The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis by Ying He, Ying He, Yongqing Liu, Min Zhang

“…These pathways are involved in cellular senescence and inflammation, and their modulation can improve cell function and help prevent disease. …”
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The Multifaceted Roles of MicroRNA-181 in Stem Cell Differentiation and Cancer Stem Cell Plasticity by Chun Yang, Rui Wang, Pierre Hardy

“…These miRNAs, particularly through the modulation of EMT-associated factors, play major roles in controlling the stemness of cancer stem cells. …”
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Gene Expression Profiling in Dermatitis Herpetiformis Skin Lesions by M. Dolcino, E. Cozzani, S. Riva, A. Parodi, E. Tinazzi, C. Lunardi, A. Puccetti

“…Finally, we observed modulation of genes involved in cell growth inhibition (CGREF1, PA2G4, and PPP2R1B), increased apoptosis (FAS, TNFSF10, and BASP1), and reduced adhesion at the dermal epidermal junction (PLEC1, ITGB4, and LAMA5). …”
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Coherent Optics for Passive Optical Networks: Flexible Access, Rapid Burst Detection, and Simplified Structure by Guangying Yang, Yixiao Zhu, Ziheng Zhang, Lina Man, Xiatao Huang, Xingang Huang, Weisheng Hu

“…Compared to intensity modulation/direct detection (IM/DD), a recently proposed coherent PON incorporates a local oscillator laser at the receiver, enabling superior receiver sensitivity, spectrally efficient modulation, linear optical field recovery, and flexible channel selection. …”
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Analysis of the VERNALIZATION-A1 exon-4 polymorphism in polyploid wheat by A. F. Muterko, E. A. Salina

“…In recent studies, an association of missense mutations within VERNALIZATION-A1 exon-4 with modulation of quantitative values of such agronomically valuable traits as frost tolerance, vernalization requirement duration and flowering time of wheat was shown. …”
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Altitude adaptation: The unseen work of gut microbiota by Jingling Guo, Runzhou Zhao, Kun Li, Yafang Tan, Likun Wang, Hui Ling, Huan Zhang, Guha Dharmarajan, Yujing Bi, Ruifu Yang

“…By examining the interaction between microbiota and host adaptation, this review aims to promote further mechanistic studies and support strategies for improving high-altitude acclimatization through gut microbiota modulation.…”
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Transverse Coupled Cavity VCSELs: Bridging Ultrabroadband Dynamics to Optical Supermodes by Martino D'Alessandro, Valerio Torrelli, Francesco Bertazzi, Michele Goano, Nikolay N. Ledentsov, Markus Lindemann, Mariangela Gioannini, Pierluigi Debernardi, Alberto Tibaldi

“…This approach sets a step towards the comprehensive physics-based modeling of transverse-coupled cavity VCSELs, providing a relation between the features of the optical supermodes and the enhancements of the intensity modulation response. The approach emphasizes how the bandwidth enhancement, ascribable to a photon-photon resonance picture, can be triggered by forcing asymmetries in the bias and modulation contacting scheme of the device, and the importance of collecting the fields from each single cavity, providing an interpretation of recent experimental observations and paving the way towards more systematic design strategies.…”
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Nonlinear Optical Signal Processing for Tbit/s Ethernet Applications by L. K. Oxenløwe, M. Galili, H. C. Hansen Mulvad, H. Hu, J. L. Areal, E. Palushani, H. Ji, A. T. Clausen, P. Jeppesen

“…In particular, we describe a successful 1.28 Tbit/s serial data generation based on single polarization 1.28 Tbaud symbol rate pulses with binary data modulation (OOK) and subsequent all-optical demultiplexing. …”
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Least Square Estimation-Based Different Fast Fading Channel Models in MIMO-OFDM Systems by Walaa Hussein, Kamil Audah, N. K. Noordin, Habib Kraiem, Aymen Flah, Mohd Fadlee, Alyani Ismail

“…OFDM is a commonly and widely used modulation method in communication systems utilized to specifically combat resonance fading in wireless channels. …”
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Full-space trifunctional metasurface with independent control of amplitude and phase for circularly polarized waves by Li Xi Ming, Zhao Yuan, Lu Ren Pan, Sun Xiao Feng, Yang Zhao, He Hai Dan, Liu Yan Hui, Du Guo Hong

“…The finding paves the way for attaining multifunctional metadevices with amplitude and phase modulation in full space, which have potential applications in high-quality imaging and high-capacity communication systems.…”
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Exploring the Chemopreventive Potential of <i>Artemisia annua</i> Methanolic Extract in Colorectal Cancer Induced by Azoxymethane in Mice by Faris Alrumaihi

“…<b>Results:</b> MEA significantly improved survival rates, reduced AOM-induced weight loss, and modulated cancer biomarkers, with marked reductions in ADA, GGT, CD73, and LDH levels. …”
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An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation by Jie Wang, Emily Manchester, Alex Skillen, Malebogo Ngoepe, Bernard Keavney, Alistair Revell

“…In particular, the results indicate that while HR modulation can influence flow dynamics, it may not significantly reduce turbulence-induced shear stresses within the coarctation zone. …”
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Role of Microbiota and Innate Immunity in Recurrent Clostridium difficile Infection by Stefano Bibbò, Loris Riccardo Lopetuso, Gianluca Ianiro, Teresa Di Rienzo, Antonio Gasbarrini, Giovanni Cammarota

“…These factors alter the intestinal homeostasis promoting the development of an ecological niche for Clostridium difficile and of the modulation of immune response. Moreover, the intestinal dysbiosis can promote a proinflammatory environment, whereas Clostridium difficile itself modulates the innate immunity through both toxin-dependent and toxin-independent mechanisms. …”
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A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice by Xi Liu, Xi Zhang, Dongxu Wang, Ya Cao, Ling Zhang, Zhonghua Li, Qin Zhang, Yu Shen, Xian Lu, Keyu Fan, Mingxia Liu, Jingqiu Wei, Siping Hu, He Liu

“…More research into the perception and modulation of pain within the central nervous system is essential. …”
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Genetic interaction between oxidative stress and body mass index in a Spanish population by Francisco Lara-Hernández, Rebeca Melero, María Elena Quiroz-Rodríguez, Celeste Moya-Valera, Mariana de Jesús Gallardo-Espinoza, Luis Álvarez, Ingrid Lizeth Valarezo-Torres, Laisa Briongos-Figuero, Jessica Abadía-Otero, Francisco Javier Mena-Martin, Guillermo Saez, Josep Redon, Juan-Carlos Martín-Escudero, Ana-Bárbara García-García, Guillermo Ayala, Felipe Javier Chaves

“…Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. …”
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Preclinical Science Regarding Cannabinoids as Analgesics: An Overview by ME Lynch

“…Since then, potent antinociceptive and antihyperalgesic effects of cannabinoid agonists in animal models of acute and chronic pain; the presence of cannabinoid receptors in pain-processing areas of the brain, spinal cord and periphery; and evidence supporting endogenous modulation of pain systems by cannabinoids has provided support that cannabinoids exhibit significant potential as analgesics. …”
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Parametrically excited nonlinear systems: a comparison of two methods by A. F. El-Bassiouny

“…Two approximate methods (the multiple scales and the generalized synchronization) are used to construct a first-order nonlinear ordinary differential equations governing the modulation of the amplitudes and phases. Steady state solutions and their stability are computed for selected values of the system parameters. …”
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More Efficient and Reliable: Identifying RRab Stars with Blazhko Effect by Deep Convolutional Neural Network by Nan Jiang, Tianrui Sun, Siyuan Pan, Lingzhi Wang, Xue Li, Bin Sheng, Xiaofeng Wang

“…Furthermore, we find that BL modulation could be primarily characterized by variations in light-curve structure.…”
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Self-Assembly Strategy for Synthesis of WO₃@TCN Heterojunction: Efficient for Photocatalytic Degradation and Hydrogen Production via Water Splitting by Li Zhou, Wenjie Zhang, Zezhao Huang, Feng Hu, Peng Li, Xiaoquan Yao

“…Additionally, this study offers valuable insights into strategically employing acid regulation modulation to enhance the performance of carbon nitride-based photocatalysts by altering the topography of WO₃@TCN composite material dramatically.…”
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Influence of Image Acquisition on Radiation Dose and Image Quality: Full versus Narrow Phase Window Acquisition Using 320 MDCT by Faisal Khosa, Atif Khan, Khurram Nasir, Waqas Shuaib, Matthew Budoff, Ron Blankstein, Melvin E. Clouse

“…To compare radiation dose and image quality using predefined narrow phase window versus complete phase window with dose modulation during R-R using 320-row MDCTA. Methods. 114 patients underwent coronary CTA study using 320-row MDCT scanner. 87 patients with mean age (61 + 13 years), mean BMI (29 + 6), and mean heart rate (HR) (58 + 7 bpm) were imaged at predefined 66–80% R-R interval and then reconstructed at 75% while 27 patients with mean age (63 + 16 years), mean BMI (28 + 5), and mean HR (57 + 7 bpm) were scanned throughout the complete R-R interval with tube current modulation. …”
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