Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

“…Gata4 LSEC−KO/BL mice characterized by vascular changes ensuing perisinusoidal liver fibrosis without steatosis also exhibited increased metastasis. Early molecular alterations in the hepatic vascular niche, rather than fibrosis or steatosis, correlated with metastasis, as shown by LSEC dedifferentiation and upregulation of endothelial adhesion molecules. …”
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Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

“…However, the direct protein targets and exact molecular mechanisms of caffeic acid in epilepsy, remain largely elusive. …”
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Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes, including short stature, scoliosis, and skeletal dysplasia by Christina G. Tise, Katie Ashton, Lachlan de Hayr, Kun-Di Lee, Omkar L. Patkar, Emma Krzesinski, Jennifer A. Bassetti, Erin M. Carter, Cathleen Raggio, Andreas Zankl, Anas M. Khanshour, Kristhen N. Atala, Jonathan J. Rios, Carol A. Wise, Ying Zhu, Futao Zhang, Tony Roscioli, Michael Buckley, Robert J. Harvey, Paul A. Dawson

“…(Tyr582His) were characterized using bioinformatics, molecular modeling, and [35S]-sulfate uptake assays in Madin-Darby canine kidney cells. …”
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Unraveling the degradation mechanism of multiple pyrethroid insecticides by Pseudomonas aeruginosa and its environmental bioremediation potential by Hui Liu, Wen-Juan Chen, Zeling Xu, Shao-Fang Chen, Haoran Song, Yaohua Huang, Kalpana Bhatt, Sandhya Mishra, Mohamed A. Ghorab, Lian-Hui Zhang, Shaohua Chen

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Standard: Human gastric organoids by Fan Hong, Ronghui Tan, Ting Wang, Nanshan Zhong, Hongling Zhao, Rui-hua Xu, Lin Shen, Yingbin Liu, Xuebiao Yao, Dongxi Xiang, Lijian Hui, Jianping Xiong, Dong Gao, Bing Zhao, Zhifeng Miao, Jie Hao, Yong Li, Shijun Hu, Boqiang Fu, Guoqiang Hua, Lei Wang, Zhao-Lei Zeng, Chong Chen, Jianmin Wu, Changlin Wang, Chunnian Wang, Xianbao Zhan, Chen Song, Chunping Yu, Yingying Yang, Gengming Niu, Yalong Wang, Tongbiao Zhao, Ye-Guang Chen

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LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…Flow cytometry was used to measure cell proportions and activation status. Molecular interactions and TCF1 status were examined using Western blotting. …”
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Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis by Roberto Buonaiuto, Aldo Caltavituro, Margherita Tafuro, Alessandra Longobardi, Giuliana Pavone, Pierluigi De Santis, Roberta Caputo, Carmine De Angelis, Lucia Del Mastro, Fabio Puglisi, Mario Giuliano, Grazia Arpino, Martina Pagliuca, Michelino De Laurentiis

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Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo by Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Irina Amorim, Rui Magalhães, Filipa João, Diogo Almeida, Sandra Amado, Justina Prada, Isabel Pires, Federica Zen, Stefania Raimondo, Ana L. Luís, Stefano Geuna, Artur S. P. Varejão, Ana C. Maurício

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Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere by R. Jin, W. Hu, W. Hu, P. Duan, M. Sheng, D. Liu, Z. Huang, M. Niu, L. Wu, J. Deng, P. Fu, P. Fu

“…Here, we cultured typical bacterial and fungal species isolated from the urban atmosphere using tryptic soy broth (TSB) and Sabouraud dextrose broth (SDB), respectively, and investigated their exometabolites to elucidate their potential roles in biogeochemical cycles. Molecular compositions of exometabolites were analyzed using ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry. …”
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A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023 by Long Zhu, Lijia Ou, Yang Yang, Danwei Zhao, Binjie Liu, Rui Liu, Ousheng Liu, Hui Feng

“…We found that current publications comprise mainly case reports, there is a significant research need to explore the molecular mechanisms, specific diagnostic criteria, and effective management options for PVL. …”
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A pharmacoinformatic approach for studying Atractylodes Lancea DC’s anticancer potential and control ROS-mediated apoptosis against prostate cancer cells by Chi-Hoon Ahn, Ji Soo Myong, Kazi Rejvee Ahmed, Md Ataur Rahman, Md. Maharub Hossain Fahim, Min Choi, Muntajin Rahman, Jinwon Choi, Kiryang Kim, Seungjoon Moon, Seungjoon Moon, Mohammed Dalli, Mohammed Dalli, Rony Abdi Syahputra, Sang-Won Shin, Abdel Halim Harrath, Moon Nyeo Park, Bonglee Kim, Hwa-Seung Yoo

“…Western blotting was performed to elucidate the underlying molecular mechanisms. Additionally, mito-chondrial membrane potential (ΔΨm) and intracellular calcium levels were measured to evaluate mitochondrial function, while reactive oxygen species (ROS) generation was assessed with and without pretreatment with N-acetylcysteine (NAC) .ResultsALD selectively reduced the viability of PC3 and DU145 prostate cancer cells while spar-ing BPH-1 normal prostate cells, demonstrating cancer-selective cytotoxicity. …”
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Effects of intra-class peer mentorship intervention programme on the academic performances of academically underperforming medical students in Nigeria by George Uchenna Eleje, David Chibuike Ikwuka, Kingsley Chinaza Nwosu, Lydia Ijeoma Eleje, Obiageli Ifeoma Ikwuka, Nasiru Sani, Jean Paul Niyoyita, Kazeem Bidemi Okesina, Uchechukwu Dimkpa, Uchechukwu Kevin Nwanna, Victor Bassey Archibong, Eric Twizeyimana, Niranjan Shridhar Divekar, Samuel Ifedioranma Ogenyi, Okwute Michael Ochayi, Marcus Bushaku, Elemi John Ani, Kingsley Chidiebere Nwaogu, Olufunke Onaadepo, Ibrahim Mohammed Sule, Emmanuel Chukwunweike Nwangwu, Chisom Adaobi Nri-Ezedi, Chinyere Ukamaka Onubogu, Arinze Anthony Onwuegbuna, Theophilus Osaje Okonoboh, Onyecherelam Monday Ogelle, Ezinne Ifeyinwa Nwaneli, Joseph Ifeanyichukwu Ikechebelu, Diresibachew Haile Wondimu, Edwin Okechukwu Nwobodo

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Rare and common single nucleotide variants in childhood-onset systemic lupus erythematosus by Elisabet Svenungsson, Iva Gunnarsson, Lars Rönnblom, Ingrid E Lundberg, Andreas Jönsen, Niklas Hagberg, Leonid Padyukov, Marie Wahren-Herlenius, Christopher Sjöwall, Solbritt Rantapää-Dahlqvist, Sule Yavuz, Øyvind Molberg, Dag Leonard, Andrei Alexsson, Maija-Leena Eloranta, Ann-Christine Syvänen, Johanna K Sandling, Gunnel Nordmark, Roland Jonsson, Roald Omdal, Christine Bengtsson, Anders A Bengtsson, Pascal Pucholt, Kerstin Lindblad-Toh, Sergey V Kozyrev, Peter Söderkvist, Johanna Dahlqvist, Jonas Carlsson Almlöf, Daniel Eriksson, Ahmed Sayadi, Åsa Karlsson, Gerli Rosengren Pielberg, Anna Lobell, Eva Murén, Kerstin M Ahlgren, Nils Landegren, Olle Kämpe, Fabiana HG Farias, Argyri Mathioudaki, Jennifer Meadows, Jessika Nordin

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Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers by Sofia V Krasik, Ekaterina A Bryushkova, George V Sharonov, Daria S Myalik, Elizaveta V Shurganova, Dmitry V Komarov, Irina A Shagina, Polina S Shpudeiko, Maria A Turchaninova, Maria T Vakhitova, Igor V Samoylenko, Dimitr T Marinov, Lev V Demidov, Vladimir E Zagaynov, Dmitriy M Chudakov, Ekaterina O Serebrovskaya

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Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements by Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo

“…In addition, according to the molecular diversity and sequence conservation, a common motif GR/PCR/KA/SXIP-XYGGC is proposed in the XIa-inhibitory Kunitz-type peptides, which might provide a new clue for further peptide engineering. …”
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Nicotine’s impact on platelet function: insights into hemostasis mechanisms by Xiayu Wu, Xiayu Wu, Yongjun Liu, Changhao Zou, Changhao Zou, Fuqin He, Fuqin He, Fang Guo, Fang Guo, Sijia Liu, Sijia Liu, Yi Fan, Yi Fan, Xuedong Zhu, Xuedong Zhu, Qianyi Zhou, Qianyi Zhou, Dan Shu, Dan Shu

“…To explore the underlying mechanisms, molecular docking software was employed to identify the platelet membrane receptors PAR1 and PAR4, which exhibited the highest docking scores with nicotine. …”
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Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis by Bruley, Apolline, Gaëtan, Juliette, Gugger, Muriel, Pancrace, Claire, Millet, Maxime, Gaschignard, Geoffroy, Dezi, Manuela, Humbert, Jean-François, Leloup, Julie, Skouri-Panet, Fériel, Callebaut, Isabelle, Benzerara, Karim, Duprat, Elodie

“…While we ignore the biological function of iACC and the molecular mechanisms driving their formation, this process may impact local geochemical cycles and/or be used for bioremediation strategies. …”
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African army ants at the forefront of virome surveillance in a remote tropical forest by Fritz, Matthieu, Reggiardo, Bérénice, Filloux, Denis, Claude, Lisa, Fernandez, Emmanuel, Mahé, Frédéric, Kraberger, Simona, Custer, Joy M., Becquart, Pierre, Mebaley, Telstar Ndong, Kombila, Linda Bohou, Lenguiya, Léadisaelle H., Boundenga, Larson, Mombo, Illich M., Maganga, Gael D., Niama, Fabien R., Koumba, Jean-Sylvain, Ogliastro, Mylène, Yvon, Michel, Martin, Darren P., Blanc, Stéphane, Varsani, Arvind, Leroy, Eric, Roumagnac, Philippe

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Revealing the biological features of the axolotl pancreas as a new research model by Hui Ma, Hui Ma, Hui Ma, Guangcong Peng, Yan Hu, Binbin Lu, Binbin Lu, Yiying Zheng, Yingxian Wu, Weimin Feng, Yu Shi, Xiangyu Pan, Li Song, Ina Stützer, Yanmei Liu, Jifeng Fei, Jifeng Fei, Jifeng Fei

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Ice-nucleating particles active below −24 °C in a Finnish boreal forest and their relationship to bioaerosols by F. Vogel, F. Vogel, M. P. Adams, L. Lacher, P. B. Foster, G. C. E. Porter, G. C. E. Porter, B. Bertozzi, B. Bertozzi, K. Höhler, J. Schneider, T. Schorr, N. S. Umo, J. Nadolny, Z. Brasseur, P. Heikkilä, E. S. Thomson, N. Büttner, M. I. Daily, R. Fösig, A. D. Harrison, J. Keskinen, U. Proske, U. Proske, U. Proske, J. Duplissy, J. Duplissy, M. Kulmala, T. Petäjä, O. Möhler, B. J. Murray

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