Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis by Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor

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Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review by Michele Lanza, Giuditta Benincasa, Dario Costa, Claudio Napoli

“…Network medicine is a molecular-bioinformatic approach analyzing gene-gene interactions that can perturb the human interactome. …”
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Identification of key genes affecting intramuscular fat deposition in pigs using machine learning models by Yumei Shi, Yumei Shi, Xini Wang, Shaokang Chen, Yanhui Zhao, Yan Wang, Xihui Sheng, Xiaolong Qi, Lei Zhou, Yu Feng, Jianfeng Liu, Chuduan Wang, Kai Xing

“…The results of this study are important for the elucidation of the molecular regulatory mechanism of intramuscular fat deposition and the effective improvement of IMF content in pigs.…”
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No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients by Bartosz Gajewski, Iwona Karlińska, Małgorzata Domowicz, Igor Bednarski, Mariola Świderek-Matysiak, Mariusz Stasiołek

“…No correlations between the analyzed molecular parameters or the results of neuropsychological tests and physical disability were observed. …”
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Interferon-γ production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles by Takeharu Watanabe, Masayuki Hayashi, Masaaki Arai, Sho Matsushita, Hiroshi Handa, Masaaki Kawano

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Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…SCZ was characterized by hyperconnectivity of the auditory network, visual system, and sensorimotor areas, and hypoconnectivity of the frontal gyrus, cerebellum, thalamus, and caudate nucleus, which were significantly linked to age, sex, duration of illness, and the severity of symptoms and functionally enriched in domains involving self, sensory, action, and social. 2922 genes were significantly over-expressed in these regions, which were enriched for important molecular functions, biological processes, and cellular components of the neurons/cells in the brain as well as SCZ and other mental diseases. …”
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Negative heterosis for meiotic recombination rate in spermatocytes of the domestic chicken Gallus gallus by L. P. Malinovskaya, K. V. Tishakova, T. I. Bikchurina, A. Yu. Slobodchikova, N. Yu. Torgunakov, A. A. Torgasheva, Y. A. Tsepilov, N. A. Volkova, P. M. Borodin

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Proteomics and metabolomics analyses of mechanism underlying bovine sperm cryoinjury by Renzheng Zhang, Xiuyuan Wang, Ruili Liu, Yanfang Mei, Xiuping Miao, Jiaxu Ma, Lei Zou, Qiuyue Zhao, Xuejin Bai, Yajuan Dong

“…This study investigated the selective effects of cryoinjury on high-motility sperm (HMS) and low-motility sperm (LMS) in frozen-thawed from the perspectives of reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and ATP levels. The molecular mechanism of decreased sperm motility caused by cryoinjury was explored through a joint analysis of 4D-label free quantitative proteomics and non-targeted metabolomics. …”
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Impact of 17-alpha ethinyl estradiol (EE2) and diethyl phthalate (DEP) exposure on microRNAs expression and their target genes in differentiated SH-SY5Y cells by Agnese Graziosi, Camilla Corrieri, Giulia Sita, Luca Ghelli, Sabrina Angelini, Roberta d’Emmanuele di Villa Bianca, Emma Mitidieri, Raffaella Sorrentino, Patrizia Hrelia, Fabiana Morroni

“…This study emphasizes the urgent need for regulatory measures to mitigate the neurotoxic effects of EDCs and offers valuable insights into their molecular impacts on brain health.…”
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Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections by Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas, Miguel Marcos, Daniel Salete-Granado, Marirene Chacón-Arnaude, María Á. Pérez-Nieto, Ulrike Kemmerling, Juan Luis Concepción, Paul A. M. Michels, Wilfredo Quiñones

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Scientific support of small fruit growing in Russia and prospects for its development by I. M. Kulikov, S. M. Evdokimenko, T. A. Tumaeva, A. V. Kelina, F. F. Sazonov, N. V. Andronova, M. A. Podgaetsky

“…The research programs of the SBC involve an integrated approach that combines the knowledge and capabilities of researchers from different disciplines, the concentration of a complex analytical instrument base in the Centers of collective use, the using of biotechnological and molecular genetic research, along with traditional methods of breeding. …”
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Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity by Yuming Zhang, Jinghua Lv, Xiaoli Sun, Yiwen Zhang, Menghua Shao, Bingbing Shi, Yajie Zhang, Jihai Gu, Chenchen Zhao, Fengsong Liu

“…To elucidate the toxicity of Sb and its mechanism of action, this study aimed to investigate the adverse effects of Sb on a cosmopolitan insect, housefly (Musca domestica), under a whole life cycle (from embryonic to adult stage) exposure through the examination of a suite of parameters, including biological, physiological, behavioral, and molecular endpoints. A range of Sb concentrations, including moderate contamination (0.07 mM), heavy contamination (0.7 mM), and extreme contamination (7 and 70 mM), were conducted in the study. …”
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Assessment of Cellular Responses after Short- and Long-Term Exposure to Silver Nanoparticles in Human Neuroblastoma (SH-SY5Y) and Astrocytoma (D384) Cells by Teresa Coccini, Luigi Manzo, Vittorio Bellotti, Uliana De Simone

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miR-223-3p Inhibits Antigen Endocytosis and Presentation and Promotes the Tolerogenic Potential of Dendritic Cells through Targeting Mannose Receptor Signaling and Rhob by Hao-Cheng Tang, Yin-Yan Lai, Jing Zheng, Hong-Yan Jiang, Geng Xu

“…This study is aimed at investigating the effect of miR-223-3p on the antigen uptake and presentation capacities of DCs and the underlying molecular mechanism. Methods. FITC-OVA antigen uptake and cell surface markers in bone marrow-derived DCs (BMDCs) were analyzed by flow cytometry. …”
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Cytogenetic features of intergeneric amphydiploids and genome-substituted forms of wheat by E. D. Badaeva, R. O. Davoyan, N. A. Tereshchenko, E. V. Lyalina, S. A. S.A. Zoshchuk, N. P. Goncharov

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Functional Involvement of Melatonin and Its Receptors in Reproductive Regulation of the Marine Teleost, Large Yellow Croaker (<i>Larimichthys crocea</i>) by Xudong Liang, Jixiu Wang, Baoyi Huang, Haojie Yuan, Yucheng Ren, Chenqian Wu, Tianming Wang, Jingwen Yang

“…In this study, we employed molecular and organizational biological techniques to examine the expression patterns of melatonin and its five receptor subtypes (<i>LcMTNR1A1</i>, <i>LcMTNR1A2</i>, <i>LcMTNR1B1</i>, <i>LcMTNR1B2</i>, and <i>LcMTNR1C</i>) in various tissues of the large yellow croaker (<i>Larimichthys crocea</i>). …”
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Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis by Simona Ceccarelli, Cristina Nodale, Enrica Vescarelli, Paola Pontecorvi, Valeria Manganelli, Giovanni Casella, Maria Giuseppina Onesti, Maurizio Sorice, Ferdinando Romano, Antonio Angeloni, Cinzia Marchese

“…Our study contributes to clarify the molecular bases of human adipogenesis, demonstrating a role of KGF in the early steps of this process, and points out a role of NRP1 as a previously unknown mediator of KGF action in ASCs.…”
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FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region by Mian Liu, Pei Chen, Bo Wei, Hai-Long Tan, Ya-Xin Zhao, Lei Ai, Ning Li, Ying-Ke Jiang, Jing Lin, Shi-Jin Li, Shi Chang

“…Abstract Papillary thyroid cancer (PTC) is often characterized by indolent behavior, small tumors with slow cell proliferation and a tendency to metastasize to cervical lymph node simultaneously, and the molecular mechanisms underlying that remain poorly understood. …”
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Clinical Value and Potential Mechanism of miRNA-33a-5p in Lung Squamous Cell Carcinoma by Xiang-Ming Wang, Shang-Wei Chen, Gang Chen, Hua-Fu Zhou, Ting-Qing Gan, Jing-Jing Zeng, Zu-Yun Li

“…This study is aimed at thoroughly exploring the expression status, clinical significance, and underlying molecular mechanism of miRNA-33a-5p in lung squamous cell carcinoma (LUSC). …”
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HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway by Min Zhao, Yao-Yao Bian, Li-Li Yang, Yan-Qi Chen, Ya-Jie Wang, Yan-Ting Ma, Yu-Qiong Pei, Wen-Lin Li, Li Zeng

“…HuoXueTongFu Formula (HXTF) plays an important role in the prevention and treatment of intraperitoneal adhesions. However, the molecular-related mechanisms are still not fully known. …”
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