Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbiome by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…These metabolites were significantly correlated with those differential bacteria modulated by QAFF. Lastly, the administration of QAFF via FMT ameliorated the colitis symptoms.Conclusion: QAFF could ameliorate inflammatory responses and intestinal barrier dysfunction in DSS-induced UC mice probably by modulating the PI3K/AKT signaling pathway and gut microbiome, offering promising evidence for the therapeutic potential of QAFF in UC treatment. …”
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Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial–mesenchymal transition by Jingying Zhao, Xiuli Wang, Yubin Wu, Chengguang Zhao

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Role of C5aR2 in prognosis of patients with acute respiratory distress syndrome through negative modulation of C5a: A prospective observational study by Muhammed Rashid, Sreedharan Nair, Pooja Gopal Poojari, Vijetha Shenoy Belle, Vijayanarayana Kunhikatta, Daniel A. Vaz, Vishal Shanbhag, Viji Pulikkel Chandran, Shravya Chitrapady, Girish Thunga

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Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice by Jing Xue, Yu Cheng, Haojie Hao, Jieqing Gao, Yaqi Yin, Songyan Yu, Junyan Zou, Jiejie Liu, Qi Zhang, Yiming Mu

“…Mesenchymal stem cells (MSCs) have been identified to alleviate β-cell dysfunction by modulating macrophage phenotype in T2D, but the restoration of β-cells by a single MSC infusion is relatively transient. …”
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hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherin/β-Catenin Signaling Modulation In Vitro by Yi Chen, Dan Tang, Linjie Zhu, Tianjie Yuan, Yingfu Jiao, Hexin Yan, Weifeng Yu

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<i>Sambucus nigra</i>-Lyophilized Fruit Extract Attenuated Acute Redox–Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephrotoxicity by Kamelia Petkova-Parlapanska, Ivaylo Stefanov, Julian Ananiev, Tsvetelin Georgiev, Petya Hadzhibozheva, Veselina Petrova-Tacheva, Nikolay Kaloyanov, Ekaterina Georgieva, Galina Nikolova, Yanka Karamalakova

“…<b>Conclusions:</b> Histological evaluation confirmed that <i>S. nigra</i> (120 mg kg⁻¹) attenuated renal dysfunction and structural damage by modulating oxidative stress and acute inflammation and could be used as an anti-fibrotic alternative in GM nephrotoxicity.…”
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Sorbitol induces flavonoid accumulation as a secondary signal via the nanoencapsulated SPc/lncRNA809-MmNAC17 module against Alternaria alternata in Malus micromalus by Tingting Du, Dong Meng, Hongyan Cao, Yi Lian, Rui Wu, Tengyue Liu, Tianyi Wang, Cai Qin, Zhihua Song, Biying Dong, Yujie Fu, Qing Yang

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Neospora caninum infection specifically suppresses the expression of a host lncRNA XR_001919077.1 to facilitate parasite propagation by modulating host cell mitochondrial function and autophagy by Shan-Shan Zhao, De-Liang Tao, Jin-Ming Chen, Ming-Yi Zhang, Xin Yang, Jun-Ke Song, Qun Liu, Guang-Hui Zhao

“…In the present study, N. caninum, but not Toxoplasma gondii, which has similar morphological and biological features to N. caninum, specifically suppresses the expression of a host lncRNA, XR_ 001919077.1, to impair host’s defense through the competitive endogenous RNA mechanism to modulate the host cell mitochondrial function and autophagy to facilitate parasite propagation. …”
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LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21/NF-κB Axis by Yaoyao Bian, Lili Yang, Bin Zhang, Wen Li, Sen Wang, Shuling Jiang, Xi Chen, Wenlin Li, Li Zeng

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Long non-coding RNA Malat1 modulates CXCR4 expression to regulate the interaction between induced neural stem cells and microglia following closed head injury by Qin Dong, Pengyu Chen, Wenqiao Qiu, Zhijun Yang, Yanteng Li, Yuhui Zhou, Lili Guo, Dan Zou, Ruxiang Xu, Mou Gao

“…Results Our results indicated that Malat1 could act as a sponge of miR-139-5p to modulate the expression of CXCR4 that exerted significant influence on the immunoregulatory effects of iNSCs on the secretion of CXCL12, TNF-α and IGF-1 by activated microglia. …”
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Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function by Jianbo Wu, Jian Gu, Shun Zhou, Hao Lu, Yunjie Lu, Ling Lu, Xuehao Wang

“…In vitro Treg induction was more efficient when CD4+CD25− T cells differentiated in the presence of CD11b+ cells obtained from IL-22Ab-treated GVHD mice, compared with cocultured untreated control cells. Finally, IL-22Ab modulated the expression of cytokines and costimulatory molecules in CD11b+ cells in aGVHD mice. …”
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Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention by Sonia Youhanna, Aurino M. Kemas, Shane C. Wright, Yi Zhong, Britta Klumpp, Kathrin Klein, Aikaterini Motso, Maurice Michel, Nicole Ziegler, Mingmei Shang, Pierre Sabatier, Aimo Kannt, Hongda Sheng, Nuria Oliva‐Vilarnau, Florian A. Büttner, Brinton Seashore‐Ludlow, Jonas Schreiner, Maike Windbergs, Martin Cornillet, Niklas K. Björkström, Andreas J. Hülsmeier, Thorsten Hornemann, Jesper V. Olsen, Yi Wang, Roberto Gramignoli, Michael Sundström, Volker M. Lauschke

“…Combined, this study presents the first patient‐derived 3D MASH model, identifies a novel signaling module with anti‐fibrotic effects, and highlights the potential of organotypic culture systems for phenotype‐based chemogenomic drug target identification at scale.…”
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Impact of tumor position displacement during end-exhalation breath-hold condition on tumor dose in lung stereotactic body radiation therapy using volumetric modulated arc therapy by Tatsuya Kamima, Shunsuke Moriya, Takeji Sakae, Hikaru Miyauchi, Yasushi Ito, Kenji Tokumasu, Yasuo Yoshioka

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Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic cation transporter 3 (OCT3) by Jamie L. Scholl, Joshua T. Rogers, Na Feng, Gina L. Forster, Michael J. Watt, Jazmine D. W. Yaeger, Michael W. Buchanan, Christopher A. Lowry, Kenneth J. Renner

“…These results suggest that ovarian hormones in combination with corticosterone modulate OCT3-mediated 5-HT clearance in the DMH, potentially representing an adaptive mechanism that allows sexually receptive females to respond rapidly to acute stressors.…”
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Mitigation of Diabetes Mellitus Using Euphorbia helioscopia Leaf Ethanolic Extract by Modulating GCK, GLUT4, IGF, and G6P Expressions in Streptozotocin-Induced Diabetic Rats by Ahmed Raza, Muhammad Naveed Mushtaq, Sadia Hassan, Ali Sharif, Bushra Akhtar, Muhammad Furqan Akhtar

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The Global Secondary Metabolite Regulator <i>AcLaeA</i> Modulates <i>Aspergillus carbonarius</i> Virulence, Ochratoxin Biosynthesis, and the Mode of Action of Biopesticides and Essential Oils by Maria K. Iliadi, Maria Varveri, Anastasia E. Kapetanakou, Panagiotis N. Skandamis, Dimitrios I. Tsitsigiannis

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Attention-enhanced optimized deep ensemble network for effective facial emotion recognition by Taimoor Khan, Muhammad Yasir, Chang Choi

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Efficacy of clomiphene citrate and tamoxifen on pregnancy rates in idiopathic male subfertility: A systematic review and meta-analysis by Shadi Khashaba, Shehab Khashaba, Anil Krishan, Angus Bruce, Abdullatif Almaghlouth, Jason Huang, Mahmoud Mima, Craig Niederberger

Subjects: “…Selective estrogen receptor modulator…”
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PARAMETRIC AMPLIFICATION OF THE SIGNALS IN THE ELECTROSTATIC GRAVIINERTIAL SENSOR by I. Z. Gilavdary, S. N. Mekid, N. N. Riznookaya

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Improving the efficiency of sanitation of urological catheters with various types of exposure to ultrasound emitters by A. A. Novikov, A. R. Putintseva

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