miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding by Juan Wen, Baiyi Tang, Lan Guo, Wei Chen, Xiaohong Tang

“…The present study was to examine whether miR-145 modulates phenotypic transformation of VSMCs under normal state and synthetic state and to explore the possible role of ADAM17-mediated ACE2 shedding and ACE2-Ang-(1–7)-Mas receptor axis. …”
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Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2 by Lan Wu, Sai Ye, Yilin Yao, Chenping Zhang, Wei Liu

“…Mechanistically, we revealed that the lncRNA UCA1, by binding to miR-134, modulated the PI3K/AKT pathway in macrophages via targeting LAMC2. …”
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Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways by Amany Abdlrehim Bekhit, Olivia N. Beshay, Michael A. Fawzy, Sara Mohamed Naguib Abdel-Hafez, Gaber El-Saber Batiha, Farid S. Ataya, Moustafa Fathy

“…In conclusion, the present findings demonstrated that AZIL improves the hepatoprotective potential of AD-MSCs against CISP-induced hepatotoxicity by modulating oxidative stress, mitogen-activated protein kinase, and apoptotic pathways.…”
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STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines by Pan Jiang, Huai Huang, Zilong Liu, Guiling Xiang, Xiaodan Wu, Shengyu Hao, Shanqun Li

“…STAT6 is crucial in the signaling pathway that modulates immune response. However, the status of phosphorylated STAT6 (p-STAT6) in an OSA-induced PH mouse model remains largely unexplored. …”
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Urban versus rural older adults: occupational balance and quality of life comparison by Emel Pekçetin, Serkan Pekçetin, Emine Sağlamoğlu, Gamze Ekici

“…OB of the participants was evaluated with the Occupational Balance Questionnaire 11-T (OBQ 11-T) The QoL of older adults assessed by the World Health Organization Quality of Life – OLD module (WHOQOL-OLD). Results The median OBQ11-T total score was 21.00 (7.00) in the urban area group and 20.00 (5.00) in the rural area group. …”
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Comprehensive analysis of the succinylome in Vero cells infected with peste des petits ruminants virus Nigeria 75/1 vaccine strain by Xuelian Meng, Xueliang Zhu, Xiangwei Wang, Rui Zhang, Zhidong Zhang, Yuefeng Sun

“…Protein-protein interaction networks of the identified proteins provided further evidence that various ATP synthase subunits and carbon metabolism were modulated by succinylation, while the overlapped proteins between succinylation and acetylation are involved in glyoxylate and dicarboxylate metabolism. …”
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The Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats by An Y, Zhang J, Ren Q, Liu J, Liu Z, Cao K

“…It also reduces the levels of inflammatory cytokines, thereby mitigating neurogenic inflammation and improving central sensitization.Conclusion: Acupuncture exerts its therapeutic effect on migraine by regulating neurotransmitter release, inhibiting inflammatory responses, modulating central analgesic mechanisms, and suppressing glial cell activation. …”
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Application of Multi Objective land Allocation technique for land use Planning Approach Case study: Hamadan County by hassan mahmodzadeh, sodabeh panahi, mahdi herischian

“…Monitoring lands means contribution of an optimized space for land utilization with realization of common upcoming and related to each other in the past, now and in the future.Therefore, the objective  of  this research is to select the suitable lands  with monitoring lands of view in the city of Hamedan using a Multi-Objective Land Allocation method.The aim of Multi-Objective Land Allocation  method use is to contribute  selection of proper lands with monitoring approach based on ideal levels concept which have been executed by 3 different ecologic, socio-economic and strategic aspects existing in the territory.The examined use include agricultural use (water system or dry farming), pasturing use and urban use which based on the highest weight of independent variables, the area has been allocated to mentioned use with land monitoring approach.In what follows, the land suitability map is obtained through MCE operation for each type of land use and the obtained land suitability areas were calculated using these maps for which the results are as follows: irrigated agriculture with 601.176 hectares, dryland farming with 961.193 hectares, urban suitability with 762.984, and rangeland management suitability with 960.552 hectares which is an important criterion for determining the area for implementing MOLA.In the next step, it was time for implementing MOLA module for resolving the contradictions among the  uses.The results of MOLA showed that in average for the three studied aspects, the maximum area was associated with dryland farming with 364.4 hectares which is equivalent to 32% of the studied uses and the maximum weight of 0.4 was associated with irrigated agriculture.These resulted were obtained based on five factors (i.e. the current area of each land use, the favorable area for each land use based on MCE method, the occupational dependencies of different individuals to each land uses, prioritizing the ecological, economic, and social aspects of each land use).Finally, the results showed that selecting the suitable lands with spatial planning point of view using a Multi-Objective Land Allocation method is carried out properly through economic, social, and ecological aspects.…”
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications by Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase

“…Intestinal microbiota can be modulated by changing one’s lifestyle but also by antibiotic, probiotic, prebiotic, and fecal transplantation. …”
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The Use of Trichostatin A during Pluripotent Stem Cell Generation Does Not Affect MHC Expression Level by Sara Farahi, Sara Hosseini, Hossein Ghanbarian, Seyed Mahmoud Hashemi, Mohammad Salehi, Samaneh Hosseini

“…Highly efficient generation of PSCs through chromatin modulators such as trichostatin A (TSA) might change their MHC molecule expression profile. …”
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Mexicanidad und Ironie durch die Revolution hindurch. Kompositionsstrategien in und diskursive Konstellationen um Revueltas’ Janitzio by Jonas Reichert

“…A method of composition with sound modules is identified, through which strong contrasts can be created. …”
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Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents by Jie Dai, Qianyue Li, Ziyi Li, Zhonglin Zang, Yan Luo, Chenghe Zhou

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Prospects for mine geological work in the intelligence age: Architecture of the intelligent geological guarantee technology system for mine exploitation by Yucheng XIA, Xueyang SUN, Lintian MIAO, Chen GUO, Rongjun DU

“…., the intelligent management subsystem for fundamental geological survey information, the intelligent prediction and early warning subsystem for geologic hazards in mines, the intelligent monitoring, prediction, and early warning subsystem for ecosystems in mining areas, the intelligent identification subsystem for favorable mining blocks, and the transparent mining face subsystem), as well as their core modules. ConclusionsNotably, with the constant advancements in technologies for geological explorations and detections, the effectiveness of the technology system depends on the accuracy and reliability of original data, ultimately relying on the number and professional quality of personnel engaged in geological surveys. …”
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Gut colonization of Bacteroides plebeius suppresses colitis-associated colon cancer development by Hung-Lin Chen, Po-Yuan Hu, Chang-Shan Chen, Wei-Han Lin, Daniel K. Hsu, Fu-Tong Liu, Tzu-Ching Meng

“…Such findings underscore the potential of harnessing specific microbes, like B. plebeius shown in this study, to modulate the gut ecosystem and mitigate the risk of colitis-associated colon cancer.…”
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Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach... by Devi Soorya Narayana S, Vino Sundararajan

“…<h4>Conclusion</h4>Our study underscores the significant role of miR-29 in modulating the expression of hub genes and the associated transcription factors, which are crucial in the comorbidity status of RA, dementia, and IBD. …”
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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…Finally, in the L1000 dataset, we identify drugs that can potentially be used to modulate expression of these genes. Conclusions Here we identify significant differences in isoform usage, disordered domain content, and variable binding partners between human epigenes and non-epigenes using various functional genomics datasets from Ensembl, ENCODE, GTEx, HPO, LINCS L1000, and BrainSpan. …”
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Decreased Hospital Length of Stay for ICH and PE after Adoption of an Artificial Intelligence-Augmented Radiological Worklist Triage System by Michael Petry, Charlotte Lansky, Yosef Chodakiewitz, Marcel Maya, Barry Pressman

“…Pre-AI and post-AI time periods were defined around the deployment dates of the ICH and PE modules, respectively. The reduction in LOS was 1.30 days (95% C.I. 0.1–2.5), resulting in an observed percentage decrease of 11.9% (p value = 0.032), for ICH and 2.07 days (95% C.I. 0.1–4.0), resulting in an observed percentage decrease of 26.3% (p value = 0.034), for PE when comparing the pre-AI and post-AI time periods. …”
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The Effects of Noxious Electrical Stimulation and Eccentric Exercise on Mechanical and Thermal Pain Sensitivity in Recreational Runners with Achilles Tendinopathy by Scott K. Stackhouse, Brian J. Eckenrode, Kathleen C. Madara

“…Both exercise and electrical stimulation have the potential to modulate the nervous system’s sensitivity to painful stimuli…”
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Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study by Hanan M. Fayed, Ali A. Ghweil, Mona M. AbdelMeguid

“…SOF/DCV therapy efficiently decreases viral load, reduces fibrosis potentials, attenuates monocyte activation, normalizes monocytes phenotypic abnormalities, and modulates monocyte subsets recruitment and differentiation later in the liver.…”
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An Investigation of Infrared Small Target Detection by Using the SPT–YOLO Technique by Yongjun Qi, Shaohua Yang, Zhengzheng Jia, Yuanmeng Song, Jie Zhu, Xin Liu, Hongxing Zheng

“…The space-to-depth convolution module is introduced as a downsampling layer in the backbone first and achieves the same sampling effect. …”
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