Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway by Qiaoli Chen MS, Quanxiang Hao MBBS, Yanping Yang MBBS, Limei Li PhD, Danping Li MS, Ran Zhao MS, Wanqi Wei MBBS, Lixian Deng MBBS, Jiaming Su MBBS, Ziyuan Liang MBBS, Shiyue Tang MS, Yaomin Lu MBBS, Yushan Liang PhD, Zhe Zhang PhD, Xiaoying Zhou PhD, Xue Xiao PhD, Ping Li PhD, Yi Huang PhD, Weilin Zhao PhD

“…Conclusion CES4A expression is silenced in NPC, functioning as a tumor suppressor by negatively modulating the PI3K/AKT signaling pathway.…”
Get full text

Transcriptome Analysis and Phytohormone Profile Reveal Core Phytohormone Regulating Parthenocarpy in Fingered Citron by Qianbin Chen, Jinjian Xu, Xinjian Zou, Yanjun Zhang, Xiaoxian Zhu, Kewei Zhang, Wenrong Chen, Fanglei Liao, Weidong Guo

“…Our findings highlight the central regulatory role of auxin in parthenocarpy in fingered citron, with ABA acting as a critical modulator. The suppression of ABA alone disrupts parthenocarpy despite stable auxin levels, emphasizing the necessity of balanced hormone interactions. …”
Get full text

Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development by Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng

“…Furthermore, rescue assays were carried out to identify that circ_0044516 modulates cell proliferation, invasion, and stemness by regulating miR-136 and MAT2A in lung cancer. …”
Get full text

Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis by Zhihui Jin, Wei Xiang, Xiaowen Shi, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang, Li Xu

“…This study aims to identify and evaluate the effects of key compounds in mulberry twig extracts (MTEs) on oxidized low-density lipoprotein (ox-LDL)-induced human umbilical vein endothelial cells (HUVECs), with a focus on understanding how these compounds modulate oxidative stress and related signaling pathways. …”
Get full text

A comprehensive analysis of the effect of quorum-sensing molecule 3-oxo-C12-homoserine lactone on Candida auris and Candida albicans by Fruzsina Kovács, Ágnes Jakab, Noémi Balla, Zoltán Tóth, Dávid Balázsi, Lajos Forgács, Andrea Harmath, Aliz Bozó, Ágota Ragyák, László Majoros, Renátó Kovács

“…Moreover, HSL reduced intracellular iron and zinc levels (p < 0.05-0.001); furthermore, it modulated C. auris metabolism toward beta-oxidation, which may be associated with the observed reduction in in vivo virulence at lower HSL concentrations compared with C. albicans. …”
Get full text

Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster by Yi Pan, Ke Fan, Linhao Zong, Yantao Luo, Xin Ni, Dong Chen, Jinjun Qian, Fei Ma, Jie Cheng, Miao Guan

“…At the epigenetic level, Cd could perturb fecundity across generations by modulating Dnmt2 expression, a pivotal regulator of methylation processes. …”
Get full text

Melatonin Enhances Maize Germination, Growth, and Salt Tolerance by Regulating Reactive Oxygen Species Accumulation and Antioxidant Systems by Wei-Qing Li, Jia-Yu Li, Shao-Jie Bi, Jia-Yue Jin, Zhong-Ling Fan, Zi-Lin Shang, Yi-Fei Zhang, Yan-Jie Wang

“…Consequently, in this research, we utilized the maize cultivars Zhengdan 958 (ZD958) and Demeiya 1 (DMY1), which are extensively marketed in northeastern China’s high-latitude cold regions, to reveal the modulating effects of melatonin on maize salinity tolerance by determining the impacts of varying concentrations of melatonin on maize seedling growth characteristics, osmoregulation, antioxidant systems, and gene expression. …”
Get full text

CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite by Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fábio Magalhães-Gama, Jacqueline Almeida Gonçalves Sachett, Iran Mendonça Silva, Kerolaine Fonseca Coelho, Eliane Campos Alves, Andréa Monteiro Tarragô, Luiz Carlos de Lima Ferreira, Adriana Malheiro, Wuelton Marcelo Monteiro, Allyson Guimarães Costa

“…These soluble immunological molecules act by modulating the inflammatory response; however, the mechanisms associated with the development of AKI are still poorly understood. …”
Get full text

Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…This review details the circadian disruptions associated with sepsis and septic shock, the influence they have on morbidity and mortality, and the potential clinical benefits of circadian-modulating therapies.…”
Get full text

THE COLLABORATIVE DESIGNING OF A PERSONALIZED HYBRID LMS USING A VIRTUAL MACHINE IN A CLOUD ENVIRONMENT by Lina Čeponienė, Péter Galambos, Tamás Haidegger, Dariusz Mikulowski, Branislav Mišota, Oliver Moravcik, Enikő Nagy, Mariya P. Shyshkina, Pavel Smolka, Stefan Svetsky

“…There are a large number of articles in the scientific literature describing the design of add-on modules for LMS. The authors offer their own approach to solving the problem of processing educational information to support a virtual team's work. …”
Get full text

Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against Paracoccidioides brasiliensis by Juliana Carvalho de Quaglia e Silva, Amanda Manoel Della Coletta, Taiane Priscila Gardizani, Graziela Gorete Romagnoli, Ramon Kaneno, Luciane Alarcão Dias-Melicio

“…The interaction between surface molecules of pathogens and homologous receptors, present on the surface membrane of phagocytes, modulates the innate immune cell activation. Studies have shown the importance of fungal recognition by the Dectin-1 receptor, which can induce a series of cellular protective responses against fungi. …”
Get full text

6‐Nitrodopamine potentiates catecholamine‐induced contractions of human isolated vas deferens by Antonio Tiago Lima, Sami Jabbour, José Britto‐Júnior, Demétrio Martinho Ramos deCarvalho, Adriano Fregonesi, Fernanda V. Mariano, Valéria Barbosa deSouza, Andre Almeida Schenka, Edson Antunes, Gilberto De Nucci

“…The results clearly demonstrate that epithelium‐derived 6‐ND is a major modulator of human vas deferens contractility.…”
Get full text

Effects of Artemisia argyi leaf water extract (AWE) on growth performance, muscle quality, intestinal microbial, and metabolomics of common carp (Cyprinus carpio) by Di Sun, Nanyang Zeng, Yingjia Pan, Qingsong Shu, Jixing Zou, Yingshi Huang, Guoxia Wang, Jun Shi

“…Analysis of intestinal microbiota revealed that Cetobacterium and Aeromonas may play crucial roles as genus-level microorganisms in modulating metabolic processes associated with AWE in carp intestines. …”
Get full text

Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis by Huann-Cheng Horng, Jin-Wei Xu, Yi-Shan Kuo, Yu-Sin Chen, Yu-Hsuan Chiu, Kuan-Hao Tsui, Yu-Tang Tung

“…This study underscores the potential of microbiome-modulating strategies in managing vaginal infections, paving the way for more targeted and side-effect-free VVC treatments.…”
Get full text

3D Point Cloud from Millimeter-wave Radar for Human Action Recognition: Dataset and Method by Biao JIN, Kangsheng SUN, Hao WU, Zixuan LI, Zhenkai ZHANG, Yan CAI, Rongmin LI, Xiangqun ZHANG, Genyuan DU

“…Data collection is conducted using Texas Instruments (TI)’s IWR1443-ISK and Vayyar’s vBlu radio imaging module, covering 12 common human actions, including walking, waving, standing, and falling. …”
Get full text

Optimized Gross Primary Productivity Over the Croplands Within the BEPS Particle Filtering Data Assimilation System (BEPS_PF v1.0) by Xiuli Xing, Mousong Wu, Huajie Zhu, Wenzhuo Duan, Weimin Ju, Xiaorong Wang, Youhua Ran, Yongguang Zhang, Fei Jiang

“…Abstract Agricultural ecosystems play an important role in modulating the global carbon balance by taking up atmospheric carbon dioxide, while large differences and uncertainties exist in the estimated crop gross primary productivity (GPP) by terrestrial ecosystem models (TEMs). …”
Get full text

HIV-Envelope–Dependent Cell-Cell Fusion: Quantitative Studies by Leonor Huerta, Nayali López-Balderas, Evelyn Rivera-Toledo, Guadalupe Sandoval, Guillermo Gómez-Icazbalceta, Carlos Villarreal, Edmundo Lamoyi, Carlos Larralde

“…We have shown that such a flow-cytometry assay is appropriate for the screening of compounds that have the potential to modulate HIV-Env–mediated cell fusion. Even those syncytia that are small or few in numbers can be detected. …”
Get full text

MSF-GhostNet: Computationally Efficient YOLO for Detecting Drones in Low-Light Conditions by Maham Misbah, Misha Urooj Khan, Zeeshan Kaleem, Ali Muqaibel, Muhamad Zeshan Alam, Ran Liu, Chau Yuen

“…To address these challenges, we present an improved YOLOv5 architecture named multiscale feature map GhostNet (MSF-GhostNet) by introducing GhostConv and C3Ghost modules to reduce the redundant operations in the head and neck. …”
Get full text

Milk fat globule membrane supplementation protects against β-lactoglobulin-induced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier... by Han Gong, Tiange Li, Dong Liang, Jingxin Gao, Xiaohan Liu, Xueying Mao

“…Results demonstrated that MFGM alleviated food allergy symptoms, decreased serum levels of lipopolysaccharide, pro-inflammatory cytokines, immunoglobulin (Ig) E, IgG1, and Th2 cytokines including interleukin (IL)-4, while increased serum levels of Th1 cytokines including interferon-γ and regulatory T cells (Tregs) cytokines including IL-10 and transforming growth factor-β. MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice, as evidenced by decreased relative abundance of Desulfobacterota, Rikenellaceae, Lachnospiraceae, and Desulfovibrionaceae, while increased relative abundance of Bacteroidetes, Lactobacillaceae and Muribaculaceae, and enhanced expressions of tight junction proteins including Occludin, Claudin-1 and zonula occludens-1. …”
Get full text

A Lightweight YOLO Model for Rice Panicle Detection in Fields Based on UAV Aerial Images by Zixuan Song, Songtao Ban, Dong Hu, Mengyuan Xu, Tao Yuan, Xiuguo Zheng, Huifeng Sun, Sheng Zhou, Minglu Tian, Linyi Li

“…Additionally, we integrate a Normalization-based Attention Module (NAM) and introduce a Minimum Point Distance-based IoU (MPDIoU) loss function to further improve the detection capability. …”
Get full text