Immunotherapy of Cancer: Reprogramming Tumor-Immune Crosstalk by Kyle K. Payne, Amir A. Toor, Xiang-Yang Wang, Masoud H. Manjili

“…Thus, the ability to modulate the tumor cell epigenome to homogenously induce expression of such antigens will likely render the tumor more immunogenic. …”
Get full text

Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance? by Gloria Lopez-Castejon, Mariola J. Edelmann

“…In this review we will give an up-to-date overview on the role of DUBs in the NF-κB pathway and inflammasome activation, two intrinsically related events triggered by activation of the membrane TLRs as well as the cytosolic NOD and NLR receptors. Modulation of DUB activity by small molecules has been proposed as a way to control dysregulation or overactivation of these key players of the inflammatory response. …”
Get full text

Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens by Chloé O. Sebilleau, Steven J. Sucheck

“…In the case of vaccines, they allow for modulation and increase of the immune response. Lipopeptides are molecules of choice because of their ability to activate specific cell surface receptors, penetrate the outer membrane of GNB, safety and ease of synthesis. …”
Get full text

Gastroesophageal reflux disease, resistant to proton pump inhibitors by V. O. Kaybysheva, A. S. Trukhmanov, V. T. Ivashkin

“…Potentials of treatment of the patients with sustained symptoms of GERD on a background of standard dose of proton pump inhibitors (PPI), include correction drug intake, doubling of PPI dose, application of intravenous forms, combination of antisecretory agents of different groups, addition to therapy of drugs, capable to adsorb bile components and modulation of psychoemotional status of patients.Conclusion. …”
Get full text

An Enhanced Inverter Controller for PV Applications Using the dSPACE Platform by M. A. Hannan, Z. Abd Ghani, A. Mohamed

“…In the dSPACE controller, the voltage regulator controls the inverter by employing a proportional integral (PI) controller and the Park transformation method to generate sinusoidal pulse-width modulation (SPWM) signals. The SPWM signals switch the insulated gate bipolar transistor (IGBT) to stabilize the 50-Hz sinusoidal AC output voltages of the inverter. …”
Get full text

Experimental and Theoretical Investigations on the Use of Pumpkin Peel as a Sustainable Biomass Anticorrosion Agent for Aluminum in HCl Solutions by Reem D. Alghamdi, Laila S. Alqarni, Maha D. Alghamdi, N. F. Alotaibi, Hend Gadow

“…Several experimental methods were used to investigate the inhibitor effect of PPE which include, AFM-XPS surface analysis, electrochemical studies (electrochemical impedance spectroscopy-electrochemical frequency modulation-potentiodynamics), and weight loss procedures. …”
Get full text

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions by Tiantian Wang, Dong Zhou, Zhen Hong

“…This review discusses the muscle microenvironment's changes contributing to these conditions, recent therapeutic approaches like lifestyle modifications, small molecules, and nutritional interventions, and emerging strategies such as gene editing, stem cell therapy, and gut microbiome modulation. We also address the challenges and opportunities of multimodal interventions, aiming to provide insights into the pathogenesis and molecular mechanisms of sarcopenia and cachexia, ultimately aiding in innovative strategy development and improved treatments.…”
Get full text

Computational Simulation and Modeling of Freak Waves Based on Longuet-Higgins Model and Its Electromagnetic Scattering Calculation by Gengkun Wu, Chuanxi Liu, Yongquan Liang

“…In order to solve the weak nonlinear problem in the simulation of strong nonlinear freak waves, an improved phase modulation method is proposed based on the Longuet-Higgins model and the comparative experiments of wave spectrum in this paper. …”
Get full text

Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue by Sofia Dias, Sílvia Paredes, Laura Ribeiro

“…Specifically, we explored how these drugs can modulate the complex pathways involved in metabolism, inflammation, atherogenesis, insulin sensitivity, and adipogenesis. …”
Get full text

Detecting Distance between Surfaces of Large Transparent Material Based on Low-Cost TOF Sensor and Deep Convolutional Neural Network by Rong Zou, Yu Zhang, Junlan Gu, Jin Chen

“…In this paper, a method based on low-cost TOF continuous-wave modulation and deep convolutional neural network technology is proposed. …”
Get full text

Role of astrocytes connexins - pannexins in acute brain injury by Juan E. Tichauer, Maximiliano Rovegno

“…In astrocytes, GJs and HCs enable intercellular communication and have active participation in normal brain physiological processes, such as calcium waves, synapsis modulation, regional blood flow regulation, and homeostatic control of the extracellular environment, among others. …”
Get full text

Surface Modification of Biomaterials: A Quest for Blood Compatibility by Achala de Mel, Brian G. Cousins, Alexander M. Seifalian

“…These modifications aim to modulate platelet responses directly through modulation of thrombogenic proteins or by inducing antithrombogenic biomolecules that can be biofunctionalised onto surfaces or through inducing an active endothelium. …”
Get full text

Three-dimensional matter wave soliton transformation between different optical lattices in a cold Rydberg atomic system by Wei Peng, Yu Wang, Yuan Zhao, Zhuo Fan, Siliu Xu

“…Redistribution of MWSs are observed due to the modulation of potentials. In certain complex optical potential wells, we demonstrate the generation of exotic MWSs, such as double gyration modes, through this transformation approach. …”
Get full text

Multi-pulse Fourier codes for bit transmission at the quantum limit by Matteo Rosati

“…Explicit JDR designs proposed so far employ the Hadamard or Fourier transform to perform a phase-to-intensity translation of the information encoding, effectively falling in the class of on-off-keying (OOK) modulation techniques; they improve over classical decoders but fall short of the Holevo capacity, particularly at large signal mean photon number $n\gtrsim1$ . …”
Get full text

Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration by Giuseppina Di Giacomo, Salvatore Rizza, Costanza Montagna, Giuseppe Filomeni

“…In particular, emphasis will be given to the possible, but still neglected implication of denitrosylation reactions in the modulation of mitochondrial SNOs and how they can affect mitochondrion-related cellular process, such as oxidative phosphorylation, mitochondrial dynamics, and mitophagy.…”
Get full text

An Empirical Analysis of the Role of Piano Performance in Alleviating Psychological Trauma in People with Psychological Isolation Disorder by Xia Cao

“…In this paper, we designed a music modulation system based on EEG signals of people with isolation disorder and designed an interface with real-time emotion recognition. …”
Get full text

Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility by Ruizhi Hu, Xizi Yang, Jianhua He, Shusong Wu

“…This review systematically examines the influence of oxidative stress on the reproductive function of male livestock, with a particular focus on the modulation of autophagy. Spermatogenesis, a highly precise biological process, is vulnerable to a range of internal and external factors, among which oxidative stress notably disrupts autophagic processes within the testes. …”
Get full text

Cell-Sonar, an Easy and Low-cost Method to Track a Target Protein by Expression Changes of Specific Protein Markers by Sabrina Brockmöller, Lara Molitor, Franz Worek, Simone Rothmiller

“…Our protocol illustrates a method to track a target protein by detecting expression changes of user-selected marker proteins that directly or indirectly interact with the target. Modulation of protein expression indicates interactions between the target and marker protein. …”
Get full text

Gene Therapy: A step toward advanced orthodontics – A narrative review by Monika Shukla, Shalu Jain, C. Munish Reddy, Pradeep Raghav, Kumar Amit, Rinchin Yangzom, Shivika Garg, Aastha Kamrani

“…Discussion: Gene therapy was found to have a major role in orthodontics, especially for: (i) Modulation in OTM, (ii) Alleviation of orthodontic pain, (iii) Enhancement of bone repair and regeneration, (iv) Improving midface hypoplasia by preventing syndromic craniosynostosis, and (v) Modifying condylar growth.…”
Get full text

A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System by Mario García-Domínguez

“…One explanation for the emergence of disrupted pain modulation in individuals with fibromyalgia is a significant reduction in opioid receptor activity or an imbalance in the levels of endogenous opioid peptides. …”
Get full text