The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis by Mingfa Liu, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, Haixiong Xu

“…KEGG analysis indicated that the DEGs were enriched in the MAPK signaling pathway, endocytosis, oxytocin signaling, and calcium signaling. PPI network and module analysis found 12 hub genes, which were enriched in synaptic vesicle cycling rheumatoid arthritis and collecting duct acid secretion. …”
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Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach by Chuwei Liu, Heng Liang, Arabella H. Wan, Min Xiao, Lei Sun, Yiling Yu, Shijia Yan, Yuan Deng, Ruonian Liu, Juan Fang, Zhi Wang, Weiling He, Guohui Wan

“…We further apply pum6a to study the dynamic regulation of m6A demethylases in gastric cancer under hypoxia, revealing distinct roles for FTO and ALKBH5 in modulating m6A modifications and uncovering key insights into m6A -mediated transcript stability. …”
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A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide by Angelo Santoro, Antonio Ricci, Manuela Rodriquez, Michela Buonocore, Anna Maria D’Ursi

“…Molecular dynamics simulations helped visualise the curcuminoids’ effect in an aqueous system and hypothesise the importance of the peptide surface exposition to the solvent, differently modulated by the curcumin derivatives.…”
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Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans by Chih Jen Yang, Lyndsey E. Shorey-Kendrick, Cristina Puy, Ashley E. Benson, Phillip A. Wilmarth, Ashok P. Reddy, Keith D. Zientek, Kilsun Kim, Adam Crosland, Chaevien S. Clendinen, Lisa M. Bramer, Olivia L. Hagen, Helen H. Vu, Joseph E. Aslan, Owen J.T. McCarty, Joseph J. Shatzel, Brian P. Scottoline, Jamie O. Lo

“…We identified proteomic modules associated with clotting time and enriched for coagulation-related pathways. …”
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Design of a High Step-Up DC-DC Converter with Voltage Doubler and Tripler Circuits for Photovoltaic Systems by Muhammad Yaseen, Ajmal Farooq, Muhammad Zeeshan Malik, Muhammad Usman, Ghulam Hafeez, Muhammad Ali

“…In this paper, a high step-up DC-DC interleaved boost converter is proposed for renewable sources with low voltages such as photovoltaic module and fuel cell. The proposed converter uses interleaving method with an additional voltage doubler and tripler circuit. …”
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Alleviating effects and mechanisms of action of large-leaf yellow tea drinking on diabetes and diabetic nephropathy in mice by Guangshan Zhao, Jianyuan Teng, Ruixia Dong, Qiuyan Ban, Lian Yang, Kang Du, Yifei Wang, Hanlin Pu, Chung S. Yang, Zhe Ren

“…The underlying mechanisms involve downregulation of gluconeogenesis (lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism (higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis (lower protein level of SREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. Moreover, LYT administration prevented diabetic nephropathy, possibly due to reduced glucose-caused osmotic diuresis and lowered levels of renal PKC-β2, NLRP3 as well as membrane PKC-α, AQP2 and glycosylated AQP2 proteins. …”
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Determination of Ischemia Onset Based on Automatically Generated Spectralis SD-OCT Values in Acute Central Retinal Artery Occlusion by Maria Casagrande, Robert Kromer, Daniel A. Wenzel, Sven Poli, Martin S. Spitzer, Vasyl Druchkiv, Maximilian Schultheiss, Spyridon Dimopoulos

“…The RRTI was calculated for the ETDRS sectors using the Segmentation Module for Single Retinal Layer Analysis. Receiver operating characteristic (ROC) analysis was performed to determine patients ≤4.5 hours by RRTI. …”
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Hydrogen Sulfide Increases Nitric Oxide Production and Subsequent S-Nitrosylation in Endothelial Cells by Ping-Ho Chen, Yaw-Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang

“…The present study provides an integrated insight of cellular responses to H2S and NO from protein expression to gaseous molecule generation, which indicates the upstream role of H2S in modulating NO production and protein S-nitrosylation.…”
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Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma by Lin Wang, Xinyu Liu, Haoze Lv, Han Zhang, Rimei Lin, Shan Xu, Chaojing Zhang, Shilei Lou, Zhidong Qiu, Cong Sun, Ning Cui

“…It discusses the mechanisms by which natural products modulate miRNA activity to influence apoptosis, ferroptosis, and autophagy in osteosarcoma cells, aiming to identify new strategies for osteosarcoma treatment. …”
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Age and moisture affect the relationship between competition and tree growth by Xinyu Han, Lushuang Gao, Mingqian Liu, Yihong Zhu, Keda Cui, Xinyu Zhang, Xiuhai Zhao, Ruibo Zhang, Klaus von Gadow, Yiyu Tian, Kangchen Wang

“…We observed that competition indirectly impacts tree growth by diminishing crown size, and this influence is modulated by both tree age and environmental moisture conditions. …”
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pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG by Jing Wu, Shuang Li, Tete Li, Xinping Lv, Mingyou Zhang, Guoxia Zang, Chong Qi, Yong-Jun Liu, Liang Xu, Jingtao Chen

“…TLR7, TLR7/8, and TLR9 ligands similarly modulated cytokine release, as well as protein expression of pDC markers, costimulatory molecules, and cytotoxic molecules. …”
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Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames by Lei Chen, Xia Gao, Xiangshen Liu, Ye Zhu, Dong Wang

“…The 5´ UTR and uORFs do not modulate downstream protein output under endoplasmic reticulum stress and oxidative stress conditions. …”
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Implementation of the STEPPS program for the treatment of self-harm behaviors in Catalonia’s prisons: barriers and facilitators by Rosa Lorente-Català, Irene Jaén, Xavier Buscà-Huertas, Berta Framis, Azucena García-Palacios

“…Conversely, implementation barriers of the STEPPS program in CS included the complexity of the intervention format and the mobility of inmates between modules and centers during the duration of the program. …”
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Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury by Lisa Debler, Annette Palmer, Sonja Braumüller, Bettina Klohs, Tom Eirik Mollnes, Karlheinz Holzmann, Markus Huber-Lang, Rebecca Halbgebauer

“…Enrichment analysis was conducted on selected genes strongly modulated by the HS. After additional HS in PT mice, the gene expression of pathways related to the innate immunity, such as IL-6 production, neutrophil chemotaxis, cell adhesion, and toll-like receptor signaling was upregulated, whereas pathways of the adaptive immune system, such as B- and T-cell activation as well as the MHC class II protein complex, were downregulated. …”
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Surface Modification by Combination of Dip-Pen Nanolithography and Soft Lithography for Reduction of Bacterial Adhesion by Santiago Arango-Santander, Alejandro Pelaez-Vargas, Sidónio C. Freitas, Claudia García

“…Modified surfaces might play a role in modulating cells and reducing bacterial adhesion and biofilm formation. …”
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Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse by Julia A. Galiza Soares, Samantha N. Sutley-Koury, Matthew B. Pomrenze, Matthew B. Pomrenze, Jason M. Tucciarone

“…Growing literature describes the opioid system as a powerful modulator of social separation distress and attachment formation in rodents and primates. …”
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Influence of mimicry on extinction risk in Aculeata: a theoretical approach by Boutin, Maxime, Costa, Manon, Fontaine, Colin, Perrard, Adrien, Llaurens, Violaine

“…However, only females are defended in Aculeata and this female-limited defence may modulate the effect of Mullerian mimicry on extinction risks. …”
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Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma by Haihua Wang, Songqing Fan, Yuting Zhan, Yue Xu, Yao Du, Jiadi Luo, Hongjing Zang, Shuping Peng, Weiyuan Wang

“…The overexpression of EGFR has been linked to its potential role in modulating major histocompatibility complex class I (MHC-I) molecules. …”
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Comparison of Immunomodulation Properties of Porcine Mesenchymal Stromal/Stem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue by Sun-A Ock, Raghavendra Baregundi Subbarao, Yeon-Mi Lee, Jeong-Hyeon Lee, Ryoung-Hoon Jeon, Sung-Lim Lee, Ji Kwon Park, Sun-Chul Hwang, Gyu-Jin Rho

“…Accordingly, we herein investigated the capacity of MSCs derived from several tissue sources to modulate both proinflammatory (interferon [IFN] γ and tumor necrosis factor [TNF] α) and immunosuppressive cytokines (transforming growth factor [TGF] β and interleukin [IL] 10) employing xenogeneic human MSC-mixed lymphocyte reaction (MLR) test. …”
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p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation by Ines Höfig, Yashodhara Ingawale, Michael J. Atkinson, Heidi Hertlein, Peter J. Nelson, Michael Rosemann

“…These results reveal that oxygen levels together with γ-irradiation and p53 status are interconnected factors modulating growth capacity of BM MSCs in long-term culture. …”
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