Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells by Melanie Giesen, Erika Fleck, Jürgen Scheele, Tanja Nicole Hartmann, Reinhard Henschler

“…In a competitive murine short-term homing model with i.v. co-injection of Rap1A+B siRNA-treated and control MSCs that were labeled with PKH 26 and PKH 67 fluorescent dyes, the Rap1A+B siRNA-treated MSCs were detected at increased frequencies in blood, liver, and spleen compared to control MSCs. Thus, Rap1 GTPase modulates the adhesion and migration of MSCs in vitro and may increase the bio-availability of i.v.…”
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Pre-treatment subjective sleep quality as a predictive biomarker of tDCS effects in preclinical Alzheimer's disease patients: Secondary analysis of a randomised clinical trial. by Hanna Lu, Xi Ni, Sandra Sau Man Chan, Calvin Pak Wing Cheng, Waichi Chan, Linda Chiu Wa Lam

“…<h4>Background</h4>Despite transcranial direct current stimulation (tDCS) has demonstrated encouraging potential for modulating the circadian rhythm, little is known about how well and sustainably tDCS might improve the subjective sleep quality in older adults. …”
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Assessing brain-muscle networks during motor imagery to detect covert command-following by Emilia Fló, Daniel Fraiman, Jacobo Diego Sitt

“…For the 15/38 participants who showed motor imagery, as indexed by common spatial filters and linear discriminant analysis, we contrasted the configuration of the networks during imagined movement and resting state at the group level, and subject-level classifiers were implemented using as features the weights of the NMF together with trial-wise power modulations and heart response to classify resting state from motor imagery. …”
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The preference for surprise in reinforcement learning underlies the differences in developmental changes in risk preference between autistic and neurotypical youth by Motofumi Sumiya, Kentaro Katahira, Hironori Akechi, Atsushi Senju

“…The computational modeling approach with reinforcement learning models revealed that individual preferences for surprise modulated such preferences. Conclusions These findings indicate that for NTP people, adolescence is a developmental period involving risk preference, possibly due to lower surprise aversion. …”
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The Plurality of Goal-setting in Pedagogical Activity: Integration of Mathematics on a Chessboard by S. N. Dvoryatkina, V. S. Karapetyan, S. A. Rozanova

“…Therefore, the authors propose to study the features of goal-setting with a plurality of alternatives during the process of training bachelors and masters majoring in pedagogy within the disciplines of the methodical module. The goal of the article is to theoretically substantiate, develop and implement the technology of integrative teaching mathematics on the basis of chess game with the actualization of the phenomenon of a plurality of goal-setting as an effective mechanism of content modernization in training programs of future math teachers. …”
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Definition of a Novel Cuproptosis-Relevant lncRNA Signature for Uncovering Distinct Survival, Genomic Alterations, and Treatment Implications in Lung Adenocarcinoma by Zhuning Wang, Junqiao Yao, Tengyu Dong, Xing Niu

“…Cuproptosis genes displayed aberrant expression and widespread genomic alterations across LUAD, potentially modulated by m6A/m5C/m1A RNA modification mechanisms. …”
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An explainable deep learning model for diabetic foot ulcer classification using swin transformer and efficient multi-scale attention-driven network by R. Karthik, Armaano Ajay, Anshika Jhalani, Kruthik Ballari, Suganthi K

“…These blocks dynamically adjust kernel sizes and leverage attention modules, enabling effective feature extraction. To the best of our knowledge, this is the first work reporting the findings of a dual track architecture for DFU classification, leveraging Swin transformer and EMADN networks. …”
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PPIH is a novel diagnostic biomarker associated with immune infiltration in cholangiocarcinoma by Jun Ye, Zhitao Chen, Chuan Zhang, Rui Xie, Haini Chen, Peng Ren

“…PPIH may also play a role in modulating the immune microenvironment, contributing to poor prognosis.…”
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Performance Comparison of Different Neuroimaging Methods for Predicting Upper Limb Motor Outcomes in Patients after Stroke by Jingyan Tao, Zhaoqing Li, Yang Liu, Jianhua Li, Ruiliang Bai

“…We used the upper extremity module of the Fugl-Meyer assessment (UE-FM) within 1 month of onset (baseline) and again 3 months poststroke. sMRI (T1- and T2-based) was used to measure CST-weighted lesion load (CST-wLL), and DTI was used to measure the fractional anisotropy asymmetry index (FAAI) and the ratio of fractional anisotropy (rFA). …”
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Specific nature of the integrative (complex) effect of environmental factors on hazelnut cultivars in the Russian humid subtropics by T. D. Besedina, A. P. Boyko, Ts. V. Tutberidze, N. S. Kiseleva

“…Dependencies between yield and weather were well expressed, with module values of 0.86–1.0 (p &lt; 0.05). The effect size of limiting factors is better measured with the coefficient of determination (%), a direct indicator of the correlations between harvest and weather factors. …”
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Involvement of Neuropeptide Y within Paraventricular Nucleus in Electroacupuncture Inhibiting Sympathetic Activities in Hypertensive Rats by Qi Zhang, Yingying Tan, Xin Wen, Fangfang Li

“…This study aimed to assess the hypothesis that EA treatment exerts a hypotensive action via suppressing sympathetic activities and modulating neuropeptide Y (NPY) function within the paraventricular nucleus (PVN) of hypertensive rats. …”
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Protease-activated receptor 1 in the pathogenesis of cystic fibrosis by Sarath Ranganathan, Philip Sutton, Sophie Day, Poshmaal Dhar, Kristy Azzopardi, Muhammad A Saeed, Sohinee Sarkar, Jia-Xi Han

“…Protease-activated receptor 1 (PAR1) is a cell surface receptor activated by serine proteases including neutrophil elastase, which is recognised as a potent modulator of inflammation. While PAR1 is known to play an important role in regulating inflammation, nothing is known about any potential role of this receptor in CF pathogenesis.Methods PAR1 (PAR1-/-) and intestinal-corrected CFTR (Cftr-/-) deficient mice were crossed to generate double knock-out (DKO) mutants lacking both PAR1 and CFTR, as well as matching sibling single mutant and wildtype (WT) littermate controls. …”
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The Regulation Effect of α7nAChRs and M1AChRs on Inflammation and Immunity in Sepsis by Song Hu, Yundong Wang, Hongbing Li

“…Firstly, the vagus nerve senses and regulates local or systemic inflammation by means of the Cholinergic Anti-inflammatory Pathway (CAP) and activation of α7-nicotinic acetylcholine receptors (α7nAChRs); thus, α7nAChRs play important roles for the central nervous system (CNS) to modulate peripheral inflammation; secondly, the activation of muscarinic acetylcholine receptors 1 (M1AChRs) in the forebrain can affect the neurons of the Medullary Visceral Zone (MVZ), the core of CAP, to regulate systemic inflammation and immunity. …”
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Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB by Bai Y, Wang X, Wang B

“…Notably, PDGFB was found to be associated with immune modulators. PDGFB, which is involved in various immune responses, influences the malignant characteristics of various cancer types and controls immune cell infiltration. …”
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Drug Target Investigation of <i>N</i>-<i>p</i>-Coumaroyl-<i>N</i>’-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from <i>Saxifraga tangutica</i> by Chuang Liu, Jun Dang, Minchen Wu

“…An in vitro study on liver (HepG2) cells and breast (MCF-7) cancer cells revealed that PCC modulates HSP90AA1, subsequently affecting Mut-p53 expression, triggering a cascade effect that reduced adriamycin-induced drug resistance in cells. …”
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Utilization of a Lightweight 3D U-Net Model for Reducing Execution Time of Numerical Weather Prediction Models by Hyesung Park, Sungwook Chung

“…We also propose a convolutional block attention module-based Half-UNet (CH-UNet), a lightweight 3D-based U-Net architecture, for faster deep-learning computations. …”
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Temporal–Spatial Acupuncture Effects on Poststroke Sensorimotor Cortex via Yanglingquan (GB34) by Ruoyi Liu, Yue Wang, Myadagbadam Boldbayar, Yuanyuan Li, Chen Chen, Xin Yu, Tianjiao Xu, Muzhao Zhang, Yihuai Zou, Hua Zhang

“…During finger movement, signal patterns matched the task module (movement–rest–movement–rest). In acupuncture, response patterns showed a high–low–high–low fluctuation trend across time segments. …”
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Expression and Secretion of CXCL-8 and CXCL-10 From Mycobacterium Bovis BCG-Infected Human Epithelial Cells: Role of IL-4 by Patricia Méndez-Samperio, Elena Miranda, Abraham Vázquez

“…CXC chemokine release can be modulated by Th2-derived cytokines. Interleukin(IL)-4 is one of the cytokines that are the hallmark of the Th-2 response, and plays an important role in human tuberculosis. …”
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Embedding Trust in the Media Access Control Protocol for Wireless Networks by Chaminda Alocious, Hannan Xiao, Bruce Christianson, Joseph Spring

“…This issue is further compounded when receivers such as Wi-Fi hotspots, normally trusted by other module nodes, also misbehave. Such issues, their detection, and mitigation have, we believe, not been sufficiently addressed in the literature. …”
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Exosomes and microRNAs as mediators of the exercise by Haoyuan Li, Guifang Liu, Bing Wang, Mohammad Reza Momeni

“…Environmental factors, such as physical exercise, can modulate miRNA expression and induce targeted changes in gene transcription. …”
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