-
6141
Genome-Wide Expression Difference of MicroRNAs in Basal Cell Carcinoma
Published 2021-01-01“…These results revealed the association between BCCs and abundant miRNA molecules that regulate target genes, functional modules, and signaling pathways in carcinogenesis.…”
Get full text
Article -
6142
Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult...
Published 2018-01-01“…In some animals, viable or nonviable F344 rat mesenchymal precursor cells (rMPCs) were injected into the lesion site two weeks after SCI to modulate the inhibitory environment. Treatment with AAV-CNTFmCherry, as well as with AAV-CNTFmCherry combined with rMPCs, yielded functional improvements over AAV-GFP alone, as assessed by open-field and Ladderwalk analyses. …”
Get full text
Article -
6143
A numerical investigation of heat transfer performance in a prismatic battery cooling system using hybrid nanofluids
Published 2025-02-01“…This research highlights the potential of hybrid nanofluids as an effective coolant for enhancing the heat transfer performance of battery modules in electric vehicles and energy storage applications.…”
Get full text
Article -
6144
Effectiveness of a family customised online FOCUS programme aimed on building resiliency in dyad relationship to support dyadic illness management in persons with heart failure and...
Published 2022-07-01“…Given the key role and limited evidence of dyad illness management in improving dyad health in the context of HF, we developed a customisable, relationship focused, family online dynamic disease management programme—FOCUS programme—to improve dyad health for HF patients and their informal caregivers in China.Methods and analysis Based on the Theory of Dyadic Illness Management and the Systemic Transactional Model of Stress and Coping, the family customised online FOCUS programme has five modules: (1) family participatory; (2) open communication; (3) coping effectiveness; (4) uncertainty reduction and 5) shared dyad life stories. …”
Get full text
Article -
6145
G Protein-Coupled Receptor 17 Inhibits Glucagon-like Peptide-1 Secretion via a Gi/o-Dependent Mechanism in Enteroendocrine Cells
Published 2024-12-01“…We previously showed that G protein-coupled receptor 17 (GPR17) is expressed in intestinal enteroendocrine cells (EECs) and modulates nutrient-induced GLP-1 secretion. However, the GPR17-mediated molecular signaling pathways in EECs have yet to be fully deciphered. …”
Get full text
Article -
6146
Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling
Published 2025-06-01“…Neurosteroid allopregnanolone is suggested to modulate the expression of various receptors or enzymes that involved in pain perception, presenting an analgesic potential. …”
Get full text
Article -
6147
Artemisia capillaris with two novel active compounds, Kawarayomogin I and II, inhibits HYBID (KIAA1199) expression as well as hyaluronic acid degradation
Published 2025-01-01“…Subsequent mechanism elucidation studies showed that ACFE epigenetically regulates the expression of HYBID by modulating the expression of a specific miRNA, miR-486-5p, which is known to directly target and inhibit HYBID expression. …”
Get full text
Article -
6148
Oxidative stress and dysregulated long noncoding RNAs in the pathogenesis of Parkinson’s disease
Published 2025-01-01“…Oxidative stress and lncRNAs also affect other processes associated with neurodegeneration, including mitochondrial dysfunction and increased neuroinflammation that lead to neuronal death. Therefore, modulating the levels of specific lncRNAs may alleviate pathological oxidative damage and have neuroprotective effects. …”
Get full text
Article -
6149
Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Published 2020-01-01“…The Bacillus Calmette–Guerin (BCG) vaccine can modulate the immune response and decelerate disease progression. …”
Get full text
Article -
6150
Cis‐Regulation of an m6A Eraser by an Insertion Variant Associated with Survival of Patients With Non‐Small Cell Lung Carcinoma
Published 2025-02-01“…Triggered by an insertion variant, this remote cis‐regulation of m6A eraser and the downstream molecular events modulate the survival of NSCLC patients.…”
Get full text
Article -
6151
Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro
Published 2014-01-01“…Blocking the function of IL-1 signal pathway could suppress the level of IL-17A, which played the major role in modulating silica-induced Th responses in vitro.…”
Get full text
Article -
6152
Multi-Task Learning for Alzheimer’s Disease Diagnosis and Mini-Mental State Examination Score Prediction
Published 2024-09-01“…Then, we propose feature sharing module to obtain shared features from candidate features and return shared features to task branches, which can promote the learning of each task. …”
Get full text
Article -
6153
DeepGlioSeg: advanced glioma MRI data segmentation with integrated local-global representation architecture
Published 2025-02-01“…First, a CTPC (CNN-Transformer Parallel Combination) module leverages parallel branches of CNN and Transformer networks to fuse local and global features of glioma images, enhancing feature representation. …”
Get full text
Article -
6154
Adaptive cognitive control in 4 to 7-year-old children and potential effects of school-based yoga-mindfulness interventions: an exploratory study in Italy
Published 2025-01-01“…Moreover, they successfully modulate interference control as a function of environmental contingencies, displaying more optimal conflict resolution when proactive control is engaged. …”
Get full text
Article -
6155
Mesenchymal stem cell-derived extracellular vesicles enriched with miR-124 exhibit anti-inflammatory effects in collagen-induced arthritis
Published 2024-01-01“…MSC-EVs overexpressed with inflammation-modulating miRNAs offer a promising cell-free approach for treating inflammatory arthritis.…”
Get full text
Article -
6156
Experimental and Modeling Study for the Solar-Driven CO<sub>2</sub> Electrochemical Reduction to CO
Published 2025-01-01“…COMSOL<sup>®</sup> Multiphysics 6.3 was used to develop a detailed finite element method model of the electrochemical cell integrated with a photovoltaic module, validated with the experimental results that demonstrated a strong correlation. …”
Get full text
Article -
6157
The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil
Published 2019-01-01“…In vitro-expanded bone marrow stromal cells (BMSCs) have long been proposed for the treatment of complex bone-related injuries because of their inherent potential to differentiate into multiple skeletal cell types, modulate inflammatory responses, and support angiogenesis. …”
Get full text
Article -
6158
Reduction of Scarce Materials in Silicon Heterojunction Solar Cells and Implications on the Performance in the Field
Published 2025-02-01“…Considering low light conditions TCO-precursor type with differences in passivation have a strong impact. On module level similar irradiation dependence of the efficiency was found and in temperature-dependent IV-measurements a positive impact of high-quality passivation on the temperature coefficients was found while an increase of the series resistance had a negative impact on the temperature dependence. …”
Get full text
Article -
6159
LINC01355 Contributes to Malignant Phenotype of Oral Squamous Cell Carcinoma and Cytotoxic T Cell Infiltration via Activating Notch Signaling Pathway
Published 2021-01-01“…In conclusion, it was implied that LINC01355 might induce the development of OSCC via modulating the Notch signal pathway, which could provide a candidate therapeutic target for OSCC.…”
Get full text
Article -
6160
Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera)
Published 2025-01-01“…Conclusions In summary, these data indicate that DWV modulates the host ArgK through transcriptional regulation and cooptation to enhance its fitness in honey bees. …”
Get full text
Article