Population-Level SARS-CoV-2 RT–PCR Cycle Threshold Values and Their Relationships with COVID-19 Transmission and Outcome Metrics: A Time Series Analysis Across Pandemic Years by Judith Carolina De Arcos-Jiménez, Ernestina Quintero-Salgado, Pedro Martínez-Ayala, Gustavo Rosales-Chávez, Roberto Miguel Damian-Negrete, Oscar Francisco Fernández-Diaz, Mariana del Rocio Ruiz-Briseño, Rosendo López-Romo, Patricia Noemi Vargas-Becerra, Ruth Rodríguez-Montaño, Ana María López-Yáñez, Jaime Briseno-Ramirez

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A heteropolysaccharide from Rhodiola rosea L.: preparation, purification and anti-tumor activities in H22-bearing mice by Yaru Wu, Qing Wang, Huiping Liu, Lulu Niu, Mengyu Li, Qi Jia

“…The chemical compositions and high performance gel permeation chromatography (HPGPC) results indicated that RLP was an acid heteropolysaccharide with the molecular weight of about 1.15×106 Da. Furthermore, ion chromatography (IC), Fourier transform infrared (FT-IR) and nuclear magnetic resoance (NMR) further indicated that RLP was main composed of →2,4)-α-Rha(1→, →5)-α-L-Araf-(1→, α-D-Glu, →6)-β-D-Galp-(1→, β-D-Man and →4)-α-GalpA-(1→. …”
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A meta-analysis of MHC diversity in Pan troglodytes verus by Christelle Vangenot, Alicia Sanchez‑Mazas

“…In the present study, we analyze the MHC molecular diversity in Chimpanzees at six different loci based on all data currently available on the IPD-MHC database and we discuss the results in relation to human HLA variation. …”
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Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines by Merve Kasan, Florian H. Geyer, Jana Siebenlist, Martin Sill, Rupert Öllinger, Tobias Faehling, Enrique de Álava, Didier Surdez, Uta Dirksen, Ina Oehme, Katia Scotlandi, Olivier Delattre, Martina Müller-Nurasyid, Roland Rad, Konstantin Strauch, Thomas G. P. Grünewald, Florencia Cidre-Aranaz

“…Here, we hypothesize that oligomutated pediatric sarcoma cell lines mainly driven by a fusion transcription factor, such as Ewing sarcoma (EwS), are genetically and phenotypically more stable than the previously investigated adult carcinoma cell lines. A comprehensive molecular and phenotypic characterization of multiple EwS cell line strains, together with a simultaneous analysis during 12 months of continuous cell culture show that fusion-driven pediatric sarcoma cell line strains are genomically more stable than adult carcinoma strains, display remarkably stable and homogenous transcriptomes, and exhibit uniform and stable drug response. …”
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Reproductive problems in water buffalo cows associated with non-diagnosed genital lepto- spirosis. Preliminary results by Rosaura Pérez-Gil

“…These findings suggest the need to develop new approaches for diagnosing this pathology using molecular techniques and bacterial cultures, as well as the evaluation of new prophylactic and therapeutic alternatives to avoid the colonization of the reproductive tract. …”
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Effects of melatonin supplementation on oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: a double-blind, randomized controlled trial by Sara Sadeghi, Amirahmad Nassiri, Monir Sadat Hakemi, Fatemeh Hosseini, Fatemeh Pourrezagholie, Fatemeh Naeini, Aylar Nadiri Niri, Hossein Imani, Hamed Mohammadi

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Detection of Antimicrobial Resistance Genes Associated with Carbapenem Resistance from the Whole-Genome Sequence of Acinetobacter baumannii Isolates from Malaysia by Mohan Rao, Fairuz A. Rashid, Surianti Shukor, Rohaidah Hashim, Norazah Ahmad

“…These findings predict that carriage of carbapenem-resistant genes possibly constitutes the underlying basis of high level of international clone II prevalence. Therefore, molecular surveillance and antimicrobial stewardship are essential in implementing policies to prevent and control the spread of CrAb in hospital settings.…”
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PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis by Zhenxiong Zhao, Hui Sun, Yingxue Liu, Yanqiu Zhang, Xin Wang, Xu Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Wenchao Gu, Jinjia Chang, Weiqi Sheng, Mi‐die Xu

“…Together, this study elucidates the mechanism by which PDPN(+) CAFs promote angiogenesis, providing a deeper understanding of the molecular processes underlying CAF‐mediated angiogenesis and suggesting potential therapeutic targets for gastric cancer treatment.…”
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High speciation in the cryptic Pristimantis celator clade (Anura: Strabomantidae) of the Mira river basin, Ecuador-Colombia by Mario H. Yánez-Muñoz, Juan P. Reyes-Puig, Carolina Reyes-Puig, Gabriela Lagla-Chimba, Christian Paucar-Veintimilla, Miguel A. Urgiles-Merchán, Julio C. Carrión-Olmedo

“…Through detailed analyses of type material and expanded molecular sampling, we found that the original description actually included specimens representing two additional species, which are described herein. …”
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Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin by Xingyuan Ma, Xingyuan Ma, Chao Sun, Xiao Ding, Yuhang Zhang, Yuhang Zhang, Tingzhen Deng, Tingzhen Deng, Yatao Wang, Yatao Wang, Haijun Yang, Haijun Yang, Ruiwen Ding, Ruiwen Ding, Haotian Li, Haotian Li, Dawen Wang, Dawen Wang, Maohua Zheng, Maohua Zheng

“…This review provides a comprehensive analysis of metformin’s molecular mechanisms in glioma treatment and highlights its potential as a novel therapeutic strategy, especially for treatment-resistant gliomas.…”
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Conjugates of Phthalocyanines With Oligonucleotides as Reagents for Sensitized or Catalytic DNA Modification

“…Metallophthalocyanines were able to induce the DNA modification: phthalocyanines of Zn(II) and Al(III) were active as photosensitizers in the generation of singlet oxygen <mml:math alttext="$^{1}$chem{O_{2}}"> <mml:mrow> <mml:msup> <mml:mi/> <mml:mn>1</mml:mn> </mml:msup> <mml:msub> <mml:mtext>O</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:mrow> </mml:math>, while phthalocyanine of Co(II) promoted DNA oxidation by molecular oxygen through the catalysis of formation of reactive oxygen species (<mml:math alttext="$^{cdot}$chem{{O_{2}}^{-}}"> <mml:msup> <mml:mi/> <mml:mo>&#x22C5;</mml:mo> </mml:msup> <mml:msubsup> <mml:mtext>O</mml:mtext> <mml:mn>2</mml:mn> <mml:mo>&#x2212;</mml:mo> </mml:msubsup> </mml:math>, <mml:math alttext="chem{H_{2}O_{2}}"> <mml:msub> <mml:mtext>O</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:math>, OH). …”
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Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors by null Chunyan-Zou, null Yanpeng-He, null Changshun-Xie, null Fulai-Gao, null Xiaoli-Xie, null Xiukun-Chai, null Chenxi-He, null Dongqiang-Zhao

“…Moreover, we discovered a new molecular landmarker for the prediction, diagnosis, and therapy of patients.…”
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Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function by Longwei Sun, Junpeng Huang, Xiangyang Dou, Zhenyu Dong, Yuan Li, Shujing Tan, Ran Yu, Chengmin Li, Weiguo Zhao

“…This study aimed to investigate the antioxidant effects and underlying molecular mechanisms of RES in NEFA-challenged BMECs. …”
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Microbes Saving Lives and Reducing Suffering by Kenneth Timmis, Zeynep Ceren Karahan, Juan Luis Ramos, Omry Koren, Ana Elena Pérez‐Cobas, Karen Steward, Victor deLorenzo, Elisabetta Caselli, Margaret Douglas, Clarissa Schwab, Virginia Rivero, Rafael Giraldo, Junkal Garmendia, Raymond J. Turner, Jessamyn Perlmutter, José M. Borrero de Acuña, Pablo Ivan Nikel, Jerome Bonnet, Angela Sessitsch, James K. Timmis, Carla Pruzzo, M. Auxiliadora Prieto, Siavash Isazadeh, Wei E. Huang, Gerard Clarke, Danilo Ercolini, Max Häggblom

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Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology by Robin Christ, Devon Siemes, Shuo Zhao, Lars Widera, Philippa Spangenberg, Julia Lill, Stephanie Thiebes, Jenny Bottek, Lars Borgards, Andreia G. Pinho, Nuno A. Silva, Susana Monteiro, Selina K. Jorch, Matthias Gunzer, Bente Siebels, Hannah Voss, Hartmut Schlüter, Olga Shevchuk, Jianxu Chen, Daniel R. Engel

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TREM-1 and TREM-2 Expression on CD14+ Cells in Bronchoalveolar Lavage Fluid in Pulmonary Sarcoidosis and Hypersensitivity Pneumonitis in the Context of T Cell Immune Response by M. Suchankova, J. Urban, M. Ganovska, E. Tibenska, K. Szaboova, E. Tedlova, F. Sandor, I. Majer, M. Bobovcak, I. Jonner, B. Konig, M. Bucova

“…The aim of the study was to analyse TREM-1 and TREM-2 expression to identify further molecular mechanisms participating in the immunopathogenesis of sarcoidosis and HP. …”
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A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors by Umberto Cillo, Caterina Lonati, Alessandra Bertacco, Lucrezia Magnini, Michele Battistin, Liver NMP Consortium, Lara Borsetto, Francesco Dazzi, David Al-Adra, Enrico Gringeri, Maria Laura Bacci, Andrea Schlegel, Daniele Dondossola

“…Abstract To fully harness mesenchymal-stromal-cells (MSCs)’ benefits during Normothermic Machine Perfusion (NMP), we developed an advanced NMP platform coupled with a MSC-bioreactor and investigated its bio-molecular effects and clinical feasibility using rat and porcine models. …”
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Unveiling the UNESCO Biosphere Reserve of the Berlengas Archipelago in Portugal as a Hotspot of Fish Species Using eDNA Metabarcoding and the Collaboration of Fishing Crews by Marco Simões, Cátia Costa, Maria da Luz Calado, Nuno Vasco-Rodrigues, Maria Jorge Campos, Sérgio Miguel Leandro, Agostinho Antunes

“…To overcome difficulties of classical methods used for fish stock management, molecular tools have shown potential to address this issue assessing both targeted and non-targeted species. …”
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Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway by Haijuan Liu, Guohua Wang, Conglu Sui, Yanan Guo, Xiangyu He

“…The aim of this study was to investigate the molecular mechanism of WXZZ on dehydroepiandrosterone sulfate and high fat diet induced PCOS with IR mice. …”
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Comparative genomics reveals low levels of inter- and intraspecies diversity in the causal agents of dwarf and common bunt of wheat and hint at conspecificity of Tilletia caries an... by Somayyeh Sedaghatjoo, Bagdevi Mishra, Monika K. Forster, Yvonne Becker, Jens Keilwagen, Berta Killermann, Marco Thines, Petr Karlovsky, Wolfgang Maier

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