I. Fernández-Vega, A. Pitiot, V. Álvarez

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Evaluating Explainable AI Methods in Deep Learning Models for Early Detection of Cerebral Palsy by Kimji N. Pellano, Inga Strumke, Daniel Groos, Lars Adde, Espen F. Alexander Ihlen

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Auditory Phenotype of a Novel Missense Variant in the CEACAM16 Gene in a Large Russian Family With Autosomal Dominant Nonsyndromic Hearing Loss by Tatiana G. Markova, Natalia N. Alekseeva, Oxana P. Ryzhkova, Olga L. Shatokhina, Anna A. Orlova, Viktoriia V. Zabnenkova, Olga S. Groznova, Olesya V. Sagaydak, Svetlana S. Chibisova, Alexander V. Polyakov, George A. Tavartkiladze

“…The objective of this study was to study the audiological and molecular genetic characteristics of a large family with CEACAM16-associated autosomal dominant nonsyndromic hearing loss. …”
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Preparation of coal kaolinite composites and study of adsorption properties by Rui LIU, Yuping FAN, Ruifeng GUO, Xianshu DONG, Xiaomin MA

“…Coal kaolinite (RK) was used as raw material, dimethyl sulfoxide (DMSO), methanol (MeOH) and cetyltrimethylammonium chloride (CTAC) were used as the intercalating agents, and modified kaolinite (CK-CTAC) was obtained by three times intercalation, and CK-CTAC/CTS composite was prepared by grafting chitosan (CTS) through the copolymerization reaction, and the batch experimental method was used to study the Pb(II) XRD, SEM and BET analyses showed that the intercalation rates of CK-D, CK-M and CK-CTAC reached 93.8%, 75.1% and 66.5%, respectively, and the morphology did not change significantly before and after the intercalation of CK-D and CK-M, while the large molecular structure of CTAC and the energy input of ultrasonic instrument changed the interlayer morphology of kaolinite into tubular, with an increase in pore space and a 4-fold increase in surface area compared with that of the CK-CTAC. …”
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Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity by Santacruz Valdés C, Ponce-Rosas ER, Jimenez-Martinez MC

“…Similarly, knowledge of the molecular basis of adenoviral conjunctivitis comes from animal models or cellular lines. …”
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The Effect of Laminin-1-Doped Nanoroughened Implant Surfaces: Gene Expression and Morphological Evaluation by Humberto Osvaldo Schwartz-Filho, Kostas Bougas, Paulo G. Coelho, Ying Xue, Mariko Hayashi, Rafael Silveira Faeda, Rosemary Adriana Chiérici Marcantonio, Daisuke Ono, Fumio Kobayashi, Kamal Mustafa, Ann Wennerberg, Ryo Jimbo

“…This study aimed to observe the morphological and molecular effect of laminin-1 doping to nanostructured implant surfaces in a rabbit model. …”
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Biodegradation of aflatoxin B1 by a novel mined aldo–keto reductase from Meyerozyma guilliermondii AF01 by Wan Zhang, Xiaojiao Chang, Yangying Han, Tiantian Li, Jianpeng Dou, Wen Du, Wenfu Wu, Wei Wang, Zhongjie Zhang, Changpo Sun

“…Biocontrol is an effective technology for managing mycotoxin contamination in food, and the improvement of its application depends largely on revealing the degradation mechanisms at the molecular level. Research in this area is much less than that on the screening of degrading strains. …”
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Innovative Diagnostic Approaches and Treatment Strategies for Endometriosis: Current Trends and Future Direction - Review by Wiktoria Domino, Joanna Śnieżna, Wojciech Florczak, Karol Dzwonnik, Urszula Zelik, Jagienka Włodyka, Gabriela Trestka, Maria Przygoda, Jakub Dziewic, Kamila Stępień, Sabina Adamczyk

“…This paper discusses current diagnostic methods used in endometriosis, such as ultrasonography, magnetic resonance imaging (MRI), and molecular tests. Treatment of endometriosis presents a significant medical challenge due to its chronic nature and the difficulty of managing it. …”
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Platycodin D inhibits tumor proliferation by modulating macrophage polarization through promoting JAK2 ubiquitination by Wei Wu, Jie Zhang, Zijiao Wang, Chuan Cheng, Dongdong Yuan, Li Peng, Le Li

“…Based on this, we hypothesized that PD could have anti-melanoma potential and set out to investigate its molecular mechanisms in relation to TAMs. Treatment with PD led to a significant reduction in melanoma tumor weight, inhibition of the mTOR pathway, and suppression of M2-polarized macrophages. …”
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Neurofilament Light Chain Levels in Serum and Cerebrospinal Fluid Do Not Correlate with Survival Times in Patients with Prion Disease by Mika Shimamura, Kong Weijie, Toshiaki Nonaka, Koki Kosami, Ryusuke Ae, Koji Fujita, Taiki Matsubayashi, Tadashi Tsukamoto, Nobuo Sanjo, Katsuya Satoh

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Conversion to Sirolimus Therapy in Kidney Transplant Recipients with New Onset Diabetes Mellitus after Transplantation by Massimiliano Veroux, Tiziano Tallarita, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Carmela Guerrieri, Antonino D'Assoro, Sebastiano Cimino, Pierfrancesco Veroux

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Analysis of Anthocyanins Extracted from the Acai Fruit (Euterpe oleracea): A Potential Novel Vital Dye for Chromovitrectomy by Cristiane S. Peris, Rafael R. Caiado, Acácio Alves Souza Lima-Filho, Eduardo B. Rodrigues, Michel Eid Farah, Mariana Batista Gonçalves, Bruno de Queiroz Alves, Joao Guilherme Palma Urushima, Raul Ragazzi, Mauricio Maia

“…The pH and osmolarity correction and lyophilization were performed without damaging the anthocyanin molecular structure. Mass spectrometry confirmed the presence of five anthocyanins in the three concentrations of the dye. …”
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Antioxidant Activity of Pomegranate Husk Ellagitannins in Enhancing Oxidative Stability of Canola Oil During Frying by Mariela R. Michel, Maritza Pacheco-Lara, Romeo Rojas, Guillermo Cristian G. Martínez-Ávila, Juan Alberto Ascacio-Valdés, Mayra Aguilar-Zárate, Pedro Aguilar-Zárate

“…Primary lipid oxidation (peroxide values) was measured using the AOCS Cd 8-53 method, and molecular structural changes were analyzed by infrared spectroscopy. …”
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Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristics by You Hu, Jun Xu, Jian Lv, Yan Qin, Yongda Lu, Fan Cen, Hongbao Yang, Kai Chen, Suhua Xia

“…This study not only provides insights into the molecular underpinnings of gastric cancer but also offers potential biomarkers for patient stratification and targets for therapeutic intervention.…”
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Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi <i>Penicillium</i> spp.: Chemical Diversity and Biological Activity by Guojun Zhou, Jin Cai, Bin Wang, Wenjiao Diao, Yu Zhong, Shaodan Pan, Weijia Xiong, Guolei Huang, Caijuan Zheng

“…This paper reviews the structural diversity and biological activity of secondary metabolites isolated from mangrove ecosystem-derived <i>Penicillium</i> species over the past 5 years (January 2020–October 2024), and 417 natural products (including 170 new compounds, among which 32 new compounds were separated under the guidance of molecular networking and the OSMAC approach) are described. …”
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Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…After validation of the R47H variant, we predicted the molecular basis and effects on protein stability and ligand-binding affinity of the R62H and D87N variants that remain unknown in current literature. …”
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Structural insights into the mechanism of phosphate recognition and transport by XPR1 by Wenhui Zhang, Yanke Chen, Zeyuan Guan, Yong Wang, Meng Tang, Zhangmeng Du, Jie Zhang, Meng Cheng, Jiaqi Zuo, Yan Liu, Qiang Wang, Yanjun Liu, Delin Zhang, Ping Yin, Ling Ma, Zhu Liu

“…Pathogenic mutations in two arginine residues, which line the translocation channel, disrupt Pi transport. Molecular dynamics simulations reveal that Pi ion undergoes a stepwise transition through the sequential recognition sites during the transport process. …”
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Immunodeficiency, Centromeric Instability, and Facial Dysmorphism (ICF) Syndrome: How HSCT alters the impairment of the DNA methylation process by Wojciech Homa, Joanna Wanat, Izabela Dzikowska, Agata Siejka, Daria Stefaniak, Aleksandra Warunek, Gabriela Gronowicz, Michał Chról, Weronika Zielińska

“…Our understanding of immunological alterations in ICF evolved from isolated defects of immunoglobulin production to a comprehensive model, which involves impairment of cellular immunity. Advances in molecular biology and genetics enabled insights into the DNA methylation machinery, which allowed us to gain a more precise understanding of the pathogenesis of ICF and also opened up opportunities for the development of new therapeutic options. …”
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