A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation by Zhishuai Ye, Shanfeng Zhang, Yubo Liu, Shujing Wang, Jianing Zhang, Rongchong Huang

Get full text

Comprehensive phenotypic analysis of multiple gene deletions of α-glucan synthase and Crh-transglycosylase gene families in Aspergillus niger highlighting the versatility of the fu... by Katharina J. Ost, Mark Arentshorst, Bruno M. Moerschbacher, Mareike E. Dirks-Hofmeister, Arthur F.J. Ram

Get full text

Emergence of a blaNDM-5-carrying extensively drug-resistant Enterobacter cloacae ST1718 in Saudi Arabia: Insights from comprehensive genome analysis by Ibrahim A. Al-Zahrani, Thamer M. Brek

“…Conclusion: The findings highlight the need for monitoring the spread of multidrug-resistant clones, conducting molecular epidemiological studies, and implementing effective infection control measures to prevent the dissemination of antimicrobial resistance in healthcare settings.…”
Get full text

Efficient amine-assisted CO2 hydrogenation to methanol co-catalyzed by metallic and oxidized sites within ruthenium clusters by Desheng Su, Yinming Wang, Haoyun Sheng, Qihao Yang, Dianhui Pan, Hao Liu, Qiuju Zhang, Sheng Dai, Ziqi Tian, Zhiyi Lu, Liang Chen

Get full text

Experimental opisthorchiasis: a study of blood cells, hematopoiesis and startle reflex in laboratory animals by D. F. Avgustinovich, I. A. Orlovskaya, L. B. Toporkova, G. B. Vishnivetskaya, A. V. Katokhin, M. N. Lvova, E. V. Kashina, N. P. Bondar, N. A. Feofanova, V. A. Mordvinov

Get full text

CRISPR/Cas9-Mediated Editing of a <i>NODULATION SIGNALING PATHWAY 1</i> Homolog Alters the Production of Strigolactones in Sunflower Roots by Maria A. Lebedeva, Maria S. Gancheva, Maksim R. Losev, Sofia V. Sokornova, Oleg S. Yuzikhin, Anna A. Krutikova, Kirill V. Plemyashov, Lyudmila A. Lutova

“…However, the selection of new resistant sunflower varieties was accompanied by the emergence of new virulent races of broomrape, which overcame the effect of resistance genes. Unraveling the molecular mechanisms underlying the resistance to broomrape in sunflowers should facilitate the development of new sunflower varieties with complex resistance to broomrape using genome editing technology. …”
Get full text

Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine by Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Aya Hasan Alshammari, Hideyuki Hatakeyama, Eric di Luccio, Andrea Vecchione, Takaaki Hirotsu, Hideshi Ishii

Get full text

The effect of general versus spinal anesthesia on perioperative innate immune function in patients undergoing total hip arthroplasty by Lotte M. C. Jacobs, Veerle Bijkerk, Lucas T. van Eijk, Leo A. B. Joosten, Christiaan Keijzer, Jetze Visser, Michiel C. Warlé

“…Immune function was assessed by determination of ex vivo cytokine production capacity upon whole blood stimulation with E. coli lipopolysaccharides (LPS) and measurement of plasma cytokines and danger-associated molecular patterns (DAMPs). Results In the general anesthesia group, ex vivo cytokine production capacity of IL-1β was significantly lower shortly after induction (p = 0.02) and both IL-1β and IL-6 were significantly lower at the end of surgery compared to the spinal anesthesia group (p = 0.002 and p = 0.02, respectively). …”
Get full text

Integrated Bioinformatics-Based Identification of Potential Diagnostic Biomarkers Associated with Diabetic Foot Ulcer Development by Long Qian, Zhipeng Xia, Ming Zhang, Qiong Han, Die Hu, Sha Qi, Danmou Xing, Yan Chen, Xin Zhao

“…GO analyses revealed these DEGs to be significantly enriched in biological processes including sarcomere organization, muscle filament sliding, and the regulation of cardiac conduction, molecular functions including structural constituent of muscle, protein binding, and calcium ion binding, and cellular components including Z disc, myosin filament, and M band. …”
Get full text

Construction and Investigation of MicroRNA-mRNA Regulatory Network of Gastric Cancer with Helicobacter pylori Infection by Ping Yang, Junjie Liu, Tianci Yang, Lei Zhang, Peiyou Gong, Boqing Li, Xiuzhi Zhou

“…The study of miRNA-mRNA expression network would provide molecular support for early diagnosis and treatment of H. pylori-related GC.…”
Get full text

An insight into brucellosis in wild boar and domestic pigs in Europe: A systematic review by Zita Martins Ruano, Teresa Letra Mateus, Madalena Vieira-Pinto

“…Brucella suis biovar 1, Brucella suis biovar 3, Brucella melitensis biovar 3 and Brucella microti were also identified from molecular investigations. We highlight the diversity in the occurrence of this infection, with the presence of Brucella species with zoonotic potential, and emphasize the need for surveillance.…”
Get full text

Effect of potato glycoside alkaloids on mitochondria energy metabolism of Fusarium solani, the root rot pathogen of Lycium barbarum by Ruiyun Li, Bin Wang, Wei Chen, Chongqing Zhang, Nan Li, Yupeng Wang, Yuke Yan, Yuyan Sun, Jing He, Jing He

“…We elucidated the antifungal mechanism of PGA from the perspective of mitochondrial proteome molecular biology. Furthermore, we identified and annotated the differentially expressed proteins (DEP) of F. solani under PGA stress. …”
Get full text

Receptor-like Kinase GOM1 Regulates Glume-Opening in Rice by Xinhui Zhao, Mengyi Wei, Qianying Tang, Lei Tang, Jun Fu, Kai Wang, Yanbiao Zhou, Yuanzhu Yang

“…Glume-opening of thermosensitive genic male sterile (TGMS) rice (<i>Oryza sativa</i> L.) lines after anthesis is a serious problem that significantly reduces the yield and quality of hybrid seeds. However, the molecular mechanisms regulating the opening and closing of rice glumes remain largely unclear. …”
Get full text

Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms by E. V. Ignatieva, E. A. Matrosova

“…The present review focuses on the molecular genetic mechanisms by which pathogenic genetic variants affect gene expression. …”
Get full text

Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation. by Constance Ciaudo, Nicolas Servant, Valérie Cognat, Alexis Sarazin, Emmanuelle Kieffer, Stéphane Viville, Vincent Colot, Emmanuel Barillot, Edith Heard, Olivier Voinnet

“…Cellular differentiation entails loss of pluripotency and gain of lineage-specific characteristics. However, the molecular controls that govern the differentiation process remain poorly understood. …”
Get full text

Transcriptomic Analysis of Wheat Under Multi LED Light Conditions by Lei Sun, Ding Li, Chunhong Ma, Bo Jiao, Jiao Wang, Pu Zhao, Fushuang Dong, Shuo Zhou

“…In this study, we conducted a comprehensive transcriptome analysis to investigate the molecular mechanisms underlying wheat plants’ response to varying light conditions. …”
Get full text

Effect of the host-specific toxin SnTOX3 from Stagonospora nodorum on ethylene signaling pathway regulation and redox-state in common wheat by S. V. Veselova, G. F. Burkhanova, T. V. Nuzhnaya, S. D. Rumyantsev, I. V. Maksimov

“…The mechanism of SnTox3 action is likely to be linked to the regulation of redox metabolism and the influence on ethylene synthesis in the wheat plants, although the molecular mechanisms are not fully unveiled. To characterize the SnTox3-Snn3 interaction, we used S. nodorum isolates differing in the expression of the NEs genes SnTox3 (SnB (Tox3+), Sn4VD (Tox3–)) and two soft spring wheat (Triticum aestivum L.) cultivars, contrasting in resistance to the SNB agent and differing in the allelic composition of the susceptibility locus Snn3-B1: Kazakhstanskaya 10 (susceptible) and Omskaya 35 (resistant). …”
Get full text

TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups by L. E. Tabikhanova, L. P. Osipova, T. V. Churkina, E. N. Voronina, M. L. Filipenko

“…A further study of population structure with respect to different metabolic prof ile genes is required to better understand the molecular genetic foundations of the adaptive potential of indigenous Siberian peoples.…”
Get full text

Characterization of physical, structural and antioxidant properties of hemp seed and seed meal protein-gallic acid conjugates by Wannawarang Tanbamrung, Suphat Phongthai, Pornchai rachtanapun, Kongsak Boonyapranai, Prem Thongchai, Liang Zhang, Kanyasiri Rakariyatham

“…Simultaneously, there was a decrease in free thiol groups and tryptophan residues to be as low as 2.05 and 2.14 %, respectively in sHPI-GA1000 and 10.34 and 17.30 %, respectively in smHPI-GA1000 with an increase in molecular masses, indicating covalent bonding between HPIs and GA. …”
Get full text

Genetic analysis of Pinna rudis L 1758 (Mollusca, Bivalvia, Pinnidae) in the Northwest Cabo Verde Islands (Central-East Atlantic) by Evandro P. Lopes, Sarah Santos, Raquel Xavier, Joana L. Santos, M. Pilar Cabezas, Fernando Sequeira, António M. Santos

Get full text