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Classifications of triple-negative breast cancer: insights and current therapeutic approaches
Published 2025-02-01“…Therefore, precisely classifying and characterizing the distinct features of TNBC subtypes is crucial for identifying the most suitable molecular-based therapies for individual patients. …”
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Advances in the detection of virulence genes of Staphylococcus aureus originate from food
Published 2020-03-01“…Immunological technology has high specificity, but false positive results are easy to occur in its detection. In recent years, molecular biology methods have developed rapidly, and various PCR techniques have been applied to detect foodborne pathogens. …”
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Survival and prognostic factors for primary lung extranodal NK/T-cell lymphoma: a retrospective study of data from China and the SEER database
Published 2025-01-01“…Future research should focus on understanding the molecular and immunological drivers of this disease, with an emphasis on discovering novel therapeutic approaches. …”
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New Approach Methodologies (NAMs) to assess killer whale (Orcinus orca) estrogen receptor alpha (ERα) transactivation potencies by DDTs and their risks
Published 2025-02-01“…We also employed in silico approaches such as molecular docking and protein-ligand network analysis (PLNA) to elucidate the interaction of kwERα protein and DDTs. …”
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Global prevalence of platelet-type von Willebrand disease
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Long non-coding RNA NEAT1 promotes ovarian granulosa cell proliferation and cell cycle progression via the miR-29a-3p/IGF1 axis
Published 2025-01-01“…Results NEAT1 promoted granulosa cell proliferation and cell cycle progression by indirectly upregulated IGF1 expression through acting as a molecular sponge for miR-29a-3p. Cell proliferation and G2/M phase proportions were increased by overexpression of NEAT1, whereas cell proliferation and G2/M phase proportions decreased with NEAT1 silencing. …”
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Assessment of Antibiotic Resistance and Efflux Pump Gene Expression in Neisseria Gonorrhoeae Isolates from South Africa by Quantitative Real-Time PCR and Regression Analysis
Published 2022-01-01“…Treatment of gonorrhoea infection is limited by the increasing prevalence of multidrug-resistant strains. Cost-effective molecular diagnostic tests can guide effective antimicrobial stewardship. …”
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Investigating lung cancer microenvironment from cell segmentation of pathological image and its application in prognostic stratification
Published 2025-01-01“…Although biomarker discovery based on molecular pathology offers a new perspective for prognostic assessment, its dependence on expensive gene panel testing limits its widespread clinical application. …”
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A Single Lung Transplant in a Patient with Fabry Disease: Causality or Far-Fetched? A Case Report
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The burden of group A Streptococcus (GAS) infections: The challenge continues in the twenty-first century
Published 2025-01-01“…Despite substantial research on GAS infections, it is still unclear what molecular pathways are responsible for their emergence and how to best manage them. …”
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Obesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones
Published 2025-01-01“…Conclusions Obesity induces sex-specific molecular remodelling in mPVAT, with male mice exhibiting unique upregulation of ECM pathways and increased collagen deposition compared to females. …”
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Genetic diversity of the Central European wild boar (Sus scrofa scrofa) population and domestic pig (Sus scrofa domesticus) breeds based on a microsatellite DNA locus
Published 2022-01-01“…The assessment of the effective size, carried out using the method based on the linkage disequilibrium and the molecular coancestry method, showed that in all studied groups, including the wild boar population, the effective size was less than 100 individuals. …”
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Development and Application of <i>Lactobacillus plantarum</i> PSCPL13 Probiotics in Olive Flounder (<i>Paralichthys olivaceus</i>) Farming
Published 2025-01-01“…This strain exhibited high acid and bile salt tolerance, which is crucial for intestinal survival. Molecular characterisation confirmed PSCPL13 to be <i>L. plantarum</i>. …”
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Maternal nutrition and offspring lung health: sex-specific pathway modulation in fibrosis, metabolism, and immunity
Published 2025-01-01“…Male offsprings showed increased susceptibility to fibrosis, as confirmed by histological and molecular analyses, including elevated expression of α-SMA, collagen I, Fn1, and TGF-β. …”
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A novel CUL4B gene variant activating Wnt4/β-catenin signal pathway to karyotype 46, XY female with disorders of sex development
Published 2025-01-01“…Our findings provide novel insights into the molecular mechanisms of 46, XY female DSD.…”
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