Circulating microRNA panels for multi-cancer detection and gastric cancer screening: leveraging a network biology approach by Leila Kamkar, Samaneh Saberi, Mehdi Totonchi, Kaveh Kavousi

“…To prioritize miRNAs, module membership measure and miRNA trait significance were employed. …”
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Alcohol, alcoholism and related consequences by M. V. Mayevskaya

“…Pharmaceutical therapy of alcohol-induced dependency made a major step forward as well with introduction of new class of drugs – opioid system modulators represented by nalmefene and naltrexone. …”
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Multi-Physical Field Coupling Analysis of Electro-Controlled Permanent Magnet Blank Holder Processes Considering Thermal Magnetic Losses by Zhanshan Wang, Linyuan Meng, Gaochao Yu, Xiaoyu Ji

“…Therefore, in practical applications, it is necessary to establish a real-time temperature monitoring system and develop a temperature-based magnetic force compensation module.…”
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Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation by Li Lu, Li Zhitao, Cui Nannan, Huang Mingzhu, Hu Xiaoping, Hong Dongsheng, Pan Zongfu, Lu Xiaoyang

“…Inhibiting Idh2 or Sirt3 reduced cellular ATP content and insulin secretion levels that increased by Mfn2 overexpression. Thus, Mfn2 modulated the induced β cell GSIS by influencing the TCA cycle through Sirt3/Idh2 activation. …”
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Chaotic spiral based reconfiguration scheme for the mitigation of power loss in solar photovoltaic (PV) systems by Karthick. B, M. Sudhakaran

“…The performance of photovoltaic (PV) arrays is significantly compromised by partial shading, which leads to reduced energy output and the formation of hotspots that can damage the modules. As the global shift towards renewable energy intensities, optimizing solar energy utilization has become a pressing concern. …”
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PATHOPHYSIOLOGIC MECHANISMS OF THE INFLUENCE OF TISSUE RESPIRATION ENZYMES ON THE MITOCHONDRIAL FUNCTION IN PATIENTS WITH CHRONIC HEPATITIS C by I.Y. Bagmut, S.M. Gramatiuk

“…Mitochondrial division is a key determinant of mitochondrial quality control, and HCV modulates these key processes in the adaptation to cellular physiological perturbations associated with infection to promote viral persistence. …”
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Mitochondrial-ER Contact Sites and Tethers Influence the Biosynthesis and Function of Coenzyme Q by Noelle Alexa Novales, Hadar Meyer, Yeynit Asraf, Maya Schuldiner, Catherine F. Clarke

“…Coq11 is suggested to act as a negative modulator of CoQ synthome assembly and CoQ synthesis, as its deletion enhances Coq polypeptide content, produces an enlarged CoQ synthome, and restores respiration in mutants lacking the CoQ chaperone polypeptide, Coq10. …”
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The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes w... by Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, Surita R Bhatia, Daniel P Raleigh

“…The triphenylmethane dye, brilliant blue G (BBG, Sodium;3-[[4-[(E)-[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]-2-methylcyclohexa-2,5-dien-1-ylidene]methyl]-N-ethyl-3-methylanilino]methyl]benzenesulfonate) has been shown to modulate Aβ amyloid formation and inhibit Aβ induced toxicity. …”
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Team Assembly Mechanisms and the Knowledge Produced in the Mexico’s National Institute of Geriatrics: A Network Analysis and Agent-Based Modeling Approach by Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Augusto Cabrera-Becerril, David Fajardo-Ortiz

“…The main result of these experiments is that by modulating just one variable (homophily), we could successfully reproduce the current situation of INGER (homophily of 79%) and simulate alternative scenarios in which interdisciplinary (46%) and transdisciplinary (14%) research could be done.…”
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Evaluation of Mast Cells in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma by Ashish Shrestha, Shashi Keshwar, Toniya Raut

“…Mast cell is a key immune modulating cell which is primarily involved in initiation and propagation of inflammation. …”
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Thesis Overview: Oscillating wave surge converters – Large eddy simulation modelling of wave farms hydrodynamics and its related energy potential by Guilherme Fuhrmeister Vargas, Alexandre Beluco

“…In this context, a detailed study of a wave farm composed of several OWSCs is necessary, which represents a case closer to reality, since most renewable systems include several modules of the same converter. Considering the complexity of the existing hydrodynamics in these cases, a numerical modeling methodology based on the Large Eddy Simulation (LES) methodology is applied to correctly represent the oscillation of the structure and the observed flow fields. …”
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Assessing the Impact of Inclusive Education on Children with Disabilities in Kisoro Municipality. by Tusingwire, Hope

“…The government should include a module on Special needs in the training of all teachers so that they all know what to do. …”
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Quel Français Pour Les Etudiants De La Faculte De Genie De L’universite De Kabale? by Ayebare, Boniface Martial

“…Notre recherche recommande l’élaboration d’un module détaillé de français sur objectifs spécifiques (FOS) spécialisé en français de l’Ingénierie. …”
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Investigating the effect of synthetic cobalt and nickel oxide nanoparticles on the growth and physiology of Mungbean (Vigna radiata L.) seedlings, and exploring tunable magnetism s... by Anjali Joshi, Simranjeet Kaur, Pargat Singh, Havneet Singh, Keya Dharamvir, Harsh Nayyar, Gaurav Verma

“…The interaction of CoO and NiO nanoparticles with plant systems revealed significant modifications in magnetic properties, offering potential avenues for modulating plant growth through external magnetic fields. …”
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Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs by Wei Li, Wei Li, Wei Li, Peiyue Luo, Peiyue Luo, Peiyue Luo, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Lifeng Gan, Lifeng Gan, Lifeng Gan, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Liying Zheng, Biao Qian, Biao Qian

“…Research has demonstrated that DNA methylation not only directly influences the expression of miRNA genes but also indirectly affects the maturation and functionality of miRNAs by modulating the methylation status of miRNA promoter regions. …”
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Exploration of the shared diagnostic genes and molecular mechanism between obesity and atherosclerosis via bioinformatic analysis by Wenrong An, Kegong Tang, Juan Liu, Wenfei Zheng, Guoxia Li, Yunsheng Xu

“…By intersecting the key module genes of WGCNA with DEGs in OB and AS, 56 shared genes with the same expression trend were identified. …”
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mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy by Tae Kwon Moon, Im Kyeung Kang, Kyoung Jin Lee, Ji Hyun Kim, Hee Jong Kim, A. Reum Han, Ha-Na Woo, Joo Yong Lee, Jun-Sub Choi, Keerang Park, Heuiran Lee

“…Previously, we demonstrated that AAV2-shmTOR, effective across distinct species, holds therapeutic promise by modulating the activated mTOR pathway, yet its mechanisms for reducing inflammation remain largely unexplored. …”
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Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice by Yang Bai, Danling Jiang, Boda Wu, Jiao Peng, Ji Wang, Yuhui Chen, Xi Li

“…The stained results indicated that Que@Gel-DA NPs attenuate inflammation by promoting the polarization of M2 macrophages to reduce apoptosis and modulate immunity. Therefore, Que@Gel-DA NPs, a ROS-sensitive nano-drug delivery system, represent a novel therapeutic approach for the clinical intervention of UC.…”
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Biotin's protective effects against nicotine withdrawal-induced anxiety and depression: Mechanistic insights into serotonin, inflammation, BDNF, and oxidative stress in male rats by Dawood Hossaini, Mohammad Jalal Nazari, Khan Baba Ghazanfar, Mohammad Edris Amiri, Mohammad Tariq Anwary, Mohammad Jawad Jawad, Murtaza Haidary

“…Given the complex neurobiological mechanisms underlying withdrawal symptoms, biotin's ability to modulate critical signaling pathways such as serotonin metabolism, neuroinflammation, and oxidative stress could provide a multifaceted treatment approach.…”
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Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103+DC cells by Fan‐lian Zeng, Xiao‐yan Wang, Ya‐wen Hu, Zhen Wang, Ya Li, Jing Hu, Jia‐dong Yu, Pei Zhou, Xiu Teng, Hong Zhou, Hua‐ping Zheng, Fu‐lei Zhao, Lin‐na Gu, Cheng‐cheng Yue, Shu‐wen Chen, Juan Cheng, Yan Hao, Qi‐xiang Zhao, Chen Zhang, Song Zou, Zhong‐lan Hu, Xiao‐qiong Wei, Xiao Liu, Guo‐lin Li, Nong‐yu Huang, Wen‐ling Wu, Yi‐fan Zhou, Wei Li, Kaijun Cui, Jiong Li

“…In a word, our results highlight that IL‐37 as an inhibitor of tumor immune surveillance through modulating CD103+DCs and establishing an important link between metabolism and immunity as a therapeutic target for skin cancer.…”
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